IT1153437B - Derivati 5-amminometil-ossazolidinici, procedimento per la loro preparazione, e loro applicazione in terapia - Google Patents

Derivati 5-amminometil-ossazolidinici, procedimento per la loro preparazione, e loro applicazione in terapia

Info

Publication number
IT1153437B
IT1153437B IT19730/82A IT1973082A IT1153437B IT 1153437 B IT1153437 B IT 1153437B IT 19730/82 A IT19730/82 A IT 19730/82A IT 1973082 A IT1973082 A IT 1973082A IT 1153437 B IT1153437 B IT 1153437B
Authority
IT
Italy
Prior art keywords
oxyzolidine
aminomethy
therapy
derivatives
procedure
Prior art date
Application number
IT19730/82A
Other languages
English (en)
Other versions
IT8219730A0 (it
Inventor
Philippe Dostert
Alain Lacour
Michel Langlois
Margherita Strolin Benedetti
Original Assignee
Delalande Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande Sa filed Critical Delalande Sa
Publication of IT8219730A0 publication Critical patent/IT8219730A0/it
Application granted granted Critical
Publication of IT1153437B publication Critical patent/IT1153437B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT19730/82A 1981-02-25 1982-02-18 Derivati 5-amminometil-ossazolidinici, procedimento per la loro preparazione, e loro applicazione in terapia IT1153437B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8103797A FR2500450A1 (fr) 1981-02-25 1981-02-25 Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
IT8219730A0 IT8219730A0 (it) 1982-02-18
IT1153437B true IT1153437B (it) 1987-01-14

Family

ID=9255633

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19730/82A IT1153437B (it) 1981-02-25 1982-02-18 Derivati 5-amminometil-ossazolidinici, procedimento per la loro preparazione, e loro applicazione in terapia

Country Status (14)

