GB1439419A - 3-thiolated-7-acylamido-cephalosporanic acid derivatives - Google Patents

3-thiolated-7-acylamido-cephalosporanic acid derivatives

Info

Publication number
GB1439419A
GB1439419A GB465474A GB465474A GB1439419A GB 1439419 A GB1439419 A GB 1439419A GB 465474 A GB465474 A GB 465474A GB 465474 A GB465474 A GB 465474A GB 1439419 A GB1439419 A GB 1439419A
Authority
GB
United Kingdom
Prior art keywords
acylamido
thiolated
cephalosporanic acid
acid derivatives
jan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB465474A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of GB1439419A publication Critical patent/GB1439419A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1439419 Silyl ester of triazolyl-thiomethyl cephalosporanic acid BRISTOL-MYERS CO 31 Jan 1974 [31 Jan 1973 18 May 1973] 4654/74 Heading C35 [Also in Division C2] In Example 2B, the corresponding trimethylsilyl ester is prepared by reacting with Me 3 SiCl, the acid of Formula II where Het is 1,2,3-triazol-4-yl.
GB465474A 1973-01-31 1974-01-31 3-thiolated-7-acylamido-cephalosporanic acid derivatives Expired GB1439419A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32823473A 1973-01-31 1973-01-31
US36169673A 1973-05-18 1973-05-18

Publications (1)

Publication Number Publication Date
GB1439419A true GB1439419A (en) 1976-06-16

Family

ID=26986279

Family Applications (1)

Application Number Title Priority Date Filing Date
GB465474A Expired GB1439419A (en) 1973-01-31 1974-01-31 3-thiolated-7-acylamido-cephalosporanic acid derivatives

Country Status (7)

Country Link
JP (1) JPS5953275B2 (en)
CA (1) CA1035353A (en)
DE (1) DE2404592C2 (en)
FR (2) FR2215942B1 (en)
GB (1) GB1439419A (en)
NL (1) NL7401361A (en)
PH (2) PH16419A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL49183A0 (en) * 1975-03-27 1976-05-31 Pfizer Novel cephalosporin derivatives,their preparation and pharmaceutical compositions containing them

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR6915169D0 (en) * 1969-04-21 1973-02-20 Bristol Myers Co CHEMICAL PROCESS
NL7112483A (en) * 1970-09-14 1972-03-16
IL38099A (en) * 1970-12-17 1976-01-30 Smith Kline French Lab 3-heterocyclyl thiomethylcephalosporins
NL7200588A (en) * 1971-01-18 1972-07-20
US3757014A (en) * 1971-05-07 1973-09-04 Bristol Myers Co Ts 1,3,4 - oxadiazol-2-yl)thiomethyl)-3-cephem-4-carboxylic acid and sal7-(d-(alpha-amino-alpha-pheyle-acetamido)) - 3-(s-(5-hydroxymethyl -
CA999574A (en) * 1972-06-14 1976-11-09 Smith Kline And French Canada Ltd. 7-hydroxyhalophenylacetamido-3-h heterocyclicthiomethyl cephalosporins
CA1076560A (en) * 1972-06-14 1980-04-29 Smith Kline And French Canada Ltd. 3-heterocyclic thiomethylcephalosporins

Also Published As

Publication number Publication date
DE2404592A1 (en) 1974-08-01
CA1035353A (en) 1978-07-25
JPS49101395A (en) 1974-09-25
FR2215942B1 (en) 1978-12-22
FR2215942A1 (en) 1974-08-30
FR2391728A1 (en) 1978-12-22
NL7401361A (en) 1974-08-02
FR2391728B1 (en) 1982-08-20
DE2404592C2 (en) 1984-01-19
PH16419A (en) 1983-09-29
PH14842A (en) 1981-12-16
JPS5953275B2 (en) 1984-12-24

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee