HUP9901590A2 - Szubsztituált aza- és diaza-cikloheptán- és -ciklooktán-származékok, alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Szubsztituált aza- és diaza-cikloheptán- és -ciklooktán-származékok, alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9901590A2
HUP9901590A2 HU9901590A HUP9901590A HUP9901590A2 HU P9901590 A2 HUP9901590 A2 HU P9901590A2 HU 9901590 A HU9901590 A HU 9901590A HU P9901590 A HUP9901590 A HU P9901590A HU P9901590 A2 HUP9901590 A2 HU P9901590A2
Authority
HU
Hungary
Prior art keywords
cyclooctane
derivatives
diazacycloheptane
compounds
disubstituted
Prior art date
Application number
HU9901590A
Other languages
English (en)
Inventor
Stefan Blank
Dorothea Starck
Hans-Jürgen Teschendorf
Hans-Jörg Treiber
Liliane Unger
Karsten Wicke
Original Assignee
Basf Ag.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag., filed Critical Basf Ag.,
Publication of HUP9901590A2 publication Critical patent/HUP9901590A2/hu
Publication of HUP9901590A3 publication Critical patent/HUP9901590A3/hu
Publication of HU228457B1 publication Critical patent/HU228457B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

A szűbsztitűált aza- és diaza-ciklőheptán- vagy ciklőőktán-származékőkAr1-A-B-Ar2 (I) általánős képletében: Ar1 adőtt esetben szűbsztitűált benzőil-aminő-, (benzőtienil-karbőnil)-aminő-csőpőrt vagy 5 vagy 6 tagú heterőarilcsőpőrt; R1 hidrőgénatőm vagy adőtt esetben szűbsztitűált alkilcsőpőrt; R2 űgyanaz, mint R1, tővábbá -COR1 vagy -CO2R1 általánős képletűcsőpőrt; B 7 vagy 8 tagú, egy, vagy 1,4- vagy 1,5-helyzetben két nitrőgénatőmőtés adőtt esetben kettős kötést tartalmazó, kétértékű telítettheterőciklűsős csőpőrt; és Ar2 adőtt esetben szűbsztitűált és/vagy egy karbőciklűssal kőndenzáltfenil-, piridil-, pirimidinil- vagy triazinilcsőpőrt, azzal amegkötéssel, hőgy jelentése 2-hidrőxi-pirimidinil-csőpőrttól eltérő. Atalálmány szerinti vegyületek a dőpamin D3-receptőrőkkal szemben nagyés szelektív affinitást műtató, ennélfőgva a D3-receptőrőkligandjaival befőlyásőlható betegségek kezelésében alkalmazhatók. ŕ
HU9901590A 1996-01-12 1997-01-10 Substituted aza- and diazacycloheptane and cyclooctane derivatives, use thereof, pharmaceutical compositions containing there of HU228457B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19600934A DE19600934A1 (de) 1996-01-12 1996-01-12 Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
PCT/EP1997/000106 WO1997025324A1 (de) 1996-01-12 1997-01-10 Substituierte aza- und diazacycloheptan- und -cyclooctanverbindungen und deren verwendung

Publications (3)

Publication Number Publication Date
HUP9901590A2 true HUP9901590A2 (hu) 1999-08-30
HUP9901590A3 HUP9901590A3 (en) 2002-01-28
HU228457B1 HU228457B1 (en) 2013-03-28

Family

ID=7782613

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901590A HU228457B1 (en) 1996-01-12 1997-01-10 Substituted aza- and diazacycloheptane and cyclooctane derivatives, use thereof, pharmaceutical compositions containing there of

Country Status (26)

Country Link
US (2) US6214822B1 (hu)
EP (1) EP0877744B1 (hu)
JP (1) JP4349657B2 (hu)
KR (1) KR100441073B1 (hu)
CN (2) CN1075070C (hu)
AR (1) AR005868A1 (hu)
AT (1) ATE273301T1 (hu)
AU (1) AU717726B2 (hu)
BG (1) BG64098B1 (hu)
CA (1) CA2241787C (hu)
CO (1) CO4790173A1 (hu)
CZ (1) CZ297981B6 (hu)
DE (2) DE19600934A1 (hu)
ES (1) ES2225947T3 (hu)
HR (1) HRP970021A2 (hu)
HU (1) HU228457B1 (hu)
IL (1) IL125076A (hu)
MX (1) MX9805499A (hu)
NO (1) NO316753B1 (hu)
NZ (1) NZ326332A (hu)
PL (1) PL327692A1 (hu)
SK (1) SK284987B6 (hu)
TR (1) TR199801302T2 (hu)
TW (1) TW475929B (hu)
WO (1) WO1997025324A1 (hu)
ZA (1) ZA97209B (hu)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19728996A1 (de) 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
SK4782001A3 (en) 1998-10-08 2001-11-06 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
AR022229A1 (es) * 1999-01-12 2002-09-04 Abbott Gmbh & Co Kg Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion
DE19922443A1 (de) * 1999-05-07 2000-11-09 Basf Ag Verwendung von Dopamin-D3-Rezeptorliganden zur Herstellung von Arzneimittel für die Behandlung von Nierenfunktionsstörungen
US7037916B2 (en) 1999-07-15 2006-05-02 Pharmacopeia Drug Discovery, Inc. Pyrimidine derivatives as IL-8 receptor antagonists
AU2001250404A1 (en) * 2000-03-27 2001-10-08 Basf Aktiengesellschaft Use of dopamine-d3 receptor ligands for the treatment of diseases of the central nervous system
ATE412638T1 (de) 2001-02-16 2008-11-15 Aventis Pharma Inc Heterocyclische substituierte carbonyl derivate und ihre verwendung als dopamin d3 rezeptor liganden
DE10109866A1 (de) * 2001-03-01 2002-09-05 Abbott Gmbh & Co Kg Triazolverbindungen und deren Verwendung zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie
DE10131543A1 (de) * 2001-06-29 2003-01-16 Abbott Lab Pyrimidinoxyalkylpiperazine und ihre therapeutische Verwendung
BR0214553A (pt) * 2001-11-28 2004-10-13 Sod Conseils Rech Applic Compostos, processo de preparação, em fase lìquida, dos compostos, e, composições farmacêuticas
WO2003077656A1 (en) * 2002-03-15 2003-09-25 Ciba Specialty Chemicals Holding Inc. 4-aminopyrimidines and their use for the antimicrobial treatment of surfaces
DE10304870A1 (de) 2003-02-06 2004-08-19 Abbott Gmbh & Co. Kg Triazolverbindungen und ihre therapeutische Verwendung
TW200507841A (en) * 2003-03-27 2005-03-01 Glaxo Group Ltd Antibacterial agents
DE10358004A1 (de) * 2003-12-11 2005-07-14 Abbott Gmbh & Co. Kg Ketolactam-Verbindungen und ihre Verwendung
DE102004027358A1 (de) * 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyrimidinverbindungen und ihre Verwendung
FR2877005A1 (fr) * 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
JP2008528604A (ja) * 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
JP2007106746A (ja) * 2005-09-13 2007-04-26 Tosoh Corp 新規アリールホモピペラジン類、またはその塩と製造方法
EP1988077A4 (en) * 2006-02-23 2009-09-02 Shionogi & Co NUCLEIC HETEROCYCLIC DERIVATIVES SUBSTITUTED BY CYCLIC GROUPS
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
EP1882688A1 (en) 2006-07-25 2008-01-30 EPFL Ecole Polytechnique Fédérale de Lausanne Labelling of fusion proteins with synthetic probes
JP4840440B2 (ja) * 2008-12-24 2011-12-21 ソニー株式会社 画像処理装置およびその方法、並びにプログラム
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
MX2012008346A (es) * 2010-01-25 2012-11-12 Chdi Foundation Inc Determinados inhibidores de cinurenina-3-monooxigenasa, composiciones farmceuticas y metodos de uso de los mismos.
WO2012003418A2 (en) * 2010-07-02 2012-01-05 The University Of North Carolina At Chapel Hill Functionally selective ligands of dopamine d2 receptors
JP2013542243A (ja) 2010-11-15 2013-11-21 カトリーケ ウニヴェルシテイト ルーヴェン 新規な抗ウイルス性化合物
CN106518845B (zh) 2011-08-30 2019-09-13 Chdi基金会股份有限公司 犬尿氨酸-3-单加氧酶抑制剂、药物组合物及其使用方法
BR112014004845A2 (pt) 2011-08-30 2017-04-04 Chdi Foundation Inc pelo menos uma entidade química; pelo menos um composto; composição farmacêutica; uso de uma quantidade terapeuticamente eficaz de pelo menos uma entidade química; composição farmacêutica embalada
EP3756666A1 (en) 2013-12-24 2020-12-30 Oncotartis Inc. Nicotinamide compound for use in the treatment of cancer
SG11201700341PA (en) 2014-07-17 2017-02-27 Chdi Foundation Inc Methods and compositions for treating hiv-related disorders

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE628766A (hu) 1962-12-26
BE792206A (hu) 1971-12-02 1973-06-01 Byk Gulden Lomberg Chem Fab
US5139998A (en) 1988-08-31 1992-08-18 Superconductor Technologies, Inc. Controlled thallous oxide evaporation for thallium superconductor films and reactor design
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
US5008267A (en) 1988-10-29 1991-04-16 Mitsui Toatsu Chemicals, Incorporated Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same
JP2815218B2 (ja) 1990-04-13 1998-10-27 三井化学株式会社 ピリミジンジオン誘導体、およびそれを含有する抗不整脈剤
FR2663638B2 (fr) 1990-04-06 1995-02-10 Institut Nal Sante Recherc Medic Polypeptides ayant une activite de recepteur dopaminergique, acides nucleiques codant pour ces polypeptides et utilisation de ces polypeptides pour le criblage de substances actives sur ces polypeptides.
JP2518965B2 (ja) 1990-09-21 1996-07-31 三井東圧化学株式会社 新規ピリジン誘導体及びそれを有効成分として含有する制癌剤効果増強剤
FR2668771B1 (fr) 1990-11-06 1995-03-17 Inst Nat Sante Rech Med Acides nucleiques codant pour des polypeptides ayant une activite de recepteur dopaminergique humain et utilisation de ces polypeptides pour le criblage de substances actives sur ces polypeptides.
DE4425144A1 (de) 1994-07-15 1996-01-18 Basf Ag Triazolverbindungen und deren Verwendung
DE4425146A1 (de) 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen
DE4425145A1 (de) 1994-07-15 1996-01-18 Basf Ag Verwendung von Thiazol- und Thiadiazolverbindungen
DE4425143A1 (de) 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
US5635503A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Company Dihydropyridine npy antagonists: piperazine derivatives
FR2742149B1 (fr) 1995-12-11 1998-02-13 Inst Nat Sante Rech Med Nouveaux derives de 2-naphtamides et leurs applications therapeutiques

Also Published As

Publication number Publication date
NO316753B1 (no) 2004-04-26
CA2241787C (en) 2006-04-04
JP4349657B2 (ja) 2009-10-21
CZ297981B6 (cs) 2007-05-16
ZA97209B (en) 1998-07-10
AU1440797A (en) 1997-08-01
IL125076A (en) 2001-05-20
DE59711847D1 (de) 2004-09-16
CN1212692A (zh) 1999-03-31
EP0877744B1 (de) 2004-08-11
WO1997025324A1 (de) 1997-07-17
TW475929B (en) 2002-02-11
CN1146551C (zh) 2004-04-21
AU717726B2 (en) 2000-03-30
IL125076A0 (en) 1999-01-26
HRP970021A2 (en) 1998-04-30
CN1075070C (zh) 2001-11-21
MX9805499A (es) 1998-11-30
EP0877744A1 (de) 1998-11-18
KR19990077127A (ko) 1999-10-25
NO983187L (no) 1998-09-09
CZ215998A3 (cs) 1999-05-12
HU228457B1 (en) 2013-03-28
SK284987B6 (sk) 2006-04-06
SK94198A3 (en) 1999-03-12
JP2000505072A (ja) 2000-04-25
DE19600934A1 (de) 1997-07-17
BG64098B1 (bg) 2003-12-31
KR100441073B1 (ko) 2004-11-16
CN1348956A (zh) 2002-05-15
ATE273301T1 (de) 2004-08-15
HUP9901590A3 (en) 2002-01-28
TR199801302T2 (xx) 1998-11-23
ES2225947T3 (es) 2005-03-16
BG102616A (en) 1999-04-30
CA2241787A1 (en) 1997-07-17
US6352981B1 (en) 2002-03-05
AR005868A1 (es) 1999-07-21
NZ326332A (en) 1999-04-29
PL327692A1 (en) 1998-12-21
CO4790173A1 (es) 1999-05-31
US6214822B1 (en) 2001-04-10

