ES518574A0 - Procedimiento para la preparacion de nuevos derivados de aminoacidos biciclicos. - Google Patents
Procedimiento para la preparacion de nuevos derivados de aminoacidos biciclicos.Info
- Publication number
- ES518574A0 ES518574A0 ES518574A ES518574A ES518574A0 ES 518574 A0 ES518574 A0 ES 518574A0 ES 518574 A ES518574 A ES 518574A ES 518574 A ES518574 A ES 518574A ES 518574 A0 ES518574 A0 ES 518574A0
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- preparation
- amino acid
- acid derivatives
- new bicycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19813151690 DE3151690A1 (de) | 1981-12-29 | 1981-12-29 | "neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung" |
DE19823210701 DE3210701A1 (de) | 1982-03-24 | 1982-03-24 | 2-azabicycloalkan-3-carbonsaeuren und verfahren zu ihrer herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
ES518574A0 true ES518574A0 (es) | 1983-10-01 |
ES8308850A1 ES8308850A1 (es) | 1983-10-01 |
Family
ID=25798350
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES518574A Expired ES8308850A1 (es) | 1981-12-29 | 1982-12-27 | Procedimiento para la preparacion de nuevos derivados de aminoacidos biciclicos. |
ES521740A Expired ES8402271A1 (es) | 1981-12-29 | 1983-04-22 | Procedimiento para la preparacion de nuevos aminoacidos biciclicos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES521740A Expired ES8402271A1 (es) | 1981-12-29 | 1983-04-22 | Procedimiento para la preparacion de nuevos aminoacidos biciclicos. |
Country Status (27)
Country | Link |
---|---|
US (3) | US5008400A (es) |
EP (1) | EP0084164B1 (es) |
JP (3) | JPS58118569A (es) |
KR (1) | KR890003424B1 (es) |
AR (1) | AR247571A1 (es) |
AU (1) | AU559140B2 (es) |
BG (1) | BG60936B2 (es) |
CA (1) | CA1341296C (es) |
CS (1) | CS409591A3 (es) |
DE (2) | DE3275293D1 (es) |
DK (2) | DK170444B1 (es) |
DZ (1) | DZ490A1 (es) |
ES (2) | ES8308850A1 (es) |
FI (1) | FI80017C (es) |
GR (1) | GR78413B (es) |
HK (1) | HK74989A (es) |
HU (1) | HU194167B (es) |
IE (1) | IE55867B1 (es) |
IL (1) | IL67572A (es) |
LU (1) | LU88263I2 (es) |
MA (1) | MA19672A1 (es) |
NL (1) | NL930048I2 (es) |
NO (1) | NO156786C (es) |
NZ (1) | NZ202903A (es) |
PH (2) | PH18918A (es) |
PT (1) | PT76052B (es) |
SG (1) | SG1389G (es) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0050800B2 (en) * | 1980-10-23 | 1995-06-07 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
GR78413B (es) * | 1981-12-29 | 1984-09-27 | Hoechst Ag | |
DE3246503A1 (de) * | 1982-12-16 | 1984-06-20 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
FI841052A (fi) * | 1983-03-16 | 1984-09-17 | Usv Pharma Corp | Foereningar foer behandling av blodtryckssjukdomar. |
DE3324263A1 (de) * | 1983-07-06 | 1985-01-17 | Hoechst Ag, 6230 Frankfurt | Derivate der 2-azabicyclo(3.1.0)hexan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(3.1.0)hexan-derivate als zwischenprodukte und verfahren zu deren herstellung |
DE3410732A1 (de) * | 1984-03-23 | 1985-09-26 | Hoechst Ag, 6230 Frankfurt | Methode zur behandlung des glaukoms |
DE3413710A1 (de) * | 1984-04-12 | 1985-10-24 | Hoechst Ag, 6230 Frankfurt | Verfahren zur behandlung der herzinsuffizienz |
US5684016A (en) * | 1984-04-12 | 1997-11-04 | Hoechst Aktiengesellschaft | Method of treating cardiac insufficiency |
AU581919B2 (en) * | 1984-07-30 | 1989-03-09 | Schering Corporation | Process for the preparation of cis, endooctahydrocyclopenta (b) pyrrole-2-carboxylate |
GB8422165D0 (en) * | 1984-09-01 | 1984-10-03 | Wellcome Found | Compounds |
US5231084A (en) * | 1986-03-27 | 1993-07-27 | Hoechst Aktiengesellschaft | Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons |
FR2605630B1 (fr) * | 1986-10-22 | 1989-06-30 | Roussel Uclaf | Procede de preparation de derives de l'octahydroindole et intermediaires de preparation |
DE3641451A1 (de) * | 1986-12-04 | 1988-06-16 | Hoechst Ag | Derivate bicyclischer aminocarbonsaeuren, verfahren und zwischenprodukte zu deren herstellung sowie deren verwendung |
