JP2009503045A5 - - Google Patents
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- Publication number
- JP2009503045A5 JP2009503045A5 JP2008524588A JP2008524588A JP2009503045A5 JP 2009503045 A5 JP2009503045 A5 JP 2009503045A5 JP 2008524588 A JP2008524588 A JP 2008524588A JP 2008524588 A JP2008524588 A JP 2008524588A JP 2009503045 A5 JP2009503045 A5 JP 2009503045A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- inflammatory
- disease
- arthritis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 200000000018 inflammatory disease Diseases 0.000 claims 8
- 230000001684 chronic Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 2
- 230000001154 acute Effects 0.000 claims 2
- 201000005569 gout Diseases 0.000 claims 2
- 206010003246 Arthritis Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010011401 Crohn's disease Diseases 0.000 claims 1
- 206010018634 Gouty arthritis Diseases 0.000 claims 1
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 1
- 210000004072 Lung Anatomy 0.000 claims 1
- 206010037162 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010038294 Reiter's syndrome Diseases 0.000 claims 1
- 206010048873 Traumatic arthritis Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000002917 arthritic Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 230000028709 inflammatory response Effects 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical group CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000002062 proliferating Effects 0.000 claims 1
- 201000001263 psoriatic arthritis Diseases 0.000 claims 1
- 201000005404 rubella Diseases 0.000 claims 1
- 201000002661 spondylitis Diseases 0.000 claims 1
- 201000006704 ulcerative colitis Diseases 0.000 claims 1
Claims (9)
- ３，１１ｂ−シス−ジヒドロテトラベナジンまたはその薬学上許容可能な塩を含んでなる、増殖性疾患または炎症性疾患の予防または治療のための医薬組成物。
- 炎症性疾患の予防または治療のための、請求項１に記載の医薬組成物。
- 炎症性疾患が、関節リウマチ、変形性関節症、外傷性関節炎、痛風性関節炎、風疹関節炎、乾癬性関節炎、および他の関節炎症状；急性または慢性炎症性疾患状態；ライター症候群、痛風、リウマチ様脊椎炎、慢性肺炎症性疾患、クローン病および潰瘍性大腸炎から選択される、請求項２に記載の医薬組成物。
- 炎症性疾患が、関節リウマチである、請求項３に記載の医薬組成物。
- 炎症性疾患が、内毒素または炎症性腸疾患によって誘発される炎症性反応である、急性または慢性炎症疾患状態である、請求項３に記載の医薬組成物。
- ３，１１ｂ−シス−ジヒドロテトラベナジンが、本明細書で定義された異性体Ｂまたは異性体Ｄである、請求項１〜５のいずれか一項に記載の医薬組成物。
- ３，１１ｂ−シス−ジヒドロテトラベナジンが、式（Ｉａ）：
- ３，１１ｂ−シス−ジヒドロテトラベナジンが、酸付加塩の形態である、請求項１〜７のいずれか一項に記載の医薬組成物。
- 塩が、メタンスルホン酸塩である、請求項８に記載の医薬組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0516168.2A GB0516168D0 (en) | 2005-08-05 | 2005-08-05 | Pharmaceutical compounds |
| PCT/GB2006/002909 WO2007017643A1 (en) | 2005-08-05 | 2006-08-04 | 3 , llB-CIS-DIHYDROTETRABENAZINE FOR THE TREATMENT OF A PROLIFERATIVE DISEASE OR AN INFLAMMATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009503045A JP2009503045A (ja) | 2009-01-29 |
| JP2009503045A5 true JP2009503045A5 (ja) | 2009-09-17 |
Family
ID=34984180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008524588A Pending JP2009503045A (ja) | 2005-08-05 | 2006-08-04 | 増殖性疾患または炎症に用いられる３，１１ｂ−シス−ジヒドロテトラベナジン |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20090275605A1 (ja) |
| EP (2) | EP1964565A1 (ja) |
| JP (1) | JP2009503045A (ja) |
| KR (1) | KR20080033501A (ja) |
| CN (1) | CN101321528B (ja) |
| AT (1) | ATE412414T1 (ja) |
| AU (1) | AU2006277836B8 (ja) |
| CA (1) | CA2620952A1 (ja) |
| CY (1) | CY1108729T1 (ja) |
| DE (1) | DE602006003415D1 (ja) |
| DK (1) | DK1861100T3 (ja) |
| ES (1) | ES2317564T3 (ja) |
| GB (1) | GB0516168D0 (ja) |
| HK (1) | HK1111084A1 (ja) |
| HR (1) | HRP20090017T3 (ja) |
| MX (1) | MX2008001546A (ja) |
| NZ (1) | NZ566010A (ja) |
| PL (1) | PL1861100T3 (ja) |
| PT (1) | PT1861100E (ja) |
| RS (1) | RS50720B (ja) |
| RU (1) | RU2409364C2 (ja) |
| SI (1) | SI1861100T1 (ja) |
| WO (1) | WO2007017643A1 (ja) |
| ZA (2) | ZA200801170B (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
| GB0514501D0 (en) * | 2005-07-14 | 2005-08-24 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| JP5290185B2 (ja) | 2006-11-08 | 2013-09-18 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 置換３−イソブチル−９，１０−ジメトキシ−１，３，４，６，７，１１ｂ−ヘキサヒドロ−２Ｈ−ピリド［２，１−ａ］イソキノリン−２−オール化合物およびそれに関連する方法 |
| GB0721669D0 (en) * | 2007-11-02 | 2007-12-12 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
| US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| GB2463451A (en) | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| CA2801061A1 (en) | 2010-06-01 | 2011-12-08 | Auspex Pharmaceuticals, Inc. | Benzoquinolone inhibitors of vmat2 |
| CN102285984B (zh) * | 2010-11-25 | 2012-10-10 | 江苏威凯尔医药科技有限公司 | (2R,3R,11bR)-二氢丁苯那嗪及相关化合物的制备方法 |
| CA2936823A1 (en) | 2014-01-27 | 2015-07-30 | Auspex Pharmaceuticals, Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| MA41177A (fr) * | 2014-12-15 | 2017-10-24 | Esteve Labor Dr | Utilisation de ligands des récepteurs sigma dans l'arthrose |
| WO2017164407A1 (ja) * | 2016-03-25 | 2017-09-28 | 国立大学法人東北大学 | 免疫チェックポイント阻害作用を有するインドールアルカロイド型化合物 |
| CN109283279B (zh) * | 2017-07-21 | 2019-11-01 | 南京正大天晴制药有限公司 | 通过高效液相色谱法分离测定雷替曲塞及其对映异构体的方法 |
| CN109283263B (zh) * | 2017-07-21 | 2019-06-25 | 南京正大天晴制药有限公司 | 用于雷替曲塞合成质量控制的检测分析方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2954382A (en) * | 1960-09-27 | Xpreparation of hexahydrobenzoquinol- | ||
| US3209005A (en) * | 1965-09-28 | Hexahydro-llbh-benzo[a] quinolizines and processes therefor | ||
| US3314966A (en) * | 1967-04-18 | Substituted benzo[a]quinolizines | ||
| US3079395A (en) * | 1963-02-26 | Novel z-oxq-benzoquinoliaine | ||
| US3095419A (en) * | 1963-06-25 | Process for preparing z-oxo-j- | ||
| US3132147A (en) * | 1964-05-05 | |||
| US3159638A (en) * | 1964-12-01 | Xcha-chj | ||
| US3009918A (en) * | 1961-11-21 | Chz ch | ||
| US3123609A (en) * | 1964-03-03 | Benzo | ||
| US2843591A (en) * | 1958-07-15 | Method for preparing same | ||
| US3053845A (en) * | 1962-09-11 | Benzofykedocolines | ||
| US2830993A (en) | 1958-04-15 | Quinolizine derivatives | ||
| US3045021A (en) * | 1959-09-24 | 1962-07-17 | Hoffmann La Roche | Preparation of substituted 2-oxobenzoquinolizines |
| GB999092A (en) * | 1959-11-24 | 1965-07-21 | Wellcome Found | Method for making benzo(a)-quinolizine derivatives |
| US3375254A (en) * | 1961-09-29 | 1968-03-26 | Burroughs Wellcome Co | Manufacture of 1, 2, 3, 4, 6, 7-hexahydro-2-oxo-11bh-benzo(a)quinolizines |
| US3105079A (en) * | 1961-12-29 | 1963-09-24 | Pfizer & Co C | 10-aminobenzopyridocolines |
| US3390152A (en) * | 1965-10-21 | 1968-06-25 | Abbott Lab | 9, 10-alkoxy-3-alkyl-2, 2-(dithiosubstituted)-benzoquinolizines |
| US3635986A (en) * | 1969-12-22 | 1972-01-18 | Miles Lab | 2-substituted amino-hexahydrobenzo(a)quinolizines |
| US3634431A (en) * | 1969-12-22 | 1972-01-11 | Miles Lab | Acylated and alkylated derivatives of 2-aminohexahydrobenzo(a)quinolizines |
| YU264675A (en) * | 1974-10-23 | 1982-05-31 | Chinoin Gyogyszer Es Vegyeszet | Process for obtaining benzo (a)-quinolizidine derivatives |
| GB1513824A (en) * | 1975-05-22 | 1978-06-14 | Wyeth John & Brother Ltd | 1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative |
| US4133812A (en) * | 1975-11-21 | 1979-01-09 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Process for producing benzo (a) quinolizine derivatives |
