IL67572A - Trans-2-aza bicyclo(3.(3+n).o)alkane-3-carboxylic acid derivatives,processes for their preparation and pharmaceutical compositions containing them - Google Patents

Trans-2-aza bicyclo(3.(3+n).o)alkane-3-carboxylic acid derivatives,processes for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL67572A
IL67572A IL67572A IL6757282A IL67572A IL 67572 A IL67572 A IL 67572A IL 67572 A IL67572 A IL 67572A IL 6757282 A IL6757282 A IL 6757282A IL 67572 A IL67572 A IL 67572A
Authority
IL
Israel
Prior art keywords
alkane
trans
processes
preparation
carboxylic acid
Prior art date
Application number
IL67572A
Other languages
English (en)
Other versions
IL67572A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25798350&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL67572(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19813151690 external-priority patent/DE3151690A1/de
Priority claimed from DE19823210701 external-priority patent/DE3210701A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL67572A0 publication Critical patent/IL67572A0/xx
Priority to IL84058A priority Critical patent/IL84058A0/xx
Publication of IL67572A publication Critical patent/IL67572A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL67572A 1981-12-29 1982-12-27 Trans-2-aza bicyclo(3.(3+n).o)alkane-3-carboxylic acid derivatives,processes for their preparation and pharmaceutical compositions containing them IL67572A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL84058A IL84058A0 (en) 1981-12-29 1987-10-01 Bicyclic heterocyclic compounds and their preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19813151690 DE3151690A1 (de) 1981-12-29 1981-12-29 "neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung"
DE19823210701 DE3210701A1 (de) 1982-03-24 1982-03-24 2-azabicycloalkan-3-carbonsaeuren und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
IL67572A0 IL67572A0 (en) 1983-05-15
IL67572A true IL67572A (en) 1992-08-18

Family

ID=25798350

Family Applications (1)