Similar Documents

Publication Publication Date Title
HUP9901590A2 (hu) Szubsztituált aza- és diaza-cikloheptán- és -ciklooktán-származékok, alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények
PT1140916E (pt) Acetais heteroarilo ciclicos
AR013184A1 (es) Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
TW369526B (en) Diazabicyclic neurokinin antagonists
HUP0401819A2 (hu) Proteinkináz inhibitorokként alkalmazható pirazolvegyületek és ezeket tartalmazó gyógyszerkészítmények
FI931370A (fi) Kvaeve innehaollande analoger av icke-aromatiska heterocykliska foereningar med en fusionerad ring
NZ502181A (en) Triazole compounds and the use thereof as dopamine-D 3-ligands
HUP9601285A2 (hu) Szubsztituált N-(indol-2-karbonil)-béta-alanin-amidok és származékaik, valamint e vegyületeket tartalmazó gyógyászati készítmények
DK1000035T3 (da) Substituerede 6-phenylphenanthridiner
DE69224196D1 (de) 3-aminopiperidine derivate und verwandete stickstoff enthaltende heterocyclische verbindungen
TR199801594A2 (xx) CCR-3 resept�r antagonistleri.
HUP0203122A2 (hu) Fab I inhibitorok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP9802865A2 (hu) N-(szubsztituált fenil-)-pirazol-származékok, előállításuk és alkalmazásuk, a vegyületeket hatóanyagként tartalmazó parazitaellenes készítmények
NZ233735A (en) Heterocyclic substituted aminophenol derivatives
DE69924292D1 (de) Pyrazol verbindungen und ihre verwendung
TW429255B (en) Pyrazine compounds having treatment of central nervous system diseases and disorders
EA200300044A1 (ru) Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции
TR200200125T2 (tr) Yeni aminotiyazol türevleri, bunların hazırlanması ve bunları içeren farmasötik kompozisyonlar.
MD502G2 (ro) Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
GB1424450A (en) Isoindoline intermediates
HUP9701921A2 (hu) Heterociklusos amino-metil-vegyületek, eljárás ezek előállítására és ezeket tartalmazó gyógyászati készítmények
HUP9904594A2 (hu) Piperazinoszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
MXPA01013148A (es) Nuevos derivados de amonio cuaternario, metodo para la preparacion de los mismos y uso farmaceutico.
MXPA03010583A (es) Derivados de pirimidina utiles como inhibidores de cox-2 selectivos.
HUP0001010A2 (hu) Benzimidazol-származékok és ezeket a vegyületeket tartalmazó gyógyszerkészítmények

Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: ABBVIE DEUTSCHLAND GMBH & CO KG, DE

Free format text: FORMER OWNER(S): ABBOTT GMBH & CO. KG, DE; BASF AG.,, DE

FH91 Appointment of a representative

Free format text: FORMER REPRESENTATIVE(S): RATHONYI ZOLTAN, S.B.G. & K. SZABADALMI UEGYVIVOEI IRODA, HU

Representative=s name: SBGK SZABADALMI ES UEGYVEDI IRODAK, HU