IL124296A0 - Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase - Google Patents

Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Info

Publication number
IL124296A0
IL124296A0 IL12429696A IL12429696A IL124296A0 IL 124296 A0 IL124296 A0 IL 124296A0 IL 12429696 A IL12429696 A IL 12429696A IL 12429696 A IL12429696 A IL 12429696A IL 124296 A0 IL124296 A0 IL 124296A0
Authority
IL
Israel
Prior art keywords
amidine
inhibitors
nitric oxide
oxide synthase
isothiourea derivatives
Prior art date
Application number
IL12429696A
Other languages
English (en)
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9600275A external-priority patent/SE9600275D0/xx
Priority claimed from SE9603301A external-priority patent/SE9603301D0/xx
Priority claimed from SE9603300A external-priority patent/SE9603300D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of IL124296A0 publication Critical patent/IL124296A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
IL12429696A 1995-11-07 1996-11-06 Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase IL124296A0 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US627695P 1995-11-07 1995-11-07
US625395P 1995-11-07 1995-11-07
SE9600275A SE9600275D0 (sv) 1996-01-25 1996-01-25 Compounds
SE9603301A SE9603301D0 (sv) 1996-09-11 1996-09-11 Compounds and compositions
SE9603300A SE9603300D0 (sv) 1996-09-11 1996-09-11 Compounds
PCT/SE1996/001425 WO1997017344A1 (en) 1995-11-07 1996-11-06 Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Publications (1)

Publication Number Publication Date
IL124296A0 true IL124296A0 (en) 1998-12-06

Family

ID=27532790

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12429696A IL124296A0 (en) 1995-11-07 1996-11-06 Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Country Status (24)

Country Link
EP (1) EP0861250B1 (xx)
JP (1) JP2000500132A (xx)
KR (1) KR19990067349A (xx)
AT (1) ATE213241T1 (xx)
AU (1) AU701329B2 (xx)
BR (1) BR9611276A (xx)
CA (1) CA2235301A1 (xx)
CZ (1) CZ139298A3 (xx)
DE (1) DE69619259T2 (xx)
DK (1) DK0861250T3 (xx)
EE (1) EE9800141A (xx)
ES (1) ES2171743T3 (xx)
HU (1) HUP9900142A3 (xx)
IL (1) IL124296A0 (xx)
IS (1) IS4725A (xx)
NO (1) NO982072L (xx)
NZ (1) NZ322227A (xx)
PL (1) PL326554A1 (xx)
PT (1) PT861250E (xx)
SI (1) SI0861250T1 (xx)
SK (1) SK61098A3 (xx)
TR (1) TR199800813T2 (xx)
TW (1) TW458978B (xx)
WO (1) WO1997017344A1 (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016526A1 (en) * 1996-10-16 1998-04-23 Glaxo Group Limited Tetrahydro-6h-pyrazino[1,2-b]isoquinoline 1,4-diones as apoprotein b-100 inhibitors
SE9701681D0 (sv) 1997-05-05 1997-05-05 Astra Ab New compounds
SE9901901D0 (sv) * 1999-05-26 1999-05-26 Astra Ab Compounds
EP1458714A1 (en) 2001-12-19 2004-09-22 H. Lundbeck A/S 3,4-dihydro-1h-isoquinoloin-2-yl-derivatives
US6608193B2 (en) * 2001-12-21 2003-08-19 The Procter & Gamble Company Methods for synthesis of amino-tetrahydroisoquinoline ring compounds
JP4664673B2 (ja) * 2002-08-07 2011-04-06 ニューラクソン インコーポレイテッド Ｎｏｓ阻害活性を有するアミノベンゾチアゾール化合物
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
WO2007004959A1 (en) * 2005-07-05 2007-01-11 Astrazeneca Ab New compounds, process for their preparation, intermediates, pharmaceutical compositions and their use in the treatment of 5-ht6 mediated disorders such as alzheimer's disease, cognitive disorders, cognitive impairment associated with schizophrenia, obesity and parkinson's disease
JP5497429B2 (ja) 2007-03-07 2014-05-21 武田薬品工業株式会社 ベンゾオキサゼピン誘導体およびその用途
KR102480808B1 (ko) 2016-12-23 2022-12-22 다이이찌 산쿄 가부시키가이샤 Ｔｎａｐ 저해 활성을 갖는 술폰아미드 화합물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0690851B1 (en) * 1993-03-23 1999-05-19 Astra Aktiebolag Guanidine derivatives useful in therapy
JPH09501918A (ja) * 1993-08-12 1997-02-25 アストラ・アクチエボラーグ 酸化窒素合成酵素活性を有するアミジン誘導体
AU7705694A (en) * 1993-10-04 1995-05-01 Glaxo Wellcome House Substituted urea and isothiourea derivatives as no synthase inhibitors
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy

Also Published As

Publication number Publication date
NO982072L (no) 1998-07-03
BR9611276A (pt) 1999-01-26
PL326554A1 (en) 1998-09-28
ATE213241T1 (de) 2002-02-15
HUP9900142A3 (en) 2001-08-28
CZ139298A3 (cs) 1998-09-16
JP2000500132A (ja) 2000-01-11
MX9803453A (es) 1998-09-30
EP0861250B1 (en) 2002-02-13
ES2171743T3 (es) 2002-09-16
DE69619259T2 (de) 2002-09-19
TR199800813T2 (xx) 1998-07-21
SK61098A3 (en) 1999-01-11
EE9800141A (et) 1998-10-15
WO1997017344A1 (en) 1997-05-15
TW458978B (en) 2001-10-11
IS4725A (is) 1998-04-24
NZ322227A (en) 1999-11-29
DE69619259D1 (de) 2002-03-21
EP0861250A1 (en) 1998-09-02
DK0861250T3 (da) 2002-04-29
CA2235301A1 (en) 1997-05-15
NO982072D0 (no) 1998-05-06
AU701329B2 (en) 1999-01-28
KR19990067349A (ko) 1999-08-16
SI0861250T1 (en) 2002-06-30
HUP9900142A2 (hu) 1999-05-28
PT861250E (pt) 2002-07-31
AU7592796A (en) 1997-05-29

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