Application Number Title Priority Date Filing Date
IL67572A IL67572A (en) 1981-12-29 1982-12-27 Trans-2-aza bicyclo(3.(3+n).o)alkane-3-carboxylic acid derivatives,processes for their preparation and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (3) US5008400A (bg)
EP (1) EP0084164B1 (bg)
JP (3) JPS58118569A (bg)
KR (1) KR890003424B1 (bg)
AR (1) AR247571A1 (bg)
AU (1) AU559140B2 (bg)
BG (1) BG60936B2 (bg)
CA (1) CA1341296C (bg)
CS (1) CS409591A3 (bg)
DE (2) DE3275293D1 (bg)
DK (2) DK170444B1 (bg)
DZ (1) DZ490A1 (bg)
ES (2) ES518574A0 (bg)
FI (1) FI80017C (bg)
GR (1) GR78413B (bg)
HK (1) HK74989A (bg)
HU (1) HU194167B (bg)
IE (1) IE55867B1 (bg)
IL (1) IL67572A (bg)
LU (1) LU88263I2 (bg)
MA (1) MA19672A1 (bg)
NL (1) NL930048I2 (bg)
NO (1) NO156786C (bg)
NZ (1) NZ202903A (bg)
PH (2) PH18918A (bg)
PT (1) PT76052B (bg)
SG (1) SG1389G (bg)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU88621I2 (fr) * 1980-10-23 1995-09-01 Schering Corp Sandopril
GR78413B (bg) * 1981-12-29 1984-09-27 Hoechst Ag
DE3246503A1 (de) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
FI841052A (fi) * 1983-03-16 1984-09-17 Usv Pharma Corp Foereningar foer behandling av blodtryckssjukdomar.
DE3324263A1 (de) * 1983-07-06 1985-01-17 Hoechst Ag, 6230 Frankfurt Derivate der 2-azabicyclo(3.1.0)hexan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(3.1.0)hexan-derivate als zwischenprodukte und verfahren zu deren herstellung
DE3410732A1 (de) * 1984-03-23 1985-09-26 Hoechst Ag, 6230 Frankfurt Methode zur behandlung des glaukoms
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
EP0190224A1 (en) * 1984-07-30 1986-08-13 Schering Corporation PROCESS FOR THE PREPARATION OF CIS, ENDOOCTAHYDROCYCLOPENTA [b] PYRROLE-2-CARBOXYLATE
GB8422165D0 (en) * 1984-09-01 1984-10-03 Wellcome Found Compounds
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
FR2605630B1 (fr) * 1986-10-22 1989-06-30 Roussel Uclaf Procede de preparation de derives de l'octahydroindole et intermediaires de preparation
DE3641451A1 (de) * 1986-12-04 1988-06-16 Hoechst Ag Derivate bicyclischer aminocarbonsaeuren, verfahren und zwischenprodukte zu deren herstellung sowie deren verwendung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
TW197945B (bg) * 1990-11-27 1993-01-11 Hoechst Ag
DE4109134A1 (de) * 1991-03-20 1992-09-24 Knoll Ag Erzeugnisse, enthaltend verapamil und trandolapril
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
US5602167A (en) * 1995-05-17 1997-02-11 Ortho Pharmaceutical Corporation 4-arylcyclohepta[c] pyrrole analgesics
EP0796855B1 (de) 1996-03-20 2002-02-06 Hoechst Aktiengesellschaft Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19703430A1 (de) * 1997-01-30 1998-08-06 Bayerische Motoren Werke Ag Knieschutzsystem für den Beifahrer in Personenkraftwagen
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19900205A1 (de) * 1999-01-07 2000-07-13 Basf Ag Verfahren zur Herstellung von (2S,4R,9S)-Octahydro-1H-indol-2-carbonsäure und Zwischenprodukte dafür
CA2363658C (en) * 2001-11-21 2005-12-13 Brantford Chemicals Inc. Improved process for the preparation of ramipril
WO2003074048A1 (en) * 2002-03-01 2003-09-12 Warner-Lambert Company Llc Method of treating osteoarthritis
MXPA05001958A (es) 2002-08-19 2005-04-28 Pfizer Prod Inc Terapia de combinacion para enfermedades hiperproliferativas.
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
CL2004000366A1 (es) * 2003-02-26 2005-01-07 Pharmacia Corp Sa Organizada B USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.
US20040220252A1 (en) * 2003-02-27 2004-11-04 Parthasaradhi Reddy Bandi Novel crystalline forms of trandolapril
DE60301980T2 (de) * 2003-02-28 2006-07-27 Les Laboratoires Servier Verfahren zur Synthese des (2S,3aS,7aS)-perhydroindol-2-carbonsäures und seiner Estern, Verwendung in der Synthese von Perindopril
SI1403275T1 (sl) * 2003-02-28 2006-02-28 Servier Lab Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
PT1403277E (pt) * 2003-02-28 2005-11-30 Servier Lab Novo processo de sintese de derivados do acido (2s, 3as, 7as)-1-((s)-alanil)-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese do perindopril
DK1319668T3 (da) * 2003-03-12 2005-02-14 Servier Lab Fremgangsmåde til syntese af (2S, 3aS, 7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese af perindopril
ATE294814T1 (de) * 2003-03-12 2005-05-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen
EP1323729B1 (fr) * 2003-03-12 2004-11-03 Les Laboratoires Servier Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril
CL2004000544A1 (es) * 2003-03-18 2005-01-28 Pharmacia Corp Sa Organizada B Uso de una combinacion farmaceutica, de un antagonista del receptor de aldosterona y un inhibidor de endopeptidasa neutral, util para el tratamiento y prevencion de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopati
US20050032784A1 (en) * 2003-04-01 2005-02-10 University Of Florida Research Foundation, Inc. Combination drug therapy for treating hypertension
WO2004092132A1 (en) * 2003-04-15 2004-10-28 Warner-Lambert Company Llc [b]-fused bicyclic proline derivatives and their use for treating arthritic conditions
PT1354874E (pt) * 2003-04-15 2005-03-31 Servier Lab Novo processo de sintese do acido (2s,3as,7as)-per-hidroindole-2-carboxilico e dos seus esteres e aplicacao a sintese do processo perindopril
EP1354875B1 (fr) * 2003-05-19 2004-11-24 Les Laboratoires Servier Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxilique et de ses esters, et application à la synthèse du perindopril
EP1354876B1 (fr) * 2003-06-13 2005-04-27 Les Laboratoires Servier Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
EP1687271A1 (en) * 2003-11-25 2006-08-09 Texcontor Etablissement A method for the preparation of (2s, 3ar, 7as)-octahydro-1h-indole-2-carboxylic acid as key intermediate in the preparation of trandolapril by reacting a cyclohexyl aziridine with a dialkyl malonate
WO2005051909A1 (de) * 2003-11-28 2005-06-09 Azad Pharmaceuticals Ingredients Ag Verfahren zur herstellung von {n-[1-(s)-carbalkoxy-3-phenylpropyl]-s-alanyl-2s, 3ar, 7as-octahydroindol-2-carbonsäure}verbindungen
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
WO2006014916A2 (en) * 2004-07-26 2006-02-09 Dr. Reddy's Laboratories Ltd. Preparation of trandolapril
US20060079698A1 (en) * 2004-10-07 2006-04-13 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of trandolapril and use thereof for the preparation of trandolapril
AU2005327440A1 (en) * 2005-02-14 2006-08-17 Lupin Limited Improved process for preparation of highly pure trandolapril
ATE386718T1 (de) * 2005-05-06 2008-03-15 Sochinaz Sa Verfahren zur herstellung von (2s, 3ar, 7as)- octahydroindole-2-carbonsäure und umwandlung zum trandolapril
EP1899300A2 (en) * 2005-07-05 2008-03-19 Cipla Limited Process for the synthesis of the ace inhibitor trandolapril
WO2007026371A2 (en) * 2005-09-01 2007-03-08 Wockhardt Limited Process for preparing trandolapril and intermediates thereof
WO2007026372A2 (en) * 2005-09-01 2007-03-08 Wockhardt Limited Novel crystalline polymorph of trandolapril and a process for preparation thereof
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7943655B2 (en) * 2006-04-05 2011-05-17 Universitat Zurich Polymorphic and pseudopolymorphic forms of trandolaprilat, pharmaceutical compositions and methods for production and use
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
CN101302218B (zh) * 2007-05-08 2011-02-23 上海医药工业研究院 群多普利双酮的制备方法
CN101302185B (zh) * 2007-05-08 2010-09-01 上海医药工业研究院 群多普利拉的制备方法
WO2011009021A1 (en) 2009-07-16 2011-01-20 Abbott Laboratories Processes for the synthesis of (2s, 3ar, 7as)-octahydro-1h-indole carboxylic acid as an intermediate for trandolapril
CN104045593B (zh) * 2013-03-12 2016-11-02 上海交通大学 一种群多普利中间体的制备方法
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
CN103288710A (zh) * 2013-05-20 2013-09-11 大连海荣科技开发有限公司 群多普利中间体（2S，3aR，7aS）-八氢-1H-吲哚-2-羧酸的制备方法
CN104086623B (zh) * 2014-07-02 2017-05-24 牡丹江友搏药业有限责任公司 一种新的具有降压和细胞保护作用的化合物
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN113574055B (zh) 2019-01-18 2024-07-23 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR31741E (fr) * 1926-03-29 1927-06-10 Essuie-glace
JPS5572169A (en) * 1978-11-27 1980-05-30 Tanabe Seiyaku Co Ltd Isoquinoline derivative and its preparation
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4294832A (en) * 1979-04-28 1981-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4616029A (en) * 1979-12-07 1986-10-07 Adir Perhydromdole-2-carboxylic acids as antihypertensives
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
ZA811493B (en) * 1980-04-02 1982-03-31 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4344449A (en) * 1980-05-16 1982-08-17 The United States Of America As Represented By The United States Department Of Energy Fast-acting valve and uses thereof
EP0046953B1 (de) * 1980-08-30 1989-12-06 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
IL63813A0 (en) * 1980-09-17 1981-12-31 Univ Miami Carboxyalkyl peptides and thioethers and ethers of peptides,antihypertensive compositions and methods for their use
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
LU88621I2 (fr) * 1980-10-23 1995-09-01 Schering Corp Sandopril
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application
US4820729A (en) * 1981-03-30 1989-04-11 Rorer Pharmaceutical Corporation N-substituted-amido-amino acids
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
GR78413B (bg) * 1981-12-29 1984-09-27 Hoechst Ag
DE3210496A1 (de) * 1982-03-23 1983-10-06 Hoechst Ag Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3211397A1 (de) * 1982-03-27 1983-11-10 Hoechst Ag, 6230 Frankfurt Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3211676A1 (de) * 1982-03-30 1983-10-06 Hoechst Ag Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
US4490386A (en) * 1982-09-23 1984-12-25 Warner-Lambert Company Phosphate salts of 1-[2-[(1-alkoxycarbonyl-3-aralkyl)-amino]-1-oxoalkyl]octahydro-1H-indole-2-carboxylic acids, preparation of, and medical compositions thereof
DE3242151A1 (de) * 1982-11-13 1984-05-17 Hoechst Ag, 6230 Frankfurt Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3246503A1 (de) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
US4468396A (en) * 1982-12-20 1984-08-28 Schering Corporation Antihypertensive benzothiadiazines
DE3300316A1 (de) * 1983-01-07 1984-07-12 Hoechst Ag, 6230 Frankfurt Disubstituierte prolinderivate, verfahren zu ihrer herstellung und ihre verwendung
DE3300774A1 (de) * 1983-01-12 1984-07-12 Hoechst Ag, 6230 Frankfurt Neue spirocyclische aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue spirocyclische aminosaeuren als zwischenprodukte und verfahren zu deren herstellung
DE3303112A1 (de) * 1983-01-31 1984-08-09 Hoechst Ag, 6230 Frankfurt Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3322530A1 (de) * 1983-06-23 1985-01-10 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren
DE3324263A1 (de) * 1983-07-06 1985-01-17 Hoechst Ag, 6230 Frankfurt Derivate der 2-azabicyclo(3.1.0)hexan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(3.1.0)hexan-derivate als zwischenprodukte und verfahren zu deren herstellung
US4559340A (en) * 1983-11-25 1985-12-17 Schering Corporation Antihypertensive agents
DE3345355A1 (de) * 1983-12-15 1985-06-27 Hoechst Ag, 6230 Frankfurt Verfahren zur racematspaltung bicyclischer imino-(alpha)-carbonsaeureester

