IE36638L - Preparing cephalosporins from penicillanic sulphoxides - Google Patents

Preparing cephalosporins from penicillanic sulphoxides

Info

Publication number
IE36638L
IE36638L IE721136A IE113672A IE36638L IE 36638 L IE36638 L IE 36638L IE 721136 A IE721136 A IE 721136A IE 113672 A IE113672 A IE 113672A IE 36638 L IE36638 L IE 36638L
Authority
IE
Ireland
Prior art keywords
sulphoxide
penicillin
alkyl
group
optionally substituted
Prior art date
Application number
IE721136A
Other versions
IE36638B1 (en
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Publication of IE36638L publication Critical patent/IE36638L/en
Publication of IE36638B1 publication Critical patent/IE36638B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/08—Preparation by forming the ring or condensed ring systems
    • C07D501/10—Preparation by forming the ring or condensed ring systems from compounds containing the penicillin ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1409415 Silyl derivatives of penicillin sulphoxides GIST-BROCADES NV 15 Aug 1972 [17 Aug 1971 21 Dec 1971] 38637/71 and 59516/71 Heading C3S [Also in Division C2] Compounds IX in which R 1 is hydrogen or a group linked to the nitrogen atom by carbon or sulphur, R 2 is hydrogen, C 1-6 alkyl or phenyl-C 1-6 alkyl or NR 1 R 2 represents an optionally substituted heterocyclic group and R 3 is the group R 4 R 5 R 6 Si- (where R 4 , R 5 and R 6 each is C 1-6 alkyl optionally substituted by Cl or CN, C 5-3 cycloalkyl phenyl, phenyl-C 1-2 alkyl, C 1-6 alkoxy optionally substituted by Cl or MeO, C 1-6 alkylthio, phenoxy, phenoxy-C 1-2 alkoxy, halogen or 6-substituted-amino-penicillenic-sulphoxide-3-carbonyloxy or R 4 and R 5 together with Si form a ring or R 4 and R 6 together represent O or S) are prepared by reacting the corresponding acid with a compound capable of introducing the R 3 group. Compounds IX prepared are the trimethylsilyl and triethylsilyl derivatives of benzylpenicillin sulphoxide; the trimethylsilyl derivatives of 2-ethoxy naphthyl penicillin sulphoxide phthalimido penicillin sulphoxide, and benzenesulpho-amidomethyl penicillin sulphoxide and the compound formed by the reaction of SiBr 4 with benzyl penicillin sulphoxide. [GB1409415A]
IE1136/72A 1971-08-17 1972-08-15 Penicillin sulphoxides and their use in preparing delta 3-7-substituted amino-desacetoxycephalosporins IE36638B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3863771 1971-08-17
GB5951671A GB1409415A (en) 1971-08-17 1971-12-21 Penicillin sulphoxides and their use in preparing delta3-7- substituted amino-descetoxy-cephalosporins

Publications (2)

Publication Number Publication Date
IE36638L true IE36638L (en) 1973-02-17
IE36638B1 IE36638B1 (en) 1977-01-19

Family

ID=26263869

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1136/72A IE36638B1 (en) 1971-08-17 1972-08-15 Penicillin sulphoxides and their use in preparing delta 3-7-substituted amino-desacetoxycephalosporins

Country Status (25)

