HUP0300259A2 - Eljárás 5'-acetilstavudin előállítására - Google Patents
Eljárás 5'-acetilstavudin előállításáraInfo
- Publication number
- HUP0300259A2 HUP0300259A2 HU0300259A HUP0300259A HUP0300259A2 HU P0300259 A2 HUP0300259 A2 HU P0300259A2 HU 0300259 A HU0300259 A HU 0300259A HU P0300259 A HUP0300259 A HU P0300259A HU P0300259 A2 HUP0300259 A2 HU P0300259A2
- Authority
- HU
- Hungary
- Prior art keywords
- acetylstavudine
- production
- preparing
- monoactivator
- methyluridine
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- XNKLLVCARDGLGL-JGVFFNPUSA-N Stavudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1C=C[C@@H](CO)O1 XNKLLVCARDGLGL-JGVFFNPUSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- XZMMMZJDMWAFNG-BPYWRXDBSA-N 1-[(2r,3r,4s,5r)-4-acetyl-3-bromo-4-hydroxy-5-(1-hydroxy-2-oxopropyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound Br[C@@H]1[C@](C(C)=O)(O)[C@@H](C(O)C(=O)C)O[C@H]1N1C(=O)NC(=O)C(C)=C1 XZMMMZJDMWAFNG-BPYWRXDBSA-N 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 150000003863 ammonium salts Chemical group 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 150000004714 phosphonium salts Chemical class 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A találmány tárgya eljárás 5'-acetilstavudin előállítására, amelyeljárás során 2'-dezoxi-2'-bróm-3',5'-diacetil-5-metiluridint 5'-acetilstavudinná konvertálnak cink mint redukálószer és egyaktiválószer kombinációjának jelenlétében, amely eljárást az jellemez,hogy az aktiválószer egy ammóniumsó és/vagy egy foszfóniumsó. Az 5'-acetilstavudin fontos intermedier a 2',3'-didehidro-3'-dezoxitimidinelőállításában, ami egy antivirális hatóanyag és amely stavudin (D4T)néven is ismert. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000MI000810A IT1318463B1 (it) | 2000-04-12 | 2000-04-12 | Procedimento per la preparazione di 5'-acetilstavudina. |
| PCT/IB2001/000588 WO2001077103A1 (en) | 2000-04-12 | 2001-04-10 | Process for preparing 5'-acetylstavudine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0300259A2 true HUP0300259A2 (hu) | 2003-06-28 |
| HUP0300259A3 HUP0300259A3 (en) | 2005-12-28 |
Family
ID=11444838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0300259A HUP0300259A3 (en) | 2000-04-12 | 2001-04-10 | Process for preparing 5'-acetylstavudine |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6350873B2 (hu) |
| EP (1) | EP1274704B1 (hu) |
| JP (1) | JP2003530394A (hu) |
| KR (1) | KR100800650B1 (hu) |
| AT (1) | ATE257835T1 (hu) |
| BR (1) | BR0109965A (hu) |
| DE (1) | DE60101791T2 (hu) |
| ES (1) | ES2213109T3 (hu) |
| HU (1) | HUP0300259A3 (hu) |
| IT (1) | IT1318463B1 (hu) |
| MX (1) | MXPA02010072A (hu) |
| WO (1) | WO2001077103A1 (hu) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP2008004389A0 (en) * | 2005-08-31 | 2008-04-30 | Cipla Ltd | Pharmaceutical combinations containing lamivudine,stavudine,stavudine and navirapine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4904770A (en) * | 1988-03-24 | 1990-02-27 | Bristol-Myers Company | Production of 2',3'-dideoxy-2',3'-didehydronucleosides |
-
2000
- 2000-04-12 IT IT2000MI000810A patent/IT1318463B1/it active
-
2001
- 2001-04-10 ES ES01917385T patent/ES2213109T3/es not_active Expired - Lifetime
- 2001-04-10 EP EP01917385A patent/EP1274704B1/en not_active Expired - Lifetime
- 2001-04-10 JP JP2001575576A patent/JP2003530394A/ja not_active Withdrawn
- 2001-04-10 WO PCT/IB2001/000588 patent/WO2001077103A1/en active IP Right Grant
- 2001-04-10 HU HU0300259A patent/HUP0300259A3/hu unknown
- 2001-04-10 BR BR0109965-5A patent/BR0109965A/pt not_active Application Discontinuation
- 2001-04-10 MX MXPA02010072A patent/MXPA02010072A/es active IP Right Grant
- 2001-04-10 KR KR1020027011340A patent/KR100800650B1/ko not_active IP Right Cessation
- 2001-04-10 AT AT01917385T patent/ATE257835T1/de not_active IP Right Cessation
- 2001-04-10 DE DE60101791T patent/DE60101791T2/de not_active Expired - Fee Related
- 2001-04-12 US US09/834,028 patent/US6350873B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02010072A (es) | 2003-03-10 |
| IT1318463B1 (it) | 2003-08-25 |
| US6350873B2 (en) | 2002-02-26 |
| ATE257835T1 (de) | 2004-01-15 |
| KR20020086912A (ko) | 2002-11-20 |
| EP1274704B1 (en) | 2004-01-14 |
| JP2003530394A (ja) | 2003-10-14 |
| US20010039342A1 (en) | 2001-11-08 |
| DE60101791D1 (de) | 2004-02-19 |
| ITMI20000810A1 (it) | 2001-10-12 |
| ITMI20000810A0 (it) | 2000-04-12 |
| DE60101791T2 (de) | 2004-10-21 |
| EP1274704A1 (en) | 2003-01-15 |
| ES2213109T3 (es) | 2004-08-16 |
| BR0109965A (pt) | 2003-05-27 |
| WO2001077103A1 (en) | 2001-10-18 |
| HUP0300259A3 (en) | 2005-12-28 |
| KR100800650B1 (ko) | 2008-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |