HUP0401617A2 - Eljárás az (R)- vagy (S)-amino-karnitin belső sójának, sóinak és ezek származékainak előállítására - Google Patents

Eljárás az (R)- vagy (S)-amino-karnitin belső sójának, sóinak és ezek származékainak előállítására

Info

Publication number
HUP0401617A2
HUP0401617A2 HU0401617A HUP0401617A HUP0401617A2 HU P0401617 A2 HUP0401617 A2 HU P0401617A2 HU 0401617 A HU0401617 A HU 0401617A HU P0401617 A HUP0401617 A HU P0401617A HU P0401617 A2 HUP0401617 A2 HU P0401617A2
Authority
HU
Hungary
Prior art keywords
derivatives
aminocarnitine
salts
preparation
inner salt
Prior art date
Application number
HU0401617A
Other languages
English (en)
Inventor
Oreste Piccolo
Roberto Castagnani
Paolo Witt Scalfaro
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of HUP0401617A2 publication Critical patent/HUP0401617A2/hu
Publication of HUP0401617A3 publication Critical patent/HUP0401617A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H

Abstract

A találmány tárgya eljárás az (R)-, illetve (S)-amino-karnitin belsősójának, sóinak és ezek származékainak előállítására, amely akövetkező lépéseket tartalmazza: a) az (R)-, illetve (S)-nitriloxi-karnitin átalakítása (R)-, illetve (S)-azido-karnitinné, b) az a)lépésben kapott (R)-, illetve (S)-azido-karnitin hidrogénezése, amely(R)-, illetve (S)-amino-karnitint eredményez, c) adott esetben az(R)-, illetve (S)-amino-karnitin sóképzése, d) adott esetben az (R)-,illetve (S)-aminokarnitin átalakítása egyik származékává. Ó
HU0401617A 2001-07-26 2002-07-17 Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof HUP0401617A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001RM000456A ITRM20010456A1 (it) 2001-07-26 2001-07-26 Procedimento per la preparazione di (r)- o (s)- amminocarnitina sale interno, dei suoi sali e dei suoi derivati.
PCT/IT2002/000468 WO2003010129A1 (en) 2001-07-26 2002-07-17 Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof

Publications (2)

Publication Number Publication Date
HUP0401617A2 true HUP0401617A2 (hu) 2004-12-28
HUP0401617A3 HUP0401617A3 (en) 2008-05-28

Family

ID=11455694

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401617A HUP0401617A3 (en) 2001-07-26 2002-07-17 Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof

Country Status (19)

Country Link
US (1) US6953865B2 (hu)
EP (1) EP1409448B1 (hu)
JP (1) JP4212473B2 (hu)
KR (1) KR100879125B1 (hu)
CN (1) CN1231460C (hu)
AT (1) ATE346837T1 (hu)
AU (1) AU2002330738B2 (hu)
CA (1) CA2453019A1 (hu)
CY (1) CY1107567T1 (hu)
DE (1) DE60216466T2 (hu)
DK (1) DK1409448T3 (hu)
ES (1) ES2280570T3 (hu)
HK (1) HK1068327A1 (hu)
HU (1) HUP0401617A3 (hu)
IT (1) ITRM20010456A1 (hu)
MX (1) MXPA04000676A (hu)
PL (1) PL367614A1 (hu)
PT (1) PT1409448E (hu)
WO (1) WO2003010129A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1299266B1 (it) * 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
US7776915B2 (en) * 2005-03-24 2010-08-17 Tracie Martyn International, Llc Topical formulations and methods of use
WO2008109991A1 (en) * 2007-03-09 2008-09-18 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer
US8680282B2 (en) 2007-08-01 2014-03-25 University Health Network Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer
CN111621541A (zh) * 2019-02-27 2020-09-04 上海艾美晶生物科技有限公司 使用电渗析技术拆分光学异构体的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767781A (en) * 1981-11-26 1988-08-30 Takeda Chemical Industries, Ltd. Derivatives of beta-amino-gamma-trimethylammonio-butyrate and their production and use
IT1261489B (it) * 1993-07-29 1996-05-23 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r amminocarnitina e s amminocarnitina.
IT1299266B1 (it) * 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
IT1306184B1 (it) * 1999-08-05 2001-05-30 Sigma Tau Ind Farmaceuti Nitrilossi derivati della (r) e (s)-carnitina.

Also Published As

Publication number Publication date
ES2280570T3 (es) 2007-09-16
US6953865B2 (en) 2005-10-11
CN1527811A (zh) 2004-09-08
CN1231460C (zh) 2005-12-14
DE60216466D1 (de) 2007-01-11
ITRM20010456A1 (it) 2003-01-27
DK1409448T3 (da) 2007-04-02
JP4212473B2 (ja) 2009-01-21
MXPA04000676A (es) 2004-04-05
DE60216466T2 (de) 2007-09-20
ITRM20010456A0 (it) 2001-07-26
ATE346837T1 (de) 2006-12-15
JP2004536867A (ja) 2004-12-09
KR100879125B1 (ko) 2009-01-19
CA2453019A1 (en) 2003-02-06
WO2003010129A1 (en) 2003-02-06
HK1068327A1 (en) 2005-04-29
CY1107567T1 (el) 2013-03-13
EP1409448B1 (en) 2006-11-29
HUP0401617A3 (en) 2008-05-28
EP1409448A1 (en) 2004-04-21
KR20040032116A (ko) 2004-04-14
AU2002330738B2 (en) 2008-05-08
US20040171875A1 (en) 2004-09-02
PL367614A1 (en) 2005-03-07
PT1409448E (pt) 2007-02-28

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees