DE602008003055D1 - Zyklokondensierte Azaindole, die als Kinase-Hemmer wirken - Google Patents

Zyklokondensierte Azaindole, die als Kinase-Hemmer wirken

Info

Publication number
DE602008003055D1
DE602008003055D1 DE602008003055T DE602008003055T DE602008003055D1 DE 602008003055 D1 DE602008003055 D1 DE 602008003055D1 DE 602008003055 T DE602008003055 T DE 602008003055T DE 602008003055 T DE602008003055 T DE 602008003055T DE 602008003055 D1 DE602008003055 D1 DE 602008003055D1
Authority
DE
Germany
Prior art keywords
cyclocondensed
azaindoles
act
kinase inhibitors
kinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602008003055T
Other languages
English (en)
Inventor
Francesco Casuscelli
Elena Casale
Daniela Faiardi
Nicola Mongelli
Claudia Piutti
Gabriella Traquandi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nerviano Medical Sciences SRL
Original Assignee
Nerviano Medical Sciences SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences SRL filed Critical Nerviano Medical Sciences SRL
Publication of DE602008003055D1 publication Critical patent/DE602008003055D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602008003055T 2007-05-31 2008-05-14 Zyklokondensierte Azaindole, die als Kinase-Hemmer wirken Active DE602008003055D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07109338 2007-05-31

Publications (1)

Publication Number Publication Date
DE602008003055D1 true DE602008003055D1 (de) 2010-12-02

Family

ID=39731692

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602008003055T Active DE602008003055D1 (de) 2007-05-31 2008-05-14 Zyklokondensierte Azaindole, die als Kinase-Hemmer wirken

Country Status (2)

Country Link
EP (1) EP2002836B1 (de)
DE (1) DE602008003055D1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010114905A1 (en) * 2009-03-31 2010-10-07 Arqule, Inc. Peri-fused pyrazolo-pyrimidine compounds
WO2010144486A1 (en) 2009-06-08 2010-12-16 Takeda Pharmaceutical Company Limited Dihydropyrrolonaphtyridinone compounds as inhibitors of jak
WO2015085007A1 (en) 2013-12-06 2015-06-11 Genentech, Inc. Serine/threonine kinase inhibitors
EP3473628B1 (de) * 2016-06-16 2019-12-11 Harbin Zhenbao Pharmaceutical Co., Ltd. Dihydropyrazol-azepin-verbindung als akt-inhibitor
FR3067349B1 (fr) 2017-06-12 2020-12-04 Cisbio Bioassays Nouveaux agents mono et di-antennes complexants hydrosolubles et complexes de lanthanide correspondants
FR3067712B1 (fr) 2017-06-14 2019-08-02 Cisbio Bioassays Nouveaux agents complexants de type trimethoxyphenyl pyridine hydrosolubles et complexes de lanthanide correspondants
JP6906105B2 (ja) * 2017-06-16 2021-07-21 成都先導薬物開発股▲ふん▼有限公司Ｈｉｔｇｅｎ Ｌｔｄ． Ｒｏｃｋを阻害する化合物及びその使用
WO2019114741A1 (zh) * 2017-12-13 2019-06-20 南京明德新药研发股份有限公司 作为Akt抑制剂的盐型及其晶型

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
US6335342B1 (en) 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
GB0117395D0 (en) * 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
US20050014942A1 (en) 2001-10-30 2005-01-20 Yasufumi Maruyama Amide derivatives and drugs
GB0330042D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
CN101068811A (zh) * 2004-12-02 2007-11-07 默克公司 Akt活性抑制剂
US7579356B2 (en) * 2005-05-04 2009-08-25 Janssen Pharmaceutica Nv Thia-tetraazaacenaphthylene kinase inhibitors

Also Published As

Publication number Publication date
EP2002836A1 (de) 2008-12-17
EP2002836B1 (de) 2010-10-20

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