HUP9903921A2 - Tumor nekrózis faktorral rokon ligandum - Google Patents
Tumor nekrózis faktorral rokon ligandumInfo
- Publication number
- HUP9903921A2 HUP9903921A2 HU9903921A HUP9903921A HUP9903921A2 HU P9903921 A2 HUP9903921 A2 HU P9903921A2 HU 9903921 A HU9903921 A HU 9903921A HU P9903921 A HUP9903921 A HU P9903921A HU P9903921 A2 HUP9903921 A2 HU P9903921A2
- Authority
- HU
- Hungary
- Prior art keywords
- trell
- necrosis factor
- protein
- granulocyte
- receptor
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 title 1
- 102000003390 tumor necrosis factor Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 210000003714 granulocyte Anatomy 0.000 abstract 2
- 230000017074 necrotic cell death Effects 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000026350 Inborn Genetic disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 208000016361 genetic disease Diseases 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
Abstract
A találmány tárgyát tűmőrnekrózis faktőrral rőkőn ligandűm vagy TRELL,a tűmőrnekrózis faktőr család tagjai közé tartőzó pőlipeptid képezi. Afehérje vagy annak receptőra felhasználható rákellenes és/vagyimműnszabályőzó alkalmazásőkban. Tővábbá a TRELL-t kódőló génnelfertőzött sejtek felhasználhatók génterápiában daganatők, aűtőimműn ésgyűlladásős betegségek vagy öröklött genetikai rendellenességekkezelésére. A találmány tárgyát képezi a TRELL-fehérje, annakhőmőlógjai és biőlógiai aktivitással rendelkező fragmentűmai, valamintaz ezeket kódőló nűkleőtidszekvenciák. A TRELL-fehérje és receptőraellen termelhető antitestek szintén a találmány őltalmi körébetartőznak űgyanúgy, mint nevezett fehérjék őldható főrmáinakelőállítására alkalmas rekőmbináns gazdaszervezetek és nevezettfehérjéket, ill. azőkat kódőló nűkleinsavakat tartalmazógyógyszerkészítmények. ŕ
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2354196P | 1996-08-07 | 1996-08-07 | |
US2851596P | 1996-10-18 | 1996-10-18 | |
US4082097P | 1997-03-18 | 1997-03-18 | |
PCT/US1997/013945 WO1998005783A1 (en) | 1996-08-07 | 1997-08-07 | A tumor necrosis factor related ligand |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP9903921A2 true HUP9903921A2 (hu) | 2000-03-28 |
HUP9903921A3 HUP9903921A3 (en) | 2000-08-28 |
HU226787B1 HU226787B1 (en) | 2009-10-28 |
Family
ID=27362110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9903921A HU226787B1 (en) | 1996-08-07 | 1997-08-07 | A tumor necrosis factor related ligand |
Country Status (26)
Country | Link |
---|---|
EP (2) | EP1591530B8 (hu) |
JP (3) | JP4161084B2 (hu) |
KR (1) | KR100543730B1 (hu) |
CN (2) | CN1308451C (hu) |
AT (1) | ATE307204T1 (hu) |
AU (1) | AU736289B2 (hu) |
BG (1) | BG64779B1 (hu) |
BR (1) | BR9711046A (hu) |
CA (1) | CA2262756C (hu) |
CZ (1) | CZ297387B6 (hu) |
DE (1) | DE69734397T2 (hu) |
DK (1) | DK0956351T3 (hu) |
EA (1) | EA003187B1 (hu) |
EE (1) | EE05276B1 (hu) |
ES (1) | ES2251737T3 (hu) |
HK (1) | HK1025994A1 (hu) |
HU (1) | HU226787B1 (hu) |
IL (1) | IL128407A (hu) |
IS (1) | IS2606B (hu) |
NO (2) | NO326967B1 (hu) |
NZ (1) | NZ334107A (hu) |
PL (1) | PL188102B1 (hu) |
SI (1) | SI0956351T1 (hu) |
SK (1) | SK288012B6 (hu) |
TR (1) | TR199900903T2 (hu) |
WO (1) | WO1998005783A1 (hu) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999011791A2 (en) * | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
IL135051A0 (en) * | 1997-10-10 | 2001-05-20 | Genentech Inc | Apo-3 ligand polypeptide |
DE19829550C1 (de) * | 1998-07-02 | 2000-01-27 | Bosch Gmbh Robert | Vorrichtung zum Verbinden von Bauteilen |
WO2000042073A1 (en) * | 1999-01-15 | 2000-07-20 | Biogen, Inc. | Antagonists of tweak and of tweak receptor and their use to treat immunological disorders |
US6994976B1 (en) | 1999-11-19 | 2006-02-07 | Tittle Thomas V | Tr3-specific binding agents and methods for their use |
EP1231937A2 (en) * | 1999-11-19 | 2002-08-21 | Thomas V. Tittle | Tr3-specific binding agents and methods for their use |
US6727225B2 (en) | 1999-12-20 | 2004-04-27 | Immunex Corporation | TWEAK receptor |
US7495086B2 (en) | 1999-12-20 | 2009-02-24 | Immunex Corporation | TWEAK receptor |
AU782067B2 (en) * | 1999-12-20 | 2005-06-30 | Immunex Corporation | TWEAK receptor |
JP2004500844A (ja) | 2000-05-08 | 2004-01-15 | バイオジェン インコーポレイテッド | Tweakアゴニストおよび血管形成因子を使用する、新血管新生を促進するための方法 |
US7208151B2 (en) | 2001-09-12 | 2007-04-24 | Biogen Idec Ma Inc. | Tweak receptor agonists as anti-angiogenic agents |
