HUP0301101A2 - Heterociklusos vegyületek, eljárás ezek előállítására, e vegyületeket tartalmazó gyógyászati készítmények diabetes és ezzel kapcsolatos betegségek kezelésére - Google Patents

Heterociklusos vegyületek, eljárás ezek előállítására, e vegyületeket tartalmazó gyógyászati készítmények diabetes és ezzel kapcsolatos betegségek kezelésére

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Publication number
HUP0301101A2
HUP0301101A2 HU0301101A HUP0301101A HUP0301101A2 HU P0301101 A2 HUP0301101 A2 HU P0301101A2 HU 0301101 A HU0301101 A HU 0301101A HU P0301101 A HUP0301101 A HU P0301101A HU P0301101 A2 HUP0301101 A2 HU P0301101A2
Authority
HU
Hungary
Prior art keywords
group
atom
alkyl
general formula
diabetes
Prior art date
Application number
HU0301101A
Other languages
English (en)
Inventor
Ranjan Chakrabarti
Ranga Madhavan Gurram
Braj Bhushan Lohray
Vidya Bhushan Lohray
Sarma K. S. Pakala
Rao Bheema H. Paraselli
Rajagopalan Ramanujam
Original Assignee
Reddy's Research Foundation
Reddy-Cheminor, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/777,627 external-priority patent/US5885997A/en
Application filed by Reddy's Research Foundation, Reddy-Cheminor, Inc. filed Critical Reddy's Research Foundation
Publication of HUP0301101A2 publication Critical patent/HUP0301101A2/hu
Publication of HUP0301101A3 publication Critical patent/HUP0301101A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

A találmány tárgyát az (I) általános képletű vegyületek valamint ezekelőállítása képezi. A találmány tárgyához tartoznak a hatóanyagként az(I) általános képletű vegyületeket tartalmazó gyógyászati készítményekis. A találmány szerinti gyógyászati készítmények eredményesenalkalmazhatók II-es típusú diabetes, csökkent glükóztolerancia,diszlipidémia, magas vérnyomás, szívkoszorúér megbetegedés, szív- ésérrendszeri betegségek, atherosclerosis, elhízással és psoriasissalkapcsolatos inzulinrezisztencia, diabetes komplikációk, soktömlőjűpetefészek-szindróma (PCOS), vesebetegségek, diabetikus eredetűvesebaj, glomerulonefritis, glomeruláris sclerosis, nefrotikusszindróma, magas vérnyomással kapcsolatos nefrosclerosis, avesebetegségek végstádiumai, mikroalbuminuria, táplálkozásirendellenességek kezelésére. A találmány tárgyát képezi ezen kívül a(III) általános képletű új közbenső termék is. Az (I) általánosképletben a szubsztituensek jelentése X, Y vagy Z közül az egyikjelentése C=O vagy C=S, továbbá X, Y és Z közül a többi csoportjelentése C= vagy C=C; az R1, R2 és R3 szubsztituensek az X, Y vagy Zcsoportokhoz vagy egy nitrogénatomhoz kapcsolódnak, és jelentésükazonosan vagy eltérően hidrogénatom, halogénatom, hidroxil- vagynitrocsoport, vagy adott esetben szubsztituált alkil-, cikloalkil-,alkoxi-, cikloalkoxi-, aril-, aralkil-, heterociklusos csoport,heteroaril-, heteroaralkil-, acil-, acil-oxi-, hidroxi-alkil-, amino-,acil-amino-, aril-amino-, amino-alkil-, aril-oxi-, alkoxi-karbonil-,alkil-amino-, alkoxi-alkil-, tio-alkil-, alkil-tio- vagykarboxilcsoport, valamint ennek származékai vagy szulfonsavcsoport ésennek származékai, azzal a feltétellel, hogy amennyiben R1, R2 vagy R3egy nitrogénatomhoz kapcsolódik, úgy jelentése hidrogénatomtól,halogénatomtól, nitro-, karboxil- vagy szulfonsavcsoporttól eltérő,vagy R1, R2 és R3 közül kettő a szomszédos atomokkal együtt,amelyekhez kapcsolódnak, adott esetben szubsztituált 4-7 tagból állógyűrűt képeznek, amelyben egy vagy több kettős kötés van, amely gyűrűkarbociklusos vagy egy vagy több heteroatomot tartalmazhat oxigénatom,nitrogénatom és/vagy kénatom közül választva; a -(CH2)n-O- kapcsolócsoport nitrogénatomhoz kötődik vagy X, Y vagy Z-n keresztülkapcsolódik, amely csoportban n értéke 1-4; Ar jelentése adott esetbenszubsztituált kétértékű aromás vagy heterociklusos csoport, R4jelentése hidrogénatom, halogénatom vagy rövid szénláncú alkilcsoportvagy a szomszédos A-val együtt egy vegyértékkötés; A jelentésenitrogénatom vagy CR5 általános képletű csoport, amelyben R5 jelentésehidrogénatom, halogénatom vagy rövid szénláncú alkilcsoport vagy R5jelentése R4-gyel együtt egy vegyértékkötés; B jelentése egyoxigénatom vagy kénatom, amennyiben A jelentése CR5 általános képletűcsoport vagy B jelentése oxigénatom, amennyiben A
HU0301101A 1996-12-31 1997-06-30 Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases HUP0301101A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/777,627 US5885997A (en) 1996-07-01 1996-12-31 Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
PCT/US1997/011522 WO1997041097A2 (en) 1996-12-31 1997-06-30 Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases

Publications (2)

Publication Number Publication Date
HUP0301101A2 true HUP0301101A2 (hu) 2003-12-29
HUP0301101A3 HUP0301101A3 (en) 2009-03-30

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Application Number Title Priority Date Filing Date
HU0301101A HUP0301101A3 (en) 1996-12-31 1997-06-30 Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases

Country Status (16)

Country Link
EP (1) EP0958296B1 (hu)
JP (1) JP4339402B2 (hu)
CN (1) CN1190434C (hu)
AT (1) ATE246190T1 (hu)
DE (1) DE69723869T2 (hu)
DK (1) DK0958296T3 (hu)
ES (1) ES2199366T3 (hu)
HK (1) HK1026204A1 (hu)
HU (1) HUP0301101A3 (hu)
IL (2) IL142649A (hu)
NO (1) NO313699B1 (hu)
PL (1) PL192664B1 (hu)
PT (1) PT958296E (hu)
RU (1) RU2200161C2 (hu)
UA (1) UA64713C2 (hu)
WO (1) WO1997041097A2 (hu)

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