HUP9903678A2 - Eljárás aza-ciklohexapeptidek előállítására - Google Patents

Eljárás aza-ciklohexapeptidek előállítására

Info

Publication number
HUP9903678A2
HUP9903678A2 HU9903678A HUP9903678A HUP9903678A2 HU P9903678 A2 HUP9903678 A2 HU P9903678A2 HU 9903678 A HU9903678 A HU 9903678A HU P9903678 A HUP9903678 A HU P9903678A HU P9903678 A2 HUP9903678 A2 HU P9903678A2
Authority
HU
Hungary
Prior art keywords
formula
give
acid
reacting
phenylthio
Prior art date
Application number
HU9903678A
Other languages
English (en)
Inventor
Kevin M. Belyk
William Leonard
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26309664&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9903678(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9614325.0A external-priority patent/GB9614325D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of HUP9903678A2 publication Critical patent/HUP9903678A2/hu
Publication of HUP9903678A3 publication Critical patent/HUP9903678A3/hu
Publication of HU227427B1 publication Critical patent/HU227427B1/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány az ismert (I) általánős képletű vegyületek - a képletben R1 jelentése CH2CH2NH2 vagy CH2CONH2 csőpőrt, RI jelentése 9-21 szénatőmőt tartalmazó alkil-, 9-21 szénatőmőttartalmazó alkenil-, az alkőxirészben 1-10 szénatőmőt tartalmazóalkőxi-fenil-, az alkőxirészben 1-10 szénatőmőt tartalmazó alkőxi-naftil- vagy az alkőxirészben 1-10 szénatőmőt tartalmazó alkőxi-terfenilcsőpőrt, RII jelentése hidrőgénatőm vagy 1-4 szénatőmőt tartalmazó alkil-, 3vagy 4 szénatőmős tartalmazó alkenil-, (CH2)2-4OH vagy (CH2)2-4NRIVRVcsőpőrt, RIII jelentése hidrőgénatőm vagy 1-4 szénatőmős tartalmazó alkil-, 3vagy 4 szénatőmős tartalmazó alkenil-, (CH2)2-4OH vagy (CH2)2-4NRIVRVcsőpőrt, vagy RII és RIII együtt (CH2)4, (CH2)5, (CH2)2O(CH2)2 vagy (CH2)2NH(CH2)2képletű csőpőrtőt alkőt, RIV jelentése hidrőgénatőm vagy 1-4 szénatőmős tartalmazóalkilcsőpőrt, RV jelentése hidrőgénatőm vagy 1-4 szénatőmős tartalmazó alkilcsőpőrt,és Q jelentése nitrőgén- vagy őxigénatőm - előállítására ismertettöbbféle új eljárást. A találmány tővábbá új köztitermékekre isvőnatkőzik. ŕ
HU9903678A 1996-06-14 1997-06-10 Eljárás aza-ciklohexapeptidek elõállítására HU227427B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2048396P 1996-06-14 1996-06-14
GBGB9614325.0A GB9614325D0 (en) 1996-07-08 1996-07-08 A process for preparing certain aza cyclohexapeptides
PCT/US1997/009833 WO1997047645A1 (en) 1996-06-14 1997-06-10 A process for preparing certain aza cyclohexapeptides

Publications (3)

Publication Number Publication Date
HUP9903678A2 true HUP9903678A2 (hu) 2000-04-28
HUP9903678A3 HUP9903678A3 (en) 2001-01-29
HU227427B1 HU227427B1 (hu) 2011-05-30

Family

ID=26309664

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903678A HU227427B1 (hu) 1996-06-14 1997-06-10 Eljárás aza-ciklohexapeptidek elõállítására

Country Status (25)

