HRP20080660T3 - Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases - Google Patents

Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases

Info

Publication number: HRP20080660T3
Authority: HR; Croatia
Prior art keywords: treatment; neurodegenerative diseases; acid halide; hydroximic acid; halide derivative
Prior art date: 2003-10-30

Application number

HR20080660T

Other languages

English (en)

Croatian (hr)

Inventor

Greensmith Linda

Burnstock Geoffrey

Urbanics Rudolf

Original Assignee

Cytrx Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-30

Filing date

2008-12-19

Publication date

2009-01-31

2008-12-19 Application filed by Cytrx Corporation filed Critical Cytrx Corporation

2009-01-31 Publication of HRP20080660T3 publication Critical patent/HRP20080660T3/xx

Links

230000004770 neurodegeneration Effects 0.000 title abstract 2
208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
150000004820 halides Chemical class 0.000 title 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
SGEIEGAXKLMUIZ-PEZBUJJGSA-N (3z)-n-(2-hydroxy-3-piperidin-1-ylpropoxy)-1-oxidopyridin-1-ium-3-carboximidoyl chloride Chemical compound C1CCCCN1CC(O)CO\N=C(/Cl)C1=CC=C[N+]([O-])=C1 SGEIEGAXKLMUIZ-PEZBUJJGSA-N 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Psychology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Pyridine Compounds (AREA)
Hydrogenated Pyridines (AREA)

HR20080660T 2003-10-30 2008-12-19 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases HRP20080660T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU0303584A HUP0303584A3 (en)	2003-10-30	2003-10-30	Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
PCT/HU2004/000098 WO2005041965A1 (en)	2003-10-30	2004-10-25	Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases

Publications (1)

Publication Number	Publication Date
HRP20080660T3 true HRP20080660T3 (en)	2009-01-31

Family

ID=89981738

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20080660T HRP20080660T3 (en)	2003-10-30	2008-12-19	Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases

Country Status (27)

Country	Link
US (3)	US20080039497A1 (hu)
EP (2)	EP1696922B1 (hu)
JP (1)	JP5077997B2 (hu)
KR (1)	KR20060103323A (hu)
CN (1)	CN1901913A (hu)
AT (1)	ATE409038T1 (hu)
AU (1)	AU2004285343B2 (hu)
BR (1)	BRPI0415625A (hu)
CA (1)	CA2544332C (hu)
CY (1)	CY1110450T1 (hu)
CZ (1)	CZ2006347A3 (hu)
DE (1)	DE602004016770D1 (hu)
DK (1)	DK1696922T3 (hu)
EA (1)	EA011301B1 (hu)
ES (1)	ES2314458T3 (hu)
HK (1)	HK1097438A1 (hu)
HR (1)	HRP20080660T3 (hu)
HU (1)	HUP0303584A3 (hu)
IL (1)	IL175334A (hu)
NO (1)	NO20062401L (hu)
NZ (1)	NZ547216A (hu)
PL (1)	PL1696922T3 (hu)
PT (1)	PT1696922E (hu)
SI (1)	SI1696922T1 (hu)
UA (1)	UA86782C2 (hu)
WO (1)	WO2005041965A1 (hu)
ZA (1)	ZA200604376B (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003202104B8 (en)	2002-01-11	2008-10-02	Cytrx Corporation	Carboxamidine derivatives and their use in the treatment of vascular diseases
US20080227813A1 (en) *	2006-09-26	2008-09-18	Jack Raymond Barber	Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration
US8540985B2 (en)	2008-06-26	2013-09-24	Orphazyme Aps	Use of Hsp70 as a regulator of enzymatic activity
EP2356988A4 (en)	2008-11-18	2012-05-09	Santen Pharmaceutical Co Ltd	THERAPEUTIC FOR CHORIORETINAL DEGENERATION WITH PYRIDINE-3-CARBALDEHYDE O- (PIPERIDIN-1-YL-PROPYL) OXIM DERIVATIVE AS ACTIVE SUBSTANCE
PT2646044T (pt)	2010-11-30	2019-11-12	Orphazyme As	Métodos para aumentar a atividade intracelular de hsp70
HUP1100534A2 (en) *	2011-09-26	2013-04-29	Balazs Dr Hazay	Pharmaceutical composition for the treatment of muscle atrophy
CN103804309B (zh) *	2012-11-09	2019-08-02	广州喜鹊医药有限公司	一种氯肟类化合物及其制备方法和在制药中的应用
PT3193840T (pt) *	2014-09-15	2021-08-10	Orphazyme Aps	Formulação de arimoclomol
EP3442530A1 (en)	2016-04-13	2019-02-20	Orphazyme A/S	Heat shock proteins and cholesterol homeostasis
ES2831764T3 (es) *	2016-04-29	2021-06-09	Orphazyme As	Arimoclomol para el tratamiento de trastornos asociados a glucocerebrosidasa
CA3063974A1 (en)	2017-05-24	2018-11-29	Orphazyme A/S	Heat shock protein inducers and frontotemporal disorders
HUP1800298A1 (hu)	2018-08-30	2020-05-28	N Gene Res Laboratories Inc	Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére
EP4247792A1 (en)	2020-11-19	2023-09-27	Zevra Denmark A/S	Processes for preparing arimoclomol citrate and intermediates thereof