| US4304913A (en) * | 1978-11-20 | 1981-12-08 | Miles Laboratories, Inc. | Trans-2-substituted-amido-hexahydrobenzo [A]quinolizines |
| US4353656A (en) * | 1980-10-14 | 1982-10-12 | Xerox Corporation | Moving coil, multiple energy print hammer system including a closed loop servo |
| US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| CA1272917A (en) * | 1985-07-30 | 1990-08-21 | Paul Kenneth Rand | Devices for administering medicaments to patients |
| GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| US6087376A (en) * | 1997-02-05 | 2000-07-11 | University Of Kentucky Research Foundation | Use of lobeline compounds in the treatment of central nervous system diseases and pathologies |
| FR2794742B1 (fr) * | 1999-06-11 | 2005-06-03 | Sanofi Synthelabo | Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
| US6632666B2 (en) * | 2000-01-14 | 2003-10-14 | Biolife Solutions, Inc. | Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media |
| MXPA02010222A (es) * | 2000-04-18 | 2003-05-23 | Agouron Pharma | Pirazoles para inhibir proteina cinasa. |
| AU2004249211A1 (en) * | 2003-06-16 | 2004-12-29 | Andrx Pharmaceuticals, Llc | Oral extended-release composition |
| GB2410947B (en) | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
| KR100682506B1 (ko) * | 2005-01-18 | 2007-02-15 | (주)젠크로스 | 프라지콴텔, 또는 이의 염을 포함하는 약학 조성물 |
| GB0514501D0 (en) * | 2005-07-14 | 2005-08-24 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
| US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| GB2463451A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
-
2005
- 2005-08-05 GB GBGB0516168.2A patent/GB0516168D0/en not_active Ceased
-
2006
- 2006-08-04 CA CA002620952A patent/CA2620952A1/en not_active Abandoned
- 2006-08-04 PT PT06765213T patent/PT1861100E/pt unknown
- 2006-08-04 RS RSP-2009/0015A patent/RS50720B/sr unknown
- 2006-08-04 SI SI200630187T patent/SI1861100T1/sl unknown
- 2006-08-04 AU AU2006277836A patent/AU2006277836B8/en not_active Expired - Fee Related
- 2006-08-04 CN CN2006800366007A patent/CN101321528B/zh not_active Expired - Fee Related
- 2006-08-04 EP EP08104275A patent/EP1964565A1/en not_active Withdrawn
- 2006-08-04 DE DE602006003415T patent/DE602006003415D1/de active Active
- 2006-08-04 ZA ZA200801170A patent/ZA200801170B/xx unknown
- 2006-08-04 US US11/997,675 patent/US20090275605A1/en not_active Abandoned
- 2006-08-04 ZA ZA200801171A patent/ZA200801171B/xx unknown
- 2006-08-04 JP JP2008524588A patent/JP2009503045A/ja active Pending
- 2006-08-04 AT AT06765213T patent/ATE412414T1/de active
- 2006-08-04 DK DK06765213T patent/DK1861100T3/da active
- 2006-08-04 ES ES06765213T patent/ES2317564T3/es active Active
- 2006-08-04 PL PL06765213T patent/PL1861100T3/pl unknown
- 2006-08-04 WO PCT/GB2006/002909 patent/WO2007017643A1/en active Application Filing
- 2006-08-04 RU RU2008108516/15A patent/RU2409364C2/ru not_active IP Right Cessation
- 2006-08-04 MX MX2008001546A patent/MX2008001546A/es active IP Right Grant
- 2006-08-04 EP EP06765213A patent/EP1861100B1/en active Active
- 2006-08-04 NZ NZ566010A patent/NZ566010A/en not_active IP Right Cessation
- 2006-08-04 KR KR1020087005309A patent/KR20080033501A/ko not_active Application Discontinuation
-
2008
- 2008-05-20 HK HK08105581.6A patent/HK1111084A1/xx not_active IP Right Cessation
-
2009
- 2009-01-14 HR HR20090017T patent/HRP20090017T3/xx unknown
- 2009-01-27 CY CY20091100100T patent/CY1108729T1/el unknown
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