IT8520242A0 - Polipeptide umano fisiologicamente attivo. - Google Patents

Polipeptide umano fisiologicamente attivo.

Info

Publication number
IT8520242A0
IT8520242A0 IT8520242A IT2024285A IT8520242A0 IT 8520242 A0 IT8520242 A0 IT 8520242A0 IT 8520242 A IT8520242 A IT 8520242A IT 2024285 A IT2024285 A IT 2024285A IT 8520242 A0 IT8520242 A0 IT 8520242A0
Authority
IT
Italy
Prior art keywords
physiologically active
active human
human polypeptide
polypeptide
physiologically
Prior art date
Application number
IT8520242A
Other languages
English (en)
Other versions
IT1218469B (it
Inventor
Robert Bruce Wallace
Hirataka Itoh
Original Assignee
Asahi Chemical Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Ind filed Critical Asahi Chemical Ind
Publication of IT8520242A0 publication Critical patent/IT8520242A0/it
Application granted granted Critical
Publication of IT1218469B publication Critical patent/IT1218469B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/525Tumour necrosis factor [TNF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/948Microorganisms using viruses or cell lines
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • Y10S530/828Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Image Analysis (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
IT20242/85A 1984-04-06 1985-04-05 Polipeptide umano fisiologicamente ettivo IT1218469B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/597,372 US4879226A (en) 1984-04-06 1984-04-06 Novel human physiologically active polypeptide

Publications (2)

Publication Number Publication Date
IT8520242A0 true IT8520242A0 (it) 1985-04-05
IT1218469B IT1218469B (it) 1990-04-19

Family

ID=24391235

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20242/85A IT1218469B (it) 1984-04-06 1985-04-05 Polipeptide umano fisiologicamente ettivo

Country Status (39)