Country Link
US (1) US4476136A (it)
JP (1) JPS5838273A (it)
AU (1) AU553462B2 (it)
BE (1) BE892270A (it)
CA (1) CA1178594A (it)
CH (1) CH653999A5 (it)
DE (1) DE3206770A1 (it)
ES (2) ES509848A0 (it)
FR (1) FR2500450A1 (it)
GB (2) GB2094299B (it)
IT (1) IT1153437B (it)
LU (1) LU83963A1 (it)
NL (1) NL8200732A (it)
SE (1) SE457258B (it)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4897409A (en) * 1986-09-03 1990-01-30 Delalande S.A. 5-aminoethyloxazolidin-2-one derivatives
FR2603279B1 (fr) * 1986-09-03 1988-12-16 Rech Ind Benzyloxy-phenyl-oxazolidinones, procede de preparation et utilisation en therapeutique
FR2609029B1 (fr) * 1986-12-30 1989-12-08 Delalande Sa Derives 5-aminoethyles de l'oxazolidinone-2, leur procede de preparation et leur application en therapeutique
DE3723797A1 (de) * 1987-07-18 1989-01-26 Merck Patent Gmbh Oxazolidinone
US5039690A (en) * 1987-10-09 1991-08-13 Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US5036092A (en) * 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US4985429A (en) * 1987-10-09 1991-01-15 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4965268A (en) * 1987-10-09 1990-10-23 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US5032605A (en) * 1987-10-09 1991-07-16 Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US5036093A (en) * 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US4942183A (en) * 1987-10-16 1990-07-17 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
CA1317594C (en) * 1987-10-21 1993-05-11 Chung-Ho Park Aminomethyloxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US4977173A (en) * 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5182403A (en) * 1988-09-15 1993-01-26 The Upjohn Company Substituted 3(5'indazolyl) oxazolidin-2-ones
US5225565A (en) * 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
EP0610265B1 (en) * 1991-11-01 1996-12-27 PHARMACIA & UPJOHN COMPANY Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
US5380778A (en) * 1992-09-30 1995-01-10 Minnesota Mining And Manufacturing Company Fluorochemical aminoalcohols
DK0673370T3 (da) * 1992-12-08 1998-09-07 Upjohn Co Troponsubstituerede phenyloxazolidinoner som antibakterielle midler
TW286317B (it) * 1993-12-13 1996-09-21 Hoffmann La Roche
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
ATE207487T1 (de) * 1995-09-01 2001-11-15 Upjohn Co Phenyloxazolidinone mit einer c-c-bindung zu 4-8 gliedrigen heterocyclen
US5883093A (en) * 1995-09-12 1999-03-16 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
FR2741071B1 (fr) * 1995-11-09 1997-12-12 Synthelabo Derives de 3-(benzofuran-5-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
PT1114819E (pt) * 1996-04-11 2008-02-28 Pharmacia & Upjohn Co Llc Processo para preparação de oxazolidinonas
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
HUP0004388A3 (en) 1997-11-07 2001-10-29 Upjohn Co Process for the preparation of oxazolidinones, intermediates and preparation thereof
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
BR9910971A (pt) 1998-06-05 2001-02-13 Astrazeneca Ab Composto, processos para a preparação de um composto e para produzir um efeito antibacteriano em um animal de sangue quente, uso de um composto, e, composição farmacêutica
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
US6444813B2 (en) * 2000-02-02 2002-09-03 Pharmacia & Upjohn Company Linezolid-crystal form II
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6410728B1 (en) * 2000-08-31 2002-06-25 Abbott Laboratories Oxazolidinone chemotherapeutic agents
WO2002018354A1 (en) * 2000-08-31 2002-03-07 Abbott Laboratories Oxazolidinones and their use as antibacterial agents
US6833453B2 (en) * 2000-10-17 2004-12-21 Pharmacia & Upjohn Company Methods of producing oxazolidinone compounds
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
MX2007001169A (es) * 2004-08-02 2007-03-12 Hoffmann La Roche Derivados de benciloxi como inhibidores de la oxidasa de monoamina b.
WO2010042887A2 (en) 2008-10-10 2010-04-15 Trius Therapeutics Methods for preparing oxazolidinones and compositions containing them
PE20120585A1 (es) 2009-02-03 2012-06-13 Trius Therapeutics Forma cristalina del fosfato de dihidrogeno r)-3-(4-(2-(2-metiltetrazol-5-il) piridin-5-il)-3-fluorofensil)-5-hidroximetil oxazolidin-2-ona
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1180089A (en) * 1967-10-20 1970-02-04 Delalande Sa Acetylenic Derivatives of 2-Oxazolidinones and processes of preparation
GB1222708A (en) * 1968-10-22 1971-02-17 Delalande Sa Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation
LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
FR2428032A1 (fr) * 1978-06-09 1980-01-04 Delalande Sa Nouvelles oxazolidimones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique
FR2435473A2 (fr) * 1978-08-17 1980-04-04 Delalande Sa Nouvelles n-aryle oxazolidinones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique
FR2458547B2 (fr) * 1978-06-09 1986-05-16 Delalande Sa Nouvelles n-aryle azolones, leur procede de preparation et leur application en therapeutique
CA1171865A (en) * 1980-06-04 1984-07-31 Alain Lacour N-aryl azolone derivatives, the process for preparing the same and their application in therapeutics

Also Published As

Publication number Publication date
GB8417905D0 (en) 1984-08-15
NL8200732A (nl) 1982-09-16
SE457258B (sv) 1988-12-12
FR2500450A1 (fr) 1982-08-27
ES8306707A1 (es) 1983-06-16
AU8075682A (en) 1982-09-02
CA1178594A (en) 1984-11-27
FR2500450B1 (it) 1983-12-02
IT8219730A0 (it) 1982-02-18
JPS5838273A (ja) 1983-03-05
GB2141716B (en) 1985-08-29
CH653999A5 (fr) 1986-01-31
US4476136A (en) 1984-10-09
AU553462B2 (en) 1986-07-17
GB2094299B (en) 1985-08-21
DE3206770A1 (de) 1982-11-11
ES8400729A1 (es) 1983-12-01
LU83963A1 (fr) 1983-09-02
JPH0261465B2 (it) 1990-12-20
BE892270A (fr) 1982-08-25
ES509848A0 (es) 1983-06-16
GB2141716A (en) 1985-01-03
ES520180A0 (es) 1983-12-01
GB2094299A (en) 1982-09-15
SE8201145L (sv) 1982-08-26

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