CN107428758B - 丙烯酸类衍生物、其制备方法及其在医药上的用途 - Google Patents
丙烯酸类衍生物、其制备方法及其在医药上的用途 Download PDFInfo
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- CN107428758B CN107428758B CN201680020252.8A CN201680020252A CN107428758B CN 107428758 B CN107428758 B CN 107428758B CN 201680020252 A CN201680020252 A CN 201680020252A CN 107428758 B CN107428758 B CN 107428758B
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Description
实施例编号 | IC<sub>50</sub>(nM) |
1 | 0.34 |
12 | 1.45 |
Claims (41)
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CN2015107711117 | 2015-11-12 | ||
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CN (1) | CN107428758B (zh) |
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US10118910B2 (en) | 2015-12-09 | 2018-11-06 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective estrogen receptor downregulators |
KR102479822B1 (ko) * | 2016-02-05 | 2022-12-21 | 인벤티스바이오 엘엘씨 | 선택적 에스트로겐 수용체 분해제 및 이들의 용도 |
CA3017388C (en) * | 2016-04-01 | 2024-03-12 | Zeno Royalties & Milestones, LLC | Estrogen receptor modulators |
WO2017182493A1 (en) | 2016-04-20 | 2017-10-26 | Astrazeneca Ab | Indazole derivatives for use in down-regulation of the estrogen receptor for the treatment of cancer |
CN109415361B (zh) * | 2016-06-29 | 2022-03-08 | 浙江海正药业股份有限公司 | 丙烯酸类衍生物及其制备方法和其在医药上的用途 |
WO2018019793A1 (en) | 2016-07-25 | 2018-02-01 | Astrazeneca Ab | N-(2-(4-((1r,3r)-3-methyl-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indol-1-yl)phenoxy)ethyl)propan-1-amine derivatives and related compounds as selective down-regulators of the estrogen receptor for treating cancer |
CN107814798B (zh) * | 2016-09-14 | 2020-11-03 | 四川科伦博泰生物医药股份有限公司 | 3-取代丙烯酸类化合物及其制备方法和用途 |
ME03547B (me) | 2016-10-24 | 2020-07-20 | Astrazeneca Ab | Derivat 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f]izohinolina koristan u tretmanu rаkа |
WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
CN110177554B (zh) | 2017-01-06 | 2023-06-02 | G1治疗公司 | 用于治疗癌症的组合疗法 |
ES2766249T3 (es) | 2017-01-30 | 2020-06-12 | Astrazeneca Ab | Moduladores del receptor de estrógeno |
EP3759075A1 (en) | 2018-02-28 | 2021-01-06 | Ferro Therapeutics, Inc. | Compounds with ferroptosis inducing activity and methods of their use |
US11040964B2 (en) | 2019-02-27 | 2021-06-22 | Ferro Therapeutics, Inc. | Compounds and methods of use |
EP3978493A4 (en) * | 2019-05-24 | 2023-02-01 | Zhejiang Hisun Pharmaceutical Co., Ltd. | CRYSTALLINE FORMS OF ACRYLIC ACID DERIVATIVES, METHOD OF MANUFACTURE THEREOF AND USE THEREOF |
CN114269342A (zh) | 2019-08-06 | 2022-04-01 | 里科瑞尔姆Ip控股有限责任公司 | 用于治疗突变的***受体调节剂 |
CN110746340A (zh) * | 2019-11-07 | 2020-02-04 | 上海易恩化学技术有限公司 | 一种5-甲氧基-2-甲基色胺的合成方法 |
WO2021228210A1 (zh) * | 2020-05-15 | 2021-11-18 | 江苏先声药业有限公司 | 吡咯烷类化合物及其应用 |
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WO2005070930A2 (en) * | 2004-01-23 | 2005-08-04 | Chiron Corporation | Tetrahydrocarboline compounds as anticancer agents |
WO2014191726A1 (en) * | 2013-05-28 | 2014-12-04 | Astrazeneca Ab | Chemical compounds |
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WO2010002835A2 (en) * | 2008-07-03 | 2010-01-07 | Osteogenex, Inc. | Vinpocetine and eburnamonine derivatives for promoting bone growth |
CA2800673A1 (en) | 2010-06-10 | 2011-12-15 | Aragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
KR20160085915A (ko) | 2013-12-06 | 2016-07-18 | 에프. 호프만-라 로슈 아게 | 국소 진행성 또는 전이성 에스트로겐 수용체 양성 유방암을 치료하기 위한 에스트로겐 수용체 조절자 |
KR102479822B1 (ko) * | 2016-02-05 | 2022-12-21 | 인벤티스바이오 엘엘씨 | 선택적 에스트로겐 수용체 분해제 및 이들의 용도 |
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WO2005070930A2 (en) * | 2004-01-23 | 2005-08-04 | Chiron Corporation | Tetrahydrocarboline compounds as anticancer agents |
WO2014191726A1 (en) * | 2013-05-28 | 2014-12-04 | Astrazeneca Ab | Chemical compounds |
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CN107428758A (zh) | 2017-12-01 |
JP6592197B2 (ja) | 2019-10-16 |
EP3378861A1 (en) | 2018-09-26 |
JP2018535216A (ja) | 2018-11-29 |
TW201716406A (zh) | 2017-05-16 |
KR102099159B1 (ko) | 2020-04-10 |
EP3378861A4 (en) | 2019-06-26 |
EP3378861B1 (en) | 2021-08-04 |
TWI615393B (zh) | 2018-02-21 |
US10519148B2 (en) | 2019-12-31 |
KR20180080245A (ko) | 2018-07-11 |
WO2017080338A1 (zh) | 2017-05-18 |
CA3011391C (en) | 2021-02-09 |
US20180291019A1 (en) | 2018-10-11 |
CA3011391A1 (en) | 2017-05-18 |
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