HUP0303309A2 - Csökkentett immunogenitású módosított interferon-alfa - Google Patents
Csökkentett immunogenitású módosított interferon-alfaInfo
- Publication number
- HUP0303309A2 HUP0303309A2 HU0303309A HUP0303309A HUP0303309A2 HU P0303309 A2 HUP0303309 A2 HU P0303309A2 HU 0303309 A HU0303309 A HU 0303309A HU P0303309 A HUP0303309 A HU P0303309A HU P0303309 A2 HUP0303309 A2 HU P0303309A2
- Authority
- HU
- Hungary
- Prior art keywords
- administered
- interferon alpha
- reduced immunogenicity
- polypeptides
- modified interferon
- Prior art date
Links
- 108010047761 Interferon-alpha Proteins 0.000 title abstract 2
- 102000006992 Interferon-alpha Human genes 0.000 title abstract 2
- 230000005847 immunogenicity Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108010078049 Interferon alpha-2 Proteins 0.000 abstract 2
- 102100039350 Interferon alpha-7 Human genes 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 230000004048 modification Effects 0.000 abstract 2
- 238000012986 modification Methods 0.000 abstract 2
- 241000282412 Homo Species 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A találmány tárgyát különösen embereknek beadandó, és különösenterápiás alkalmazású polipeptidek képezik. A polipeptidek módosítottpolipeptidek, amelyekben a módosítás a polipeptid csökkentett hajlamáteredményezi immunválasz kiváltására emberi személynek történő beadásesetén. A találmány tárgya különösen humán interferon-alfa, ésspecifikusan interferon-alfa-2 (INFa2) módosítása, olyan fehérjéketeredményezve, amelyek lényegében nem immunogének, vagy kevésbéimmunogének, mint bármilyen módosítatlan társuk, amikor in vivo vanalkalmazva. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01105088 | 2001-03-02 | ||
| PCT/EP2002/002218 WO2002085941A2 (en) | 2001-03-02 | 2002-03-01 | Modified interferon alpha with reduced immunogenicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0303309A2 true HUP0303309A2 (hu) | 2003-12-29 |
Family
ID=8176646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0303309A HUP0303309A2 (hu) | 2001-03-02 | 2002-03-01 | Csökkentett immunogenitású módosított interferon-alfa |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060062761A1 (hu) |
| EP (1) | EP1379555A2 (hu) |
| JP (1) | JP2004535173A (hu) |
| KR (1) | KR20030081479A (hu) |
| CN (1) | CN1529714A (hu) |
| BR (1) | BR0207704A (hu) |
| CA (1) | CA2439690A1 (hu) |
| HU (1) | HUP0303309A2 (hu) |
| MX (1) | MXPA03007838A (hu) |
| PL (1) | PL363181A1 (hu) |
| RU (1) | RU2003129056A (hu) |
| WO (1) | WO2002085941A2 (hu) |
| ZA (1) | ZA200307677B (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003277088A1 (en) * | 2002-10-01 | 2004-04-23 | Xencor, Inc | Interferon variants with improved properties |
| PL376673A1 (pl) * | 2003-02-18 | 2006-01-09 | Merck Patent Gmbh | Białka fuzyjne mutein interferonu alfa o ulepszonych właściwościach |
| US20080260820A1 (en) * | 2007-04-19 | 2008-10-23 | Gilles Borrelly | Oral dosage formulations of protease-resistant polypeptides |
| US20090010966A1 (en) * | 2007-06-21 | 2009-01-08 | Angelica Therapeutics, Inc. | Modified diphtheria toxins |
| EP2268297A4 (en) * | 2008-02-29 | 2011-11-16 | Angelica Therapeutics Inc | MODIFIED TOXINS |
| WO2010030671A1 (en) * | 2008-09-09 | 2010-03-18 | University Of Medicine And Dentistry Of New Jersey | Type i interferon antagonists |
| US10059750B2 (en) | 2013-03-15 | 2018-08-28 | Angelica Therapeutics, Inc. | Modified toxins |
| CN105200017A (zh) * | 2015-10-16 | 2015-12-30 | 西安医学院 | 一种去除a47l降低痘苗病毒免疫优势的方法及病毒 |
| CN105255840A (zh) * | 2015-10-16 | 2016-01-20 | 西安医学院 | 通过去除显性表位b8r重组痘苗病毒的方法及其病毒 |
| US11932867B2 (en) | 2017-04-28 | 2024-03-19 | National Jewish Health | Methods of treating rheumatoid arthritis using RNA-guided genome editing of HLA gene |
| AR117715A1 (es) * | 2019-12-17 | 2021-08-25 | Univ Nacional Del Litoral Unl | Interferón hiperglicosilado con inmunogenicidad reducida |
| CA3218757A1 (en) * | 2021-05-10 | 2022-11-17 | The Regents Of The University Of Colorado, A Body Corporate | Hla engineering methods and compositions for treatment of autoimmunity. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000506865A (ja) * | 1996-03-14 | 2000-06-06 | ジ イミューン リスポンス コーポレイション | インターフェロンをコードする遺伝子の標的を定めた送達 |
-
2002
- 2002-03-01 MX MXPA03007838A patent/MXPA03007838A/es unknown
- 2002-03-01 CN CNA028058658A patent/CN1529714A/zh active Pending
- 2002-03-01 PL PL02363181A patent/PL363181A1/xx unknown
- 2002-03-01 CA CA002439690A patent/CA2439690A1/en not_active Abandoned
- 2002-03-01 EP EP02727340A patent/EP1379555A2/en not_active Withdrawn
- 2002-03-01 BR BR0207704-3A patent/BR0207704A/pt not_active IP Right Cessation
- 2002-03-01 KR KR10-2003-7011451A patent/KR20030081479A/ko not_active Application Discontinuation
- 2002-03-01 HU HU0303309A patent/HUP0303309A2/hu unknown
- 2002-03-01 WO PCT/EP2002/002218 patent/WO2002085941A2/en not_active Application Discontinuation
- 2002-03-01 US US10/469,679 patent/US20060062761A1/en not_active Abandoned
- 2002-03-01 RU RU2003129056/13A patent/RU2003129056A/ru not_active Application Discontinuation
- 2002-03-01 JP JP2002583467A patent/JP2004535173A/ja active Pending
-
2003
- 2003-10-01 ZA ZA200307677A patent/ZA200307677B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002085941A2 (en) | 2002-10-31 |
| BR0207704A (pt) | 2004-07-06 |
| MXPA03007838A (es) | 2003-12-08 |
| US20060062761A1 (en) | 2006-03-23 |
| CN1529714A (zh) | 2004-09-15 |
| JP2004535173A (ja) | 2004-11-25 |
| EP1379555A2 (en) | 2004-01-14 |
| ZA200307677B (en) | 2004-07-13 |
| RU2003129056A (ru) | 2005-04-20 |
| KR20030081479A (ko) | 2003-10-17 |
| CA2439690A1 (en) | 2002-10-31 |
| WO2002085941A3 (en) | 2003-10-30 |
| PL363181A1 (en) | 2004-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |