CO2019012271A2 - Péptido activador de receptor de gip - Google Patents
Péptido activador de receptor de gipInfo
- Publication number
- CO2019012271A2 CO2019012271A2 CONC2019/0012271A CO2019012271A CO2019012271A2 CO 2019012271 A2 CO2019012271 A2 CO 2019012271A2 CO 2019012271 A CO2019012271 A CO 2019012271A CO 2019012271 A2 CO2019012271 A2 CO 2019012271A2
- Authority
- CO
- Colombia
- Prior art keywords
- activating peptide
- gip receptor
- receptor activating
- peptide
- peptide compound
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 230000003213 activating effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 108010036598 gastric inhibitory polypeptide receptor Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención proporciona un compuesto peptídico novedoso que tiene una acción activadora en los receptores de GIP y el uso del compuesto peptídico como un medicamento. Específicamente, se proporcionan un péptido que contiene una secuencia representada por la fórmula (I) o una sal de este y un medicamento que lo comprende. P1-Tyr-A2-Glu-Gly-Thr-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-P2 (I) en donde cada símbolo es como se definió en la presente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017072556 | 2017-03-31 | ||
PCT/JP2018/013540 WO2018181864A1 (en) | 2017-03-31 | 2018-03-30 | Gip receptor activating peptide |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2019012271A2 true CO2019012271A2 (es) | 2020-08-21 |
Family
ID=62089992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2019/0012271A CO2019012271A2 (es) | 2017-03-31 | 2019-10-31 | Péptido activador de receptor de gip |
Country Status (21)
Country | Link |
---|---|
US (2) | US10435445B2 (es) |
EP (1) | EP3601329A1 (es) |
JP (2) | JP7175912B2 (es) |
KR (1) | KR20190134626A (es) |
CN (1) | CN110709414A (es) |
AR (1) | AR111346A1 (es) |
AU (2) | AU2018246553B2 (es) |
BR (1) | BR112019020438A2 (es) |
CA (1) | CA3058361A1 (es) |
CL (1) | CL2019002790A1 (es) |
CO (1) | CO2019012271A2 (es) |
EA (1) | EA201992327A1 (es) |
EC (1) | ECSP19078239A (es) |
IL (1) | IL269581B1 (es) |
JO (2) | JOP20180028A1 (es) |
MA (1) | MA48998A (es) |
PE (1) | PE20200675A1 (es) |
PH (1) | PH12019502252A1 (es) |
SG (1) | SG11201908542QA (es) |
TW (1) | TWI801373B (es) |
WO (1) | WO2018181864A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2022500483A (ja) * | 2018-09-24 | 2022-01-04 | 武田薬品工業株式会社 | Gip受容体アゴニストペプチド化合物及びその使用 |
JP2022503793A (ja) * | 2018-09-24 | 2022-01-12 | 武田薬品工業株式会社 | Gip受容体アゴニストペプチド化合物及びその使用 |
AR119471A1 (es) | 2019-08-01 | 2021-12-22 | Lilly Co Eli | Compuestos agonistas de gipr |
CN115884982A (zh) * | 2020-03-06 | 2023-03-31 | 赛诺菲 | 作为选择性gip受体激动剂的肽 |
EP4126920A2 (en) * | 2020-03-25 | 2023-02-08 | Takeda Pharmaceutical Company Limited | Gif receptor agonist peptide compounds and uses thereof |
AU2021241257A1 (en) * | 2020-03-25 | 2022-10-13 | Takeda Pharmaceutical Company Limited | QD dosing of GIP receptor agonist peptide compounds and uses thereof |
