JP2002510982A - 移送による薬伝達システム - Google Patents
移送による薬伝達システムInfo
- Publication number
- JP2002510982A JP2002510982A JP51483398A JP51483398A JP2002510982A JP 2002510982 A JP2002510982 A JP 2002510982A JP 51483398 A JP51483398 A JP 51483398A JP 51483398 A JP51483398 A JP 51483398A JP 2002510982 A JP2002510982 A JP 2002510982A
- Authority
- JP
- Japan
- Prior art keywords
- porous medium
- platen
- substance
- outer boundary
- micro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Refuse Collection And Transfer (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Surgical Instruments (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1 多孔性媒体の外部境界を横切って物質を移送させる方法であって、 各々が該多孔性媒体の第1区域から該第1区域に最も近い該多孔性媒体の第 2区域まで達する少なくとも1つの経路に沿って圧力勾配を生じさせ、該多孔 性媒体の該外面で該第2区域の圧力が周囲の圧力未満になるようにさせ、 少なくとも1つの微小裂を通して該多孔性媒体の該外部境界を横切って物 質を移送させるようにすることから成る物質移送方法。 2 該物質が該多孔性媒体内に引き込まれる、請求項1の方法。 3 該物質が該多孔性媒体外に引き出される、請求項1の方法。 4 該物質が流体である、請求項1の方法。 5 該物質が治療薬剤である、請求項1の方法。 6 該多孔性媒体が人体組織である、請求項1の方法。 7 該多孔性媒体の区域間で伸びる少なくとも1つの経路に沿って圧力勾配を生 じさせる該段階が、少なくとも1つの微小侵入体を有する該多孔性媒体の該外 部境界内の少なくとも1つの微小裂に穴をあけることを含む、請求項1の方法 。 8 該多孔性媒体の区域間で伸びる少なくとも1つの経路に沿って圧力勾配を生 じさせる該段階が、該多孔性媒体の該外部境界の一部を吸引することを含む、 請求項1の方法。 9 該多孔性媒体の区域間に圧力勾配を生じさせる該段階が、複数の微小侵入体 で該多孔性媒体の複数の微小裂に穴をあけて該微小侵入体の小部分を吸引する ことを含む、請求項1の方法。 10 該多孔性媒体の区域間に圧力勾配を生じさせる該段階が、複数の微小侵入体 で該多孔性媒体の複数の微小裂に穴をあけて該微小裂の小部分を吸引すること を含む、請求項1の方法。 11 少なくとも1つの微小侵入体を有する該多孔性媒体の該外面内の少なくとも 1つの微小裂に穴をあける該段階が、少なくとも1つの微小侵入体及び該多 孔性媒体の該外部境界間の該接点を実質的に囲む該多孔性媒体の該外部境界の 一部分を吸引することを含む、請求項1の方法。 12 多孔性媒体の外部境界を横切って物質を移送させる装置であって、 少なくとも1経路に沿って圧力勾配を生じさせる真空装置であって、各経路 が微小裂から該多孔性媒体の第1区域まで及び該第1区域から該第1区域に最 も近い該多孔性媒体の第2区域まで達し、該第2区域での圧力が該多孔性媒体 の外部境界での周囲圧力未満になるようにさせる真空装置と、 該多孔性媒体内に該物質を移送するようにさせるために、少なくとも1つ の微小侵入体に物質を供給する貯蔵器とから成る物質移送装置。 13 該多孔性媒体の該外部境界を横切って移送される物質の量を監視する出力を 有する少なくとも1つのセンサと、 各センサの該出力に基づいて該貯蔵器によって供給される該物質の速度を制 御する制御器とをさらに含む、請求項12の装置。 14 該多孔性媒体の該外部境界を横切って移送される物質に対する生物的応答を 監視する出力を有する少なくとも1つのセンサと、 各センサの該出力に基づいて該貯蔵器によって供給される該物質の速度を制 御する制御器とをさらに含む、請求項12の装置。 15 該多孔性媒体の該外面に侵入する少なくとも1つの微小侵入体をさらに含む 、請求項12の装置。 16 少なくとも1つの微小侵入体に対して該多孔性媒体の該外面を引き込む部分 真空をさらに含む、請求項15の装置。 17 多孔性媒体の外部境界を横切って物質を移送させる装置であって、 少なくとも1つの穴を有するプラテンと、 該プラテンと結合される、該多孔性媒体の該外部境界の少なくとも1つの微 小裂を切り裂く少なくとも1つの微小侵入体と、 該少なくとも1つの微小裂を介して物質を該多孔性媒体内へ導く装置とから 成る物質移送装置。 18 多孔性媒体の外部境界を横切って物質を移送させる装置を製造する方法であ って、 薄い平らなプラテンの表面に中央穴を有する一連の突起を打抜き、 第1充実空間を該プラテンの該穴の第1小部分と結合させ、 第2充実空間を該プラテンの該穴の第2小部分と結合させることから成る物 質移送装置製造方法。 19 −連の突起を打抜く該段階が、円錐状突起を含む、請求項18の方法。 20 多孔性媒体の外部境界を横切って物質を移送させる装置を製造する方法であ って、 薄い平らなプラテンの表面に一連の半島形舌状体を打抜き、 該半島形舌状体を該プラテンの該表面より下に押し付け、該プラテンに孔を 生成するようにさせ、 第1充実空間を該プラテンの該穴の第1小部分と結合させ、 第2充実空間を該プラテンの該穴の第2小部分と結合させることから成る物 質移送装置製造方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2626696P | 1996-09-17 | 1996-09-17 | |
US60/026,266 | 1996-09-17 | ||
US3903697P | 1997-02-24 | 1997-02-24 | |
US60/039,036 | 1997-02-24 | ||
