HUP0500095A2 - Enzimes, ciklusos homocisztein- és cisztationinvizsgálatok - Google Patents

Enzimes, ciklusos homocisztein- és cisztationinvizsgálatok

Info

Publication number
HUP0500095A2
HUP0500095A2 HU0500095A HUP0500095A HUP0500095A2 HU P0500095 A2 HUP0500095 A2 HU P0500095A2 HU 0500095 A HU0500095 A HU 0500095A HU P0500095 A HUP0500095 A HU P0500095A HU P0500095 A2 HUP0500095 A2 HU P0500095A2
Authority
HU
Hungary
Prior art keywords
cystathionine
homocysteine
amount
pyruvate
ammonia
Prior art date
Application number
HU0500095A
Other languages
English (en)
Inventor
Heather Kay Webb
Jeffrey Owens
Raymond Liedtke
Doreen Forest
Mark Legaz
Glen Kawasaki
Sobomabo Lawson
Original Assignee
Catch, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21756556&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0500095(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Catch, Inc. filed Critical Catch, Inc.
Publication of HUP0500095A2 publication Critical patent/HUP0500095A2/hu
Publication of HUP0500095A3 publication Critical patent/HUP0500095A3/hu
Publication of HU228343B1 publication Critical patent/HU228343B1/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A találmány tárgyát képezi enzimes, ciklusos vizsgálat homociszteinés/vagy cisztationin oldatban lévő mennyiségének megállapítására,amely során a homociszteint és/vagy cisztationint tartalmazó oldatotreakciókeverék formájában kapcsolatba hozzák cisztationin-b-szintázzalvagy származékával, L-szerinnel, és cisztationin-b-liázzal vagyszármazékával elegendő ideig ahhoz, hogy az enzimek homociszteinnekcisztationinná és cisztationinnak homociszteinné történő ciklusosátalakulását és visszaalakulását katalizálják, amelyet piruvát ésammónia termelődése kísér; a reakciókeverékben lévő piruvát és/vagyammónia mennyiségét meghatározzák; és az oldatban lévő homociszteinés/vagy cisztationin mennyiségét a termelődött piruvát és/vagy ammóniamennyisége alapján kiértékelik. A találmány tárgyát képezi továbbá avizsgálat végrehajtását biztosító vizsgálati reagenskészlet és atalálmány szerint alkalmazható, izolált enzimek. Ó
HU0500095A 2001-11-06 2002-11-06 Enzymatic cycling assays for homocysteine and cystathionine HU228343B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/012,762 US6635438B2 (en) 1999-11-02 2001-11-06 Enzymatic cycling assays for homocysteine and cystathionine
PCT/US2002/035777 WO2003040694A2 (en) 2001-11-06 2002-11-06 Enzymatic cycling assays for homocysteine and cystathionine

Publications (3)

Publication Number Publication Date
HUP0500095A2 true HUP0500095A2 (hu) 2005-05-30
HUP0500095A3 HUP0500095A3 (en) 2010-03-29
HU228343B1 HU228343B1 (en) 2013-03-28

Family

ID=21756556

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0500095A HU228343B1 (en) 2001-11-06 2002-11-06 Enzymatic cycling assays for homocysteine and cystathionine

Country Status (12)

Country Link
US (2) US6635438B2 (hu)
EP (1) EP1470242B1 (hu)
CN (1) CN1612937B (hu)
AU (1) AU2002352538A1 (hu)
BR (1) BRPI0213936B8 (hu)
DK (1) DK1470242T3 (hu)
HU (1) HU228343B1 (hu)
NO (1) NO20042144L (hu)
RU (1) RU2344176C2 (hu)
SK (1) SK288189B6 (hu)
WO (1) WO2003040694A2 (hu)
ZA (1) ZA200403395B (hu)

