HUP0303584A2 - Egy hidroximsav-halogenid-származék alkalmazása neurodegeneratív betegségek kezelésére - Google Patents

Egy hidroximsav-halogenid-származék alkalmazása neurodegeneratív betegségek kezelésére

Info

Publication number
HUP0303584A2
HUP0303584A2 HU0303584A HUP0303584A HUP0303584A2 HU P0303584 A2 HUP0303584 A2 HU P0303584A2 HU 0303584 A HU0303584 A HU 0303584A HU P0303584 A HUP0303584 A HU P0303584A HU P0303584 A2 HUP0303584 A2 HU P0303584A2
Authority
HU
Hungary
Prior art keywords
treatment
neurodegenerative diseases
acid halide
hydroximic acid
halide derivative
Prior art date
Application number
HU0303584A
Other languages
English (en)
Inventor
Linda Greensmith
Geoffrey Burnstock
Rudolf Urbanics
Original Assignee
BIOREX Kutató és Fejlesztő Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOREX Kutató és Fejlesztő Rt. filed Critical BIOREX Kutató és Fejlesztő Rt.
Priority to HU0303584A priority Critical patent/HUP0303584A3/hu
Publication of HU0303584D0 publication Critical patent/HU0303584D0/hu
Priority to DK04791657T priority patent/DK1696922T3/da
Priority to ES04791657T priority patent/ES2314458T3/es
Priority to JP2006537449A priority patent/JP5077997B2/ja
Priority to ZA200604376A priority patent/ZA200604376B/xx
Priority to CNA2004800396198A priority patent/CN1901913A/zh
Priority to SI200430887T priority patent/SI1696922T1/sl
Priority to CA2544332A priority patent/CA2544332C/en
Priority to PL04791657T priority patent/PL1696922T3/pl
Priority to NZ547216A priority patent/NZ547216A/en
Priority to PT04791657T priority patent/PT1696922E/pt
Priority to EA200600866A priority patent/EA011301B1/ru
Priority to EP04791657A priority patent/EP1696922B1/en
Priority to DE602004016770T priority patent/DE602004016770D1/de
Priority to EP08157425A priority patent/EP2020233A3/en
Priority to PCT/HU2004/000098 priority patent/WO2005041965A1/en
Priority to CZ20060347A priority patent/CZ2006347A3/cs
Priority to KR1020067010489A priority patent/KR20060103323A/ko
Priority to AU2004285343A priority patent/AU2004285343B2/en
Priority to UAA200605899A priority patent/UA86782C2/ru
Priority to BRPI0415625-0A priority patent/BRPI0415625A/pt
Priority to AT04791657T priority patent/ATE409038T1/de
Priority to US10/582,124 priority patent/US20080039497A1/en
Publication of HUP0303584A2 publication Critical patent/HUP0303584A2/hu
Priority to IL175334A priority patent/IL175334A/en
Priority to NO20062401A priority patent/NO20062401L/no
Priority to HK07102495.9A priority patent/HK1097438A1/xx
Priority to CY20081101426T priority patent/CY1110450T1/el
Priority to HR20080660T priority patent/HRP20080660T3/xx
Publication of HUP0303584A3 publication Critical patent/HUP0303584A3/hu
Priority to US13/229,862 priority patent/US8962604B2/en
Priority to US14/594,817 priority patent/US20150126551A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