Country Link
JP (1) JPS5438117B2 (en)
AR (1) AR193426A1 (en)
AT (1) AT336181B (en)
BE (1) BE787618A (en)
CA (1) CA1014146A (en)
CH (1) CH576982A5 (en)
CS (1) CS197212B2 (en)
DD (1) DD100263A5 (en)
DE (2) DE2240224C3 (en)
DK (1) DK142174B (en)
ES (1) ES405883A1 (en)
FI (1) FI58643C (en)
FR (1) FR2150785B1 (en)
GB (1) GB1409415A (en)
HU (1) HU169534B (en)
IE (1) IE36638B1 (en)
IL (1) IL40143A (en)
LU (1) LU65904A1 (en)
NL (1) NL177597C (en)
NO (2) NO144153C (en)
PH (2) PH13845A (en)
RO (1) RO63401A (en)
SE (1) SE404927B (en)
SU (1) SU500754A3 (en)
YU (1) YU39899B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2222094A1 (en) * 1972-05-05 1973-11-15 Hoechst Ag PROCESS FOR THE PRODUCTION OF AMINOACETIDINONES
GB1472866A (en) * 1974-06-12 1977-05-11 Farmaceutici Italia Cephalosporins and intermediates therefor
GB1467355A (en) * 1974-08-07 1977-03-16 Lepetit Spa Preparation of 6-aminopenicillanic acid 7-aminocephalospo ranic acid and derivatives thereof
ES431585A1 (en) * 1974-11-02 1976-11-16 Gema Sa Process for the conversion of 6-aminopenicillanic acid (6-APA) in 7-aminodesacetoxycephalosporanic acid (7-ADCA)
PL94023B1 (en) * 1974-12-18 1977-07-30 Politechnika Gdanska
GB1472864A (en) * 1975-04-05 1977-05-11 Farmaceutici Italia Method of preparing cephalosporins
US4008231A (en) * 1975-09-15 1977-02-15 Eli Lilly And Company Preparation of 3-methoxymethylcephalosporins
IT1063088B (en) * 1976-06-01 1985-02-11 Dobfar Spa AZETIDINONIC DERIVATIVES AND PROCEDURE FOR THE PREPARATION OF CEPHALOSPORINE
US4310459A (en) * 1978-04-03 1982-01-12 Bristol-Myers Company Process for producing carbamoyl substituted penams and carbamoyl substituted cephams from penicillin sulfoxide esters
US4322347A (en) 1978-04-03 1982-03-30 Bristol-Myers Company 2-Carbamoyloxymethyl-penicillin derivatives
US4518773A (en) * 1978-04-03 1985-05-21 Bristol-Myers Company "3-Carbamoyloxy cephalosporins"
US4426520A (en) 1978-04-03 1984-01-17 Bristol-Myers Company 3-Carbamoyloxy-cepham-4-carboxylic acid derivatives
IT1124802B (en) * 1979-10-29 1986-05-14 Dobfar Spa BORONATED DERIVATIVES OF 6-PENICILLANIC ACID AND PROCEDURE FOR THEIR PREPARATION
US4374982A (en) 1979-11-07 1983-02-22 Bristol-Myers Company Cepham compounds
JPS5716006A (en) * 1980-07-03 1982-01-27 Mitsui Toatsu Chem Inc Suspension polymerization of vinyl chloride

Also Published As

Publication number Publication date
SU500754A3 (en) 1976-01-25
FR2150785B1 (en) 1976-03-05
CH576982A5 (en) 1976-06-30
DE2240224A1 (en) 1973-03-01
LU65904A1 (en) 1974-02-18
NO144153B (en) 1981-03-23
JPS5438117B2 (en) 1979-11-19
RO63401A (en) 1978-10-15
DE2240224B2 (en) 1979-07-26
SE404927B (en) 1978-11-06
FI58643B (en) 1980-11-28
CS197212B2 (en) 1980-04-30
AT336181B (en) 1977-04-25
HU169534B (en) 1976-12-28
PH15675A (en) 1983-03-11
DK142174C (en) 1981-02-16
IL40143A (en) 1976-03-31
ES405883A1 (en) 1977-02-01
NL7211213A (en) 1973-02-20
CA1014146A (en) 1977-07-19
NO144152C (en) 1981-07-01
YU210072A (en) 1982-02-28
PH13845A (en) 1980-10-16
IL40143A0 (en) 1972-10-29
NL177597C (en) 1985-10-16
JPS4829795A (en) 1973-04-19
IE36638B1 (en) 1977-01-19
YU39899B (en) 1985-06-30
DE2240224C3 (en) 1980-04-10
GB1409415A (en) 1975-10-08
DE2264648A1 (en) 1974-07-25
ATA704072A (en) 1976-08-15
NO144153C (en) 1981-07-01
DK142174B (en) 1980-09-15
FI58643C (en) 1981-03-10
DD100263A5 (en) 1973-09-12
AR193426A1 (en) 1973-04-23
NO144152B (en) 1981-03-23
FR2150785A1 (en) 1973-04-13
BE787618A (en) 1973-02-16

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