HUP9900040A3 - Tetrahydroquinolines as nmda antagonists, process for producing them and pharmaceutical compositions containing them - Google Patents

Tetrahydroquinolines as nmda antagonists, process for producing them and pharmaceutical compositions containing them

Info

Publication number: HUP9900040A3
Authority: HU; Hungary
Prior art keywords: tetrahydroquinolines; producing; pharmaceutical compositions; compositions containing; nmda antagonists
Prior art date: 1995-09-29

Application number

HU9900040A

Other languages

English (en)

Original Assignee

Glaxo Wellcome Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-29

Filing date

1996-09-26

Publication date

2001-01-29

1995-09-29 Priority claimed from GBGB9519893.3A external-priority patent/GB9519893D0/en

1996-08-17 Priority claimed from GBGB9617306.7A external-priority patent/GB9617306D0/en

1996-09-26 Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa

1999-04-28 Publication of HUP9900040A2 publication Critical patent/HUP9900040A2/hu

2001-01-29 Publication of HUP9900040A3 publication Critical patent/HUP9900040A3/hu

Links

HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000003530 tetrahydroquinolines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Virology (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

HU9900040A 1995-09-29 1996-09-26 Tetrahydroquinolines as nmda antagonists, process for producing them and pharmaceutical compositions containing them HUP9900040A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9519893.3A GB9519893D0 (en)	1995-09-29	1995-09-29	Heterocyclic compounds
GBGB9617306.7A GB9617306D0 (en)	1996-08-17	1996-08-17	Heterocyclic compounds

Publications (2)

Publication Number	Publication Date
HUP9900040A2 HUP9900040A2 (hu)	1999-04-28
HUP9900040A3 true HUP9900040A3 (en)	2001-01-29

Family

ID=26307841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9900040A HUP9900040A3 (en)	1995-09-29	1996-09-26	Tetrahydroquinolines as nmda antagonists, process for producing them and pharmaceutical compositions containing them

Country Status (29)

Country	Link
US (1)	US5977136A (hu)
EP (1)	EP0854867B1 (hu)
JP (1)	JP4108123B2 (hu)
KR (1)	KR100464895B1 (hu)
CN (1)	CN1130346C (hu)
AP (1)	AP876A (hu)
AR (1)	AR005233A1 (hu)
AT (1)	ATE221520T1 (hu)
AU (1)	AU708148B2 (hu)
BR (1)	BR9610733A (hu)
CA (1)	CA2232509A1 (hu)
CZ (1)	CZ292379B6 (hu)
DE (1)	DE69622731T2 (hu)
DK (1)	DK0854867T3 (hu)
EA (1)	EA000875B1 (hu)
ES (1)	ES2180799T3 (hu)
HK (1)	HK1009133A1 (hu)
HU (1)	HUP9900040A3 (hu)
IL (1)	IL123322A0 (hu)
IS (1)	IS4677A (hu)
MX (1)	MX9801967A (hu)
NO (1)	NO310355B1 (hu)
NZ (1)	NZ319596A (hu)
PL (1)	PL186781B1 (hu)
PT (1)	PT854867E (hu)
SI (1)	SI0854867T1 (hu)
TR (1)	TR199800531T1 (hu)
TW (1)	TW460465B (hu)
WO (1)	WO1997012870A1 (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9617305D0 (en) *	1996-08-17	1996-09-25	Glaxo Wellcome Spa	Heterocyclic compounds
GB9706294D0 (en) *	1997-03-26	1997-05-14	Glaxo Wellcome Spa	Heterocyclic compound
MY125037A (en)	1998-06-10	2006-07-31	Glaxo Wellcome Spa	1,2,3,4 tetrahydroquinoline derivatives
TW555757B (en) *	1998-07-31	2003-10-01	Akzo Nobel Nv	Aminomethylcarboxylic acid derivatives
WO2000008018A1 (fr) *	1998-08-07	2000-02-17	Takeda Chemical Industries, Ltd.	Derives de benzothiepine, leur procede de preparation et leurs utilisations
GB9929037D0 (en) *	1999-12-08	2000-02-02	Glaxo Wellcome Spa	Heterocyclic derivatives
CA2470578C (en) *	2001-12-28	2010-10-12	Acadia Pharmaceuticals, Inc.	Tetrahydroquinoline analogues as muscarinic agonists
DE10236910A1 (de) *	2002-08-12	2004-03-11	Grünenthal GmbH	Substituierte 1,2,3,4-Tetrahydrochinolinderivate
US7910751B2 (en) *	2005-07-22	2011-03-22	Mochida Pharmaceutical Co., Ltd.	Heterocyclidene acetamide derivative
RU2451014C2 (ru) *	2005-07-22	2012-05-20	Мотида Фармасьютикал Ко., Лтд.	Новое производное гетероциклиден ацетамида
PL2268644T3 (pl)	2008-03-05	2012-01-31	Boehringer Ingelheim Int	Tricykliczne pochodne piperydyny, leki zawierające te związki, ich zastosowanie i sposoby ich wytwarzania
EP2286808A1 (en) *	2009-08-18	2011-02-23	Rheinische Friedrich-Wilhelms Universität	Cytohesin inhibitors
WO2011101774A1 (en)	2010-02-16	2011-08-25	Pfizer Inc.	(r)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2h-pyran-4-ol, a partial agonist of 5-ht4 receptors
SG183321A1 (en)	2010-02-19	2012-09-27	Boehringer Ingelheim Int	Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
EP2760868B1 (en)	2011-08-17	2018-04-25	Boehringer Ingelheim International GmbH	Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation
WO2016114655A1 (en) *	2015-01-12	2016-07-21	Ry Pharma B.V.	Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation
WO2017065602A1 (en) *	2015-10-13	2017-04-20	Ry Pharma B.V.	Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0386839B1 (en) *	1989-03-08	1997-01-15	Merck Sharp & Dohme Ltd.	Tetrahydroquinoline derivatives useful for neurodegenerative disorders