Country Link
EP (1) EP0912603B1 (hu)
JP (1) JP3089037B2 (hu)
KR (1) KR100341953B1 (hu)
CN (1) CN1122672C (hu)
AR (2) AR008393A3 (hu)
AT (1) ATE252112T1 (hu)
AU (1) AU712857B2 (hu)
BR (1) BR9709691B1 (hu)
CA (1) CA2256620C (hu)
CZ (2) CZ287742B6 (hu)
DE (1) DE69725580T2 (hu)
DK (1) DK0912603T3 (hu)
EA (1) EA002049B1 (hu)
ES (1) ES2208914T3 (hu)
HR (1) HRP970318B1 (hu)
HU (1) HU227427B1 (hu)
NZ (1) NZ332798A (hu)
PL (1) PL187035B1 (hu)
PT (1) PT912603E (hu)
RS (1) RS49572B (hu)
SI (1) SI0912603T1 (hu)
SK (1) SK284043B6 (hu)
TW (1) TW450975B (hu)
UA (1) UA54433C2 (hu)
WO (1) WO1997047645A1 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE267210T1 (de) * 1998-08-28 2004-06-15 Lilly Co Eli Reversible borkomplexe von 1,2-(cis)-diol zyklischen peptiden
EP1785432A1 (en) 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
SI2049142T2 (sl) 2006-07-26 2016-04-29 Sandoz Ag Formulacije kaspofungina
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
EP2240507A2 (en) * 2008-06-25 2010-10-20 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Processes for preparing high purity aza cyclohexapeptides
CN101648994B (zh) * 2009-08-06 2012-09-05 上海天伟生物制药有限公司 一种氮杂环己肽或其药学上可接受的盐及其制备方法和用途
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
CN102219833A (zh) * 2011-04-18 2011-10-19 深圳市健元医药科技有限公司 一种更加安全的棘白菌类抗真菌药的制备方法
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
CN107778360B (zh) * 2016-08-27 2020-06-12 鲁南制药集团股份有限公司 一种制备醋酸卡泊芬净的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides

Also Published As

Publication number Publication date
AU3303997A (en) 1998-01-07
YU56098A (sh) 1999-09-27
ES2208914T3 (es) 2004-06-16
AR017997A3 (es) 2001-10-31
ATE252112T1 (de) 2003-11-15
AU712857B2 (en) 1999-11-18
CA2256620A1 (en) 1997-12-18
KR100341953B1 (ko) 2002-10-31
SK284043B6 (sk) 2004-08-03
CN1122672C (zh) 2003-10-01
TW450975B (en) 2001-08-21
EP0912603A1 (en) 1999-05-06
CZ411998A3 (cs) 1999-05-12
CA2256620C (en) 2003-12-30
DE69725580T2 (de) 2004-08-05
CN1222161A (zh) 1999-07-07
HU227427B1 (hu) 2011-05-30
RS49572B (sr) 2007-04-10
WO1997047645A1 (en) 1997-12-18
HRP970318B1 (en) 2002-06-30
PL330400A1 (en) 1999-05-10
SI0912603T1 (en) 2004-02-29
CZ287742B6 (en) 2001-01-17
DE69725580D1 (de) 2003-11-20
EA002049B1 (ru) 2001-12-24
NZ332798A (en) 2000-05-26
BR9709691A (pt) 1999-08-10
UA54433C2 (uk) 2003-03-17
HUP9903678A3 (en) 2001-01-29
AR008393A3 (es) 2000-01-19
EA199900027A1 (ru) 1999-06-24
KR20000016564A (ko) 2000-03-25
BR9709691B1 (pt) 2010-02-23
SK169498A3 (en) 1999-08-06
PL187035B1 (pl) 2004-05-31
CZ287743B6 (cs) 2001-01-17
JPH11514665A (ja) 1999-12-14
HRP970318A2 (en) 1998-08-31
JP3089037B2 (ja) 2000-09-18
EP0912603B1 (en) 2003-10-15
PT912603E (pt) 2004-02-27
DK0912603T3 (da) 2004-02-09

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: MERCK SHARP & DOHME CORP., US

Free format text: FORMER OWNER(S): MERCK & CO., INC., US

GB9A Succession in title

Owner name: MERCK SHARP & DOHME CORP., US

Free format text: FORMER OWNER(S): MERCK & CO., INC., US; MERCK SHARP & DOHME CORP., US

MM4A Lapse of definitive patent protection due to non-payment of fees