Country Link
US (1) US4879226A (it)
EP (2) EP0158286A3 (it)
JP (1) JPS60252496A (it)
KR (1) KR920007399B1 (it)
AR (1) AR240475A1 (it)
AU (2) AU595480B2 (it)
BE (1) BE902119A (it)
BG (1) BG43355A3 (it)
BR (1) BR8501624A (it)
CA (1) CA1341348C (it)
CH (2) CH672790A5 (it)
DD (1) DD251785A5 (it)
DK (1) DK151985A (it)
EG (1) EG17965A (it)
ES (1) ES8704976A1 (it)
FI (1) FI86992C (it)
FR (1) FR2564097B1 (it)
GB (1) GB2158829B (it)
GR (1) GR850836B (it)
HK (1) HK102192A (it)
HU (1) HUT37813A (it)
IE (1) IE58833B1 (it)
IL (1) IL74804A (it)
IN (1) IN163653B (it)
IT (1) IT1218469B (it)
JO (1) JO1365B1 (it)
LU (1) LU85835A1 (it)
MA (1) MA20402A1 (it)
MT (1) MTP963B (it)
MY (1) MY101887A (it)
NO (1) NO174473C (it)
NZ (2) NZ231317A (it)
OA (1) OA07983A (it)
PL (1) PL156392B1 (it)
PT (1) PT80239B (it)
RO (1) RO93650B (it)
SG (1) SG77892G (it)
YU (1) YU57885A (it)
ZA (1) ZA852563B (it)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0695939B2 (ja) * 1983-12-02 1994-11-30 大日本製薬株式会社 ウサギ癌壊死因子をコ−ドするクロ−ン化dνa
DE3582183D1 (de) * 1984-03-06 1991-04-25 Dainippon Pharmaceutical Co Dns den menschlichen tumornekrosisfaktor kodierend und das menschliche tumornekronisfaktor-polypeptid.
US5288852A (en) * 1984-03-06 1994-02-22 Dainippon Pharmaceutical Co., Ltd. Human tumor necrosis factor polypeptides
JP2584206B2 (ja) * 1984-08-17 1997-02-26 大日本製薬株式会社 ヒト癌壊死因子
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
JPS60228297A (ja) * 1984-04-24 1985-11-13 株式会社 東京タツノ 給油装置
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
GR851626B (it) * 1984-07-05 1985-11-26 Genentech Inc
US6686455B1 (en) * 1984-07-05 2004-02-03 Genentech, Inc. Tumor necrosis factor
JP2675294B2 (ja) * 1984-10-15 1997-11-12 カイロン コーポレイション ヒト腫瘍壊死因子
AU589919B2 (en) * 1984-10-15 1989-10-26 Cetus Corp Human tumor necrosis factor
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
JPS61124392A (ja) * 1984-11-22 1986-06-12 Asahi Chem Ind Co Ltd 遺伝子組換体の産生する生理活性物質の精製法
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
EP0313104A3 (en) * 1984-12-21 1989-07-12 Biogen, Inc. Purification, production and use of tumor necrosis factors
JPS6248634A (ja) * 1985-07-23 1987-03-03 Mochida Pharmaceut Co Ltd 新規アミノ酸組成物、その製造方法及び該アミノ酸組成物を含有する医療組成物
JPH0698004B2 (ja) * 1985-09-30 1994-12-07 サントリー株式会社 Tnf発現用新規プラスミド
US5059530A (en) * 1985-09-30 1991-10-22 Suntory Ltd. Expression vector for human TNF
US4677197A (en) * 1985-10-30 1987-06-30 Cetus Corporation Purification method for tumor necrosis factor
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
US4828830A (en) * 1986-01-24 1989-05-09 Genentech, Inc. Method and composition for prophylaxis and treatment of viral infections
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
CA1310924C (en) * 1986-04-24 1992-12-01 Francis P. Mccormick Infective drug delivery system
GB2194146A (en) * 1986-07-31 1988-03-02 Genentech Inc Treatment of retroviral infections
DE3716513A1 (de) * 1987-05-16 1988-11-24 Basf Ag Proteine mit tnf-wirkung
GB2217325B (en) * 1988-04-08 1991-11-20 British Bio Technology Synthetic gene for tumour necrosis factor alpha.
US5071834A (en) * 1988-09-16 1991-12-10 Genentech, Inc. Purified activin B composition
US5342613A (en) * 1988-12-27 1994-08-30 Health Research Inc. Pharmaceutical compositions and use thereof in the treatment of psoriasis
CA2003981C (en) * 1988-12-27 2000-06-13 Hiroshi Ishimaru Pharmaceutical compositions and use thereof in the treatment of psoriasis
AU648020B2 (en) * 1989-02-21 1994-04-14 Washington University Modified forms of reproductive hormones
US5998378A (en) * 1989-08-16 1999-12-07 Chiron Corporation Compositions for the inhibition of TNF hormone formation and uses thereof
US6586222B1 (en) 1989-08-16 2003-07-01 Chiron Corporation Recombinant PR-3 and compositions thereof
DK0491878T3 (da) 1989-08-16 1997-06-23 Chiron Corp Præparater til inhibering af proteinhormondannelse og anvendelser deraf
US5843693A (en) * 1989-08-16 1998-12-01 Chiron Corporation Assay method for screening for inhibitors of proTNF conversion
WO1991006658A2 (en) * 1989-10-24 1991-05-16 Cetus Corporation Infective protein delivery system
US5653974A (en) * 1990-10-18 1997-08-05 Board Of Regents,The University Of Texas System Preparation and characterization of liposomal formulations of tumor necrosis factor
