KR840006013A - A 53868인자 a의 제조방법 - Google Patents
A 53868인자 a의 제조방법 Download PDFInfo
- Publication number
- KR840006013A KR840006013A KR1019830004518A KR830004518A KR840006013A KR 840006013 A KR840006013 A KR 840006013A KR 1019830004518 A KR1019830004518 A KR 1019830004518A KR 830004518 A KR830004518 A KR 830004518A KR 840006013 A KR840006013 A KR 840006013A
- Authority
- KR
- South Korea
- Prior art keywords
- salt
- hydrogen
- alkyl
- factor
- further step
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000010647 peptide synthesis reaction Methods 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 102000002704 Leucyl aminopeptidase Human genes 0.000 claims 1
- 108010004098 Leucyl aminopeptidase Proteins 0.000 claims 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical group [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- 241000187747 Streptomyces Species 0.000 claims 1
- 241000946853 Streptomyces luridus Species 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 238000010564 aerobic fermentation Methods 0.000 claims 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims 1
- 235000008206 alpha-amino acids Nutrition 0.000 claims 1
- -1 amine salt Chemical class 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical class NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 238000007654 immersion Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 229910052717 sulfur Chemical group 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Wood Science & Technology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도 A53868인자 A의 적외부 흡수스펙트럼(KBr 펠렛법)
Claims (12)
- A53868인자 A를 생산하는스트렙토마이세스 루리두스NRRL 15101(기탁번호 : KFCC-10057) 또는 그의 돌연변이체 또는 재조합체를 탄소, 질소 및 무기염의 동화 가능한 공급원을 함유하는 배지중에서 액침호기성 발효조건하에 실질량의 항생물질 활성이 생성될 때까지 배양시킴을 특징으로 하여 A53868인자 A를 제조하는 방법.
- 제1항에 있어서스트렙토마이세스 루리두스NRRL 15101(기탁번호:KFCC-10057)을 배양함을 특징으로 하는 방법.
- 제1 또는 2항에 있어서 A53868인자 A를 분리하는 추가 단계를 포함하는 방법.
- 제3항에 있어서, A53868인자 A를 로이신 아미노 펩티다제와 반응시키거나 선택적 산 가수분해시킨 뒤, 통상적인 용액상 펩타이드 합성법에 의해 일반식(2a) 화합물 및 그의 염을 제공하는 추가 단계를 포함하는 방법.
-
- 상기식에서 R1은 단백에서 통상 발견되는 α-아미노산 형태의 특성화 그룹을 나타내며, R2및 R3는 독립적으로, 수소 또는 C1-C3-알킬을 나타내고, Z는 수소, C1~C6-알킬, C1~C6-알카노일, 페닐-C1~C3-알킬, 페닐-(X)m-C1~C3-알카노일 또는 아미노 보호그룹을 나타내며, Z'는 수소 또는 C1~C6-알킬을 나타내고, X는 산소 또는 황이며; m은 0 또는 1이고, n은 0, 1, 2 또는 3이며, 단, 1) R2및 R3가 모두 알킬인 경우에는 동일해야 하고, 2) n이 1인 경우에는 R1, R2, R3, Z 또는 Z'중 하나는 수소가 아니어야 한다.
- 제3항에 있어서, A53868인자 A를 통상적인 용액상 펩타이드 합성법에 의해 반응시켜 R1이 수소이며 Z 또는 Z'가 수소가 아닌 제4항에서 정의된 일반식(2a) 화합물을 제공하는 추가 단계를 포함하는 방법.
- 제3, 4 또는 5항에 있어서, R2, R3, Z 또는 Z'중 적어도 하나가 수소가 아닌 일반식(2a)의 화합물을 유도체화 하는 추가단계를 포함하는 방법.
- 제1, 3, 4, 5 또는 6항 중 어느 하나에 있어서 염이 약학적으로 무독한 염인 방법.
- 제7항에 있어서 포스포네이트 염이 모노나트륨염, 디나트륨염, 모노암모늄염, 디암모늄염 또는 모노사이클로헥실 암모늄염인 방법.
- 제7항에 있어서 아민염이 하이드로클로라이드인 방법.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/424,805 US4463092A (en) | 1982-09-27 | 1982-09-27 | Process for production antibiotic A53868 |
| US424,805 | 1982-09-27 | ||
| US424805 | 1982-09-27 | ||
| US46741983A | 1983-02-17 | 1983-02-17 | |
| US467419 | 1983-02-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR840006013A true KR840006013A (ko) | 1984-11-21 |
| KR860001291B1 KR860001291B1 (ko) | 1986-09-10 |
Family
ID=23683938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830004518A KR860001291B1 (ko) | 1982-09-27 | 1983-09-27 | A 53868인자 a의 제조방법 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4463092A (ko) |
| JP (1) | JPS5998094A (ko) |
| KR (1) | KR860001291B1 (ko) |
| AU (1) | AU1956783A (ko) |
| GR (1) | GR79046B (ko) |
| PH (1) | PH18630A (ko) |
| ZA (1) | ZA836996B (ko) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1315480C (en) * | 1986-06-12 | 1993-03-30 | Eric Charles Reynolds | Phosphopeptides |
| CN116396359A (zh) * | 2020-02-17 | 2023-07-07 | 中国医学科学院医药生物技术研究所 | 一组具有抗病毒活性的肽类化合物奥米克欣a族化合物及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3639590A (en) * | 1967-07-25 | 1972-02-01 | Merck & Co Inc | Antibacterial composition containing (-) (cis-1 2-epoxypropyl) phosphoric acid |
| IL48835A (en) * | 1975-01-27 | 1979-05-31 | Sparamedica Ag | Amino acyl and peptidyl derivatives of phophonic acids, their preparation and pharmaceutical compositions containingthem |
| GB1585275A (en) * | 1976-07-21 | 1981-02-25 | Roche Products Ltd | Peptide derivatives of phosphonic and phosphinic acids |
| PH13967A (en) * | 1976-07-27 | 1980-11-12 | Fujisawa Pharmaceutical Co | Antibiotics phosphonic acid derivatives and production and use thereof |
| US4206156A (en) * | 1976-07-27 | 1980-06-03 | Fujisawa Pharmaceutical Company, Limited | Hydroxyaminohydrocarbonphosphonic acids |
| US4331591A (en) * | 1978-10-05 | 1982-05-25 | Ciba-Geigy Corporation | Chemical process for the production of α-aminophosphonic acids and peptide derivatives |
-
1982
- 1982-09-27 US US06/424,805 patent/US4463092A/en not_active Expired - Fee Related
-
1983
- 1983-09-19 GR GR72473A patent/GR79046B/el unknown
- 1983-09-20 ZA ZA836996A patent/ZA836996B/xx unknown
- 1983-09-22 PH PH29574A patent/PH18630A/en unknown
- 1983-09-26 AU AU19567/83A patent/AU1956783A/en not_active Abandoned
- 1983-09-27 JP JP58181744A patent/JPS5998094A/ja active Pending
- 1983-09-27 KR KR1019830004518A patent/KR860001291B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PH18630A (en) | 1985-08-23 |
| ZA836996B (en) | 1985-04-24 |
| JPS5998094A (ja) | 1984-06-06 |
| US4463092A (en) | 1984-07-31 |
| AU1956783A (en) | 1984-04-05 |
| GR79046B (ko) | 1984-10-02 |
| KR860001291B1 (ko) | 1986-09-10 |
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|---|---|---|---|
| G160 | Decision to publish patent application | ||
| O035 | Opposition [patent]: request for opposition |
Free format text: OPPOSITION NUMBER: 001986001360; OPPOSITION DATE: 19861011 |
|
| SUBM | Surrender of laid-open application requested |