ES2171743T3 - Derivados de amidinas e isotioureas como inhibidores de la enzima sintasa de oxido nitrico. - Google Patents

Derivados de amidinas e isotioureas como inhibidores de la enzima sintasa de oxido nitrico.

Info

Publication number
ES2171743T3
ES2171743T3 ES96938584T ES96938584T ES2171743T3 ES 2171743 T3 ES2171743 T3 ES 2171743T3 ES 96938584 T ES96938584 T ES 96938584T ES 96938584 T ES96938584 T ES 96938584T ES 2171743 T3 ES2171743 T3 ES 2171743T3
Authority
ES
Spain
Prior art keywords
isotioures
amidines
inhibitors
derivatives
nitric oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96938584T
Other languages
English (en)
Inventor
James Macdonald
James Matz
William Shakespeare
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9600275A external-priority patent/SE9600275D0/xx
Priority claimed from SE9603301A external-priority patent/SE9603301D0/xx
Priority claimed from SE9603300A external-priority patent/SE9603300D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2171743T3 publication Critical patent/ES2171743T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

SE PROPORCIONAN NUEVOS COMPUESTOS DE FORMULA (I), DONDE X, R 1 , R 2 , R 3 , R 4 Y R 5 SON GRUPOS FUNCIONALES DEFINIDOS EN LA ESPECIFICACION E ISOMEROS OPTICOS Y RACEMATOS DE LOS MISMOS Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS; JUNTO CON PROCESOS PARA SU PREPARACION, COMPOSICION QUE LOS CONTIENE Y SU USO TERAPEUTICO.
ES96938584T 1995-11-07 1996-11-06 Derivados de amidinas e isotioureas como inhibidores de la enzima sintasa de oxido nitrico. Expired - Lifetime ES2171743T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US627695P 1995-11-07 1995-11-07
US625395P 1995-11-07 1995-11-07
SE9600275A SE9600275D0 (sv) 1996-01-25 1996-01-25 Compounds
SE9603301A SE9603301D0 (sv) 1996-09-11 1996-09-11 Compounds and compositions
SE9603300A SE9603300D0 (sv) 1996-09-11 1996-09-11 Compounds
PCT/SE1996/001425 WO1997017344A1 (en) 1995-11-07 1996-11-06 Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Publications (1)

Publication Number Publication Date
ES2171743T3 true ES2171743T3 (es) 2002-09-16

Family

ID=27532790

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96938584T Expired - Lifetime ES2171743T3 (es) 1995-11-07 1996-11-06 Derivados de amidinas e isotioureas como inhibidores de la enzima sintasa de oxido nitrico.

Country Status (24)

Country Link
EP (1) EP0861250B1 (es)
JP (1) JP2000500132A (es)
KR (1) KR19990067349A (es)
AT (1) ATE213241T1 (es)
AU (1) AU701329B2 (es)
BR (1) BR9611276A (es)
CA (1) CA2235301A1 (es)
CZ (1) CZ139298A3 (es)
DE (1) DE69619259T2 (es)
DK (1) DK0861250T3 (es)
EE (1) EE9800141A (es)
ES (1) ES2171743T3 (es)
HU (1) HUP9900142A3 (es)
IL (1) IL124296A0 (es)
IS (1) IS4725A (es)
NO (1) NO982072L (es)
NZ (1) NZ322227A (es)
PL (1) PL326554A1 (es)
PT (1) PT861250E (es)
SI (1) SI0861250T1 (es)
SK (1) SK61098A3 (es)
TR (1) TR199800813T2 (es)
TW (1) TW458978B (es)
WO (1) WO1997017344A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4947197A (en) * 1996-10-16 1998-05-11 Glaxo Group Limited Tetrahydro-6h-pyrazino{1,2-b}isoquinoline 1,4-diones as apoprotein b-100 inhibitors
SE9701681D0 (sv) 1997-05-05 1997-05-05 Astra Ab New compounds
SE9901901D0 (sv) * 1999-05-26 1999-05-26 Astra Ab Compounds
AU2002351733A1 (en) * 2001-12-19 2003-06-30 H. Lundbeck A/S 3,4-dihydro-1h-isoquinoloin-2-yl-derivatives
US6608193B2 (en) * 2001-12-21 2003-08-19 The Procter & Gamble Company Methods for synthesis of amino-tetrahydroisoquinoline ring compounds
ATE375333T1 (de) * 2002-08-07 2007-10-15 Neuraxon Inc Aminobenzothiazolverbindungen mit nos-hemmender wirkung
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US20100105657A1 (en) * 2005-07-05 2010-04-29 Astrazeneca Ab Compounds, Process for their Preparation, Intermediates, Pharmaceutical Compositions and their use in the Treatment of 5-HT6 Mediated Disorders such as Alzheimer's Disease, Cognitive Disorders, Cognitive Impairment Associated with Schizophrenia, Obesity and Parkinson's Disease
JP5497429B2 (ja) 2007-03-07 2014-05-21 武田薬品工業株式会社 ベンゾオキサゼピン誘導体およびその用途
US11046710B2 (en) 2016-12-23 2021-06-29 Daiichi Sankyo Company, Limited Sulfonamide compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504278A (ja) * 1944-06-01 1997-04-28 ザ、ウェルカム、ファンデーション、リミテッド Ｎｏシンターゼインヒビターとしての置換尿素およびイソチオ尿素誘導体
DE69418601T2 (de) * 1993-03-23 1999-09-30 Astra Ab Guanidinderivate mit therapeutischer wirkung
IL110643A (en) * 1993-08-12 1998-07-15 Astra Ab History of amidine, their preparation and the pharmaceutical preparations containing them
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy

Also Published As

Publication number Publication date
AU7592796A (en) 1997-05-29
BR9611276A (pt) 1999-01-26
EP0861250B1 (en) 2002-02-13
TR199800813T2 (xx) 1998-07-21
EP0861250A1 (en) 1998-09-02
IL124296A0 (en) 1998-12-06
HUP9900142A2 (hu) 1999-05-28
WO1997017344A1 (en) 1997-05-15
AU701329B2 (en) 1999-01-28
IS4725A (is) 1998-04-24
NO982072L (no) 1998-07-03
EE9800141A (et) 1998-10-15
PT861250E (pt) 2002-07-31
JP2000500132A (ja) 2000-01-11
SI0861250T1 (en) 2002-06-30
PL326554A1 (en) 1998-09-28
ATE213241T1 (de) 2002-02-15
SK61098A3 (en) 1999-01-11
CZ139298A3 (cs) 1998-09-16
TW458978B (en) 2001-10-11
NZ322227A (en) 1999-11-29
MX9803453A (es) 1998-09-30
HUP9900142A3 (en) 2001-08-28
NO982072D0 (no) 1998-05-06
CA2235301A1 (en) 1997-05-15
KR19990067349A (ko) 1999-08-16
DK0861250T3 (da) 2002-04-29
DE69619259D1 (de) 2002-03-21
DE69619259T2 (de) 2002-09-19

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