JOP20190090B1 - مشتقات 9،8،7،6-رابع هيدرو-3h-بيرازولو [4،3-f]أيزوكينولين مفيدة في علاج السرطان - Google Patents
مشتقات 9،8،7،6-رابع هيدرو-3h-بيرازولو [4،3-f]أيزوكينولين مفيدة في علاج السرطانInfo
- Publication number
- JOP20190090B1 JOP20190090B1 JOP/2019/0090A JOP20190090A JOP20190090B1 JO P20190090 B1 JOP20190090 B1 JO P20190090B1 JO P20190090 A JOP20190090 A JO P20190090A JO P20190090 B1 JOP20190090 B1 JO P20190090B1
- Authority
- JO
- Jordan
- Prior art keywords
- treatment
- pyrazolo
- tetrahydro
- cancer
- derivatives useful
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
تتعلق المواصفة بمركبات الصيغة (I) والأملاح المقبولة صيدلانياً منها، والعمليات والوسائط المستخدمة لإعدادها، والتركيبات الصيدلانية التي تحتوي عليها واستخدامها في علاج اضطرابات تكاثر الخلايا. صورة(I) شكل 1: يوضح نمط حيود مسحوق أشعة إكس للصورة أ من N-(1-(3-فلورو بروبيل)أزيتيدين-3-يل)-6- ((6S،8R)-8- مثيل-7-(2،2،2- ثالث فلورو اثيل)-6،7،8،9- رابع هيدرو-3H- بيرازولو[4،3-f] أيزوكينولين-6-يل)بيريدين-3-أمين صورة
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662411799P | 2016-10-24 | 2016-10-24 | |
US201662435159P | 2016-12-16 | 2016-12-16 | |
PCT/EP2017/076191 WO2018077630A1 (en) | 2016-10-24 | 2017-10-13 | 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
JOP20190090A1 JOP20190090A1 (ar) | 2019-04-23 |
JOP20190090B1 true JOP20190090B1 (ar) | 2023-03-28 |
Family
ID=60083331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2019/0090A JOP20190090B1 (ar) | 2016-10-24 | 2017-10-13 | مشتقات 9،8،7،6-رابع هيدرو-3h-بيرازولو [4،3-f]أيزوكينولين مفيدة في علاج السرطان |
Country Status (35)
Country | Link |
---|---|
US (4) | US10131663B2 (ar) |
EP (2) | EP3640251B1 (ar) |
JP (2) | JP6744489B2 (ar) |
KR (1) | KR102178692B1 (ar) |
CN (2) | CN109843888B (ar) |
AU (1) | AU2017349797B2 (ar) |
BR (1) | BR112019007393A2 (ar) |
CA (1) | CA3040040A1 (ar) |
CL (1) | CL2019001077A1 (ar) |
CO (1) | CO2019003950A2 (ar) |
CR (1) | CR20190204A (ar) |
CY (1) | CY1122566T1 (ar) |
DK (2) | DK3433256T3 (ar) |
DO (1) | DOP2019000104A (ar) |
EC (1) | ECSP19028657A (ar) |
ES (2) | ES2751902T3 (ar) |
HR (1) | HRP20220255T1 (ar) |
HU (2) | HUE057524T2 (ar) |
IL (1) | IL266245B (ar) |
JO (1) | JOP20190090B1 (ar) |
LT (2) | LT3640251T (ar) |
ME (1) | ME03547B (ar) |
MX (1) | MX2019004685A (ar) |
NI (1) | NI201900039A (ar) |
NZ (1) | NZ753459A (ar) |
PE (1) | PE20191078A1 (ar) |
PH (1) | PH12019500830A1 (ar) |
PL (2) | PL3433256T3 (ar) |
PT (2) | PT3640251T (ar) |
RS (1) | RS59445B1 (ar) |
SG (1) | SG11201903182XA (ar) |
SI (2) | SI3433256T1 (ar) |
TW (1) | TWI735681B (ar) |
UA (1) | UA125824C2 (ar) |
WO (1) | WO2018077630A1 (ar) |
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TW201815789A (zh) | 2016-07-25 | 2018-05-01 | 瑞典商阿斯特捷利康公司 | 化合物 |
EP3640251B1 (en) | 2016-10-24 | 2021-12-08 | Astrazeneca AB | 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer |
HUE059274T2 (hu) | 2016-12-16 | 2022-11-28 | Janssen Pharmaceutica Nv | Imidazo[4,5-d]pirrolo[2,3-b]piridin-származékok mint janus-kinázok inhibitorai |
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