(57) A találmány tárgya egy, az N-[2-hidroxi-3-(1-piperidinil)-propoxi]- piridin-1-oxid-3-karboximidoil-klorid, annak optikailagaktív enantiomerjei, az enantiomerek keverékei, valamint a racémvegyület és az optikailag aktív vegyületek gyógyászati szempontbólelfogadható sói által alkotott csoporthoz tartozó kémiai vegyületalkalmazása neurodegeneratív betegségek kezelésére vagy megelőzésérehasználható gyógyászati kompozíció előállításában.
HU0303584A 2003-10-30 2003-10-30 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases HUP0303584A3 (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
HU0303584A HUP0303584A3 (en) 2003-10-30 2003-10-30 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
EP04791657A EP1696922B1 (en) 2003-10-30 2004-10-25 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
EP08157425A EP2020233A3 (en) 2003-10-30 2004-10-25 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
KR1020067010489A KR20060103323A (ko) 2003-10-30 2004-10-25 신경변성 질환의 치료에서 히드록심산 할라이드 유도체의용도
PCT/HU2004/000098 WO2005041965A1 (en) 2003-10-30 2004-10-25 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
ZA200604376A ZA200604376B (en) 2003-10-30 2004-10-25 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
CNA2004800396198A CN1901913A (zh) 2003-10-30 2004-10-25 羟肟酸卤化物衍生物在治疗神经变性疾病中的用途
SI200430887T SI1696922T1 (sl) 2003-10-30 2004-10-25 Uporaba halogenidnega derivata hidroksimske kisline pri zdravljenju nevrodegenerativnih bolezni
CA2544332A CA2544332C (en) 2003-10-30 2004-10-25 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
PL04791657T PL1696922T3 (pl) 2003-10-30 2004-10-25 Zastosowanie pochodnych halogenków kwasu hydroksymowego w leczeniu chorób neurodegeneracyjnych
NZ547216A NZ547216A (en) 2003-10-30 2004-10-25 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
PT04791657T PT1696922E (pt) 2003-10-30 2004-10-25 Utilização de um derivado de halogeneto de ácido hidroxímico no tratamento de doenças neurodegenerativas
EA200600866A EA011301B1 (ru) 2003-10-30 2004-10-25 Применение галоидного производного гидроксимовой кислоты для лечения нейродегенеративных заболеваний
ES04791657T ES2314458T3 (es) 2003-10-30 2004-10-25 Uso de un derivado de haluro de acido hidroximico para el tratamiento de enfermedades neurodegenerativas.
DE602004016770T DE602004016770D1 (de) 2003-10-30 2004-10-25 Verwendung eines hydroximinsäure-halogenid-derivats bei der behandlung von neurodegenerativen erkrankungen
DK04791657T DK1696922T3 (da) 2003-10-30 2004-10-25 Anvendelse af et hydroximinsyre-halogenid-derivat til behandling af neurodegenerative sygdomme
JP2006537449A JP5077997B2 (ja) 2003-10-30 2004-10-25 神経変性疾患の治療におけるヒドロキシム酸クロライドの使用
CZ20060347A CZ2006347A3 (cs) 2003-10-30 2004-10-25 Pouzití derivátu halogenidu kyseliny hydroximové pro lécbu neurodegenerativních chorob
US10/582,124 US20080039497A1 (en) 2003-10-30 2004-10-25 Use Of A Hydroximic Acid Halide Derivative In The Treatment Of Neurodegenerative Diseases
AU2004285343A AU2004285343B2 (en) 2003-10-30 2004-10-25 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
UAA200605899A UA86782C2 (ru) 2003-10-30 2004-10-25 Применение галоидного производного гидроксамовой кислоты в лечении нейродегенеративных заболеваний центральной нервной системы
BRPI0415625-0A BRPI0415625A (pt) 2003-10-30 2004-10-25 uso de um derivado de halogeneto de ácido hidroxìmico no tratamento de hidroxìmico no tratamento de doenças neurogenerativas
AT04791657T ATE409038T1 (de) 2003-10-30 2004-10-25 Verwendung eines hydroximinsäure-halogenid- derivats bei der behandlung von neurodegenerativen erkrankungen
IL175334A IL175334A (en) 2003-10-30 2006-04-30 Use of a hydroximic acid halide derivative in the preparation of a medicament for the treatment of neurodegenerative diseases and composition comprising same
NO20062401A NO20062401L (no) 2003-10-30 2006-05-26 Anvendelse av et hydroksimsyrehalidderivat i behandling av neurodegenerative sykdommer
HK07102495.9A HK1097438A1 (en) 2003-10-30 2007-03-06 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
CY20081101426T CY1110450T1 (el) 2003-10-30 2008-12-10 Χρησιμοποιηση ενος παραγωγου αλογονιδιου υδροξιμικου οξεος στη θεραπευτικη αγωγη νευροεκφυλιστικων νοσων
HR20080660T HRP20080660T3 (en) 2003-10-30 2008-12-19 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
US13/229,862 US8962604B2 (en) 2003-10-30 2011-09-12 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
US14/594,817 US20150126551A1 (en) 2003-10-30 2015-01-12 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0303584A HUP0303584A3 (en) 2003-10-30 2003-10-30 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases

Publications (3)

Publication Number Publication Date
HU0303584D0 HU0303584D0 (en) 2003-12-29
HUP0303584A2 true HUP0303584A2 (hu) 2005-12-28
HUP0303584A3 HUP0303584A3 (en) 2009-12-28

Family

ID=89981738

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303584A HUP0303584A3 (en) 2003-10-30 2003-10-30 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases

Country Status (27)

