HUP0303534A2 - Csökkent immunogenitású módosított interferon-béta - Google Patents

Csökkent immunogenitású módosított interferon-béta

Info

Publication number
HUP0303534A2
HUP0303534A2 HU0303534A HUP0303534A HUP0303534A2 HU P0303534 A2 HUP0303534 A2 HU P0303534A2 HU 0303534 A HU0303534 A HU 0303534A HU P0303534 A HUP0303534 A HU P0303534A HU P0303534 A2 HUP0303534 A2 HU P0303534A2
Authority
HU
Hungary
Prior art keywords
administered
interferon beta
reduced immunogenicity
polypeptides
modified interferon
Prior art date
Application number
HU0303534A
Other languages
English (en)
Inventor
Matthew Baker
Francis J. Carr
Graham Carter
Tim Jones
John Watkins
Original Assignee
Merck Patent Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh. filed Critical Merck Patent Gmbh.
Publication of HUP0303534A2 publication Critical patent/HUP0303534A2/hu
Publication of HUP0303534A3 publication Critical patent/HUP0303534A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgyát különösen embereknek beadandó, és különösenterápiás alkalmazású polipeptidek képezik. A polipeptidek módosítottpolipeptidek, amelyekben a módosítás a polipeptid csökkentett hajlamáteredményezi immunválasz kiváltására emberi személynek történő beadásesetén. A találmány tárgya különösen humán interferon-béta módosítása,olyan fehérjéket eredményezve, amelyek lényegében nem immunogének,vagy kevésbé immunogének, mint bármilyen módosítatlan társuk, amikorin vivo beadják azokat. Ó
HU0303534A 2001-03-15 2002-03-15 Modified interferon beta with reduced immunogenicity HUP0303534A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01106539 2001-03-15
PCT/EP2002/002925 WO2002074783A2 (en) 2001-03-15 2002-03-15 Modified interferon beta with reduced immunogenicity

Publications (2)

Publication Number Publication Date
HUP0303534A2 true HUP0303534A2 (hu) 2004-01-28
HUP0303534A3 HUP0303534A3 (en) 2005-12-28

Family

ID=8176796

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303534A HUP0303534A3 (en) 2001-03-15 2002-03-15 Modified interferon beta with reduced immunogenicity

Country Status (13)

Country Link
US (2) US7381795B2 (hu)
EP (1) EP1368377A2 (hu)
JP (1) JP2004529633A (hu)
KR (1) KR20030084992A (hu)
CN (1) CN1496369A (hu)
BR (1) BR0208041A (hu)
CA (1) CA2441095A1 (hu)
HU (1) HUP0303534A3 (hu)
MX (1) MXPA03008310A (hu)
PL (1) PL362870A1 (hu)
RU (1) RU2003129072A (hu)
WO (1) WO2002074783A2 (hu)
ZA (1) ZA200307992B (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002074783A2 (en) * 2001-03-15 2002-09-26 Merck Patent Gmbh Modified interferon beta with reduced immunogenicity
AU2003224650A1 (en) * 2002-03-02 2003-09-16 University Of South Florida A method for treating allergic disease and asthma by recombinant adenovirus-and adeno-associated virus-mediated ifn-gamma gene
CA2484251C (en) 2002-04-30 2015-06-23 University Of South Florida Materials and methods for inhibition of respiratory syncytial virus infection
EP1578772B1 (en) * 2002-05-01 2010-05-12 Danisco US Inc. Cytokines and cytokine receptors with reduced immunogenicity
US7595303B1 (en) * 2002-09-05 2009-09-29 University Of South Florida Genetic adjuvants for immunotherapy
EP1539960B1 (en) * 2002-09-09 2010-04-28 Hanall Pharmaceutical Co., Ltd. Protease-resistant modified interferon alpha polypeptides
EP1594547A2 (en) * 2003-02-14 2005-11-16 University Of South Florida Research Foundation, Inc. Chitosan-microparticles for ifn gene delivery
WO2005003157A2 (en) * 2003-06-10 2005-01-13 Xencor, Inc. Interferon variants with improved properties
WO2005105136A1 (en) * 2004-04-27 2005-11-10 University Of South Florida Nanogene therapy for cell proliferation disorders
US7670595B2 (en) * 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
US20080038224A1 (en) * 2006-03-28 2008-02-14 Thierry Guyon Modified interferon-beta (IFN-beta) polypeptides
EP2450369A1 (en) 2007-01-30 2012-05-09 Epivax, Inc. Regulatory t cell epitopes, compositions and uses thereof
AU2008247815B2 (en) 2007-05-02 2012-09-06 Ambrx, Inc. Modified interferon beta polypeptides and their uses
US20090010966A1 (en) * 2007-06-21 2009-01-08 Angelica Therapeutics, Inc. Modified diphtheria toxins
EP2268297A4 (en) * 2008-02-29 2011-11-16 Angelica Therapeutics Inc MODIFIED TOXINS
BRPI1016204A2 (pt) * 2009-04-22 2016-04-19 Merck Patent Gmbh proteínas de fusão de anticorpos com sítios de ligação fcrn modificados
BR112014007766B1 (pt) 2011-10-01 2022-05-10 Glytech, Inc Polipeptídeo glicosilado, método para fabricação do mesmo e composição farmacêutica
US10059750B2 (en) 2013-03-15 2018-08-28 Angelica Therapeutics, Inc. Modified toxins
AU2014245917B2 (en) 2013-03-29 2017-09-28 Glytech, Inc. Polypeptide having sialylated sugar chains attached thereto

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737462A (en) * 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
GB8317880D0 (en) * 1983-07-01 1983-08-03 Searle & Co Structure and synthesis of interferons
EP1724282B1 (en) * 1997-05-21 2013-05-15 Merck Patent GmbH Method for the production of non-immunogenic proteins
SK287491B6 (sk) * 1998-10-16 2010-11-08 Biogen Idec Ma Inc. Fúzne proteíny interferónu- beta-1a a ich použitie
CA2342967A1 (en) * 1998-12-08 2000-06-15 Biovation Limited Modifying protein immunogenicity
US6514729B1 (en) * 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
US6531122B1 (en) * 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
WO2002074783A2 (en) * 2001-03-15 2002-09-26 Merck Patent Gmbh Modified interferon beta with reduced immunogenicity

Also Published As

Publication number Publication date
US20090043076A1 (en) 2009-02-12
PL362870A1 (en) 2004-11-02
US20050054052A1 (en) 2005-03-10
WO2002074783A3 (en) 2003-08-28
ZA200307992B (en) 2005-01-14
JP2004529633A (ja) 2004-09-30
RU2003129072A (ru) 2005-04-20
US7381795B2 (en) 2008-06-03
MXPA03008310A (es) 2003-12-11
WO2002074783A2 (en) 2002-09-26
HUP0303534A3 (en) 2005-12-28
CA2441095A1 (en) 2002-09-26
KR20030084992A (ko) 2003-11-01
US7615615B2 (en) 2009-11-10
CN1496369A (zh) 2004-05-12
BR0208041A (pt) 2004-02-25
EP1368377A2 (en) 2003-12-10

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished