IE62879B1 - Novel insulin derivatives - Google Patents

Novel insulin derivatives

Info

Publication number
IE62879B1
IE62879B1 IE49988A IE49988A IE62879B1 IE 62879 B1 IE62879 B1 IE 62879B1 IE 49988 A IE49988 A IE 49988A IE 49988 A IE49988 A IE 49988A IE 62879 B1 IE62879 B1 IE 62879B1
Authority
IE
Ireland
Prior art keywords
insulin
preparation
compound
thr
gly
Prior art date
Application number
IE49988A
Other languages
English (en)
Other versions
IE880499L (en
Inventor
Jan Markussen
Klavs Holger Jorgenson
Liselotte Langkjaer
Kjeld Norris
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27221014&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE62879(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DK94887A external-priority patent/DK94887D0/da
Priority claimed from DK356987A external-priority patent/DK356987D0/da
Priority claimed from DK540087A external-priority patent/DK157901C/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IE880499L publication Critical patent/IE880499L/en
Publication of IE62879B1 publication Critical patent/IE62879B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IE49988A 1987-02-25 1988-02-24 Novel insulin derivatives IE62879B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK94887A DK94887D0 (da) 1987-02-25 1987-02-25 Praeparat med fordelagtige egenskaber
DK356987A DK356987D0 (ja) 1987-07-10 1987-07-10
DK540087A DK157901C (da) 1986-10-20 1987-10-16 Insulinpraeparat til parenteral administration indeholdende magnesiumioner

Publications (2)

Publication Number Publication Date
IE880499L IE880499L (en) 1988-08-25
IE62879B1 true IE62879B1 (en) 1995-03-08

Family

ID=27221014

Family Applications (1)

Application Number Title Priority Date Filing Date
IE49988A IE62879B1 (en) 1987-02-25 1988-02-24 Novel insulin derivatives

Country Status (12)

Country Link
EP (1) EP0280534B1 (ja)
JP (1) JP2606915B2 (ja)
AU (1) AU612141B2 (ja)
CA (1) CA1339416C (ja)
DE (2) DE10075034I1 (ja)
ES (1) ES2053723T3 (ja)
FI (1) FI884914A0 (ja)
IE (1) IE62879B1 (ja)
NL (1) NL300029I1 (ja)
NZ (1) NZ223630A (ja)
PT (1) PT86819B (ja)
WO (1) WO1988006599A1 (ja)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
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DK257988D0 (da) * 1988-05-11 1988-05-11 Novo Industri As Nye peptider
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
KR910700262A (ko) * 1988-12-23 1991-03-14 안네 제케르 사람 인슐린 유사체
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
TW222643B (ja) * 1991-06-21 1994-04-21 Lilly Co Eli
US6869930B1 (en) 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
AU1272295A (en) * 1993-12-17 1995-07-03 Novo Nordisk A/S Proinsulin-like compounds
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
AUPP609198A0 (en) * 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
RU2376379C2 (ru) 2001-11-19 2009-12-20 Ново Нордиск А/С Способ получения инсулиновых соединений
GB0206792D0 (en) 2002-03-22 2002-05-01 Leuven K U Res & Dev Normoglycemia
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
EP2301749A1 (en) 2003-06-27 2011-03-30 Novo Nordisk A/S High moisture barrier container for medical liquid compositions
JP2007515235A (ja) 2003-12-22 2007-06-14 ノボ・ノルデイスク・エー／エス 医薬液を保存するための、透明で、可撓性且つ不浸透性のプラスチック製容器
DK2842576T3 (en) 2004-01-21 2017-10-16 Novo Nordisk Healthcare Ag Transglutaminase-mediated peptide conjugation
EP1817049B1 (en) 2004-11-22 2012-08-01 Novo Nordisk A/S Soluble, stable insulin-containing formulations with a protamine salt
WO2008049711A1 (en) 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins
EP2514412A1 (en) * 2007-04-30 2012-10-24 Novo Nordisk A/S Highly Concentrated Insulin Solutions and Compositions
AU2009203810B2 (en) 2008-01-09 2013-07-25 Sanofi-Aventis Deutschland Gmbh Novel insulin derivatives having an extremely delayed time-action profile
DK2229407T3 (en) 2008-01-09 2017-02-27 Sanofi Aventis Deutschland NEW INSULIN DERIVATIVES WITH EXTREMELY DELAYED TIME / EFFECTS PROFILE
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
MX2011001408A (es) 2008-08-07 2011-05-02 Biocon Ltd Proceso para la preparacion de compuestos de insulina.
MX344293B (es) 2008-10-17 2016-12-13 Sanofi Aventis Deutschland Combinacion de una insulina y un agonista de glp-1.
US9018190B2 (en) 2009-03-27 2015-04-28 Adocia Functionalized oligosaccharides
FR2943538B1 (fr) 2009-03-27 2011-05-20 Adocia Formulation a action rapide d'insuline recombinante humaine
PT2498802E (pt) 2009-11-13 2015-04-13 Sanofi Aventis Deutschland Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina
BR112012011403B8 (pt) 2009-11-13 2021-05-25 Sanofi Aventis Deutschland composição farmacêutica líquida compreendendo um agonista glp-1 e metionina e uso da mesma
EP2460527A1 (en) 2010-01-21 2012-06-06 Sanofi Pharmaceutical composition for treating a metabolic syndrome
UY33326A (es) 2010-04-14 2011-12-01 Sanofi Aventis Conjugados de insulina-sirna
RU2546520C2 (ru) 2010-08-30 2015-04-10 Санофи-Авентис Дойчланд Гмбх Применение ave0010 для производства лекарственного средства для лечения сахарного диабета 2 типа
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
EP2548570A1 (en) 2011-07-19 2013-01-23 Sanofi Pharmaceutical composition for treating a metabolic syndrome
US9408893B2 (en) 2011-08-29 2016-08-09 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
US20130231281A1 (en) 2011-11-02 2013-09-05 Adocia Rapid acting insulin formulation comprising an oligosaccharide
PL2919804T3 (pl) 2012-11-13 2018-07-31 Adocia Szybko działająca formulacja insuliny zawierająca podstawiony związek anionowy
FR3020947B1 (fr) 2014-05-14 2018-08-31 Adocia Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations
US9795678B2 (en) 2014-05-14 2017-10-24 Adocia Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound
WO2015196174A1 (en) 2014-06-20 2015-12-23 Greene Howard E Infusion delivery devices and methods
LT3229828T (lt) 2014-12-12 2023-06-12 Sanofi-Aventis Deutschland Gmbh Insulino glargino/liksisenatido fiksuoto santykio kompozicija
TW201630622A (zh) 2014-12-16 2016-09-01 美國禮來大藥廠 速效胰島素組合物
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
FR3043557B1 (fr) 2015-11-16 2019-05-31 Adocia Composition a action rapide d'insuline comprenant un citrate substitue
CN110662551B (zh) 2017-06-01 2023-07-18 伊莱利利公司 速效胰岛素组合物
EP3915571A1 (en) * 2020-05-29 2021-12-01 Adocia Pharmaceutical composition in the form of an injectable aqueous solution including at least a rapid acting insulin analog and a glucagon suppressor with prandial action
EP3915572A1 (en) * 2020-05-29 2021-12-01 Adocia Pharmaceutical composition in the form of an injectable aqueous solution including at least a rapid acting insulin analog and a glucagon suppressor with prandial action

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3364116A (en) * 1964-11-02 1968-01-16 Squibb & Sons Inc Method of use of desalanino insulin compositions
US3758683A (en) * 1971-04-30 1973-09-11 R Jackson Insulin product
DE2252157C3 (de) * 1972-10-25 1976-03-18 Hoechst Ag Zwischenprodukte zur herstellung von insulin, insulin-analogen und -derivaten und verfahren zur herstellung von insulin, insulin analogen und derivaten
NL7314766A (ja) * 1972-10-31 1974-05-02
DE2253327A1 (de) * 1972-10-31 1974-05-09 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
AU550068B2 (en) * 1981-03-10 1986-02-27 Novo Nordisk A/S Zinc insulin stabilized with calcium or magnesium salts
IL66611A0 (en) * 1981-08-27 1982-12-31 Lilly Co Eli Pharmaceutical formulations comprising human insulin and human c-peptide
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation

Also Published As

Publication number Publication date
IE880499L (en) 1988-08-25
ES2053723T3 (es) 1994-08-01
WO1988006599A1 (en) 1988-09-07
JP2606915B2 (ja) 1997-05-07
FI884914A (fi) 1988-10-24
CA1339416C (en) 1997-09-02
FI884914A0 (fi) 1988-10-24
DE3880346D1 (de) 1993-05-27
JPH01502434A (ja) 1989-08-24
PT86819A (pt) 1988-03-01
NL300029I1 (nl) 2001-02-01
DE10075034I1 (de) 2001-05-23
DE3880346T2 (de) 1993-07-29
PT86819B (pt) 1992-05-29
EP0280534B1 (en) 1993-04-21
EP0280534A3 (en) 1990-01-31
AU612141B2 (en) 1991-07-04
EP0280534A2 (en) 1988-08-31
NZ223630A (en) 1989-11-28
AU1397688A (en) 1988-09-26

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