NO20045137L - Diketohydrazinderivatforbindelser og legemidler inneholdende forbindelser som aktiv ingrediens - Google Patents

Diketohydrazinderivatforbindelser og legemidler inneholdende forbindelser som aktiv ingrediens

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Publication number
NO20045137L
NO20045137L NO20045137A NO20045137A NO20045137L NO 20045137 L NO20045137 L NO 20045137L NO 20045137 A NO20045137 A NO 20045137A NO 20045137 A NO20045137 A NO 20045137A NO 20045137 L NO20045137 L NO 20045137L
Authority
NO
Norway
Prior art keywords
compounds
formula
active ingredient
drugs containing
diketohydrazine
Prior art date
Application number
NO20045137A
Other languages
English (en)
Other versions
NO333952B1 (no
Inventor
Kazuyuki Ohmoto
Haruo Imawaka
Akira Hatayama
Hiroshi Tsuruta
Yasuo Ochi
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of NO20045137L publication Critical patent/NO20045137L/no
Publication of NO333952B1 publication Critical patent/NO333952B1/no

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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Abstract

Foreliggende oppfinnelse vedrører et diketohydrazinderivat med formel (I) og et farmasøytisk akseptabelt salt derav. (Symbolene i formelen har den sarmne betydning som beskrevet i beskrivelsen). Forbindelsen med formel (I) har en hermnende aktivitet overfor cysteinprotease, og den er nyttig for behandling av inflammatoriske sykdorrmier, irrmiimsykdormner, iskemiske sykdorrmier, respiratoriske sykdonmier, sirkulasjonssykdommer, blodsykdommer, neuronale sykdommer, hepatiske eller bihære sykdonmier, ben- eller leddsykdommer, metaboliske sykdonmier, etc, og forbindelsen har inhiberende aktivitet overfor elastase, og den er også nyttig for behandling av eOPD ("chronic obstacle puhnonary diseases").
NO20045137A 2002-04-25 2004-11-25 Diketohydrazinderivatforbindelser og anvendelser inneholdende forbindelsene som aktiv ingrediens NO333952B1 (no)

