JP2000511416A5 - - Google Patents
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- JP2000511416A5 JP2000511416A5 JP1997541828A JP54182897A JP2000511416A5 JP 2000511416 A5 JP2000511416 A5 JP 2000511416A5 JP 1997541828 A JP1997541828 A JP 1997541828A JP 54182897 A JP54182897 A JP 54182897A JP 2000511416 A5 JP2000511416 A5 JP 2000511416A5
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- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Description
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9610967.3 | 1996-05-24 | ||
GB9610967A GB9610967D0 (en) | 1996-05-24 | 1996-05-24 | Specific binding members,materials and methods |
PCT/GB1997/001412 WO1997045544A1 (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ed-b domain of fibronectin, their construction and uses |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008204682A Division JP2009050261A (ja) | 1996-05-24 | 2008-08-07 | フィブロネクチンのed―bドメインに対する抗体、それらの構造及び用途 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2000511416A JP2000511416A (ja) | 2000-09-05 |
JP2000511416A5 true JP2000511416A5 (ja) | 2005-02-10 |
JP4750912B2 JP4750912B2 (ja) | 2011-08-17 |
Family
ID=10794298
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54182897A Expired - Lifetime JP4750912B2 (ja) | 1996-05-24 | 1997-05-23 | フィブロネクチンのed―bドメインに対する抗体、それらの構造及び用途 |
JP2008204682A Pending JP2009050261A (ja) | 1996-05-24 | 2008-08-07 | フィブロネクチンのed―bドメインに対する抗体、それらの構造及び用途 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008204682A Pending JP2009050261A (ja) | 1996-05-24 | 2008-08-07 | フィブロネクチンのed―bドメインに対する抗体、それらの構造及び用途 |
Country Status (29)
Country | Link |
---|---|
US (3) | US7273924B1 (ja) |
EP (1) | EP0906426B1 (ja) |
JP (2) | JP4750912B2 (ja) |
KR (2) | KR20050010081A (ja) |
CN (1) | CN100447159C (ja) |
AT (1) | ATE361364T1 (ja) |
AU (1) | AU729081B2 (ja) |
BG (1) | BG65138B1 (ja) |
BR (1) | BR9709350B1 (ja) |
CA (1) | CA2256308C (ja) |
CZ (1) | CZ295531B6 (ja) |
DE (1) | DE69737683T2 (ja) |
DK (1) | DK0906426T3 (ja) |
EA (1) | EA004329B1 (ja) |
ES (1) | ES2286831T3 (ja) |
GB (1) | GB9610967D0 (ja) |
HK (1) | HK1020990A1 (ja) |
HU (1) | HUP0200546A2 (ja) |
IL (2) | IL127216A0 (ja) |
IS (1) | IS2508B (ja) |
NO (1) | NO324904B1 (ja) |
NZ (1) | NZ333083A (ja) |
PL (1) | PL188557B1 (ja) |
PT (1) | PT906426E (ja) |
SI (1) | SI0906426T1 (ja) |
SK (1) | SK285916B6 (ja) |
TR (1) | TR199802416T2 (ja) |
UA (1) | UA74129C2 (ja) |
WO (1) | WO1997045544A1 (ja) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
US6685943B1 (en) | 1997-01-21 | 2004-02-03 | The Texas A&M University System | Fibronectin binding protein compositions and methods of use |
US7244826B1 (en) | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
US20030176663A1 (en) * | 1998-05-11 | 2003-09-18 | Eidgenossische Technische Hochscule | Specific binding molecules for scintigraphy |
TWI259837B (en) * | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
US20030045681A1 (en) * | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
ATE526039T1 (de) * | 2000-02-24 | 2011-10-15 | Philogen Spa | Zusammensetzungen und verfahren zur behandlung von angiogenese in pathologischen schädigungen |
JP2003524018A (ja) * | 2000-02-24 | 2003-08-12 | アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ | フィブロネクチンのed‐bドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用 |
AU2001259837A1 (en) | 2000-05-09 | 2001-11-20 | Greenville Hospital System | Therapeutic pore-forming peptides |
AU2001281824A1 (en) * | 2000-06-15 | 2001-12-24 | Patrizia Castellani | Methods for quantitative determination of b-fibronectin in biological fluids and tissues |
PL364358A1 (en) * | 2000-09-07 | 2004-12-13 | Schering Ag | Receptor in the edb fibronectin domain (ii) |
IT1317108B1 (it) * | 2000-12-06 | 2003-05-26 | Philogen Srl | Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso. |
US7456146B2 (en) * | 2001-05-09 | 2008-11-25 | Ghc Research Development Corporation | Lytic peptide prodrugs |
AU2003210149B2 (en) | 2002-01-03 | 2008-10-09 | Bayer Schering Pharma Aktiengesellschaft | Conjugates comprising an antibody specific for the ED-B domain of fibronectin and their use for the detection and treatment of tumours |
