CY1107567T1 - Μεθοδος για την παρασκευη του εσωτepικου αλατος της (r)-ή (s) αμινοκαρνιτινης, των αλατων και των παραγωγων της - Google Patents
Μεθοδος για την παρασκευη του εσωτepικου αλατος της (r)-ή (s) αμινοκαρνιτινης, των αλατων και των παραγωγων τηςInfo
- Publication number
- CY1107567T1 CY1107567T1 CY20071100269T CY071100269T CY1107567T1 CY 1107567 T1 CY1107567 T1 CY 1107567T1 CY 20071100269 T CY20071100269 T CY 20071100269T CY 071100269 T CY071100269 T CY 071100269T CY 1107567 T1 CY1107567 T1 CY 1107567T1
- Authority
- CY
- Cyprus
- Prior art keywords
- aminocarnitine
- preparation
- salts
- producers
- internal salt
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- DAWBGYHPBBDHMQ-LURJTMIESA-N (3s)-3-amino-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@@H](N)CC([O-])=O DAWBGYHPBBDHMQ-LURJTMIESA-N 0.000 title abstract 2
- DAWBGYHPBBDHMQ-ZCFIWIBFSA-N (3r)-3-amino-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@H](N)CC([O-])=O DAWBGYHPBBDHMQ-ZCFIWIBFSA-N 0.000 abstract 2
- SKMSOHALMZCXFM-ZETCQYMHSA-N N[C@@](O)(C[N+](C)(C)C)CC([O-])=O Chemical class N[C@@](O)(C[N+](C)(C)C)CC([O-])=O SKMSOHALMZCXFM-ZETCQYMHSA-N 0.000 abstract 2
- WPWLZCVABVFBGW-UHFFFAOYSA-N 3-azido-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)CC(O)(CC([O-])=O)N=[N+]=[N-] WPWLZCVABVFBGW-UHFFFAOYSA-N 0.000 abstract 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical class N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
- C07C273/1827—X being H
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Περιγράφεται μία μέθοδος για την παρασκευή (R)- ή (S)- αμινοκαρνιτίνης ξεκινώντας ανάλογα από την (R)- ή (S)-νιτριλοξυκαρνιτίνη, μέσα από το σχηματισμό και την υδρογόνωση της ενδιάμεσης αζιδοκαρνιτίνης με την ίδια απόλυτη απεικόνιση. Το εσωτερικό αλάτι της (R)- αμινοκαρνιτίνης αποκτάται μετά από καθαρισμό, το οποίο μετά μετατρέπεται σε μη-ρευστοποιούμενα άλατα. Ένα ακόμη θέμα της παρούσας εφεύρεσης είναι μια διαδικασία για την παρασκευή παραγώγων της (R)- ή (S)- αμινοκαρνιτίνης, συγκεκριμένα ακυλιωμένων ή ουρικών παραγώγων, γνωρίζοντας φαρμακολογικές ιδιότητες, ξεκινώντας από (R)- και (S)- άλατα αμινοκαρνιτίνης, απελευθερώνοντας την αμινομάδα in situ.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001RM000456A ITRM20010456A1 (it) | 2001-07-26 | 2001-07-26 | Procedimento per la preparazione di (r)- o (s)- amminocarnitina sale interno, dei suoi sali e dei suoi derivati. |
EP02767834A EP1409448B1 (en) | 2001-07-26 | 2002-07-17 | Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107567T1 true CY1107567T1 (el) | 2013-03-13 |
Family
ID=11455694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100269T CY1107567T1 (el) | 2001-07-26 | 2007-02-26 | Μεθοδος για την παρασκευη του εσωτepικου αλατος της (r)-ή (s) αμινοκαρνιτινης, των αλατων και των παραγωγων της |
Country Status (19)
Country | Link |
---|---|
US (1) | US6953865B2 (el) |
EP (1) | EP1409448B1 (el) |
JP (1) | JP4212473B2 (el) |
KR (1) | KR100879125B1 (el) |
CN (1) | CN1231460C (el) |
AT (1) | ATE346837T1 (el) |
AU (1) | AU2002330738B2 (el) |
CA (1) | CA2453019A1 (el) |
CY (1) | CY1107567T1 (el) |
DE (1) | DE60216466T2 (el) |
DK (1) | DK1409448T3 (el) |
ES (1) | ES2280570T3 (el) |
HK (1) | HK1068327A1 (el) |
HU (1) | HUP0401617A3 (el) |
IT (1) | ITRM20010456A1 (el) |
MX (1) | MXPA04000676A (el) |
PL (1) | PL367614A1 (el) |
PT (1) | PT1409448E (el) |
WO (1) | WO2003010129A1 (el) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1299266B1 (it) * | 1998-05-15 | 2000-02-29 | Sigma Tau Ind Farmaceuti | Inibitori reversibili della carnitina palmitoil trasferasi |
