HUP0301339A2 - Kondenzált azepinszármazékok és alkalmazásuk vizeletkiválasztást gátló szerként - Google Patents
Kondenzált azepinszármazékok és alkalmazásuk vizeletkiválasztást gátló szerkéntInfo
- Publication number
- HUP0301339A2 HUP0301339A2 HU0301339A HUP0301339A HUP0301339A2 HU P0301339 A2 HUP0301339 A2 HU P0301339A2 HU 0301339 A HU0301339 A HU 0301339A HU P0301339 A HUP0301339 A HU P0301339A HU P0301339 A2 HUP0301339 A2 HU P0301339A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- group
- fluorine
- hydrogen atom
- atom
- Prior art date
Links
- 150000001538 azepines Chemical class 0.000 title abstract 2
- 229940124538 antidiuretic agent Drugs 0.000 title 1
- 239000003160 antidiuretic agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- -1 phenyl- Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 101100134927 Gallus gallus COR8 gene Chemical group 0.000 abstract 1
- 102000004136 Vasopressin Receptors Human genes 0.000 abstract 1
- 108090000643 Vasopressin Receptors Proteins 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Az (1) és (2) általános képletű vegyületek, ahol G1 jelentéseazepinszármazék és G2 jelentése (9), (10) vagy (11) általános képletűcsoport, újak. A találmány szerinti vegyületek vazopresszin V2receptor agonisták. A vegyületeket tartalmazó gyógyszerészetikészítményeket vizeletkiválasztást gátló szerként lehet használni. Afenti képletekben W jelentése nitrogénatom vagy C-R4 általános képletűcsoport; R1 - R4 jelentése egymástól függetlenül hidrogén-, fluor-,klór-, brómatom, alkil-, CF3-, fenil-, OH-, O-alkil-, NH2-, NH-alkil-,N(alkil)2-, NO2- vagy CN-csoport vagy R2 és R3 együtt -CH=CH-CH=CH-csoportot alkot; Ar jelentése fenil-, piridil-, naftil- vagy mono-vagy poliszubsztituált fenil- vagy piridilcsoport, ahol aszubsztituensek jelentése fluor-, klór-, brómatom, alkil-, hidroxil-,alkoxi-, NH2, NH-alkil-, N(alkil)2, NO2 vagy CN-csoport; D jelentésevegyértékkötés vagy NH csoport; E1 és E2 jelentése egyidejűleghidrogénatom, metoxicsoport vagy fluoratom, vagy E1 és E2 közül azegyik jelentése OH, O-alkil-, OBn, OPh, OAc csoport, fluor-, klór-,brómatom, N3, NH2, NHBn vagy NHAc csoport és a másik jelentésehidrogénatom, vagy E1 és E2 együtt =O, -O(CH2)gO- vagy -S(CH2)gS-csoport; F1 és F2 jelentése hidrogénatom vagy együtt =O vagy =Scsoport; L jelentése hidroxil-, alkoxi-, amino-, NH-alkil- vagy NR9R10csoport; R7 jelentése hidrogénatom, alkil-, alkenil- vagy COR8általános képletű csoport; R8 jelentése OH, O-alkil-, NH2, NH-alkil-,N(alkil)2, pirrolidinil- vagy piperidinilcsoport; V jelentése O, N-CNvagy S csoport; c értéke 0 vagy 1; d értéke 0 vagy 1; e értéke 0 vagy1; f értéke 0, 1, 2, 3 vagy 4; g értéke 2 vagy 3; és h értéke 3, 4vagy 5. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0015601.8A GB0015601D0 (en) | 2000-06-26 | 2000-06-26 | Novel antidiuretic agents |
PCT/GB2001/002737 WO2002000626A1 (en) | 2000-06-26 | 2001-06-21 | Fused azepine derivatives and their use as antidiuretic agents |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0301339A2 true HUP0301339A2 (hu) | 2003-08-28 |
HUP0301339A3 HUP0301339A3 (en) | 2004-10-28 |
HU229315B1 HU229315B1 (en) | 2013-10-28 |
Family
ID=9894399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301339A HU229315B1 (en) | 2000-06-26 | 2001-06-21 | Fused azepine derivatives and their use as antidiuretic agents |
Country Status (22)
Country | Link |
---|---|
US (1) | US7176195B2 (hu) |
EP (1) | EP1294698B1 (hu) |
JP (2) | JP3935071B2 (hu) |
KR (1) | KR100805808B1 (hu) |
CN (1) | CN1308313C (hu) |
AT (1) | ATE368650T1 (hu) |
AU (2) | AU2001274290B9 (hu) |
CA (1) | CA2412555A1 (hu) |
CZ (1) | CZ304037B6 (hu) |
DE (1) | DE60129697T2 (hu) |
GB (1) | GB0015601D0 (hu) |
HK (1) | HK1059780A1 (hu) |
HU (1) | HU229315B1 (hu) |
IL (1) | IL153358A0 (hu) |
MX (1) | MXPA02012779A (hu) |
NO (1) | NO324217B1 (hu) |
NZ (1) | NZ523066A (hu) |
PL (1) | PL359187A1 (hu) |
RU (1) | RU2269517C2 (hu) |
UA (1) | UA73177C2 (hu) |
WO (1) | WO2002000626A1 (hu) |
ZA (1) | ZA200300403B (hu) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7138393B2 (en) | 1998-07-24 | 2006-11-21 | Wyeth | Biologically active vasopressin agonist metabolites |
GB0000079D0 (en) * | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
GB0115515D0 (en) * | 2001-06-25 | 2001-08-15 | Ferring Bv | Oxytocin agonisys |
GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
EP2426122A1 (en) * | 2002-10-24 | 2012-03-07 | Merck Patent GmbH | Methylene urea derivative as RAF kinasse inhibitors |
EP1615878B1 (en) | 2003-01-14 | 2012-04-04 | Cytokinetics, Inc. | Compounds, compositions and methods of treatment for heart failure |
US7700583B2 (en) | 2003-04-11 | 2010-04-20 | High Point Pharmaceuticals, Llc | 11β-hydroxysteroid dehydrogenase type 1 active compounds |
DE602004027171D1 (de) * | 2003-04-11 | 2010-06-24 | High Point Pharmaceuticals Llc | Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase |
ATE454203T1 (de) * | 2003-05-02 | 2010-01-15 | Worcester Polytech Inst | Verbundgastrennmodule mit zwischenschichten auf höher tammanntemperatur |
EP1512687A1 (en) * | 2003-09-05 | 2005-03-09 | Ferring B.V. | Piperazines as oxytocin agonists |
ES2260563T3 (es) * | 2003-11-13 | 2006-11-01 | Ferring B.V. | Paquete de blister y forma farmaceutica solida para ello. |
JP5080970B2 (ja) * | 2004-06-17 | 2012-11-21 | サイトキネティクス・インコーポレーテッド | 心疾患を治療するための置換尿素誘導体 |
US7176222B2 (en) | 2004-07-27 | 2007-02-13 | Cytokinetics, Inc. | Syntheses of ureas |
EP1627876A1 (en) * | 2004-08-20 | 2006-02-22 | Ferring B.V. | Heterocyclic condensed compounds useful as antidiuretic agents |
EP1632494A1 (en) * | 2004-08-24 | 2006-03-08 | Ferring B.V. | Vasopressin v1a antagonists |
CA2588768A1 (en) * | 2004-11-17 | 2006-05-26 | Kissei Pharmaceutical Co., Ltd. | Aromatic amide derivatives, medicinal compositions containing the same, medical uses of both |
US7538223B2 (en) | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
EP1959960B1 (en) | 2005-12-15 | 2013-04-10 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
US7718657B2 (en) | 2005-12-16 | 2010-05-18 | Cytokinetics, Inc. | Certain indanyl urea modulators of the cardiac sarcomere |
JP5178526B2 (ja) | 2005-12-19 | 2013-04-10 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
SE528446C2 (sv) * | 2006-03-02 | 2006-11-14 | Ferring Int Ct Sa | Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse |
KR20100017766A (ko) * | 2007-05-10 | 2010-02-16 | 에이엠알 테크놀로지, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤조-1,4-디아제핀 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 이의 용도 |
CA2695634C (en) | 2007-08-06 | 2018-01-23 | Serenity Pharmaceuticals Corporation | Methods and devices for desmopressin drug delivery |
DK3225250T3 (da) * | 2008-05-21 | 2019-11-04 | Ferring Bv | Orodispersibel desmopressin til forlængelse af den indledende søvnperiode, som ikke forstyrres af nykturi |
US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
GB201005623D0 (en) | 2010-04-01 | 2010-05-19 | Vantia Ltd | New polymorph |