AU2021250319A1 (en) | 2020-03-31 | 2022-12-01 | Antaros Medical Ab | Selective GIP receptor agonists comprising a chelating moiety for imaging and therapy purposes |
KR20230029480A (ko) | 2020-07-22 | 2023-03-03 | 노보 노르디스크 에이/에스 | 경구 전달에 적합한 glp-1 및 gip 수용체에서의 공-작용제 |
EP4317178A1 (en) * | 2021-05-28 | 2024-02-07 | Guangdong Raynovent Biotech Co., Ltd. | Preparation and application of polypeptide |
KR20240055069A (ko) | 2021-09-06 | 2024-04-26 | 사노피 | 효력있는 선택적 gip 수용체 작용제로서의 신규 펩티드 |
EP4180060A1 (en) | 2021-11-15 | 2023-05-17 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
EP4299057A1 (en) | 2022-06-30 | 2024-01-03 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
WO2023084118A1 (en) | 2021-11-15 | 2023-05-19 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
TW202330584A (zh) | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
CN116891522B (zh) * | 2022-04-01 | 2024-05-14 | 南京知和医药科技有限公司 | 一种长效胰高血糖素样肽-1衍生物及其制备方法和用途 |
WO2023193727A1 (zh) * | 2022-04-07 | 2023-10-12 | 广东众生睿创生物科技有限公司 | 多肽在制备治疗和/或预防糖尿病及肥胖症及其相关疾病药物中的制药用途 |
EP4299052A1 (en) | 2022-06-30 | 2024-01-03 | Adocia | Solid compositions comprising a peptide or a protein and a permeation enhancer |
EP4299071A1 (en) | 2022-07-01 | 2024-01-03 | Adocia | Compositions comprising a peptide or a protein and an acylated amino acid |
Family Cites Families (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04145099A (ja) | 1990-10-05 | 1992-05-19 | Sanwa Kagaku Kenkyusho Co Ltd | Gip様活性を有するポリペプチド誘導体及びその用途 |
AU6944296A (en) | 1995-09-13 | 1997-04-01 | Takeda Chemical Industries Ltd. | Benzoxazepine compounds, their production and use as lipid lowering agents |
GB0404124D0 (en) | 2004-02-25 | 2004-03-31 | Univ Ulster | Antagonists of GIP |
US6329336B1 (en) | 1999-05-17 | 2001-12-11 | Conjuchem, Inc. | Long lasting insulinotropic peptides |
CA2416384A1 (en) | 2000-07-17 | 2003-01-16 | Takeda Chemical Industries, Ltd. | Sulfone derivatives, their production and use |
US20030232761A1 (en) | 2002-03-28 | 2003-12-18 | Hinke Simon A. | Novel analogues of glucose-dependent insulinotropic polypeptide |
BR0315815A (pt) | 2002-11-01 | 2005-09-13 | Takeda Pharmaceutical | Agentes para prevenir ou tratar neuropatia, para promover a produção ou a secreção de um fator neurotrópico, para melhorar a dor, neuroprotetor e farmacêutico, composto, métodos para prevenir ou tratar neuropatia e para promover a produção ou a secreção de um fator neurotrópico, para melhorar a dor para proteger um nervo em um mamìfero e para produzir um composto e uso de um composto |
EP1559422B1 (en) | 2002-11-08 | 2014-04-30 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
CA2507026A1 (en) | 2002-11-22 | 2004-06-10 | Takeda Pharmaceutical Company Limited | Imidazole derivatives, their production and use |
EP1630152A4 (en) | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | CONNECTION WITH CONDENSED RING |
US7534887B2 (en) | 2003-09-30 | 2009-05-19 | Takeda Pharmaceutical Company Limited | Thiazoline derivative and use of the same |
