JP2005206534A - 抗リーシュマニア剤 - Google Patents
抗リーシュマニア剤 Download PDFInfo
- Publication number
- JP2005206534A JP2005206534A JP2004015622A JP2004015622A JP2005206534A JP 2005206534 A JP2005206534 A JP 2005206534A JP 2004015622 A JP2004015622 A JP 2004015622A JP 2004015622 A JP2004015622 A JP 2004015622A JP 2005206534 A JP2005206534 A JP 2005206534A
- Authority
- JP
- Japan
- Prior art keywords
- roxb
- benth
- wall
- antiprotozoal
- linn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
【解決手段】 Dipterocarpus tuberculatus Roxb.;Grevillea robusta A-Cun.;Xylocarpus moluccensis(Lam.)Roem.;Tectona grandis Linn.f.;Lagerstroemia tomentosa Presl.;Terminalia chebula Retz.;Haplophragma adenophyllum (Wall.) Dep;Xylia dolabriformis Benth.;Cananga odorata Hook.f.&.T.;Michelia champaca Linn.;Cordia fragrantissima Kurz.;Acacia catechu Willd.;Albizzia procera Benth.;Dalbergia oliveri Gamble.;Terminalia tomentosa W&A.;Cedrela serrata Royle.;Calophyllum kunstleri King.;Cedrela toona Roxb.;Albizzia odoratissima Benth.;Dalbergia cultrata Grah.;Chukrasia tabularis A. Juss.;Anogeissus acuminata Wall.;Lagerstroemia villosa Wall.およびDillenia pentagyna Roxb.からなる群から選択される少なくとも1種の植物に由来し、抗原虫活性を示す物質を有効成分として含有する抗原虫剤。
【選択図】 なし
Description
しかし、現在でも、より安価で副作用が少ない治療薬の開発が望まれている。
本発明は、安価で副作用が少ない抗リーシュマニア剤を提供することを目的とする。
(1)Dipterocarpus tuberculatus Roxb.;Grevillea robusta A-Cun.;Xylocarpus moluccensis(Lam.)Roem.;Tectona grandis Linn.f.;Lagerstroemia tomentosa Presl.;Terminalia chebula Retz.;Haplophragma adenophyllum (Wall.) Dep;Xylia dolabriformis Benth.;Cananga odorata Hook.f.&.T.;Michelia champaca Linn.;Cordia fragrantissima Kurz.;Acacia catechu Willd.;Albizzia procera Benth.;Dalbergia oliveri Gamble.;Terminalia tomentosa W&A.;Cedrela serrata Royle.;Calophyllum kunstleri King.;Cedrela toona Roxb.;Albizzia odoratissima Benth.;Dalbergia cultrata Grah.;Chukrasia tabularis A. Juss.;Anogeissus acuminata Wall.;Lagerstroemia villosa Wall.およびDillenia pentagyna Roxb.からなる群から選択される少なくとも1種の植物に由来し、抗原虫活性を示す物質を有効成分として含有する抗原虫剤。
(2)抗リーシュマニア剤である(1)記載の抗原虫剤。
(4)前記植物の心材の抽出物またはその処理物を有効成分として含有する(3)記載の抗原虫剤。
(5)抗リーシュマニア剤である(3)または(4)記載の抗原虫剤。
本発明の抗原虫剤は材料が安価であり、製造が容易であるため、安価である。
Medium 199培地(Life Technologies Co. Ltd.)を用いて、Leishmania major のプロマスチゴート(MHOM/SU/73/5ASKH)を培養した。プロマスチゴートは、熱不活化(56℃で30分)ウシ胎仔血清(10%)を補充した培地中、5% CO2下、27℃にて培養した。
ミャンマー産の植物75種の材部30〜50gをメタノール100 mlずつを用いて4時間、50℃で3回抽出し、抽出液を合わせて減圧下濃縮し、メタノール抽出エキスを得た。
Claims (6)
- Dipterocarpus tuberculatus Roxb.;Grevillea robusta A-Cun.;Xylocarpus moluccensis(Lam.)Roem.;Tectona grandis Linn.f.;Lagerstroemia tomentosa Presl.;Terminalia chebula Retz.;Haplophragma adenophyllum (Wall.) Dep;Xylia dolabriformis Benth.;Cananga odorata Hook.f.&.T.;Michelia champaca Linn.;Cordia fragrantissima Kurz.;Acacia catechu Willd.;Albizzia procera Benth.;Dalbergia oliveri Gamble.;Terminalia tomentosa W&A.;Cedrela serrata Royle.;Calophyllum kunstleri King.;Cedrela toona Roxb.;Albizzia odoratissima Benth.;Dalbergia cultrata Grah.;Chukrasia tabularis A. Juss.;Anogeissus acuminata Wall.;Lagerstroemia villosa Wall.およびDillenia pentagyna Roxb.からなる群から選択される少なくとも1種の植物に由来し、抗原虫活性を示す物質を有効成分として含有する抗原虫剤。
- 抗リーシュマニア剤である請求項1記載の抗原虫剤。
- Dipterocarpus tuberculatus Roxb.;Grevillea robusta A-Cun.;Xylocarpus moluccensis(Lam.)Roem.;Tectona grandis Linn.f.;Lagerstroemia tomentosa Presl.;Terminalia chebula Retz.;Haplophragma adenophyllum (Wall.) Dep;Xylia dolabriformis Benth.;Cananga odorata Hook.f.&.T.;Michelia champaca Linn.;Cordia fragrantissima Kurz.;Acacia catechu Willd.;Albizzia procera Benth.;Dalbergia oliveri Gamble.;Terminalia tomentosa W&A.;Cedrela serrata Royle.;Calophyllum kunstleri King.;Cedrela toona Roxb.;Albizzia odoratissima Benth.;Dalbergia cultrata Grah.;Chukrasia tabularis A. Juss.;Anogeissus acuminata Wall.;Lagerstroemia villosa Wall.およびDillenia pentagyna Roxb.からなる群から選択される少なくとも1種の植物の抽出物またはその処理物を有効成分として含有する抗原虫剤。
- 前記植物の心材の抽出物またはその処理物を有効成分として含有する請求項3記載の抗原虫剤。
- 抗リーシュマニア剤である請求項3または4記載の抗原虫剤。
- Dipterocarpus tuberculatus Roxb.;Grevillea robusta A-Cun.;Xylocarpus moluccensis(Lam.)Roem.;Tectona grandis Linn.f.;Lagerstroemia tomentosa Presl.;Terminalia chebula Retz.;Haplophragma adenophyllum (Wall.) Dep;Xylia dolabriformis Benth.;Cananga odorata Hook.f.&.T.;Michelia champaca Linn.;Cordia fragrantissima Kurz.;Acacia catechu Willd.;Albizzia procera Benth.;Dalbergia oliveri Gamble.;Terminalia tomentosa W&A.;Cedrela serrata Royle.;Calophyllum kunstleri King.;Cedrela toona Roxb.;Albizzia odoratissima Benth.;Dalbergia cultrata Grah.;Chukrasia tabularis A. Juss.;Anogeissus acuminata Wall.;Lagerstroemia villosa Wall.およびDillenia pentagyna Roxb.からなる群から選択される少なくとも1種の植物を粉砕する工程、得られた粉砕物を抽出する工程、および必要に応じて精製処理を行う工程を含む、抗原虫剤の製造方法。
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Cited By (2)
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KR101458062B1 (ko) | 2012-10-16 | 2014-11-04 | 한국생명공학연구원 | 딥터로카퍼스 투버큘라투스 추출물 또는 이의 분획물을 함유하는 대사성 질환 예방 및 치료용 약학적 조성물 |
CN110241243A (zh) * | 2019-06-14 | 2019-09-17 | 浙江省检验检疫科学技术研究院 | 奥氏黄檀的分子鉴定方法及其引物和探针 |
Citations (1)
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JPH08208498A (ja) * | 1995-02-07 | 1996-08-13 | Sunstar Inc | 皮膚外用剤組成物 |
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JPH08208498A (ja) * | 1995-02-07 | 1996-08-13 | Sunstar Inc | 皮膚外用剤組成物 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101458062B1 (ko) | 2012-10-16 | 2014-11-04 | 한국생명공학연구원 | 딥터로카퍼스 투버큘라투스 추출물 또는 이의 분획물을 함유하는 대사성 질환 예방 및 치료용 약학적 조성물 |
CN110241243A (zh) * | 2019-06-14 | 2019-09-17 | 浙江省检验检疫科学技术研究院 | 奥氏黄檀的分子鉴定方法及其引物和探针 |
CN110241243B (zh) * | 2019-06-14 | 2024-02-27 | 浙江省检验检疫科学技术研究院 | 奥氏黄檀的分子鉴定方法及其引物和探针 |
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