DE3722007A1 (de) * | 1987-07-03 | 1989-01-12 | Hoechst Ag | Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung |
TW197945B (es) * | 1990-11-27 | 1993-01-11 | Hoechst Ag | |
DE4109134A1 (de) * | 1991-03-20 | 1992-09-24 | Knoll Ag | Erzeugnisse, enthaltend verapamil und trandolapril |
LT3872B (en) | 1993-12-06 | 1996-04-25 | Hoechst Ag | Novel peptides and pharmaceutical compositions containing them |
US5602167A (en) * | 1995-05-17 | 1997-02-11 | Ortho Pharmaceutical Corporation | 4-arylcyclohepta[c] pyrrole analgesics |
FR2746394B1 (fr) | 1996-03-20 | 1998-05-29 | Roussel Uclaf | Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
EP0796855B1 (de) | 1996-03-20 | 2002-02-06 | Hoechst Aktiengesellschaft | Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
DE19653647A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
DE19703430A1 (de) * | 1997-01-30 | 1998-08-06 | Bayerische Motoren Werke Ag | Knieschutzsystem für den Beifahrer in Personenkraftwagen |
DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19751251A1 (de) | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19900205A1 (de) | 1999-01-07 | 2000-07-13 | Basf Ag | Verfahren zur Herstellung von (2S,4R,9S)-Octahydro-1H-indol-2-carbonsäure und Zwischenprodukte dafür |
CA2363658C (en) * | 2001-11-21 | 2005-12-13 | Brantford Chemicals Inc. | Improved process for the preparation of ramipril |
CA2477391A1 (en) * | 2002-03-01 | 2003-09-12 | Denis Schrier | Method of treating osteoarthritis |
EP1545519B1 (en) | 2002-08-19 | 2011-03-23 | Pfizer Inc. | Combination therapy for hyperproliferative diseases |
US6812355B2 (en) | 2002-10-22 | 2004-11-02 | Sekhsaria Chemicals Limited | Process for the manufacture of citalopram hydrobromide from 5-bromophthalide |
CL2004000366A1 (es) * | 2003-02-26 | 2005-01-07 | Pharmacia Corp Sa Organizada B | USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA. |
TR200503398T1 (tr) * | 2003-02-27 | 2007-01-22 | Hetero Drugs Umited | Trandolapril'in yeni kristal formları. |
EP1403275B1 (fr) * | 2003-02-28 | 2005-10-19 | Les Laboratoires Servier | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
SI1338591T1 (sl) * | 2003-02-28 | 2006-02-28 | Servier Lab | NOV POSTOPEK ZA SINTEZO (2S,3aS,7aS)-PERHIDROINDOL-2-KARBOKSILNE KISLINE IN NJENIH ESTROV TER UPORABA PRI SINTEZI PERINDOPRILA |
ES2249691T3 (es) * | 2003-02-28 | 2006-04-01 | Les Laboratoires Servier | Procedimiento de sintesis de derivados del acido (2s,3as,7as)-1-(s)-alanil)-octahidro-1h-indol-2-carboxilico y su utilizacion en la sintesis de perindopril. |
EP1321471B1 (fr) * | 2003-03-12 | 2005-05-04 | Les Laboratoires Servier | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
ES2231760T3 (es) * | 2003-03-12 | 2005-05-16 | Les Laboratoires Servier | Nuevo procedimiento de sintesis del acido(2s, 3as,7as)perhidroindol-2-carboxilico y de sus esteres, y su aplicacion a la sintesis de perindopril. |
ATE280775T1 (de) * | 2003-03-12 | 2004-11-15 | Servier Lab | Verfahren zur synthese von (2s,3as,7as)-1-((s)- |
CL2004000544A1 (es) * | 2003-03-18 | 2005-01-28 | Pharmacia Corp Sa Organizada B | Uso de una combinacion farmaceutica, de un antagonista del receptor de aldosterona y un inhibidor de endopeptidasa neutral, util para el tratamiento y prevencion de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopati |
US20050032784A1 (en) * | 2003-04-01 | 2005-02-10 | University Of Florida Research Foundation, Inc. | Combination drug therapy for treating hypertension |
SI1354874T1 (en) * | 2003-04-15 | 2005-04-30 | Les Laboratoires Servier | Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril |
MXPA05011168A (es) * | 2003-04-15 | 2005-12-14 | Warner Lambert Co | Derivados de prolina biciclicos [b]-condensados y sus usos para tratar afecciones artriticas. |
EP1354875B1 (fr) * | 2003-05-19 | 2004-11-24 | Les Laboratoires Servier | Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxilique et de ses esters, et application à la synthèse du perindopril |
ATE294161T1 (de) * | 2003-06-13 | 2005-05-15 | Servier Lab | Verfahren zur synthese von (2s,3as,7as)- perhydroindol-2-carbonsäure und seiner estern, und verwendung in der synthese von perindopril |
US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
EP1687271A1 (en) * | 2003-11-25 | 2006-08-09 | Texcontor Etablissement | A method for the preparation of (2s, 3ar, 7as)-octahydro-1h-indole-2-carboxylic acid as key intermediate in the preparation of trandolapril by reacting a cyclohexyl aziridine with a dialkyl malonate |
US20070135513A1 (en) * | 2003-11-28 | 2007-06-14 | Mirko Pogutter | Method for producing {n-[1-(s)-carbalkoxy-3-phenylpropyl]-s-alanyl-2s, 3ar, 7as-octahydroindole-2-carboxylic acid} compounds |
GB2413128A (en) * | 2004-04-13 | 2005-10-19 | Neopharma Ltd | Process for the preparation of perindopril |
WO2006014916A2 (en) * | 2004-07-26 | 2006-02-09 | Dr. Reddy's Laboratories Ltd. | Preparation of trandolapril |
US20060079698A1 (en) * | 2004-10-07 | 2006-04-13 | Glenmark Pharmaceuticals Limited | Process for the preparation of intermediates of trandolapril and use thereof for the preparation of trandolapril |
EP1866327A1 (en) * | 2005-02-14 | 2007-12-19 | Lupin Ltd. | Improved process for preparation of highly pure trandolapril |
EP1724260B1 (en) * | 2005-05-06 | 2008-02-20 | Sochinaz SA | Process for the synthesis of (2S, 3aR, 7aS)octahydroindole-2-carboxylic acid and its conversion to trandolapril |
US7973173B2 (en) * | 2005-07-05 | 2011-07-05 | Cipla Limited | Process for the synthesis of an ACE inhibitor |
WO2007026371A2 (en) * | 2005-09-01 | 2007-03-08 | Wockhardt Limited | Process for preparing trandolapril and intermediates thereof |
WO2007026372A2 (en) * | 2005-09-01 | 2007-03-08 | Wockhardt Limited | Novel crystalline polymorph of trandolapril and a process for preparation thereof |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
US7943655B2 (en) | 2006-04-05 | 2011-05-17 | Universitat Zurich | Polymorphic and pseudopolymorphic forms of trandolaprilat, pharmaceutical compositions and methods for production and use |
EP2094643B1 (en) | 2006-12-01 | 2012-02-29 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
CN101302185B (zh) * | 2007-05-08 | 2010-09-01 | 上海医药工业研究院 | 群多普利拉的制备方法 |
CN101302218B (zh) * | 2007-05-08 | 2011-02-23 | 上海医药工业研究院 | 群多普利双酮的制备方法 |
EP2454235A1 (en) | 2009-07-16 | 2012-05-23 | Abbott Laboratories | Processes for the synthesis of (2s, 3ar, 7as)-octahydro-1h-indole carboxylic acid as an intermediate for trandolapril |
CN104045593B (zh) * | 2013-03-12 | 2016-11-02 | 上海交通大学 | 一种群多普利中间体的制备方法 |
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CN104086623B (zh) * | 2014-07-02 | 2017-05-24 | 牡丹江友搏药业有限责任公司 | 一种新的具有降压和细胞保护作用的化合物 |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
EP3911648A4 (en) | 2019-01-18 | 2022-10-26 | Astrazeneca AB | PCSK9 INHIBITORS AND METHODS OF USE THEREOF |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR31741E (fr) * | 1926-03-29 | 1927-06-10 | Essuie-glace | |
JPS5572169A (en) * | 1978-11-27 | 1980-05-30 | Tanabe Seiyaku Co Ltd | Isoquinoline derivative and its preparation |
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
US4294832A (en) * | 1979-04-28 | 1981-10-13 | Tanabe Seiyaku Co., Ltd. | Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof |
US4616029A (en) * | 1979-12-07 | 1986-10-07 | Adir | Perhydromdole-2-carboxylic acids as antihypertensives |
FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
FR2487829A2 (fr) * | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
US4508729A (en) * | 1979-12-07 | 1985-04-02 | Adir | Substituted iminodiacids, their preparation and pharmaceutical compositions containing them |
US4350704A (en) * | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
IE52663B1 (en) * | 1980-04-02 | 1988-01-20 | Warner Lambert Co | Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids |
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DE3226768A1 (de) * | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
GR78413B (es) * | 1981-12-29 | 1984-09-27 | Hoechst Ag | |
DE3210496A1 (de) * | 1982-03-23 | 1983-10-06 | Hoechst Ag | Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung |
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DE3300774A1 (de) * | 1983-01-12 | 1984-07-12 | Hoechst Ag, 6230 Frankfurt | Neue spirocyclische aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue spirocyclische aminosaeuren als zwischenprodukte und verfahren zu deren herstellung |
DE3303112A1 (de) * | 1983-01-31 | 1984-08-09 | Hoechst Ag, 6230 Frankfurt | Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren |
DE3315464A1 (de) * | 1983-04-28 | 1984-10-31 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern |
DE3322530A1 (de) * | 1983-06-23 | 1985-01-10 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren |
DE3324263A1 (de) * | 1983-07-06 | 1985-01-17 | Hoechst Ag, 6230 Frankfurt | Derivate der 2-azabicyclo(3.1.0)hexan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(3.1.0)hexan-derivate als zwischenprodukte und verfahren zu deren herstellung |
US4559340A (en) * | 1983-11-25 | 1985-12-17 | Schering Corporation | Antihypertensive agents |
DE3345355A1 (de) * | 1983-12-15 | 1985-06-27 | Hoechst Ag, 6230 Frankfurt | Verfahren zur racematspaltung bicyclischer imino-(alpha)-carbonsaeureester |
-
1982
- 1982-12-23 GR GR70162A patent/GR78413B/el unknown
- 1982-12-23 NZ NZ202903A patent/NZ202903A/en unknown
- 1982-12-23 CA CA000418453A patent/CA1341296C/en not_active Expired - Lifetime
- 1982-12-23 IE IE3065/82A patent/IE55867B1/en active Protection Beyond IP Right Term
- 1982-12-24 EP EP82112007A patent/EP0084164B1/de not_active Expired
- 1982-12-24 DE DE8282112007T patent/DE3275293D1/de not_active Expired
- 1982-12-24 AU AU91931/82A patent/AU559140B2/en not_active Expired
- 1982-12-24 DE DE8585103730T patent/DE3280014D1/de not_active Expired
- 1982-12-24 LU LU88263C patent/LU88263I2/xx unknown
- 1982-12-27 MA MA19890A patent/MA19672A1/fr unknown
- 1982-12-27 JP JP57227179A patent/JPS58118569A/ja active Granted
- 1982-12-27 ES ES518574A patent/ES8308850A1/es not_active Expired
- 1982-12-27 FI FI824474A patent/FI80017C/fi not_active IP Right Cessation
- 1982-12-27 KR KR8205823A patent/KR890003424B1/ko active
- 1982-12-27 PH PH28321A patent/PH18918A/en unknown
- 1982-12-27 IL IL67572A patent/IL67572A/xx not_active IP Right Cessation
- 1982-12-28 NO NO824394A patent/NO156786C/no not_active IP Right Cessation
- 1982-12-28 HU HU844653A patent/HU194167B/hu unknown
- 1982-12-28 DK DK576782A patent/DK170444B1/da not_active IP Right Cessation
- 1982-12-29 DZ DZ826743A patent/DZ490A1/fr active
- 1982-12-29 PT PT76052A patent/PT76052B/pt unknown
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1983
- 1983-04-22 ES ES521740A patent/ES8402271A1/es not_active Expired
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1984
- 1984-06-06 PH PH30781A patent/PH19771A/en unknown
- 1984-11-21 US US06/673,605 patent/US5008400A/en not_active Expired - Lifetime
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1985
- 1985-02-18 AR AR85299524A patent/AR247571A1/es active
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1989
- 1989-01-07 SG SG13/89A patent/SG1389G/en unknown
- 1989-01-18 JP JP1007871A patent/JPH064586B2/ja not_active Expired - Lifetime
- 1989-01-18 JP JP1007870A patent/JPH01301695A/ja active Pending
- 1989-04-28 US US07/346,339 patent/US4933361A/en not_active Expired - Lifetime
- 1989-09-14 HK HK749/89A patent/HK74989A/xx not_active IP Right Cessation
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1990
- 1990-01-23 US US07/468,567 patent/US5101039A/en not_active Expired - Lifetime
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1991
- 1991-12-27 CS CS914095A patent/CS409591A3/cs unknown
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1992
- 1992-09-28 DK DK119992A patent/DK171232B1/da not_active IP Right Cessation
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1993
- 1993-06-03 NL NL930048C patent/NL930048I2/nl unknown
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1994
- 1994-02-24 BG BG98551A patent/BG60936B2/bg unknown
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