JP4769082B2 (ja) | 2003-12-17 | 2011-09-07 | 武田薬品工業株式会社 | ウレア誘導体、その製造法及び用途 |
BRPI0418148A (pt) | 2003-12-25 | 2007-04-17 | Takeda Pharmaceutical | composto, prodroga de um composto, modulador da função do receptor gpr40, agente farmacêutico, uso de um composto e métodos de modificação de uma função do receptor gpr40 em um mamìfero, de profilaxia ou tratamento de diabetes em um mamìfero e de produção de um composto |
EP1698624B1 (en) | 2003-12-26 | 2012-06-27 | Takeda Pharmaceutical Company Limited | Phenylpropanoic acid derivatives |
CA2560111A1 (en) | 2004-03-15 | 2005-09-22 | Takeda Pharmaceutical Company Limited | Aminophenylpropanoic acid derivative |
EP1731505B1 (en) | 2004-03-30 | 2015-01-14 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
JP2008530130A (ja) | 2005-02-11 | 2008-08-07 | アミリン・ファーマシューティカルズ,インコーポレイテッド | Gip類似体および選択可能な特性を備えるハイブリッドポリペプチド |
EP2308839B1 (en) | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
WO2006121904A1 (en) | 2005-05-06 | 2006-11-16 | Bayer Pharmaceuticals Corporation | Glucose-dependent insulinotropic polypeptide (gip) receptor agonists and their pharmacological methods of use |
US8153694B2 (en) | 2005-07-29 | 2012-04-10 | Takeda Pharmaceutical Company Limited | Cyclopropanecarboxylic acid compound |
US20090054435A1 (en) | 2005-07-29 | 2009-02-26 | Hiroshi Imoto | Phenoxyalkanoic Acid Compound |
KR20080033524A (ko) | 2005-08-10 | 2008-04-16 | 다케다 야쿠힌 고교 가부시키가이샤 | 당뇨병 치료제 |
JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
EP1943274A2 (en) | 2005-09-08 | 2008-07-16 | Uutech Limited | Treatment of diabetes related obesity |
AU2006289259A1 (en) | 2005-09-08 | 2007-03-15 | Uutech Limited | Analogs of gastric inhibitory polypeptide as a treatment for age related decreased pancreatic beta cell function |
JP5412273B2 (ja) | 2006-03-21 | 2014-02-12 | アミリン・ファーマシューティカルズ,リミテッド・ライアビリティ・カンパニー | ペプチド−ぺプチダーゼ阻害剤及びその使用 |
RS53230B (en) | 2006-06-27 | 2014-08-29 | Takeda Pharmaceutical Company Limited | CONDENSED CYCLICAL UNITS AS GPR40 RECEPTOR MODULATORS |
US8497240B2 (en) * | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
WO2008021560A2 (en) | 2006-08-17 | 2008-02-21 | Amylin Pharmaceuticals, Inc. | Dpp-iv resistant gip hybrid polypeptides with selectable properties |
US8492405B2 (en) | 2006-10-18 | 2013-07-23 | Takeda Pharmaceutical Company Limited | Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity |
EP2074119A1 (en) | 2006-10-19 | 2009-07-01 | Takeda Pharmaceutical Company Limited | Indole compound |
WO2008093639A1 (ja) | 2007-01-29 | 2008-08-07 | Takeda Pharmaceutical Company Limited | ピラゾール化合物 |
MX2009008103A (es) | 2007-02-09 | 2009-08-18 | Takeda Pharmaceutical | Compuestos anulares fusionados como agonistas parciales de prar-gamma. |
EP2149550A4 (en) | 2007-04-27 | 2010-08-11 | Takeda Pharmaceutical | HETEROCYCLIC COMPOUND WITH FIVE NITROGEN CHAINS |
EP2157859A4 (en) | 2007-06-19 | 2011-01-12 | Takeda Pharmaceutical | INDAZOL COMPOUNDS FOR THE ACTIVATION OF GLUCCOKINASE |
