IL205753A0 - Isoxazolo-pyridazine derivatives - Google Patents

Isoxazolo-pyridazine derivatives

Info

Publication number
IL205753A0
IL205753A0 IL205753A IL20575310A IL205753A0 IL 205753 A0 IL205753 A0 IL 205753A0 IL 205753 A IL205753 A IL 205753A IL 20575310 A IL20575310 A IL 20575310A IL 205753 A0 IL205753 A0 IL 205753A0
Authority
IL
Israel
Prior art keywords
isoxazolo
pyridazine derivatives
pyridazine
derivatives
Prior art date
Application number
IL205753A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL205753A0 publication Critical patent/IL205753A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL205753A 2007-12-04 2010-05-13 Isoxazolo-pyridazine derivatives IL205753A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07122293 2007-12-04
PCT/EP2008/066226 WO2009071477A1 (en) 2007-12-04 2008-11-26 Isoxazolo-pyridazine derivatives

Publications (1)

Publication Number Publication Date
IL205753A0 true IL205753A0 (en) 2010-11-30

Family

ID=40328910

Family Applications (1)

Application Number Title Priority Date Filing Date
IL205753A IL205753A0 (en) 2007-12-04 2010-05-13 Isoxazolo-pyridazine derivatives

Country Status (15)

Country Link
US (1) US7943619B2 (zh)
EP (1) EP2231651B1 (zh)
JP (1) JP5301558B2 (zh)
KR (1) KR101175855B1 (zh)
CN (1) CN101868458B (zh)
AR (1) AR069525A1 (zh)
AU (1) AU2008333327B2 (zh)
BR (1) BRPI0820113A2 (zh)
CA (1) CA2707821C (zh)
CL (1) CL2008003593A1 (zh)
IL (1) IL205753A0 (zh)
MX (1) MX2010006182A (zh)
PE (1) PE20091446A1 (zh)
TW (1) TW200924775A (zh)
WO (1) WO2009071477A1 (zh)

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CA2760597C (en) * 2009-05-05 2017-08-22 F. Hoffmann-La Roche Ag Isoxazole-pyridazine derivatives
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AR081626A1 (es) * 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
EP2638035B1 (en) * 2010-11-09 2014-12-17 F.Hoffmann-La Roche Ag Triazole derivatives as ligands for Gaba receptors
MX346185B (es) * 2010-11-15 2017-03-10 Agenebio Inc Derivados de piridazina, composiciones y metodos para tratar deterioro cognitivo.
WO2013045519A1 (en) 2011-09-27 2013-04-04 Genfit Derivatives of 6-substituted triazolopyridazines as rev-erb agonists
US8604062B2 (en) 2011-10-20 2013-12-10 Hoffman-La Roche Inc. Process for the preparation of isoxazolyl-methoxy nicotinic acids
US9273011B2 (en) * 2011-10-28 2016-03-01 Inhibitaxin Limited Substituted pyridazines for the treatment of pain
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WO2014001279A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001281A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001280A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001278A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
JP6223443B2 (ja) 2012-06-26 2017-11-01 サニオナ・エイピイエス フェニルトリアゾール誘導体及びｇａｂａａ受容体複合体を調節するための該フェニルトリアゾール誘導体の使用
US10329301B2 (en) 2013-12-20 2019-06-25 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US10815242B2 (en) 2015-06-19 2020-10-27 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN107344939A (zh) * 2016-05-06 2017-11-14 如东赛默罗生物科技有限公司 咪唑[2,1-a]酞嗪类衍生物、其制备方法、药物组合物和用途
JP7084405B2 (ja) * 2016-12-08 2022-06-14 エフ．ホフマン－ラ ロシュ アーゲー Ｇａｂａ ａ ａｌｐｈａ５ ｐａｍとしての新規イソキサゾリルエーテル誘導体
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2019238633A1 (en) 2018-06-13 2019-12-19 F. Hoffmann-La Roche Ag New isoxazolyl ether derivatives as gaba a alpha5 pam
WO2019246300A1 (en) 2018-06-19 2019-12-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
BR102019014802A2 (pt) * 2018-07-20 2020-02-04 Boehringer Ingelheim Int difluorometil-fenil triazóis
HU231223B1 (hu) 2018-09-28 2022-01-28 Richter Gedeon Nyrt. GABAA A5 receptor modulátor hatású biciklusos vegyületek
CN112979655A (zh) * 2019-12-16 2021-06-18 上海赛默罗生物科技有限公司 ***并哒嗪类衍生物、其制备方法、药物组合物和用途
US20240043418A1 (en) 2020-03-26 2024-02-08 Richter Gedeon Nyrt. 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators
TW202202495A (zh) 2020-03-26 2022-01-16 匈牙利商羅特格登公司 作為ｇａｍｍａ－胺基丁酸Ａ受體次單元ａｌｐｈａ ５受體調節劑之㖠啶及吡啶并〔３，４－ｃ〕嗒𠯤衍生物
WO2022234271A1 (en) 2021-05-05 2022-11-10 University College Cardiff Consultants Limited Heteroaryl compounds useful in the treatment of cognitive disorders
HUP2100338A1 (hu) 2021-09-29 2023-04-28 Richter Gedeon Nyrt GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok
CN116854680A (zh) * 2022-03-28 2023-10-10 上海赛默罗生物科技有限公司 异噁唑-杂环类衍生物、药物组合物和用途
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Also Published As

Publication number Publication date
AU2008333327B2 (en) 2012-12-06
MX2010006182A (es) 2010-07-01
AU2008333327A1 (en) 2009-06-11
BRPI0820113A2 (pt) 2015-05-05
CA2707821C (en) 2016-06-07
PE20091446A1 (es) 2009-09-24
KR20100074320A (ko) 2010-07-01
JP2011505402A (ja) 2011-02-24
KR101175855B1 (ko) 2012-08-24
CN101868458A (zh) 2010-10-20
US7943619B2 (en) 2011-05-17
US20090143385A1 (en) 2009-06-04
EP2231651B1 (en) 2018-11-21
JP5301558B2 (ja) 2013-09-25
CL2008003593A1 (es) 2010-01-04
EP2231651A1 (en) 2010-09-29
AR069525A1 (es) 2010-01-27
TW200924775A (en) 2009-06-16
CA2707821A1 (en) 2009-06-11
WO2009071477A1 (en) 2009-06-11
CN101868458B (zh) 2012-11-28

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