Family Cites Families (15)

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Publication number	Priority date	Publication date	Assignee	Title
HU177578B (en)	1976-08-27	1981-11-28	Chinoin Gyogyszer Es Vegyeszet	Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives
DE2651083A1 (de)	1976-11-09	1978-05-18	Hoechst Ag	Neue o-alkylierte hydroxylamine, verfahren zu ihrer herstellung und ihre verwendung
HU207988B (en) *	1988-10-20	1993-07-28	Biorex Kutato Fejlesztoe Kft	Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HUT54347A (en) *	1989-01-10	1991-02-28	Chinoin Gyogyszer Es Vegyeszet	Improved process for producing amidoximes
US5334600A (en) *	1991-07-30	1994-08-02	Ciba-Geigy Corporation	Isoquinolyl substituted hydroxylamine derivatives
BR9507619A (pt)	1994-05-06	1997-09-23	Biorex Kutato Fejlesztoe Kft	Novos derivados de ácido hidroxímico composições farmacêuticas contendo os mesmos e processo para preparação dos mesmos
HU9502843D0 (en) *	1995-09-29	1995-11-28	Livigene Ltd	Pharmaceutical composition
HU222994B1 (hu) *	1995-11-02	2004-01-28	BIOREX Kutató és Fejlesztő Rt.	Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
UA64716C2 (en)	1996-08-09	2004-03-15		Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells
HU220971B1 (hu)	1997-04-03	2002-07-29	BIOREX Kutató és Fejlesztő Rt.	Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására
UA65635C2 (uk) *	1998-09-03	2004-04-15	Н-Гене Кутато Кфт.	НЕНАСИЧЕНІ ПОХІДНІ ГІДРОКСИМОВОЇ КИСЛОТИ, ЩО МАЮТЬ ВЛАСТИВОСТІ ІНГІБІТОРІВ NAD<sup>+</sup>-ADP-РИБОЗИЛТРАНСФЕРАЗИ
HUP9900475D0 (en) *	1999-02-26	1999-04-28	Biorex Kutato Fejlesztoe Kft	O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
HUP0001583A2 (hu)	2000-04-18	2002-11-28	BIOREX Kutató és Fejlesztő Rt.	Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké
HU0103939D0 (en) *	2001-09-27	2001-11-28	Biorex Kutato Fejlesztoe Kft	Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride
ITMI20012573A1 (it)	2001-12-06	2003-06-06	D B P Dev Biotechonologica L P	Gli acilsalicilati:una nuova classe di induttori di risposta heat shock