US8598314B2 (en) | 2007-09-27 | 2013-12-03 | Amylin Pharmaceuticals, Llc | Peptide-peptidase-inhibitor conjugates and methods of making and using same |
CN104945500B (zh) | 2008-06-17 | 2019-07-09 | 印第安纳大学研究及科技有限公司 | 基于gip的混合激动剂用于治疗代谢紊乱和肥胖症 |
AU2009280017B2 (en) | 2008-08-07 | 2013-01-10 | Ipsen Pharma S.A.S. | Analogues of glucose-dependent insulinotropic polypeptide |
KR101593155B1 (ko) | 2008-08-07 | 2016-02-12 | 입센 파마 에스.에이.에스. | 포도당 의존적인 인슐린 분비 자극성 폴리펩타이드 유사체 |
AU2009280021B2 (en) | 2008-08-07 | 2012-10-04 | Ipsen Pharma S.A.S. | Analogues of glucose-dependent insulinotropic polypeptide (GIP) modified at N-terminal |
CN102170896A (zh) | 2008-08-07 | 2011-08-31 | 益普生制药股份有限公司 | 糖依赖性胰岛素释放肽的截短类似物 |
JP2012512903A (ja) | 2008-12-19 | 2012-06-07 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | アミド系グルカゴンスーパーファミリーペプチドプロドラッグ |
RU2012101274A (ru) | 2009-06-16 | 2013-07-27 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Соединения глюкагона, активные в отношении рецептора gip |
WO2011014680A2 (en) | 2009-07-31 | 2011-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | Gastric inhibitory peptide variants and their uses |
WO2011094337A1 (en) | 2010-01-27 | 2011-08-04 | Indiana University Research And Technology Corporation | Glucagon antagonist - gip agonist conjugates and compositions for the treatment of metabolic disorders and obesity |
AR080592A1 (es) | 2010-03-26 | 2012-04-18 | Lilly Co Eli | Peptido con actividad para el gip-r y glp-1-r, formulacion famaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de diabetes mellitus y para inducir la perdida de peso |
US9023986B2 (en) | 2010-10-25 | 2015-05-05 | Hoffmann-La Roche Inc. | Glucose-dependent insulinotropic peptide analogs |
WO2012088379A2 (en) | 2010-12-22 | 2012-06-28 | Marcadia Biotech, Inc. | Methods for treating metabolic disorders and obesity with gip and glp-1 receptor-active glucagon-based peptides |
US8507428B2 (en) | 2010-12-22 | 2013-08-13 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting GIP receptor activity |
EP2718317B1 (en) | 2011-06-10 | 2018-11-14 | Beijing Hanmi Pharmaceutical Co., Ltd. | Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof |
WO2013003449A2 (en) | 2011-06-27 | 2013-01-03 | Phasebio Pharmaceuticals, Inc. | Methods of treatment with glp-1 receptor agonists |
KR102184241B1 (ko) | 2012-05-03 | 2020-12-01 | 질랜드 파마 에이/에스 | Gip-glp-1 이원 작용제 화합물 및 방법 |
SI2864350T1 (en) | 2012-06-21 | 2018-08-31 | Indiana University Research And Technology Corporation | GLUCAGON ANALOGUE ANALOGUE WITH ACTIVITY OF GIP RECEPTOR |
WO2013192129A1 (en) | 2012-06-21 | 2013-12-27 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting gip receptor activity |
WO2014096150A1 (en) | 2012-12-21 | 2014-06-26 | Sanofi | Dual glp1/gip or trigonal glp1/gip/glucagon agonists |
MX2015015464A (es) * | 2013-05-28 | 2016-03-21 | Takeda Pharmaceutical | Compuesto peptidico. |
EP3033355A1 (en) | 2013-08-16 | 2016-06-22 | Medimmune Limited | Gip and glp-1 receptor dual-agonists for the treatment of diabetes |