US7776915B2 (en) * | 2005-03-24 | 2010-08-17 | Tracie Martyn International, Llc | Topical formulations and methods of use |
US8410150B2 (en) | 2007-03-09 | 2013-04-02 | University Health Network | Inhibitors of carnitine palmitoyltransferase and treating cancer |
US8680282B2 (en) | 2007-08-01 | 2014-03-25 | University Health Network | Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer |
CN111621541A (zh) * | 2019-02-27 | 2020-09-04 | 上海艾美晶生物科技有限公司 | 使用电渗析技术拆分光学异构体的方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4767781A (en) * | 1981-11-26 | 1988-08-30 | Takeda Chemical Industries, Ltd. | Derivatives of beta-amino-gamma-trimethylammonio-butyrate and their production and use |
IT1261489B (it) | 1993-07-29 | 1996-05-23 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di r amminocarnitina e s amminocarnitina. |
IT1299266B1 (it) * | 1998-05-15 | 2000-02-29 | Sigma Tau Ind Farmaceuti | Inibitori reversibili della carnitina palmitoil trasferasi |
IT1306184B1 (it) | 1999-08-05 | 2001-05-30 | Sigma Tau Ind Farmaceuti | Nitrilossi derivati della (r) e (s)-carnitina. |
-
2001
- 2001-07-26 IT IT2001RM000456A patent/ITRM20010456A1/it unknown
-
2002
- 2002-07-17 PL PL02367614A patent/PL367614A1/xx unknown
- 2002-07-17 AT AT02767834T patent/ATE346837T1/de not_active IP Right Cessation
- 2002-07-17 KR KR1020037017244A patent/KR100879125B1/ko not_active IP Right Cessation
- 2002-07-17 ES ES02767834T patent/ES2280570T3/es not_active Expired - Lifetime
- 2002-07-17 AU AU2002330738A patent/AU2002330738B2/en not_active Ceased
- 2002-07-17 WO PCT/IT2002/000468 patent/WO2003010129A1/en active IP Right Grant
- 2002-07-17 EP EP02767834A patent/EP1409448B1/en not_active Expired - Lifetime
- 2002-07-17 PT PT02767834T patent/PT1409448E/pt unknown
- 2002-07-17 HU HU0401617A patent/HUP0401617A3/hu unknown
- 2002-07-17 CA CA002453019A patent/CA2453019A1/en not_active Abandoned
- 2002-07-17 DK DK02767834T patent/DK1409448T3/da active
- 2002-07-17 MX MXPA04000676A patent/MXPA04000676A/es active IP Right Grant
- 2002-07-17 DE DE60216466T patent/DE60216466T2/de not_active Expired - Lifetime
- 2002-07-17 JP JP2003515489A patent/JP4212473B2/ja not_active Expired - Fee Related
- 2002-07-17 US US10/482,729 patent/US6953865B2/en not_active Expired - Fee Related
- 2002-07-17 CN CNB028140222A patent/CN1231460C/zh not_active Expired - Fee Related
-
2005
- 2005-01-13 HK HK05100341A patent/HK1068327A1/xx not_active IP Right Cessation
-
2007
- 2007-02-26 CY CY20071100269T patent/CY1107567T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2280570T3 (es) | 2007-09-16 |
CN1527811A (zh) | 2004-09-08 |
EP1409448A1 (en) | 2004-04-21 |
US20040171875A1 (en) | 2004-09-02 |
PT1409448E (pt) | 2007-02-28 |
HUP0401617A3 (en) | 2008-05-28 |
WO2003010129A1 (en) | 2003-02-06 |
JP4212473B2 (ja) | 2009-01-21 |
EP1409448B1 (en) | 2006-11-29 |
ITRM20010456A1 (it) | 2003-01-27 |
HK1068327A1 (en) | 2005-04-29 |
HUP0401617A2 (hu) | 2004-12-28 |
CN1231460C (zh) | 2005-12-14 |
KR20040032116A (ko) | 2004-04-14 |
AU2002330738B2 (en) | 2008-05-08 |
CA2453019A1 (en) | 2003-02-06 |
US6953865B2 (en) | 2005-10-11 |
DE60216466T2 (de) | 2007-09-20 |
ATE346837T1 (de) | 2006-12-15 |
ITRM20010456A0 (it) | 2001-07-26 |
DE60216466D1 (de) | 2007-01-11 |
JP2004536867A (ja) | 2004-12-09 |
MXPA04000676A (es) | 2004-04-05 |
KR100879125B1 (ko) | 2009-01-19 |
DK1409448T3 (da) | 2007-04-02 |
PL367614A1 (en) | 2005-03-07 |
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