CN103502218B (zh) * | 2011-03-04 | 2016-08-17 | 生命科技公司 | 用于缀合生物分子的化合物和方法 |
GB201105537D0 (en) | 2011-03-31 | 2011-05-18 | Vantia Ltd | New process |
CN103159641A (zh) * | 2011-12-14 | 2013-06-19 | 天津泰普药品科技发展有限公司 | 托伐普坦中间体2-甲酸-5-(2-甲基苯甲酰氨基)甲苯的制备方法 |
RU2480468C1 (ru) * | 2012-02-16 | 2013-04-27 | Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" | КРИСТАЛЛИЧЕСКАЯ МОДИФИКАЦИЯ ПАРА-МЕТОКСИАНИЛИДА 6-ГИДРОКСИ-4-ОКСО-2,4-ДИГИДРО-1Н-ПИРРОЛО[3,2,1-ij]ХИНОЛИН-5-КАРБОНОВОЙ КИСЛОТЫ |
CN103373960B (zh) * | 2012-04-24 | 2017-03-01 | 江苏康缘药业股份有限公司 | 一种托伐普坦中间体及其制备方法 |
WO2020154581A1 (en) * | 2019-01-24 | 2020-07-30 | Assia Chemical Industries Ltd | Solid state forms of fedovapagon-salicyclic acid co-crystal |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US5516774A (en) | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
WO1995034540A1 (en) | 1994-06-15 | 1995-12-21 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic derivatives useful as vasopressin or oxytocin modulators |
CN1183134C (zh) | 1997-07-30 | 2005-01-05 | 惠氏公司 | 三环后叶加压素激动剂 |
WO1999006403A1 (en) | 1997-07-30 | 1999-02-11 | American Home Products Corporation | Tricyclic vasopressin agonists |
GB2355454A (en) * | 1999-10-20 | 2001-04-25 | Ferring Bv | Antidiuretic agents |
GB0000079D0 (en) * | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
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2000
- 2000-06-26 GB GBGB0015601.8A patent/GB0015601D0/en not_active Ceased
-
2001
- 2001-06-21 AT AT01940792T patent/ATE368650T1/de not_active IP Right Cessation
- 2001-06-21 JP JP2002505374A patent/JP3935071B2/ja not_active Expired - Fee Related
- 2001-06-21 RU RU2003101970/04A patent/RU2269517C2/ru not_active IP Right Cessation
- 2001-06-21 NZ NZ523066A patent/NZ523066A/en not_active IP Right Cessation
- 2001-06-21 IL IL15335801A patent/IL153358A0/xx unknown
- 2001-06-21 WO PCT/GB2001/002737 patent/WO2002000626A1/en active IP Right Grant
- 2001-06-21 EP EP01940792A patent/EP1294698B1/en not_active Expired - Lifetime
- 2001-06-21 AU AU2001274290A patent/AU2001274290B9/en not_active Ceased
- 2001-06-21 CZ CZ20024157A patent/CZ304037B6/cs not_active IP Right Cessation
- 2001-06-21 KR KR1020027017214A patent/KR100805808B1/ko not_active IP Right Cessation
- 2001-06-21 HU HU0301339A patent/HU229315B1/hu not_active IP Right Cessation
- 2001-06-21 CN CNB018118135A patent/CN1308313C/zh not_active Expired - Fee Related
- 2001-06-21 UA UA20021210560A patent/UA73177C2/uk unknown
- 2001-06-21 DE DE60129697T patent/DE60129697T2/de not_active Expired - Lifetime
- 2001-06-21 PL PL01359187A patent/PL359187A1/xx not_active IP Right Cessation
- 2001-06-21 US US10/311,301 patent/US7176195B2/en not_active Expired - Fee Related
- 2001-06-21 CA CA002412555A patent/CA2412555A1/en not_active Abandoned
- 2001-06-21 AU AU7429001A patent/AU7429001A/xx active Pending
- 2001-06-21 MX MXPA02012779A patent/MXPA02012779A/es active IP Right Grant
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2002
- 2002-12-18 NO NO20026094A patent/NO324217B1/no not_active IP Right Cessation
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2003
- 2003-01-15 ZA ZA200300403A patent/ZA200300403B/xx unknown
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2004
- 2004-04-15 HK HK04102625A patent/HK1059780A1/xx unknown
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2005
- 2005-01-19 JP JP2005011930A patent/JP2005104990A/ja not_active Withdrawn
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