Also Published As

Publication number Publication date
US5101039A (en) 1992-03-31
DK119992D0 (da) 1992-09-28
NO824394L (no) 1983-06-30
JPS58118569A (ja) 1983-07-14
PH19771A (en) 1986-06-27
EP0084164B1 (de) 1987-01-28
DE3280014D1 (en) 1989-12-14
IL67572A0 (en) 1983-05-15
CA1341296C (en) 2001-09-25
MA19672A1 (fr) 1983-07-01
PT76052A (de) 1983-01-01
ES8308850A1 (es) 1983-10-01
CS409591A3 (en) 1992-04-15
NO156786C (no) 1987-11-25
DK170444B1 (da) 1995-09-04
DZ490A1 (fr) 2004-09-13
FI824474A0 (fi) 1982-12-27
NL930048I2 (nl) 1994-01-03
JPH064586B2 (ja) 1994-01-19
IE55867B1 (en) 1991-02-14
GR78413B (bg) 1984-09-27
JPH0587504B2 (bg) 1993-12-16
DK576782A (da) 1983-06-30
FI80017C (fi) 1990-04-10
AU9193182A (en) 1983-07-07
DK119992A (da) 1992-09-28
JPH01301695A (ja) 1989-12-05
ES8402271A1 (es) 1984-01-16
JPH01301659A (ja) 1989-12-05
LU88263I2 (bg) 1994-02-03
FI824474L (fi) 1983-06-30
NL930048I1 (nl) 1993-09-01
BG60936B2 (bg) 1996-06-28
IE823065L (en) 1983-06-29
PT76052B (de) 1985-11-28
DK171232B1 (da) 1996-08-05
KR890003424B1 (ko) 1989-09-20
EP0084164A2 (de) 1983-07-27
US4933361A (en) 1990-06-12
US5008400A (en) 1991-04-16
NO156786B (no) 1987-08-17
FI80017B (fi) 1989-12-29
HU194167B (en) 1988-01-28
ES518574A0 (es) 1983-10-01
ES521740A0 (es) 1984-01-16
NZ202903A (en) 1988-01-08
KR840002810A (ko) 1984-07-21
SG1389G (en) 1989-06-02
EP0084164A3 (en) 1983-10-12
DE3275293D1 (en) 1987-03-05
AU559140B2 (en) 1987-02-26
HK74989A (en) 1989-09-22
AR247571A1 (es) 1995-01-31
PH18918A (en) 1985-11-06