US5420019A (en) * 1993-02-02 1995-05-30 Xoma Corporation Stable bactericidal/permeability-increasing protein muteins
KR970005042B1 (ko) * 1993-02-09 1997-04-11 한일합성섬유공업 주식회사 종양괴사인자-알파 뮤테인
RU2139092C1 (ru) 1993-06-03 1999-10-10 Терапьютик Антибодиз Инк. Фрагменты антител в терапии
US6551623B1 (en) 1993-09-09 2003-04-22 Lorus Therapeutics Inc. Immunomodulating compositions from bile
WO1995024501A1 (en) 1994-03-07 1995-09-14 Cetus Oncology Corporation Compositions for the inhibition of tnf formation and uses thereof
KR19980703088A (ko) 1995-03-16 1998-09-05 라카일레 지, 필리페 신규의 침전탄산칼슘 안료를 포함하는 잉크젯 기록지
FR2733421B1 (fr) * 1995-04-28 1997-06-06 Oreal Utilisation de derives de l'hormone stimulatrice des melanocytes de type alpha pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
US6001812A (en) * 1995-04-28 1999-12-14 Societe L'oreal S.A. Modulating body/cranial hair growth with derivatives of the α-type melanocyte-stimulating hormone
US6617171B2 (en) * 1998-02-27 2003-09-09 The General Hospital Corporation Methods for diagnosing and treating autoimmune disease
US6599710B1 (en) 1999-03-10 2003-07-29 The General Hospital Corporation Treatment of autoimmune disease
US7056695B2 (en) 2000-03-02 2006-06-06 Xencor TNF-α variants
US20070172449A1 (en) * 2000-03-02 2007-07-26 Xencor, Inc. TNF-alpha VARIANT FORMULATIONS FOR THE TREATMENT OF TNF-alpha RELATED DISORDERS
US7101974B2 (en) 2000-03-02 2006-09-05 Xencor TNF-αvariants
US7244823B2 (en) * 2000-03-02 2007-07-17 Xencor TNF-alpha variants proteins for the treatment of TNF-alpha related disorders
US7446174B2 (en) 2001-03-02 2008-11-04 Xencor, Inc. Protein based TNF-α variants for the treatment of TNF-α related disorders
US7662367B2 (en) * 2000-03-02 2010-02-16 Xencor, Inc. Pharmaceutical compositions for the treatment of TNF-α related disorders
US7687461B2 (en) * 2000-03-02 2010-03-30 Xencor, Inc. Treatment of TNF-α related disorders with TNF-α variant proteins
US6579522B1 (en) 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
WO2002102363A1 (en) * 2001-06-20 2002-12-27 Lorus Therapeutics Inc. Biological response modifier composition and uses thereof
US20030086903A1 (en) * 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
US7582313B2 (en) 2002-06-27 2009-09-01 The General Hospital Corporation Methods of organ regeneration using Hox 11-expressing pluripotent cells
US7628988B2 (en) 2002-06-27 2009-12-08 The General Hospital Corporation Methods and compositions for treating type 1 diabetes
US20040229785A1 (en) * 2002-11-15 2004-11-18 Denise Faustman Screening methods to identify treatments for autoimmune disease
RU2377253C2 (ru) 2002-12-02 2009-12-27 Амген Фремонт,Инк. Антитела, специфичные к фактору некроза опухолей, и их применение
US7101978B2 (en) * 2003-01-08 2006-09-05 Applied Molecular Evolution TNF-α binding molecules
ES2340038T3 (es) * 2003-11-14 2010-05-28 Genvec, Inc. Composicion farmaceutica para tratar cancer de pancreas localmente avanzado (cpla) no extirpable.
US7435799B2 (en) * 2004-01-08 2008-10-14 Applied Molecular Evolution TNF-α binding molecules
US20080102054A1 (en) * 2005-01-18 2008-05-01 Faustman Denise L Compositions Containing Agm Cells And Methods Of Use Thereof
US9605844B2 (en) * 2009-09-01 2017-03-28 Cree, Inc. Lighting device with heat dissipation elements
EP2742127B1 (en) 2011-08-12 2019-10-09 Mello Biotechnology, Inc. Inducable expression from the eukaryotic pol-2 promoter in prokaryotes
US10196662B2 (en) 2012-08-10 2019-02-05 Mello Biotechnology, Inc. Composition for producing microRNA precursors as drugs for enhancing wound healing and production method of the microRNA precursors
DK2953634T3 (da) 2013-02-07 2021-08-30 Massachusetts Gen Hospital Fremgangsmåder til udvidelse eller udtømning af regulerende t-celler
FI3447075T3 (fi) 2015-05-15 2023-11-07 Massachusetts Gen Hospital Antagonistisia anti-tuumorinekroositekijäreseptorin superperheen vasta-aineita
WO2017059132A1 (en) 2015-09-29 2017-04-06 The General Hospital Corporation Methods of treating and diagnosing disease using biomarkers for bcg therapy
AU2017263833B2 (en) 2016-05-13 2023-08-03 The General Hospital Corporation Antagonistic anti-tumor necrosis factor receptor superfamily antibodies
WO2018087172A1 (en) 2016-11-09 2018-05-17 Philogen S.P.A Il2 and tnf mutant immunoconjugates

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309418A (en) * 1980-03-25 1982-01-05 Sloan-Kettering Research Institute For Cancer Anti-tumor agent from human serum and process
US4359415A (en) * 1981-06-03 1982-11-16 University Of Tennessee Research Corporation Isolation of an antineoplastic protein fraction and an antineoplastic peptide fraction from human urine
JPS5821621A (ja) * 1981-07-31 1983-02-08 Hayashibara Biochem Lab Inc ヒトツモア・ネクロシス・ファクタ−を含有する悪性腫瘍治療剤
JPS6011890B2 (ja) * 1981-12-21 1985-03-28 株式会社林原生物化学研究所 ツモアネクロシスフアクタ−の製造方法
FR2513124B1 (fr) * 1981-07-21 1989-11-17 Hayashibara Biochem Lab Production et applications du facteur de lyse des cellules-cibles
JPS57140725A (en) * 1981-12-28 1982-08-31 Dainippon Pharmaceut Co Ltd Physiologically active substance having carcinostatic action
JPS58141785A (ja) * 1982-02-16 1983-08-23 Nippon Shinyaku Co Ltd 抗腫瘍物質の製法
US4481137A (en) * 1982-02-26 1984-11-06 Mochida Pharmaceutical Co., Ltd. Glycoproteins and processes for their production
HU189251B (en) * 1982-04-07 1986-06-30 Asahi Kasei Kogyo Kk,Jp Process for stabilizing tumor necrosis factor
JPS591288A (ja) * 1982-06-29 1984-01-06 Sato :Kk 連続値札印字装置
WO1984001288A1 (en) * 1982-10-06 1984-04-12 Takeshi Makitsubo Process for extracting tumor necrosis factor from macrophage
JPS59169492A (ja) * 1983-03-15 1984-09-25 Asahi Chem Ind Co Ltd ヒト融合細胞からの生理活性物質の産生方法
CA1265444A (en) * 1983-06-27 1990-02-06 Lloyd J. Old Effect of human tumor necrosis factor and human interferon on human cancer cells and methods
JPS6019719A (ja) * 1983-07-15 1985-01-31 Asahi Chem Ind Co Ltd 抗腫瘍活性を有する蛋白質
JPS5943617Y2 (ja) * 1983-08-26 1984-12-25 株式会社潤工社 広い周波数帯域において均一な特性を有する伝送線路用導体
JPS60112718A (ja) * 1983-11-21 1985-06-19 Kyorin Pharmaceut Co Ltd 抗腫瘍作用を示す蛋白性物質及びその製造方法
JPH0695939B2 (ja) * 1983-12-02 1994-11-30 大日本製薬株式会社 ウサギ癌壊死因子をコ−ドするクロ−ン化dνa
DE3582183D1 (de) * 1984-03-06 1991-04-25 Dainippon Pharmaceutical Co Dns den menschlichen tumornekrosisfaktor kodierend und das menschliche tumornekronisfaktor-polypeptid.
JPS60185799A (ja) * 1984-03-06 1985-09-21 Dainippon Pharmaceut Co Ltd ヒト癌壊死因子
JPS60260522A (ja) * 1984-06-07 1985-12-23 Asahi Chem Ind Co Ltd 遺伝子組換体が生産する生理活性物質の安定化法
DE3423234A1 (de) * 1984-06-23 1986-02-06 Boehringer Ingelheim International GmbH, 6507 Ingelheim Synergistische mischungen von interferonen und tumor-nekrose-faktor
JPS61124392A (ja) * 1984-11-22 1986-06-12 Asahi Chem Ind Co Ltd 遺伝子組換体の産生する生理活性物質の精製法