PCT/US1997/016454 WO1998011937A1 (en) | 1996-09-17 | 1997-09-15 | System for delivery of drugs by transport |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007216091A Division JP2007325955A (ja) | 1996-09-17 | 2007-08-22 | 移送による薬伝達システム |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2002510982A true JP2002510982A (ja) | 2002-04-09 |
JP2002510982A5 JP2002510982A5 (ja) | 2005-05-12 |
JP4054381B2 JP4054381B2 (ja) | 2008-02-27 |
Family
ID=26700996
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51483398A Expired - Lifetime JP4054381B2 (ja) | 1996-09-17 | 1997-09-15 | 移送による薬伝達システム |
JP2007216091A Pending JP2007325955A (ja) | 1996-09-17 | 2007-08-22 | 移送による薬伝達システム |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007216091A Pending JP2007325955A (ja) | 1996-09-17 | 2007-08-22 | 移送による薬伝達システム |
Country Status (7)
Country | Link |
---|---|
US (1) | US5983136A (ja) |
EP (1) | EP0934093B1 (ja) |
JP (2) | JP4054381B2 (ja) |
AT (1) | ATE231015T1 (ja) |
CA (1) | CA2265906C (ja) |
DE (1) | DE69718495T2 (ja) |
WO (1) | WO1998011937A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003531698A (ja) * | 2000-05-01 | 2003-10-28 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | 生物流体のサンプリングおよび活性物質の配給のための剪断力による組織切除 |
JP2008521610A (ja) * | 2004-11-26 | 2008-06-26 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 微細構造製造方法および微細構造製造装置 |
WO2014126101A1 (ja) | 2013-02-13 | 2014-08-21 | 久光製薬株式会社 | マイクロニードル・アレイ |
JP2017507766A (ja) * | 2014-02-10 | 2017-03-23 | エルテーエス ローマン テラピー−ジステーメ アーゲー | マイクロニードルシステムおよびその製造方法 |
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- 1997-09-15 DE DE69718495T patent/DE69718495T2/de not_active Expired - Lifetime
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JP2003531698A (ja) * | 2000-05-01 | 2003-10-28 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | 生物流体のサンプリングおよび活性物質の配給のための剪断力による組織切除 |
JP2008521610A (ja) * | 2004-11-26 | 2008-06-26 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 微細構造製造方法および微細構造製造装置 |
WO2014126101A1 (ja) | 2013-02-13 | 2014-08-21 | 久光製薬株式会社 | マイクロニードル・アレイ |
US9717893B2 (en) | 2013-02-13 | 2017-08-01 | Hisamitsu Pharmaceutical Co., Ltd. | Microneedle array |
JP2017507766A (ja) * | 2014-02-10 | 2017-03-23 | エルテーエス ローマン テラピー−ジステーメ アーゲー | マイクロニードルシステムおよびその製造方法 |
Also Published As
Publication number | Publication date |
---|---|
DE69718495D1 (de) | 2003-02-20 |
CA2265906C (en) | 2003-11-11 |
WO1998011937A1 (en) | 1998-03-26 |
US5983136A (en) | 1999-11-09 |
JP2007325955A (ja) | 2007-12-20 |
JP4054381B2 (ja) | 2008-02-27 |
EP0934093B1 (en) | 2003-01-15 |
ATE231015T1 (de) | 2003-02-15 |
CA2265906A1 (en) | 1998-03-26 |
EP0934093A1 (en) | 1999-08-11 |
DE69718495T2 (de) | 2003-11-20 |
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