Similar Documents

Publication Publication Date Title
IL67572A (en) Trans-2-aza bicyclo(3.(3+n).o)alkane-3-carboxylic acid derivatives,processes for their preparation and pharmaceutical compositions containing them
DE3263633D1 (en) Imidazodiazepines, process for their preparation and pharmaceutical compositions containing them
PH19003A (en) New 2-cyl-cycloalka (c) pyrrol-3-carboxylic acid derivatives,pharmaceutical compositions containing them and their use
IL84446A0 (en) 3-pyrrolidinylthio-1-azabicyclo-(3.2.0)hept-2-ene-2-carboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL65257A0 (en) Arylcyclo-butanealkylamine derivatives,their preparation and pharmaceutical compositions containing them
IL65803A (en) Cyclobutene-dione derivatives,their preparation and pharmaceutical compositions containing them
IL65076A (en) 3,4-dihydro-5h-2,3-benzo-diazepine derivatives,their preparation and pharmaceutical compositions containing them
DE3374686D1 (en) 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IL64777A0 (en) 3-aminopropoxyaryl derivatives,their preparation and pharmaceutical compositions containing them
DE3275296D1 (en) Azabicyclo-(3,3,1)-nonylbenzamide derivatives, processes for their preparation, and pharmaceutical compositions containing them
DE3270202D1 (en) 3,5-di-tert-butylstyrene derivatives, processes for their preparations, and pharmaceutical compositions containing them
IL85290A0 (en) Substituted 3,4-dihydro-2h-benzopyrans,processes for their preparation and pharmaceutical compositions containing same
IL65327A0 (en) Acylquinolinone derivatives,their preparation and pharmaceutical compositions containing them
IL65858A (en) 4-demethoxy-6(11)-deoxy-doxorubicin and daunorubicin derivatives,their preparation and pharmaceutical compositions containing them
IL64732A0 (en) Carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
DE3273629D1 (en) New ribofuranuronic acid derivatives, processes for preparation thereof and pharmaceutical compositions thereof
IL66238A0 (en) Benzothiazolesulfonamide derivatives,their preparation and pharmaceutical compositions containing them
DE3162626D1 (en) Phenylalkanoic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IL65422A0 (en) 2-piperazino-pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
EP0069784A4 (en) THIAZOLYL UREA COMBINATIONS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCT CONTAINING THE SAME.
IL57705A0 (en) Bicyclo(3,1,0)hexyl-substituted carbonyl-aminophenoxy derivatives,their preparation and pharmaceutical compositions containing them
IL64859A (en) 7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives,their preparation and pharmaceutical compositions comprising them
DE3573428D1 (en) Novel delta4- and delta5- androstene derivatives, processes for their preparation and pharmaceutical compositions containing these derivatives
IL68619A (en) 11-oxo-11h-pyrido(2,1-h)quinazolinecarboxylic acid derivatives,their manufacture and pharmaceutical compositions containing them
IL66277A (en) 3,7-dialkyl-3,7-diazabicyclo(3.3.1)nonan-9-ol derivatives,a process for the preparation thereof and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
HP Change in proprietorship
EXP Patent expired