2003
- 2003-10-30 HU HU0303584A patent/HUP0303584A3/hu unknown
2004
- 2004-10-25 US US10/582,124 patent/US20080039497A1/en not_active Abandoned
- 2004-10-25 ES ES04791657T patent/ES2314458T3/es active Active
- 2004-10-25 EP EP04791657A patent/EP1696922B1/en active Active
- 2004-10-25 AU AU2004285343A patent/AU2004285343B2/en not_active Ceased
- 2004-10-25 CN CNA2004800396198A patent/CN1901913A/zh active Pending
- 2004-10-25 PT PT04791657T patent/PT1696922E/pt unknown
- 2004-10-25 UA UAA200605899A patent/UA86782C2/ru unknown
- 2004-10-25 EA EA200600866A patent/EA011301B1/ru not_active IP Right Cessation
- 2004-10-25 PL PL04791657T patent/PL1696922T3/pl unknown
- 2004-10-25 WO PCT/HU2004/000098 patent/WO2005041965A1/en active IP Right Grant
- 2004-10-25 CZ CZ20060347A patent/CZ2006347A3/cs unknown
- 2004-10-25 CA CA2544332A patent/CA2544332C/en not_active Expired - Fee Related
- 2004-10-25 KR KR1020067010489A patent/KR20060103323A/ko not_active Application Discontinuation
- 2004-10-25 BR BRPI0415625-0A patent/BRPI0415625A/pt not_active Application Discontinuation
- 2004-10-25 DE DE602004016770T patent/DE602004016770D1/de active Active
- 2004-10-25 SI SI200430887T patent/SI1696922T1/sl unknown
- 2004-10-25 NZ NZ547216A patent/NZ547216A/en unknown
- 2004-10-25 DK DK04791657T patent/DK1696922T3/da active
- 2004-10-25 AT AT04791657T patent/ATE409038T1/de active
- 2004-10-25 JP JP2006537449A patent/JP5077997B2/ja not_active Expired - Fee Related
- 2004-10-25 ZA ZA200604376A patent/ZA200604376B/xx unknown
- 2004-10-25 EP EP08157425A patent/EP2020233A3/en not_active Withdrawn
2006
- 2006-04-30 IL IL175334A patent/IL175334A/en not_active IP Right Cessation
- 2006-05-26 NO NO20062401A patent/NO20062401L/no not_active Application Discontinuation
2007
- 2007-03-06 HK HK07102495.9A patent/HK1097438A1/xx not_active IP Right Cessation
2008
- 2008-12-10 CY CY20081101426T patent/CY1110450T1/el unknown
- 2008-12-19 HR HR20080660T patent/HRP20080660T3/xx unknown
2011
- 2011-09-12 US US13/229,862 patent/US8962604B2/en not_active Expired - Fee Related
2015
- 2015-01-12 US US14/594,817 patent/US20150126551A1/en not_active Abandoned

Also Published As

Publication number	Publication date
IL175334A0 (en)	2008-04-13
EP1696922A1 (en)	2006-09-06
AU2004285343A1 (en)	2005-05-12
CN1901913A (zh)	2007-01-24
PT1696922E (pt)	2008-10-17
IL175334A (en)	2010-12-30
DE602004016770D1 (de)	2008-11-06
BRPI0415625A (pt)	2006-12-12
NO20062401L (no)	2006-07-27
JP5077997B2 (ja)	2012-11-21
CZ2006347A3 (cs)	2006-10-11
HUP0303584A3 (en)	2009-12-28
CA2544332A1 (en)	2005-05-12
DK1696922T3 (da)	2008-12-01
US20120115908A1 (en)	2012-05-10
US20080039497A1 (en)	2008-02-14
WO2005041965A1 (en)	2005-05-12
HU0303584D0 (en)	2003-12-29
EA011301B1 (ru)	2009-02-27
NZ547216A (en)	2009-03-31
EP1696922B1 (en)	2008-09-24
ATE409038T1 (de)	2008-10-15
KR20060103323A (ko)	2006-09-28
AU2004285343B2 (en)	2010-05-13
ES2314458T3 (es)	2009-03-16
ZA200604376B (en)	2009-04-29
US8962604B2 (en)	2015-02-24
HUP0303584A2 (hu)	2005-12-28
EP2020233A3 (en)	2009-09-30
UA86782C2 (ru)	2009-05-25
JP2007509920A (ja)	2007-04-19
CA2544332C (en)	2014-09-23
EA200600866A1 (ru)	2006-10-27
SI1696922T1 (sl)	2008-12-31
HK1097438A1 (en)	2007-06-29
US20150126551A1 (en)	2015-05-07
CY1110450T1 (el)	2015-04-29
PL1696922T3 (pl)	2009-03-31
EP2020233A2 (en)	2009-02-04