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Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ335276A (en) 1996-10-18 2000-09-29 Vertex Pharma Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease
AU2003235118C1 (en) * 2002-04-25 2010-01-07 Ono Pharmaceutical Co., Ltd. Diketohydrazine derivative compounds and drugs containing the compounds as the active ingredient
WO2005000793A1 (ja) * 2003-06-26 2005-01-06 Taisho Pharmaceutical Co., Ltd. ２位置換シクロアルキルカルボン酸誘導体
MY148123A (en) 2003-09-05 2013-02-28 Vertex Pharma Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
JP2008505849A (ja) * 2004-02-04 2008-02-28 バーテックス　ファーマシューティカルズ　インコーポレイテッド セリンプロテアーゼ、特に、ｈｃｖ、ｎｓ３−ｎｓ４ａプロテアーゼの阻害剤
JPWO2005102381A1 (ja) * 2004-04-26 2008-03-06 小野薬品工業株式会社 カテプシンｋ阻害薬およびｐｔｈ類を併用することを特徴とする骨密度増加剤
JP4513517B2 (ja) * 2004-11-12 2010-07-28 宇部興産株式会社 ３−（ｎ−アシルアミノ）−２−アシルオキシ−３−（４−テトラヒドロピラニル）−２−プロペン酸エステル及びその製法
US20090005323A1 (en) * 2005-01-19 2009-01-01 Michael David Percival Cathepsin K Inhibitors and Obesity
JP5034277B2 (ja) * 2005-03-11 2012-09-26 宇部興産株式会社 ３−（ｎ−アシルアミノ）−３−（４−テトラヒドロピラニル）−２−オキソプロパン酸エステル及び３−（ｎ−アシルアミノ）−３−（４−テトラヒドロピラニル）−２−オキソプロパノヒドラジドの製造方法
US20100292298A1 (en) * 2006-02-21 2010-11-18 Agency For Science, Technology And Research Method and reagents for treating hepatic fibrosis and inflammation
RU2478620C2 (ru) * 2006-06-01 2013-04-10 Санофи-Авентис Спироциклические нитрилы в качестве ингибиторов протеазы
CN101970007A (zh) 2007-06-08 2011-02-09 日本化学医药株式会社 脑动脉瘤的治疗或预防药
US20100331545A1 (en) 2007-10-24 2010-12-30 Nippon Chemiphar Co., Ltd. Regulator for signaling toll-like receptor, which comprises cathepsin inhibitor as active ingredient
CA2631071A1 (en) * 2008-05-09 2009-11-09 Tong-Jun Lin Inhibition of calpain reduces allergic inflammation
US8895497B2 (en) * 2009-12-04 2014-11-25 Dcb-Usa, Llc Cathepsin S inhibitors
KR20120093423A (ko) * 2009-12-10 2012-08-22 메디버 유케이 리미티드 시스테인 프로테아제 억제제
CN102241627B (zh) * 2010-05-14 2014-07-02 中国人民解放军总医院 脲类化合物及其医药用途
CN102675061B (zh) * 2011-10-31 2016-01-20 合肥市济泉医药科技有限公司 白藜芦醇的醚衍生物和医疗用途
WO2014113068A1 (en) * 2013-01-18 2014-07-24 Loma Linda University Compositions and methods for diagnosing and treating sepsis
US9481707B2 (en) * 2013-06-14 2016-11-01 Seikagaku Corporation α-oxoacyl amino-caprolactam derivative
CN108110140B (zh) 2013-08-12 2022-01-28 科迪华公司 用于可印刷有机发光二极管油墨制剂的基于酯的溶剂体系
WO2017156071A1 (en) 2016-03-09 2017-09-14 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
US11292801B2 (en) 2016-07-05 2022-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
US20190175690A1 (en) * 2016-08-16 2019-06-13 Children's Medical Center Corporation Compositions and methods for cardiac repair
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
CA3038331A1 (en) 2016-09-28 2018-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
CN111788204B (zh) 2018-02-26 2023-05-05 吉利德科学公司 作为hbv复制抑制剂的取代吡咯嗪化合物
CN113372368B (zh) * 2020-03-09 2022-04-12 苏州爱科百发生物医药技术有限公司 一种弹性蛋白酶抑制剂前药及其用途
KR20230038457A (ko) 2020-06-10 2023-03-20 알리고스 테라퓨틱스 인코포레이티드 코로나바이러스, 피코르나바이러스 및 노로바이러스 감염을 치료하기 위한 항바이러스 화합물
WO2022072975A1 (en) * 2020-10-01 2022-04-07 University Of Georgia Research Foundation, Inc. Compositions and methods of treatment for sars-cov-2 through papain protease inhibition
PE20240775A1 (es) 2021-07-09 2024-04-17 Aligos Therapeutics Inc Compuestos antivirales
CN115192564B (zh) * 2022-05-23 2023-11-17 四川大学华西医院 一种苯丙氨酸衍生物、药物组合物及其在肿瘤治疗中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110898A0 (en) 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
US6083944A (en) * 1997-10-07 2000-07-04 Cephalon, Inc. Quinoline-containing α-ketoamide cysteine and serine protease inhibitors
US6117870A (en) * 1998-11-12 2000-09-12 Fujirebio Kabushiki Kaisha Cyclic amide derivatives
US20050107616A1 (en) 2001-08-03 2005-05-19 David Gene Barrett Alpha-ketoamide derivatives as cathepsin k inhibitors
AU2003235118C1 (en) * 2002-04-25 2010-01-07 Ono Pharmaceutical Co., Ltd. Diketohydrazine derivative compounds and drugs containing the compounds as the active ingredient
JPWO2005102381A1 (ja) * 2004-04-26 2008-03-06 小野薬品工業株式会社 カテプシンｋ阻害薬およびｐｔｈ類を併用することを特徴とする骨密度増加剤

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NO333952B1 (no) 2013-10-28
JP3812678B2 (ja) 2006-08-23
AU2003235118A1 (en) 2003-11-10

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