KR102310389B1 (ko) | 2013-11-06 | 2021-10-13 | 질랜드 파마 에이/에스 | Gip-glp-1 이원 효능제 화합물 및 방법 |
TR201902516T4 (tr) | 2013-11-06 | 2019-03-21 | Zealand Pharma As | Glukagon-glp-1-gıp üçlü agonist bileşikleri. |
EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物 |
GB2528436A (en) | 2014-07-15 | 2016-01-27 | Lancaster Univ Business Entpr Ltd | Treatment of neurological diseases |
EP3530671A3 (en) | 2014-09-05 | 2019-11-13 | University of Copenhagen | Gip peptide analogues |
US10253078B2 (en) | 2014-10-29 | 2019-04-09 | Zealand Pharma A/S | GIP agonist compounds and methods |
WO2016077220A1 (en) | 2014-11-10 | 2016-05-19 | Mb2 Llc | Gip/glp-1 co-agonist peptides for human administration |
JP2018012644A (ja) | 2014-11-26 | 2018-01-25 | 武田薬品工業株式会社 | ペプチド化合物 |
JOP20200119A1 (ar) | 2015-01-09 | 2017-06-16 | Lilly Co Eli | مركبات مساعد مشترك من gip وglp-1 |
WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
JP6326394B2 (ja) | 2015-10-09 | 2018-05-16 | Kyb株式会社 | ミキサ車の積載量計量装置 |
JP2019504106A (ja) | 2015-10-28 | 2019-02-14 | タフツ ユニバーシティー | タンパク質分解安定性が改善された新規ポリペプチド並びにその調製方法及び使用方法 |
HRP20220995T1 (hr) | 2015-12-31 | 2022-11-11 | Hanmi Pharm. Co., Ltd. | Trostruki aktivator koji aktivira glukagonski, glp-1 i gip receptore |
US10501516B2 (en) | 2016-05-24 | 2019-12-10 | Takeda Pharmaceutical Company Limited | Peptide compound |
-
2017
- 2017-03-31 JO JOP/2018/0028A patent/JOP20180028A1/ar unknown
- 2017-06-16 JO JOP/2019/0211A patent/JOP20190211A1/ar unknown
-
2018
- 2018-03-28 AR ARP180100762A patent/AR111346A1/es unknown
- 2018-03-30 US US15/941,030 patent/US10435445B2/en active Active
- 2018-03-30 CN CN201880035168.2A patent/CN110709414A/zh active Pending
- 2018-03-30 JP JP2019553587A patent/JP7175912B2/ja active Active
- 2018-03-30 IL IL269581A patent/IL269581B1/en unknown
- 2018-03-30 WO PCT/JP2018/013540 patent/WO2018181864A1/en active Application Filing
- 2018-03-30 EP EP18721166.9A patent/EP3601329A1/en active Pending
- 2018-03-30 SG SG11201908542Q patent/SG11201908542QA/en unknown
- 2018-03-30 CA CA3058361A patent/CA3058361A1/en active Pending
- 2018-03-30 PE PE2019001962A patent/PE20200675A1/es unknown
- 2018-03-30 TW TW107111293A patent/TWI801373B/zh active
- 2018-03-30 AU AU2018246553A patent/AU2018246553B2/en active Active
- 2018-03-30 MA MA048998A patent/MA48998A/fr unknown
- 2018-03-30 KR KR1020197028353A patent/KR20190134626A/ko not_active Application Discontinuation
- 2018-03-30 EA EA201992327A patent/EA201992327A1/ru unknown
- 2018-03-30 BR BR112019020438A patent/BR112019020438A2/pt unknown
-
2019
- 2019-08-29 US US16/555,085 patent/US11174301B2/en active Active
- 2019-09-30 PH PH12019502252A patent/PH12019502252A1/en unknown
- 2019-09-30 CL CL2019002790A patent/CL2019002790A1/es unknown
- 2019-10-30 EC ECSENADI201978239A patent/ECSP19078239A/es unknown
- 2019-10-31 CO CONC2019/0012271A patent/CO2019012271A2/es unknown
-
2022
- 2022-02-09 AU AU2022200837A patent/AU2022200837A1/en not_active Abandoned
