HUT72309A - Piperazine and piperidine derivatives, having antipsychotic activity pharmaceutical compositions containing them and process for their preparation - Google Patents

Piperazine and piperidine derivatives, having antipsychotic activity pharmaceutical compositions containing them and process for their preparation Download PDF

Info

Publication number
HUT72309A
HUT72309A HU9402343A HU9402343A HUT72309A HU T72309 A HUT72309 A HU T72309A HU 9402343 A HU9402343 A HU 9402343A HU 9402343 A HU9402343 A HU 9402343A HU T72309 A HUT72309 A HU T72309A
Authority
HU
Hungary
Prior art keywords
formula
piperazinyl
butyl
group
benzisothiazol
Prior art date
Application number
HU9402343A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9402343D0 (en
Inventor
Frank Navas Iii
Mark Henry Norman
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of HU9402343D0 publication Critical patent/HU9402343D0/hu
Publication of HUT72309A publication Critical patent/HUT72309A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU9402343A 1992-02-12 1993-02-11 Piperazine and piperidine derivatives, having antipsychotic activity pharmaceutical compositions containing them and process for their preparation HUT72309A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929202915A GB9202915D0 (en) 1992-02-12 1992-02-12 Chemical compounds

Publications (2)

Publication Number Publication Date
HU9402343D0 HU9402343D0 (en) 1994-10-28
HUT72309A true HUT72309A (en) 1996-04-29

Family

ID=10710223

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9402343A HUT72309A (en) 1992-02-12 1993-02-11 Piperazine and piperidine derivatives, having antipsychotic activity pharmaceutical compositions containing them and process for their preparation

Country Status (16)

Country Link
EP (1) EP0625978A1 (no)
JP (1) JPH07503723A (no)
KR (1) KR950700290A (no)
AU (1) AU3460393A (no)
CA (1) CA2117434A1 (no)
CZ (1) CZ194994A3 (no)
FI (1) FI943718A0 (no)
GB (1) GB9202915D0 (no)
HU (1) HUT72309A (no)
IL (1) IL104690A0 (no)
MX (1) MX9300786A (no)
NO (1) NO942977L (no)
RU (1) RU94038064A (no)
SK (1) SK96494A3 (no)
WO (1) WO1993016073A1 (no)
ZA (1) ZA93958B (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
RU2118322C1 (ru) * 1993-07-05 1998-08-27 Дюфар Интернэшнл Рисерч Б.В. 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли
ATE246682T1 (de) * 1993-12-24 2003-08-15 Daiichi Suntory Pharma Co Ltd Benzothiazinderivate
US5874429A (en) * 1993-12-24 1999-02-23 Suntory Limited Benzothiazine derivative
JPH0912562A (ja) * 1995-06-22 1997-01-14 Suntory Ltd 置換ベンゾチアジン誘導体
US6001827A (en) * 1993-12-24 1999-12-14 Suntory Limited Benzothiazine derivative
JP3948744B2 (ja) * 1994-11-04 2007-07-25 大日本住友製薬株式会社 新規なラクタム誘導体
EP0732332B1 (en) * 1995-03-17 2001-12-19 Aventis Pharmaceuticals Inc. Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
US6087364A (en) * 1998-01-29 2000-07-11 Warner-Lambert Company Dopamine D4 receptor antagonists
DE19814084B4 (de) 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
US7030142B1 (en) 1999-04-06 2006-04-18 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites
EP1165083A2 (en) * 1999-04-06 2002-01-02 Sepracor Inc. Methods and compositions for the treatment of psychotic and related disorders using ziprasidone metabolites
AR028685A1 (es) 2000-06-14 2003-05-21 Lundbeck & Co As H Derivados de indol
US8246979B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
DE10234673B4 (de) 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
US8246980B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
DE60327634D1 (de) 2002-08-22 2009-06-25 Dainippon Sumitomo Pharma Co Mittel zur behandlung des integrationsdysfunktionssyndroms
DE10261696A1 (de) 2002-12-30 2004-07-15 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
EP1637530A4 (en) * 2003-06-23 2009-04-01 Dainippon Sumitomo Pharma Co THERAPEUTIC AGENT FOR SENILE DEMENTIA
DE10334188B4 (de) 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
EP1726952A4 (en) 2004-02-20 2008-06-18 Dainippon Sumitomo Pharma Co METHOD FOR IN VIVO SCREENING OF A THERAPEUTIC FOR A MEMORY / LEARNING FUNCTION THROUGH SCHIZOPHRENIA
EA200900937A1 (ru) * 2007-01-03 2009-12-30 Кортекс Фармасеутикалс, Инк. Соединения 3-замещенного-[1,2,3]бензотриазинона для усиления глутаматергических синаптических ответов
US8258139B2 (en) 2010-11-08 2012-09-04 Dainippon Sumitomo Pharma Co., Ltd. Method of treatment for mental disorders
GB201102248D0 (en) 2011-02-09 2011-03-23 Isis Innovation Treatment of bipolar disorder
EP2736905A4 (en) * 2011-07-28 2015-07-29 Mapi Pharma Ltd INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF LURASIDONE AND SALTS THEREOF
WO2015014442A1 (en) * 2013-07-31 2015-02-05 Merck Patent Gmbh Oxoquinazolinyl-butanamide derivatives
CN105669665A (zh) * 2016-03-15 2016-06-15 烟台贝森医药科技有限公司 哌罗匹隆的制备方法
US11246905B2 (en) 2016-08-15 2022-02-15 President And Fellows Of Harvard College Treating infections using IdsD from Proteus mirabilis
CN115124464B (zh) * 2022-07-04 2023-06-06 新乡学院 一种喹啉二酮磺酰哌嗪杂合体及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2258843B1 (no) * 1974-01-30 1977-09-09 Roussel Uclaf
US4335127A (en) * 1979-01-08 1982-06-15 Janssen Pharmaceutica, N.V. Piperidinylalkyl quinazoline compounds, composition and method of use
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
NZ230045A (en) * 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
US4968792A (en) * 1989-09-25 1990-11-06 American Home Products Corporation Psychotropic benzisothiazole derivatives
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体

Also Published As

Publication number Publication date
ZA93958B (en) 1994-08-11
AU3460393A (en) 1993-09-03
EP0625978A1 (en) 1994-11-30
NO942977L (no) 1994-10-10
KR950700290A (ko) 1995-01-16
SK96494A3 (en) 1995-07-11
FI943718A (fi) 1994-08-11
NO942977D0 (no) 1994-08-11
MX9300786A (es) 1994-03-31
CZ194994A3 (en) 1995-09-13
GB9202915D0 (en) 1992-03-25
FI943718A0 (fi) 1994-08-11
WO1993016073A1 (en) 1993-08-19
HU9402343D0 (en) 1994-10-28
CA2117434A1 (en) 1993-08-19
IL104690A0 (en) 1993-06-10
JPH07503723A (ja) 1995-04-20
RU94038064A (ru) 1997-05-27

Similar Documents

Publication Publication Date Title
HUT72309A (en) Piperazine and piperidine derivatives, having antipsychotic activity pharmaceutical compositions containing them and process for their preparation
AU2014348191B2 (en) Tetrahydroquinoline compositions as BET bromodomain inhibitors
CA2711655C (en) Condensed aminodihydrothiazine derivative
US11124486B2 (en) 6-membered heterocyclic derivatives and pharmaceutical composition comprising the same
AU685785B2 (en) Saccharin derivative proteolytic enzyme inhibitors
US20080021217A1 (en) Heterocyclic inhibitors of rho kinase
JPH06508366A (ja) イミダゾ〔１，５−ａ〕キノキサリン
CA3103048A1 (en) Oga inhibitor compounds
JPWO2006051704A1 (ja) イミン化合物
CN107295799A (zh) Parg抑制化合物
CZ2002936A3 (cs) Pyrazolopyrimidiny jako terapeutické prostředky
MX2007012234A (es) Compuestos de pirazol biciclico como agentes antibacterianos.
TW201300381A (zh) 用於降低β－類澱粉製造之化合物
CZ410397A3 (cs) Deriváty 4-fenylaminothiazolu, způsob jejich přípravy a farmaceutické přípravky, které je obsahují
IL104154A (en) History of Sakharin preparation and pharmaceutical preparations containing them
TW200838508A (en) Chemical compounds
AU2017379024B2 (en) Condensed ring group azacyclobutyl triazole derivative, preparation method therefor and use thereof in medicine
KR100222774B1 (ko) N-(아릴옥시알킬)헤테로아릴-8-아자비사이클로(3.2.1)옥탄, 중간체, 이의 제조방법 및 이를 함유하는 약제학적 조성물
CZ386892A3 (en) Novel 2-saccharinylmethyl heterocyclic carboxylates usable as proteolytic enzymes inhibitors and their compositions and method of application
HUT73654A (en) Piperazine and piperidine derivatives with antipsychotic activity, pharmaceutical compositions containing them and process for their preparation
KR100309215B1 (ko) 항정신병제로서의피리딘이미닐-1,2-벤즈이속사졸및-벤즈이소티아졸
JPS5993047A (ja) 融合芳香族オキサゼピノン類およびそれらのイオウ類似体類
KR20070094949A (ko) 2-(시클릭 아미노카르보닐)인돌린 유도체 및 그것을함유하는 약제학적 조성물
MXPA97009450A (en) Piridiniminil-1,2-benzoisoxazoles and -benzoisotiazoles as agents antipsicoti

Legal Events

Date Code Title Description
DFD9 Temporary protection cancelled due to non-payment of fee