Publication	Publication Date	Title
HRP20080660T3 (en)	2009-01-31	Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
NO20051966L (no)	2005-04-22	Nye pyrimidinamidderivater og anvendelse derav
TW200624431A (en)	2006-07-16	Phthalazinone derivatives, their manufacture and use as pharmaceutical agents
BR9810841A (pt)	2001-07-10	Inibidores de metaloprotease alicìclicos
BRPI0508107A (pt)	2007-07-17	derivados de indazol e composições farmacêuticas contendo os mesmos
DE602004027936D1 (de)	2010-08-12	Tocopherolmodifizierte therapeutische arzneimittelverbindung
TW200730502A (en)	2007-08-16	Isoquinoline aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
DK0725779T3 (da)	2001-10-29	Hidtil ukendte (R)-5-Carbamoyl-8-fluor-3-N,N-disubstitueret-amino-3,4-dihydro-2H-1-benzopyraner
NO962841D0 (no)	1996-07-05	Anvendelse av 2-hydroksy-5-fenylazobenzosyrederivater som colon cancer kjemopreventativer og kjemoterapeutiske midler
TW200531688A (en)	2005-10-01	Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents
ATE357438T1 (de)	2007-04-15	1,2,4-triaminobenzolderivate zur behandlung von erkrankungen des zentralnervensystems
DE602006009556D1 (de)	2009-11-12	Chinolin-derivate zur behandlung von mglur5-rezeptor-vermittelten erkrankungen
ATE332894T1 (de)	2006-08-15	Ein pyridin-n-oxid-derivat und ein prozess zu seiner umsetzung in pharmazeutische wirkstoffe
HRP20050831A2 (en)	2006-09-30	Novel oxazole derivatives, their manufacture and use as pharmaceutical agents
MXPA05014143A (es)	2006-02-24	Derivados de cumarina para el tratamiento de trastornos oftalmicos.
TW200736220A (en)	2007-10-01	Pyridylsulfonamide derivatives, their manufacture and use as pharmaceutical agents
TW200720239A (en)	2007-06-01	Styrylsulfonamides, their manufacture and use as pharmaceutical agents
MXPA05011671A (es)	2005-12-15	Nuevos derivados de anilina, su manufactura y su uso como agentes farmaceuticos.
TW200626149A (en)	2006-08-01	Tricycles, their manufacture and use as pharmaceutical agents
TW200602329A (en)	2006-01-16	Novel diazine derivatives, their manufacture and use as pharmaceutical agents
DE60221104D1 (de)	2007-08-23	Substituierte diarylharnstoffe als stimulatoren der fas-vermittelten apoptose
WO2006053778A3 (en)	2006-08-10	Amide derivatives, their manufacture and use as pharmaceutical agents
TW200626590A (en)	2006-08-01	Triazole derivatives, their manufacture and use as pharmaceutical agents
HUP0000552A2 (hu)	2001-12-28	Egy O-(3-piperidino-2hidroxi-1-propil)-hidroximsav halogenidszármazék, annak alkalmazása, valamint ilyen származékot hatóanyagként tartalmazó gyógyászati készítmény
BRPI0515767A (pt)	2008-03-04	método eficiente para preparação de (s)-3-[(1-dimetilamino) etil] - fenil-n-etil-n-metil-carbamato