1996
- 1996-09-26 CA CA002232509A patent/CA2232509A1/en not_active Abandoned
- 1996-09-26 CZ CZ1998940A patent/CZ292379B6/cs not_active IP Right Cessation
- 1996-09-26 US US09/029,860 patent/US5977136A/en not_active Expired - Fee Related
- 1996-09-26 SI SI9630523T patent/SI0854867T1/xx unknown
- 1996-09-26 CN CN96198560A patent/CN1130346C/zh not_active Expired - Fee Related
- 1996-09-26 HU HU9900040A patent/HUP9900040A3/hu unknown
- 1996-09-26 PL PL96325966A patent/PL186781B1/pl not_active IP Right Cessation
- 1996-09-26 AP APAP/P/1998/001212A patent/AP876A/en active
- 1996-09-26 DE DE69622731T patent/DE69622731T2/de not_active Expired - Lifetime
- 1996-09-26 KR KR10-1998-0702321A patent/KR100464895B1/ko not_active IP Right Cessation
- 1996-09-26 AT AT96933399T patent/ATE221520T1/de not_active IP Right Cessation
- 1996-09-26 PT PT96933399T patent/PT854867E/pt unknown
- 1996-09-26 IL IL12332296A patent/IL123322A0/xx not_active IP Right Cessation
- 1996-09-26 JP JP51394797A patent/JP4108123B2/ja not_active Expired - Fee Related
- 1996-09-26 ES ES96933399T patent/ES2180799T3/es not_active Expired - Lifetime
- 1996-09-26 NZ NZ319596A patent/NZ319596A/en not_active IP Right Cessation
- 1996-09-26 DK DK96933399T patent/DK0854867T3/da active
- 1996-09-26 EA EA199800230A patent/EA000875B1/ru not_active IP Right Cessation
- 1996-09-26 BR BR9610733A patent/BR9610733A/pt not_active IP Right Cessation
- 1996-09-26 TR TR1998/00531T patent/TR199800531T1/xx unknown
- 1996-09-26 WO PCT/EP1996/004206 patent/WO1997012870A1/en active IP Right Grant
- 1996-09-26 AU AU72148/96A patent/AU708148B2/en not_active Ceased
- 1996-09-26 EP EP96933399A patent/EP0854867B1/en not_active Expired - Lifetime
- 1996-09-30 AR ARP960104543A patent/AR005233A1/es active IP Right Grant
- 1996-10-04 TW TW085112168A patent/TW460465B/zh not_active IP Right Cessation
1998
- 1998-02-27 IS IS4677A patent/IS4677A/is unknown
- 1998-03-12 MX MX9801967A patent/MX9801967A/es not_active IP Right Cessation
- 1998-03-27 NO NO19981396A patent/NO310355B1/no not_active IP Right Cessation
- 1998-08-24 HK HK98110117A patent/HK1009133A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT854867E (pt)	2002-12-31
HK1009133A1 (en)	1999-05-28
IS4677A (is)	1998-02-27
TR199800531T1 (xx)	1998-06-22
ES2180799T3 (es)	2003-02-16
JP4108123B2 (ja)	2008-06-25
DE69622731T2 (de)	2003-02-20
NO981396D0 (no)	1998-03-27
NO981396L (no)	1998-05-27
AU7214896A (en)	1997-04-28
AU708148B2 (en)	1999-07-29
CN1202887A (zh)	1998-12-23
SI0854867T1 (en)	2003-02-28
US5977136A (en)	1999-11-02
JPH11512728A (ja)	1999-11-02
IL123322A0 (en)	1998-09-24
KR19990063850A (ko)	1999-07-26
WO1997012870A1 (en)	1997-04-10
CA2232509A1 (en)	1997-04-10
PL325966A1 (en)	1998-08-17
CZ94098A3 (cs)	1998-07-15
NZ319596A (en)	1999-09-29
DK0854867T3 (da)	2002-12-02
EA000875B1 (ru)	2000-06-26
TW460465B (en)	2001-10-21
AP9801212A0 (en)	1998-03-31
KR100464895B1 (ko)	2005-05-16
PL186781B1 (pl)	2004-02-27
DE69622731D1 (de)	2002-09-05
EA199800230A1 (ru)	1998-10-29
AR005233A1 (es)	1999-04-28
CN1130346C (zh)	2003-12-10
EP0854867B1 (en)	2002-07-31
EP0854867A1 (en)	1998-07-29
HUP9900040A2 (hu)	1999-04-28
AP876A (en)	2000-09-27
MX9801967A (es)	1998-08-30
BR9610733A (pt)	1999-07-13
ATE221520T1 (de)	2002-08-15
NO310355B1 (no)	2001-06-25
CZ292379B6 (cs)	2003-09-17

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