WO2003076469A2 (en) * | 2002-03-11 | 2003-09-18 | Philogen S.P.A. | Antibodies derived rom anti ed-b l19 and targeting tumor vasculature |
CN104225610B (zh) | 2002-07-15 | 2017-03-01 | 得克萨斯大学体系董事会 | 与阴离子磷脂和氨基磷脂结合的选定抗体及其治疗用途 |
NZ542306A (en) | 2003-03-14 | 2008-04-30 | Wyeth Corp | Antibodies against human IL-21 receptor and uses therefor |
DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
EP1702069A2 (en) | 2004-01-05 | 2006-09-20 | EMD Lexigen Research Center Corp. | Interleukin-12 targeted to oncofoetal fibronectin |
WO2006026020A2 (en) | 2004-07-30 | 2006-03-09 | Adeza Biomedical Corporation | Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin |
US7785591B2 (en) * | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
EP1803814A1 (en) * | 2005-12-27 | 2007-07-04 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Method of improving the antibody selection capacity in phage-display library |
EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
US8253725B2 (en) * | 2007-12-28 | 2012-08-28 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and system for generating surface models of geometric structures |
ATE548052T1 (de) * | 2008-01-17 | 2012-03-15 | Philogen Spa | Kombination aus einem anti-edb-fibronectin- antikörper-il-2-fusionsprotein und einem b-zellen bindenden molekül, b-zellen-vorläufern und/oder deren krebserregendem gegenspieler |
EP2100621A1 (en) | 2008-03-10 | 2009-09-16 | mivenion GmbH | Polyether polyol dendron conjugates with effector molecules for biological targeting |
EP2116555A1 (en) | 2008-05-08 | 2009-11-11 | Bayer Schering Pharma Aktiengesellschaft | Use of a radioactively labelled molecule specifically binding to ED-B fibronectin in a method of treatment of Hodgkin lymphoma |
IT1392027B1 (it) * | 2008-12-12 | 2012-02-09 | Castellani | Anticorpo monoclonale e suo uso per la identificazione della isoforma oncofetale della fibronettina (b-fn) a scopo diagnostico o terapeutico. |
BR112012014194A2 (pt) | 2009-12-14 | 2017-01-10 | Scil Proteins Gmbh | um método para identificar proteínas ubiquitinas modificadas hetero-multiméricas com capacidade de ligação a ligandos |
WO2011110490A1 (en) | 2010-03-09 | 2011-09-15 | Bayer Pharma Aktiengesellschaft | Process for the production of radioactively labelled scfv antibody fragments, kits and compositions |
WO2012172055A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Dimeric binding proteins based on modified ubiquitins |
WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
WO2013186329A1 (en) | 2012-06-13 | 2013-12-19 | Scil Proteins Gmbh | Human fusion proteins comprising single chain tnfalpha and targeting domains |
WO2014094799A1 (en) | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Ubiquitin moieties as a means for prolonging serum half-life |
WO2014194784A1 (zh) * | 2013-06-06 | 2014-12-11 | 合肥立方制药股份有限公司 | 人源抗纤连蛋白ed-b结构域的抗体及其用途 |
CA2975362A1 (en) | 2015-02-06 | 2016-08-11 | Navigo Proteins Gmbh | Egfr binding proteins comprising ubiquitin muteins |
KR102064396B1 (ko) | 2015-07-16 | 2020-01-09 | 나피고 프로타인스 게엠베하 | 신규한 면역글로불린-결합 단백질 및 친화도 정제에서의 이의 용도 |
US10584152B2 (en) | 2015-07-20 | 2020-03-10 | Navigo Proteins Gmbh | Binding proteins based on di-ubiquitin muteins and methods for generation |
EP3378947B1 (en) * | 2015-11-16 | 2024-01-24 | Hefei Lifeon Pharmaceutical Co. Ltd. | Use of ed-b protein in diagnosis of tissue hyperplasia |
CA3022751A1 (en) | 2016-05-04 | 2017-11-09 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
KR102578256B1 (ko) | 2016-08-11 | 2023-09-15 | 리플리겐 코포레이션 | 친화성 크로마토그래피를 위한 알칼리 안정 fc-결합 단백질 |
SG11201903400WA (en) | 2016-10-17 | 2019-05-30 | Pfizer | Anti-edb antibodies and antibody-drug conjugates |
AU2018281871B2 (en) | 2017-06-07 | 2022-07-28 | Philogen S.P.A. | Vascular endothelial growth factor/anti-fibronectin antibody fusion proteins |
CN111148759B (zh) | 2017-09-30 | 2023-09-19 | 合肥立方制药股份有限公司 | 结合至纤维连接蛋白b结构域的蛋白 |
EP3706804B1 (en) | 2017-11-07 | 2022-02-23 | Navigo Proteins GmbH | Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer |
WO2020070150A1 (en) | 2018-10-02 | 2020-04-09 | Philogen S.P.A | Il2 immunoconjugates |
EP3660039A1 (en) | 2018-11-30 | 2020-06-03 | Philogen S.p.A. | Il2 immunoconjugates |
MX2022001799A (es) | 2019-08-15 | 2022-03-11 | Janssen Biotech Inc | Materiales y metodos para fragmentos variables de cadena unica mejorados. |
AU2020401755A1 (en) | 2019-12-11 | 2022-08-04 | Cilag Gmbh International | Multispecific binding molecules comprising LTBR and EDB binding domains and uses thereof |
CN111234016B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的全人源单克隆抗体及应用 |
CN111171149B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的人源化单链抗体及其应用 |
KR102614063B1 (ko) | 2020-12-24 | 2023-12-19 | 대화제약 주식회사 | 엑스트라도메인 b 피브로넥틴에 특이적으로 결합하는 신규한 항체 |
CA3242326A1 (en) | 2022-01-04 | 2023-07-13 | Cipo | Combination of an immunocytokine comprising il-12 and a kinase inhibitor |
WO2024028258A1 (en) | 2022-08-01 | 2024-02-08 | Philochem Ag | Conjugates of psma-binding moieties with cytotoxic agents |
WO2024052333A1 (en) | 2022-09-06 | 2024-03-14 | Philochem Ag | Multivalent fibroblast activation protein ligands for targeted delivery applications |
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GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
KR870700095A (ko) | 1985-01-28 | 1987-02-28 | 원본미기재 | AraB 프로모터 및 미생물학적 방법에 의해 세크로핀을 포함한 폴리펩타이드를 제조하는 방법 |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US4894326A (en) | 1986-04-09 | 1990-01-16 | Fred Hutchinson Cancer Research Center | Monoclonal antibody defining oncofetal structure of fibronectin |
US5243029A (en) | 1986-04-09 | 1993-09-07 | Fred Hutchinson Cancer Research Center | Oncofetal structure of fibronectin |
CA1341235C (en) | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
EP0311434A3 (en) * | 1987-10-09 | 1990-05-09 | The De La Rue Company Plc | Integrated circuit card |
DE68926882T2 (de) | 1988-01-11 | 1997-02-13 | Xoma Corp | Plasmidvektor mit pectatlyase-signalsequenz |
IT1217724B (it) | 1988-05-26 | 1990-03-30 | Ist Naz Ric Sul Cancro | Anticorpo monoclonale specifico per una sequenza di fibronettina espressa in cellule trasformate ibridoma secernente tale anticorpo e impiego dell'anticorpo monoclonale per la diagnosi di tumori |
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JPH0276598A (ja) | 1988-09-14 | 1990-03-15 | Fujita Gakuen | 抗ed−b抗体 |
JPH04169195A (ja) | 1990-10-31 | 1992-06-17 | Fujita Gakuen | 抗ed―bモノクローナル抗体 |
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US5629291A (en) | 1992-01-31 | 1997-05-13 | La Jolla Cancer Research Foundation | Methods of modulating fibronectin extracellular matrix assembly |
US6036955A (en) | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
US5877289A (en) | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
US6093399A (en) | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
US6004555A (en) | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US5976535A (en) | 1992-06-09 | 1999-11-02 | Neorx Corporation | Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore |
WO1994007598A1 (en) | 1992-09-25 | 1994-04-14 | Otsuka Pharmaceutical Factory, Inc. | Adsorbent for cellular fibronectin, separation and purification of fibronectin, and purification of blood |
US5491130A (en) | 1992-11-10 | 1996-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Peptide inhibitors of fibronectin and related collagen-binding proteins |
EP0672142B1 (en) | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
US6015897A (en) | 1993-12-07 | 2000-01-18 | Neorx Corporation | Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota |
US5523229A (en) | 1994-03-22 | 1996-06-04 | Trustees Of The University Of Pennsylvania | Antibodies specific for oncofetal fibronectin |
DE4417865A1 (de) | 1994-05-20 | 1995-11-23 | Behringwerke Ag | Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie |
ITFI940095A1 (it) | 1994-05-23 | 1995-11-23 | Molteni & C | Coniugati fotodinamici aventi proprieta' biocide |
US5648485A (en) | 1994-10-26 | 1997-07-15 | University Of British Columbia | β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins |
WO1996023816A1 (en) | 1995-02-01 | 1996-08-08 | British Technology Group Limited | Radiolabelled proteins |
US6140470A (en) | 1995-06-30 | 2000-10-31 | Yale University | Human monoclonal anti-tumor antibodies |
US5808146A (en) | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
US5913884A (en) | 1996-09-19 | 1999-06-22 | The General Hospital Corporation | Inhibition of fibrosis by photodynamic therapy |
GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
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US6394952B1 (en) | 1998-02-03 | 2002-05-28 | Adeza Biomedical Corporation | Point of care diagnostic systems |
TWI259837B (en) | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
ATE526039T1 (de) | 2000-02-24 | 2011-10-15 | Philogen Spa | Zusammensetzungen und verfahren zur behandlung von angiogenese in pathologischen schädigungen |
JP2003524018A (ja) | 2000-02-24 | 2003-08-12 | アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ | フィブロネクチンのed‐bドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用 |
AU2003210149B2 (en) | 2002-01-03 | 2008-10-09 | Bayer Schering Pharma Aktiengesellschaft | Conjugates comprising an antibody specific for the ED-B domain of fibronectin and their use for the detection and treatment of tumours |
JP4169195B2 (ja) * | 2003-06-24 | 2008-10-22 | 株式会社河合楽器製作所 | 電子楽音発生装置の記録制御装置 |
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1996
- 1996-05-24 GB GB9610967A patent/GB9610967D0/en active Pending
-
1997
- 1997-05-23 KR KR10-2005-7000518A patent/KR20050010081A/ko not_active Application Discontinuation
- 1997-05-23 US US09/194,356 patent/US7273924B1/en not_active Expired - Fee Related
- 1997-05-23 SI SI9730765T patent/SI0906426T1/sl unknown
- 1997-05-23 ES ES97923243T patent/ES2286831T3/es not_active Expired - Lifetime
- 1997-05-23 PL PL97330075A patent/PL188557B1/pl not_active IP Right Cessation
- 1997-05-23 PT PT97923243T patent/PT906426E/pt unknown
- 1997-05-23 DE DE1997637683 patent/DE69737683T2/de not_active Expired - Lifetime
- 1997-05-23 HU HU0200546A patent/HUP0200546A2/hu unknown
- 1997-05-23 CA CA 2256308 patent/CA2256308C/en not_active Expired - Lifetime
- 1997-05-23 DK DK97923243T patent/DK0906426T3/da active
- 1997-05-23 KR KR1020067006008A patent/KR100741452B1/ko not_active IP Right Cessation
- 1997-05-23 AU AU29101/97A patent/AU729081B2/en not_active Expired
- 1997-05-23 WO PCT/GB1997/001412 patent/WO1997045544A1/en active IP Right Grant
- 1997-05-23 AT AT97923243T patent/ATE361364T1/de active
- 1997-05-23 CN CNB971949026A patent/CN100447159C/zh not_active Expired - Lifetime
- 1997-05-23 TR TR1998/02416T patent/TR199802416T2/xx unknown
- 1997-05-23 NZ NZ33308397A patent/NZ333083A/xx not_active IP Right Cessation
- 1997-05-23 IL IL12721697A patent/IL127216A0/xx active IP Right Grant
- 1997-05-23 CZ CZ19983815A patent/CZ295531B6/cs not_active IP Right Cessation
- 1997-05-23 JP JP54182897A patent/JP4750912B2/ja not_active Expired - Lifetime
- 1997-05-23 EP EP19970923243 patent/EP0906426B1/en not_active Expired - Lifetime
- 1997-05-23 BR BRPI9709350-5A patent/BR9709350B1/pt not_active IP Right Cessation
- 1997-05-23 SK SK1612-98A patent/SK285916B6/sk not_active IP Right Cessation
- 1997-05-23 EA EA199801043A patent/EA004329B1/ru not_active IP Right Cessation
- 1997-05-23 UA UA98126836A patent/UA74129C2/uk unknown
-
1998
- 1998-10-29 IS IS4883A patent/IS2508B/is unknown
- 1998-11-23 IL IL127216A patent/IL127216A/en not_active IP Right Cessation
- 1998-11-23 NO NO19985459A patent/NO324904B1/no not_active IP Right Cessation
- 1998-11-24 BG BG102950A patent/BG65138B1/bg unknown
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1999
- 1999-12-14 HK HK99105868A patent/HK1020990A1/xx not_active IP Right Cessation
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2007
- 2007-08-21 US US11/842,774 patent/US8703143B2/en not_active Expired - Fee Related
-
2008
- 2008-08-07 JP JP2008204682A patent/JP2009050261A/ja active Pending
-
2013
- 2013-10-04 US US14/046,224 patent/US9096670B2/en not_active Expired - Fee Related