BR0207704A - Alfa interferon modificado com imunogenicidade reduzida - Google Patents
Alfa interferon modificado com imunogenicidade reduzidaInfo
- Publication number
- BR0207704A BR0207704A BR0207704-3A BR0207704A BR0207704A BR 0207704 A BR0207704 A BR 0207704A BR 0207704 A BR0207704 A BR 0207704A BR 0207704 A BR0207704 A BR 0207704A
- Authority
- BR
- Brazil
- Prior art keywords
- alpha interferon
- reduced immunogenicity
- polypeptides
- modified
- modified alpha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"ALFA INTERFERON MODIFICADO COM IMUNOGENICIDADE REDUZIDA". A presente invenção refere-se a polipeptídeos a serem administrados especialmente a seres humanos e em particular para uso terapêutico. Os polipeptídeos são polipeptídeos modificados em que a modificação resulta em uma propensão reduzida para que o polipeptídeo estimule uma resposta imune quando de administração ao ser humano. A invenção refere-se, em particular, à modificação de alfa interferon humano e especificamente alfa interferon 2 humano (INF<244>2) para resultar em proteínas que são substancialmente não imunogênicas ou menos imunogênicas do que qualquer contra-parte não-modificada quando usadas in vivo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01105088 | 2001-03-02 | ||
PCT/EP2002/002218 WO2002085941A2 (en) | 2001-03-02 | 2002-03-01 | Modified interferon alpha with reduced immunogenicity |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0207704A true BR0207704A (pt) | 2004-07-06 |
Family
ID=8176646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0207704-3A BR0207704A (pt) | 2001-03-02 | 2002-03-01 | Alfa interferon modificado com imunogenicidade reduzida |
Country Status (13)
Country | Link |
---|---|
US (1) | US20060062761A1 (pt) |
EP (1) | EP1379555A2 (pt) |
JP (1) | JP2004535173A (pt) |
KR (1) | KR20030081479A (pt) |
CN (1) | CN1529714A (pt) |
BR (1) | BR0207704A (pt) |
CA (1) | CA2439690A1 (pt) |
HU (1) | HUP0303309A2 (pt) |
MX (1) | MXPA03007838A (pt) |
PL (1) | PL363181A1 (pt) |
RU (1) | RU2003129056A (pt) |
WO (1) | WO2002085941A2 (pt) |
ZA (1) | ZA200307677B (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003277088A1 (en) * | 2002-10-01 | 2004-04-23 | Xencor, Inc | Interferon variants with improved properties |
MXPA05008704A (es) * | 2003-02-18 | 2005-10-05 | Merck Patent Gmbh | Proteinas de fusion de muteinas de interferon alfa con propiedades mejoradas. |
US20080260820A1 (en) * | 2007-04-19 | 2008-10-23 | Gilles Borrelly | Oral dosage formulations of protease-resistant polypeptides |
US20090010966A1 (en) * | 2007-06-21 | 2009-01-08 | Angelica Therapeutics, Inc. | Modified diphtheria toxins |
EP2268297A4 (en) * | 2008-02-29 | 2011-11-16 | Angelica Therapeutics Inc | MODIFIED TOXINS |
US20110224407A1 (en) * | 2008-09-09 | 2011-09-15 | University Of Medicine And Dentistry Of New Jersey | Type I Interferon Antagonists |
US10059750B2 (en) | 2013-03-15 | 2018-08-28 | Angelica Therapeutics, Inc. | Modified toxins |
CN105255840A (zh) * | 2015-10-16 | 2016-01-20 | 西安医学院 | 通过去除显性表位b8r重组痘苗病毒的方法及其病毒 |
CN105200017A (zh) * | 2015-10-16 | 2015-12-30 | 西安医学院 | 一种去除a47l降低痘苗病毒免疫优势的方法及病毒 |
AU2018258061A1 (en) | 2017-04-28 | 2019-11-28 | National Jewish Health | Methods of treating rheumatoid arthritis using RNA-guided genome editing of HLA gene |
AR117715A1 (es) * | 2019-12-17 | 2021-08-25 | Univ Nacional Del Litoral Unl | Interferón hiperglicosilado con inmunogenicidad reducida |
JP2024517475A (ja) * | 2021-05-10 | 2024-04-22 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイト | 自己免疫を治療するための操作されたhla対立遺伝子 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU728146B2 (en) * | 1996-03-14 | 2001-01-04 | Immune Response Corporation, The | Targeted delivery of genes encoding interferon |
-
2002
- 2002-03-01 BR BR0207704-3A patent/BR0207704A/pt not_active IP Right Cessation
- 2002-03-01 CN CNA028058658A patent/CN1529714A/zh active Pending
- 2002-03-01 HU HU0303309A patent/HUP0303309A2/hu unknown
- 2002-03-01 JP JP2002583467A patent/JP2004535173A/ja active Pending
- 2002-03-01 PL PL02363181A patent/PL363181A1/xx unknown
- 2002-03-01 KR KR10-2003-7011451A patent/KR20030081479A/ko not_active Application Discontinuation
- 2002-03-01 MX MXPA03007838A patent/MXPA03007838A/es unknown
- 2002-03-01 EP EP02727340A patent/EP1379555A2/en not_active Withdrawn
- 2002-03-01 RU RU2003129056/13A patent/RU2003129056A/ru not_active Application Discontinuation
- 2002-03-01 US US10/469,679 patent/US20060062761A1/en not_active Abandoned
- 2002-03-01 WO PCT/EP2002/002218 patent/WO2002085941A2/en not_active Application Discontinuation
- 2002-03-01 CA CA002439690A patent/CA2439690A1/en not_active Abandoned
-
2003
- 2003-10-01 ZA ZA200307677A patent/ZA200307677B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2002085941A2 (en) | 2002-10-31 |
RU2003129056A (ru) | 2005-04-20 |
PL363181A1 (en) | 2004-11-15 |
US20060062761A1 (en) | 2006-03-23 |
KR20030081479A (ko) | 2003-10-17 |
WO2002085941A3 (en) | 2003-10-30 |
CA2439690A1 (en) | 2002-10-31 |
EP1379555A2 (en) | 2004-01-14 |
HUP0303309A2 (hu) | 2003-12-29 |
JP2004535173A (ja) | 2004-11-25 |
ZA200307677B (en) | 2004-07-13 |
CN1529714A (zh) | 2004-09-15 |
MXPA03007838A (es) | 2003-12-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5O, 6O E 7O ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2029 DE 24/11/2009. |