- 2022-11-09 JP JP2022179703A patent/JP2023012547A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2018181864A1 (en) | 2018-10-04 |
JP2020515612A (ja) | 2020-05-28 |
US10435445B2 (en) | 2019-10-08 |
CN110709414A (zh) | 2020-01-17 |
KR20190134626A (ko) | 2019-12-04 |
JP7175912B2 (ja) | 2022-11-21 |
BR112019020438A2 (pt) | 2020-06-09 |
AR111346A1 (es) | 2019-07-03 |
EA201992327A1 (ru) | 2020-02-19 |
TW201841936A (zh) | 2018-12-01 |
PE20200675A1 (es) | 2020-06-11 |
IL269581B1 (en) | 2024-02-01 |
CL2019002790A1 (es) | 2020-05-29 |
TWI801373B (zh) | 2023-05-11 |
SG11201908542QA (en) | 2019-10-30 |
PH12019502252A1 (en) | 2020-06-29 |
EP3601329A1 (en) | 2020-02-05 |
AU2022200837A1 (en) | 2022-03-03 |
US20180298070A1 (en) | 2018-10-18 |
JP2023012547A (ja) | 2023-01-25 |
US20200140505A1 (en) | 2020-05-07 |
MA48998A (fr) | 2020-02-05 |
JOP20190211A1 (ar) | 2019-09-15 |
US11174301B2 (en) | 2021-11-16 |
AU2018246553B2 (en) | 2021-11-11 |
JOP20180028A1 (ar) | 2019-01-30 |
AU2018246553A1 (en) | 2019-10-17 |
ECSP19078239A (es) | 2019-12-27 |
CA3058361A1 (en) | 2018-10-04 |
IL269581A (en) | 2019-11-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2019012271A2 (es) | Péptido activador de receptor de gip | |
ECSP15044389A (es) | Compuesto peptídico | |
CO2020001879A2 (es) | Compuesto heterocíclico y su uso | |
CL2019000415A1 (es) | Compuestos terapéuticos útiles para el tratamiento profiláctico o terapéuticos de una infección por el virus del vih. | |
CR20150454A (es) | Compuestos amida para el tratamiento de vih | |
AR110400A1 (es) | Compuestos de amino-triazolopiridina y su uso en el tratamiento del cáncer | |
ECSP17002135A (es) | Compuestos antiproliferativos y métodos de uso de los mismos | |
AR094309A1 (es) | Compuesto heterociclico fusionado y uso del mismo para el control de plagas | |
CR20160241A (es) | Nuevas dihidroquinolizinonas para el tratamiento y profilaxis de la infección por virus de la hepatitis b | |
NI202000092A (es) | Compuestos | |
CL2020000487A1 (es) | Agentes antivirales contra la hepatitis b. | |
ECSP16067137A (es) | Compuesto heterocíclico fusionado | |
BR112016025819A2 (pt) | vetores de vírus adeno-associados para o tratamento de doenças de depósito lisossômico | |
CL2022001529A1 (es) | Nuevos derivados de metilquinazolinona | |
CY1124413T1 (el) | Ανταγωνιστες του υποδοχεα cgrp | |
UY36217A (es) | Compuestos piridona sustituídos, composiciones farmacéuticas y métodos de uso. | |
ECSP16096831A (es) | Derivados de naftiridinadiona | |
BR112017013286A2 (pt) | composto de isoxazolina, e, uso de um composto de isoxazolina. | |
CO2018003909A2 (es) | Compuestos terapéuticos y sus métodos de uso | |
UY37166A (es) | Nucleósidos ánalogos de alquinilo como inhibidores de rinovirus humano | |
CR20150533A (es) | Compuesto peptídico | |
AR122557A2 (es) | Oligonucleótido modificado | |
UA112287U (xx) | Застосування вінборону для нівелювання антипроліферативного впливу ібупрофену на шлунковий епітелій | |
TH165161A (th) | สารประกอบเพพไทด์ | |
TH165161B (th) | สารประกอบเพพไทด์ |