AR022229A1 - Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion - Google Patents

Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion

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Publication number
AR022229A1
AR022229A1 ARP000100079A ARP000100079A AR022229A1 AR 022229 A1 AR022229 A1 AR 022229A1 AR P000100079 A ARP000100079 A AR P000100079A AR P000100079 A ARP000100079 A AR P000100079A AR 022229 A1 AR022229 A1 AR 022229A1
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Argentina
Prior art keywords
alkyl
halogen
phenyl
optionally substituted
aromatic
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ARP000100079A
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English (en)
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Abbott Gmbh & Co Kg
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Publication of AR022229A1 publication Critical patent/AR022229A1/es

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D491/04—Ortho-condensed systems

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  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos de triazol de la Formula general (1) en donde: R1 representa H, alquilo C1-6, sustituido opcionalmente por OH, alquilo OC1-6, halogeno o fenilo,cicloalquilo C3-6 o fenilo; R2 representa H, alquilo C1-6, sustituido opcionalmente por OH,alq uilo OC1-6, halogeno o fenilo, alcoxi C1-6, alquiltio C1-6,alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, halogeno, CN, COOR3, CONR3R4, NR3R4, SO2R3, SO2NR3R', o un resto aromático, seleccionado entre fenilo,naftilo y un resto heterocíclicode 5 o 6 miembros con 1, 2, 3 o 4 heteroátomos, seleccionados independientemente uno de otro entre O, N y S, pudiendopresentar el resto aromático uno o dos sustituyentes, seleccionados independientemente uno de otro entre alquilo C1-6, sustituidoopcional mente por OH, alquiloOC1-6, halogeno o fenilo, alcoxi C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, halogeno, CN, COR3, NR3R4, NO2, SO2R3, SO2NR3R4 y fenilo, sustituidoopcionalmente por uno o dos restos seleccionadosindependientemente uno de otro entre alquilo C1-6, alcoxi C1-6, NR3R4, CN, CF3, CHF2 o halogeno; R3 y R4representan independientemente uno de otro H, alquilo C1-6 sustituido opcionalmente por OH, alquilo OC1-6, halogeno o fenilo, o fenilo; Arepresenta alquilenoC4-10 o al quileno C3-10, que comprende por lo menos un grupo Z, seleccionado entre O, S, CONR3, COO, CO, cicloalquilo C3-6 y un enlace doble o triple; Bsignifica un resto de la formula (2) en donde: X representa CH2 o CH2CH2;R6, R7 y R8 seleccionados independ ientemente uno de otro entre H, alquilo C1-6opcionalmente sustituido por OH, alquilo OC1-6 opcionalmente sustituido por amino, mono- o di-alquilamino C1-4, alquiltio C1-6, halogeno o fenilo; OH, alcoxiC1-6, OCF3,OSO2CF3, SH, alquiltio C1-6, alquenil o C2-6, alquinilo C2-6, halogeno, CN, NO2, CO2R3, SO2R3, SO2NR3R4, en donde R3 y R4 tienen el significadoarriba mencionado y junto con el átomo de N, al cual están ligados, pueden formar también un heterociclosaturado o no saturado con 5-7 miembros del anillo y 1o 2 heteroátomos N; CONR3R4, NHSO2R3, NR3R4, un anillo aromático o no aromático carbocíclico de 5 o 6 miembros y un anillo aromático o no aromático
ARP000100079A 1999-01-12 2000-01-10 Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion AR022229A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19900811 1999-01-12

Publications (1)

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AR022229A1 true AR022229A1 (es) 2002-09-04

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Application Number Title Priority Date Filing Date
ARP000100079A AR022229A1 (es) 1999-01-12 2000-01-10 Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion
ARP000100080A AR022230A1 (es) 1999-01-12 2000-01-10 Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion
ARP000100078A AR022228A1 (es) 1999-01-12 2000-01-10 Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para la preparar dicha composicion

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ARP000100080A AR022230A1 (es) 1999-01-12 2000-01-10 Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion
ARP000100078A AR022228A1 (es) 1999-01-12 2000-01-10 Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para la preparar dicha composicion

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US (3) US6602867B1 (es)
EP (3) EP1140907B1 (es)
JP (3) JP4615125B2 (es)
KR (3) KR100730667B1 (es)
CN (3) CN1267430C (es)
AR (3) AR022229A1 (es)
AT (3) ATE424398T1 (es)
AU (3) AU772948B2 (es)
BG (2) BG65105B1 (es)
BR (2) BR0007500A (es)
CA (3) CA2359942A1 (es)
CO (3) CO5150227A1 (es)
CZ (2) CZ303926B6 (es)
DE (3) DE50015802D1 (es)
ES (2) ES2334326T3 (es)
HK (1) HK1045311B (es)
HR (1) HRP20010590A2 (es)
HU (2) HUP0200522A3 (es)
ID (2) ID29552A (es)
IL (3) IL144137A0 (es)
NO (2) NO20013443L (es)
NZ (2) NZ512830A (es)
PL (2) PL200238B1 (es)
SK (2) SK9852001A3 (es)
TR (2) TR200102025T2 (es)
TW (1) TWI274750B (es)
WO (3) WO2000042037A1 (es)
ZA (2) ZA200106584B (es)

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