CA2887716C (en) | 2002-04-09 | 2017-01-24 | Biogen Idec Ma Inc. | Methods for treating tweak-related conditions |
CN101899106A (zh) * | 2002-10-29 | 2010-12-01 | 阿纳福公司 | 三聚细胞因子的三聚结合蛋白 |
AU2006214179A1 (en) | 2005-02-17 | 2006-08-24 | Biogen Idec Ma Inc. | Treating neurological disorders |
EP1885388B1 (en) | 2005-05-10 | 2013-09-11 | Biogen Idec MA Inc. | Treating and evaluating inflammatory disorders |
PL2460831T3 (pl) | 2005-05-27 | 2017-05-31 | Biogen Ma Inc. | Przeciwciała wiążące tweak |
WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
US8093006B2 (en) | 2009-04-02 | 2012-01-10 | Hoffmann-La Roche Inc. | Antibodies against human tweak and uses thereof |
US9187564B2 (en) | 2010-10-05 | 2015-11-17 | Hoffmann-La Roche Inc. | Antibodies against human TWEAK and uses thereof |
JP6007310B2 (ja) | 2012-04-05 | 2016-10-12 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ヒトtweak及びヒトil17に対する二重特異性抗体並びにその使用 |
EP3530738A4 (en) * | 2016-10-24 | 2020-06-03 | KIM, Sung-Chun | TNF-ALPHA BINDING APTAMER, AND THERAPEUTIC USE |
JP7397446B2 (ja) * | 2018-04-20 | 2023-12-13 | 中央研究院 | Tnf関連炎症性疾患を治療または診断するtnf指向性アプタマーおよびその使用 |
WO2022217283A1 (en) | 2021-04-08 | 2022-10-13 | Joslin Diabetes Center, Inc. | Methods of diagnosing and predicting renal decline |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5176996A (en) | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
US5256775A (en) | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
IE902820A1 (en) | 1989-08-07 | 1991-02-27 | Merck & Co Inc | Peptide inhibitors of human papilloma virus protein binding¹to retinoblastoma gene proteins |
US5264564A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
JPH05310784A (ja) | 1991-09-04 | 1993-11-22 | Merck & Co Inc | ヒト乳頭腫ウイルスタンパク質と網膜芽細胞腫遺伝子タンパク質との結合のペプチド阻害剤 |
-
1997
- 1997-08-07 WO PCT/US1997/013945 patent/WO1998005783A1/en active IP Right Grant
- 1997-08-07 BR BR9711046-9A patent/BR9711046A/pt not_active Application Discontinuation
- 1997-08-07 KR KR1019997001045A patent/KR100543730B1/ko not_active IP Right Cessation
- 1997-08-07 IL IL128407A patent/IL128407A/en not_active IP Right Cessation
- 1997-08-07 SK SK157-99A patent/SK288012B6/sk not_active IP Right Cessation
- 1997-08-07 EE EEP199900043A patent/EE05276B1/xx unknown
- 1997-08-07 JP JP50823998A patent/JP4161084B2/ja not_active Expired - Lifetime
- 1997-08-07 EP EP05011540.1A patent/EP1591530B8/en not_active Expired - Lifetime
- 1997-08-07 TR TR1999/00903T patent/TR199900903T2/xx unknown
- 1997-08-07 DK DK97935334T patent/DK0956351T3/da active
- 1997-08-07 CA CA2262756A patent/CA2262756C/en not_active Expired - Lifetime
- 1997-08-07 HU HU9903921A patent/HU226787B1/hu unknown
- 1997-08-07 PL PL97331583A patent/PL188102B1/pl unknown
- 1997-08-07 CN CNB971984018A patent/CN1308451C/zh not_active Expired - Lifetime
- 1997-08-07 CN CNA2007100059560A patent/CN101024831A/zh active Pending
- 1997-08-07 DE DE69734397T patent/DE69734397T2/de not_active Expired - Lifetime
- 1997-08-07 CZ CZ0040399A patent/CZ297387B6/cs not_active IP Right Cessation
- 1997-08-07 EP EP97935334A patent/EP0956351B1/en not_active Expired - Lifetime
- 1997-08-07 EA EA199900187A patent/EA003187B1/ru not_active IP Right Cessation
- 1997-08-07 NZ NZ334107A patent/NZ334107A/en not_active IP Right Cessation
- 1997-08-07 AU AU38294/97A patent/AU736289B2/en not_active Ceased
- 1997-08-07 AT AT97935334T patent/ATE307204T1/de active
- 1997-08-07 ES ES97935334T patent/ES2251737T3/es not_active Expired - Lifetime
- 1997-08-07 SI SI9730718T patent/SI0956351T1/sl unknown
-
1999
- 1999-02-05 IS IS4967A patent/IS2606B/is unknown
- 1999-02-05 NO NO990550A patent/NO326967B1/no not_active IP Right Cessation
- 1999-02-11 BG BG103169A patent/BG64779B1/bg unknown
-
2000
- 2000-05-17 HK HK00102948A patent/HK1025994A1/xx not_active IP Right Cessation
-
2007
- 2007-02-07 JP JP2007028621A patent/JP4411330B2/ja not_active Expired - Lifetime
-
2008
- 2008-11-21 NO NO20084906A patent/NO20084906L/no not_active Application Discontinuation
-
2009
- 2009-03-27 JP JP2009080644A patent/JP2009183294A/ja not_active Withdrawn
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC9A | Change of name, address |
Owner name: THE FACULTY OF MEDICINE OF THE UNIVERSITY OF G, CH Free format text: FORMER OWNER(S): BIOGEN INC., US Owner name: BIOGEN IDEC MA INC., US Free format text: FORMER OWNER(S): BIOGEN INC., US |