Also Published As

Publication number Publication date
ZA852563B (en) 1986-05-28
GB2158829B (en) 1992-04-22
OA07983A (en) 1987-01-31
FI86992C (fi) 1992-11-10
YU57885A (en) 1989-02-28
IE850863L (en) 1985-10-06
BG43355A3 (en) 1988-05-16
IL74804A0 (en) 1985-07-31
AU4088285A (en) 1985-10-10
GB2158829A (en) 1985-11-20
RO93650A (ro) 1988-03-30
AU4016289A (en) 1989-12-07
CH672790A5 (it) 1989-12-29
NZ211666A (en) 1990-01-29
EP0158286A3 (en) 1987-05-13
DK151985D0 (da) 1985-04-03
FI86992B (fi) 1992-07-31
HUT37813A (en) 1986-02-28
EP0354592A1 (en) 1990-02-14
NZ231317A (en) 1991-01-29
EG17965A (en) 1994-01-30
CH675423A5 (it) 1990-09-28
PL156392B1 (pl) 1992-03-31
CA1341348C (en) 2002-03-19
ES541920A0 (es) 1987-05-01
US4879226A (en) 1989-11-07
FI851336L (fi) 1985-10-07
SG77892G (en) 1992-10-02
IN163653B (it) 1988-10-22
JO1365B1 (en) 1986-11-30
JPS60252496A (ja) 1985-12-13
NO174473C (no) 1994-05-11
GB8508864D0 (en) 1985-05-09
LU85835A1 (fr) 1985-12-16
HK102192A (en) 1992-12-24
NO174473B (no) 1994-01-31
IT1218469B (it) 1990-04-19
PT80239B (pt) 1988-02-17
PT80239A (en) 1985-05-01
ES8704976A1 (es) 1987-05-01
JPH025760B2 (it) 1990-02-05
KR850007273A (ko) 1985-12-02
IE58833B1 (en) 1993-11-17
DK151985A (da) 1985-10-07
GR850836B (it) 1985-06-26
FI851336A0 (fi) 1985-04-03
RO93650B (ro) 1988-03-31
KR920007399B1 (ko) 1992-08-31
AR240475A1 (es) 1990-04-30
BE902119A (fr) 1985-10-04
AU637054B2 (en) 1993-05-20
MTP963B (en) 1985-11-25
MA20402A1 (fr) 1985-12-31
MY101887A (en) 1992-02-15
EP0158286A2 (en) 1985-10-16
BR8501624A (pt) 1985-12-03
DD251785A5 (de) 1987-11-25
AU595480B2 (en) 1990-04-05
PL252807A1 (en) 1986-02-25
IL74804A (en) 1991-06-30
NO851400L (no) 1985-10-07
FR2564097A1 (fr) 1985-11-15
FR2564097B1 (fr) 1989-09-22

Similar Documents

Publication Publication Date Title
IT8520242A0 (it) Polipeptide umano fisiologicamente attivo.
DE3689246D1 (de) Physiologisch aktives Polypeptid BUF-3.
IT8619338A0 (it) Peptide sintetico ad attivita'interleukina 1 umana.
DE3582894D1 (de) Hautbehandlungsmittel.
FI850946L (fi) Medicinska plaoster.
DE3581730D1 (de) Menschlicher tumornekrosisfaktor.
IT8522058A0 (it) Perfezionamenti riguardanti la terapia con ciclosporine.
FI853249A0 (fi) Cdna-kloner foer human erytropoietin.
FI850193A0 (fi) Terapeutiska lhrh analoger.
NO870533D0 (no) Terapeutisk aktive 3-alkoksy-2-aminopropylaminer.
DK394084D0 (da) Fysiologisk aktive praeparater
DE3886517D1 (de) Menschlicher Prourokinase ähnliches Polypeptid.
DE3853743D1 (de) Rekombinanter menschlicher ADF.
NO165542C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 5-aryl-2,4-dialkyl-3h-1,2,4-triazol-3-thioner.
DE3481420D1 (de) Physiologisch aktives proteinmaterial.
EP0445304A4 (en) Isolated, physiologically active human thrombomodulin polypeptide
DE3853380D1 (de) Physiologisch aktives Lymphotoxin.
DE3782199D1 (de) Biologisch aktive peptide tan-866.
IT8822398A0 (it) Copertura mimetica e procedimento per la sua fabbricazione.
NO874552D0 (no) Rekombinant human endotelial cellevekstfaktor.
GB8525730D0 (en) Physiologically active substance
IL74760A0 (en) Human physiologically active polypeptide,its production and pharmaceutical compositions containing it
ATE62593T1 (de) Physiologisch wirksame und naehrende zusammensetzung.
AU2809384A (en) Human physiologically active substance
ATE98990T1 (de) Menschlicher prourokinase aehnliches polypeptid.

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970429