JP2014005225A - 食欲増進かつ体重増加抑制剤 - Google Patents
食欲増進かつ体重増加抑制剤 Download PDFInfo
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- JP2014005225A JP2014005225A JP2012141283A JP2012141283A JP2014005225A JP 2014005225 A JP2014005225 A JP 2014005225A JP 2012141283 A JP2012141283 A JP 2012141283A JP 2012141283 A JP2012141283 A JP 2012141283A JP 2014005225 A JP2014005225 A JP 2014005225A
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- weight gain
- appetite
- food
- body weight
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Abstract
【解決手段】ラクトバチラス・ブレビス(Lactobacillus brevis)に属するSBC8803(受託番号:FERM BP−10632)菌株の菌体又はその処理物を有効成分として含有する食欲増進かつ体重増加抑制剤。
【選択図】なし
Description
(試験方法)
<菌体処理物の調製>
SBL88株を培地(組成:マルトース2質量%、酵母エキス1.4質量%、酢酸ナトリウム0.5質量%、硫酸マンガン0.005質量%、pH6.5〜7.0)に植菌し、30℃で1日間静置培養した。得られた培養液(約8×108cfu/ml)を8,000rpmで10分間遠心分離し、菌体を回収した。回収した菌体を蒸留水に再懸濁し、8,000rpmで10分遠心分離し、菌体を回収した。この操作を2度繰り返した。回収した菌体を蒸留水に懸濁し、105℃で10分間加熱処理した後、凍結乾燥して加熱処理菌体粉末(菌体処理物)を得た。
粉末飼料CE−2(日本クレア株式会社製)にSBL88株の菌体処理物を0.5質量%添加した後、ペレット化して菌体処理物を含むマウス飼料(SBL88含有CE−2飼料)を調製した。対照として、粉末飼料CE−2をペレット化して菌体処理物を含まないマウス飼料(CE−2飼料)を調製した。
C3H/HeN系統のマウス(3週齢の雄性、日本エスエルシー株式会社)を2週間馴化飼育した。馴化後、マウスを2群(各群5匹)に分け、対照群には食餌としてCE−2飼料を、被検群(SBL88群)には食餌としてSBL88含有CE−2飼料を与え、4週間自由摂食させた。
自由摂食期間中1週間毎に摂餌量及びマウスの体重を測定した。摂餌量(g/day)は、1週間の餌の減少量を測定し、1日あたりの減少量に換算して求めた。各群の摂餌量及び体重は、各群5匹のマウスの平均値として求めた。有意差の有無は、Studentのt検定を用いて判定した。
図1は、マウスの摂餌量推移を示すグラフである。試験開始2週間後(飼育期間2週)には、対照群と比べてSBL88群の摂餌量は危険率5%で有意に増加した。この傾向は試験開始3週間後(飼育期間3週)及び4週間後(飼育期間4週)にかけてより顕著となり、いずれも対照群と比べてSBL88群の摂餌量は危険率5%で有意に増加した。
Claims (4)
- ラクトバチラス・ブレビス(Lactobacillus brevis)に属するSBC8803(受託番号:FERM BP−10632)菌株の菌体又はその処理物を有効成分として含有する食欲増進かつ体重増加抑制剤。
- 請求項1に記載の食欲増進かつ体重増加抑制剤を含有する医薬品。
- 請求項1に記載の食欲増進かつ体重増加抑制剤を含有する飲食品。
- 請求項1に記載の食欲増進かつ体重増加抑制剤を含有する飲食品添加物。
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WO2018012578A1 (ja) * | 2016-07-14 | 2018-01-18 | 株式会社明治 | グレリン分泌促進剤 |
JP2019048849A (ja) * | 2018-11-14 | 2019-03-28 | 株式会社明治 | グレリン分泌促進剤 |
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JP2001321163A (ja) * | 2000-05-17 | 2001-11-20 | Bioneer Corp | 肥満又は糖尿病治療用微生物及びその微生物を含む医薬組成物 |
JP2005269968A (ja) * | 2004-03-24 | 2005-10-06 | Aaku Giken:Kk | 乳酸菌生産物質 |
JP2012036158A (ja) * | 2010-08-11 | 2012-02-23 | Sapporo Breweries Ltd | 中性脂肪低減剤 |
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JP2001321163A (ja) * | 2000-05-17 | 2001-11-20 | Bioneer Corp | 肥満又は糖尿病治療用微生物及びその微生物を含む医薬組成物 |
JP2005269968A (ja) * | 2004-03-24 | 2005-10-06 | Aaku Giken:Kk | 乳酸菌生産物質 |
JP2012036158A (ja) * | 2010-08-11 | 2012-02-23 | Sapporo Breweries Ltd | 中性脂肪低減剤 |
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WO2018012578A1 (ja) * | 2016-07-14 | 2018-01-18 | 株式会社明治 | グレリン分泌促進剤 |
JP2018008901A (ja) * | 2016-07-14 | 2018-01-18 | 株式会社明治 | グレリン分泌促進剤 |
JP2019048849A (ja) * | 2018-11-14 | 2019-03-28 | 株式会社明治 | グレリン分泌促進剤 |
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