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US6635438B2 (en) * 1999-11-02 2003-10-21 Catch, Inc. Enzymatic cycling assays for homocysteine and cystathionine
GB0008784D0 (en) * 2000-04-10 2000-05-31 Axis Shield Plc Assay
GB0311804D0 (en) * 2003-05-22 2003-06-25 Univ Glasgow Improved homocysteine assay
US8476034B2 (en) * 2003-07-10 2013-07-02 General Atomics Methods and compositions for assaying homocysteine
US7097968B2 (en) * 2003-07-10 2006-08-29 General Atomics Methods and compositions for assaying homocysteine
DE10342264C5 (de) 2003-09-12 2012-10-31 Leica Biosystems Nussloch Gmbh System zum eindeutigen Zuordnen von histologischen Kassetten und Objektträgern
GB0428130D0 (en) * 2004-12-22 2005-01-26 Oxford Biosensors Ltd Selective HDL cholesterol assay
EP1915446B1 (en) * 2005-08-11 2017-06-14 Synthetic Genomics, Inc. In vitro recombination method
CA2634495A1 (en) * 2005-12-22 2007-06-28 Conjuchem Biotechnologies Inc. Process for the production of preformed conjugates of albumin and a therapeutic agent
WO2009039298A2 (en) 2007-09-18 2009-03-26 University Of Florida Research Foundation, Inc. Sensors using aigan/gan high electron mobility transistors
WO2009091581A2 (en) * 2008-01-18 2009-07-23 Vatrix Medical, Inc. Diagnostic biomarkers for vascular aneurysm
US20110117669A1 (en) * 2008-11-06 2011-05-19 Fan Ren Materials and methods for detecting toxins, pathogens and other biological materials
EP2574193A4 (en) * 2009-12-30 2013-12-25 Oregon State DETECTION OF A THIOL
US9216209B1 (en) 2011-06-06 2015-12-22 Kilmer S. McCully Compositions and method for utilization of thioretinamide in therapy of degenerative diseases of aging
RU2471181C1 (ru) * 2011-06-20 2012-12-27 Открытое акционерное общество Научно-производственное объединение "Химавтоматика" Способ определения суммарного содержания антиоксидантов и суммарного содержания антоцианов в пищевых продуктах и напитках
US9034318B2 (en) * 2011-08-30 2015-05-19 The Regents Of The University Of Colorado, A Body Corporate Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria
JP5914019B2 (ja) * 2012-02-03 2016-05-11 旭化成ファーマ株式会社 酵素サイクリング反応によるメバロン酸の測定方法およびその校正試料
CN104755926B (zh) 2012-08-24 2017-12-01 卡斯西部储备大学 用于检测α‑甲酰基‑CoA消旋酶(AMACR)和***癌的***和方法
CN103674873B (zh) * 2013-11-22 2015-05-20 杭州利安生物科技有限公司 一种定量检测丝氨酸的方法
CN104111338B (zh) * 2014-05-07 2016-03-02 山东博科生物产业有限公司 一种抗干扰性强的同型半胱氨酸检测试剂盒
US11009479B2 (en) 2014-05-27 2021-05-18 Case Western Reserve University Systems and methods for the detection of HbA1c
US10465229B2 (en) 2014-05-27 2019-11-05 Case Western Reserve University System and method for detecting neural injury
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CN104198726B (zh) * 2014-08-14 2016-07-06 上海睿康生物科技有限公司 一种稳定的同型半胱氨酸检测试剂盒
CN105039368A (zh) * 2015-07-08 2015-11-11 北京嘉万生物技术有限公司 一种重组酵母胱硫醚beta合酶催化中心的表达及放大生产
CN105181970B (zh) * 2015-08-28 2017-05-03 宁波瑞源生物科技有限公司 一种稳定的同型半胱氨酸检测试剂盒
CN106970230B (zh) * 2017-03-29 2019-06-11 广州市伊川生物科技有限公司 一种同型半胱氨酸测定试剂盒
CN110346572A (zh) * 2018-04-04 2019-10-18 浙江力耐得传动科技有限公司 偶联丙酮酸氧化酶测定同型半胱氨酸（Hcy）的方法及测定试剂盒
CN108802125B (zh) * 2018-08-28 2023-09-15 长沙理工大学 基于七(6-巯基-6-去氧)-β-环糊精的L-半胱氨酸的检测方法及传感器
CN109975279B (zh) * 2019-03-07 2021-05-28 广州悦蜂生物防治科技有限公司 一种检测脂肪酶活性的方法、试剂盒及速测卡
US11697807B2 (en) 2019-09-30 2023-07-11 Case Western Reserve University Electrochemical biosensor
CN110954581A (zh) * 2019-12-19 2020-04-03 湖南海源医疗科技股份有限公司 一种快速检测同型半胱氨酸的电化学方法
CN114689415A (zh) * 2020-12-31 2022-07-01 桂林优利特医疗电子有限公司 一种稳定性好的同型半胱氨酸检测试剂盒及制备方法
CN114277021B (zh) * 2021-11-19 2022-09-20 武汉瀚海新酶生物科技有限公司 胱硫醚-β-裂解酶及其制备方法和应用
CN114807199A (zh) * 2022-02-22 2022-07-29 三诺生物传感股份有限公司 重组胱硫醚β-裂解酶的制备方法及其应用
CN115725556B (zh) * 2022-09-20 2024-05-03 青岛硕景生物科技有限公司 一种稳定性提高的突变胱硫醚β裂解酶及其制备方法和应用

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Also Published As

Publication number Publication date
WO2003040694A3 (en) 2004-08-19
EP1470242B1 (en) 2013-08-14
HU228343B1 (en) 2013-03-28
CN1612937B (zh) 2010-05-05
BRPI0213936B8 (pt) 2021-07-27
WO2003040694A2 (en) 2003-05-15
AU2002352538A1 (en) 2003-05-19
US6867014B2 (en) 2005-03-15
US20040096929A1 (en) 2004-05-20
SK288189B6 (sk) 2014-05-06
SK2042004A3 (en) 2004-10-05
CN1612937A (zh) 2005-05-04
DK1470242T3 (da) 2013-11-11
EP1470242A4 (en) 2007-01-03
RU2344176C2 (ru) 2009-01-20
HUP0500095A3 (en) 2010-03-29
US6635438B2 (en) 2003-10-21
US20030138872A1 (en) 2003-07-24
NO20042144L (no) 2004-08-06
BRPI0213936B1 (pt) 2015-08-25
RU2004117087A (ru) 2005-04-27
BR0213936A (pt) 2004-08-31
ZA200403395B (en) 2006-06-28
EP1470242A2 (en) 2004-10-27

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Owner name: AXIS-SHIELD DIAGNOSTICS, LTD., GB

Free format text: FORMER OWNER(S): CATCH, INC., US