Country Link
US (3) US20080039497A1 (hu)
EP (2) EP1696922B1 (hu)
JP (1) JP5077997B2 (hu)
KR (1) KR20060103323A (hu)
CN (1) CN1901913A (hu)
AT (1) ATE409038T1 (hu)
AU (1) AU2004285343B2 (hu)
BR (1) BRPI0415625A (hu)
CA (1) CA2544332C (hu)
CY (1) CY1110450T1 (hu)
CZ (1) CZ2006347A3 (hu)
DE (1) DE602004016770D1 (hu)
DK (1) DK1696922T3 (hu)
EA (1) EA011301B1 (hu)
ES (1) ES2314458T3 (hu)
HK (1) HK1097438A1 (hu)
HR (1) HRP20080660T3 (hu)
HU (1) HUP0303584A3 (hu)
IL (1) IL175334A (hu)
NO (1) NO20062401L (hu)
NZ (1) NZ547216A (hu)
PL (1) PL1696922T3 (hu)
PT (1) PT1696922E (hu)
SI (1) SI1696922T1 (hu)
UA (1) UA86782C2 (hu)
WO (1) WO2005041965A1 (hu)
ZA (1) ZA200604376B (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1615296A (zh) 2002-01-11 2005-05-11 拜奥列克斯研究发展公司 甲脒衍生物及其在治疗血管疾病中的用途
US20080227813A1 (en) * 2006-09-26 2008-09-18 Jack Raymond Barber Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration
PL2659904T3 (pl) 2008-06-26 2016-01-29 Orphazyme Aps Zastosowanie Hsp70 jako regulatora aktywności enzymatycznej
EA201100805A1 (ru) 2008-11-18 2011-10-31 Сантен Фармасьютикал Ко., Лтд. Терапевтический агент при хориоретинальном дегенеративном заболевании, содержащий в качестве активного ингредиента производное пиридин-3-карбальдегид-o-(пиперидин-1-илпропил)оксима
PL2646044T3 (pl) 2010-11-30 2020-03-31 Orphazyme A/S Sposoby zwiększenia aktywności wewnątrzkomórkowej Hsp70
HUP1100534A2 (en) * 2011-09-26 2013-04-29 Balazs Dr Hazay Pharmaceutical composition for the treatment of muscle atrophy
CN103804309B (zh) * 2012-11-09 2019-08-02 广州喜鹊医药有限公司 一种氯肟类化合物及其制备方法和在制药中的应用
JP6678676B2 (ja) * 2014-09-15 2020-04-08 オーファザイム エー／エス アリモクロモル製剤
US10898476B2 (en) 2016-04-13 2021-01-26 Orphazyme A/S Heat shock proteins and cholesterol homeostasis
EP3448382B1 (en) 2016-04-29 2020-10-14 Orphazyme A/S Arimoclomol for treating glucocerebrosidase associated disorders
US20200085812A1 (en) 2017-05-24 2020-03-19 Orphazyme A/S Heat shock protein inducers and frontotemporal disorders
HUP1800298A1 (hu) 2018-08-30 2020-05-28 N Gene Res Laboratories Inc Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére
US20230416224A1 (en) 2020-11-19 2023-12-28 Zevra Denmark A/S Processes for preparing arimoclomol citrate and intermediates thereof

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HU177578B (en) 1976-08-27 1981-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives
DE2651083A1 (de) * 1976-11-09 1978-05-18 Hoechst Ag Neue o-alkylierte hydroxylamine, verfahren zu ihrer herstellung und ihre verwendung
HU207988B (en) 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
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Also Published As

Publication number Publication date
CN1901913A (zh) 2007-01-24
EP2020233A3 (en) 2009-09-30
CA2544332C (en) 2014-09-23
US20120115908A1 (en) 2012-05-10
WO2005041965A1 (en) 2005-05-12
IL175334A0 (en) 2008-04-13
NO20062401L (no) 2006-07-27
CA2544332A1 (en) 2005-05-12
EP1696922A1 (en) 2006-09-06
CZ2006347A3 (cs) 2006-10-11
HK1097438A1 (en) 2007-06-29
IL175334A (en) 2010-12-30
ATE409038T1 (de) 2008-10-15
NZ547216A (en) 2009-03-31
SI1696922T1 (sl) 2008-12-31
PL1696922T3 (pl) 2009-03-31
DE602004016770D1 (de) 2008-11-06
ZA200604376B (en) 2009-04-29
AU2004285343B2 (en) 2010-05-13
EA011301B1 (ru) 2009-02-27
EP2020233A2 (en) 2009-02-04
EA200600866A1 (ru) 2006-10-27
DK1696922T3 (da) 2008-12-01
UA86782C2 (ru) 2009-05-25
BRPI0415625A (pt) 2006-12-12
PT1696922E (pt) 2008-10-17
JP2007509920A (ja) 2007-04-19
KR20060103323A (ko) 2006-09-28
US20080039497A1 (en) 2008-02-14
HRP20080660T3 (en) 2009-01-31
CY1110450T1 (el) 2015-04-29
US20150126551A1 (en) 2015-05-07
HUP0303584A3 (en) 2009-12-28
HU0303584D0 (en) 2003-12-29
JP5077997B2 (ja) 2012-11-21
US8962604B2 (en) 2015-02-24
ES2314458T3 (es) 2009-03-16
EP1696922B1 (en) 2008-09-24
AU2004285343A1 (en) 2005-05-12

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GB9A Succession in title

Owner name: CYTRX CORPORATION, US

Free format text: FORMER OWNER(S): BIOREX KUTATO ES FEJLESZTOE RT., HU

FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished