TR200102501T2 - Antiviral nükleozid analoglar. - Google Patents

Antiviral nükleozid analoglar.

Info

Publication number
TR200102501T2
TR200102501T2 TR2001/02501T TR200102501T TR200102501T2 TR 200102501 T2 TR200102501 T2 TR 200102501T2 TR 2001/02501 T TR2001/02501 T TR 2001/02501T TR 200102501 T TR200102501 T TR 200102501T TR 200102501 T2 TR200102501 T2 TR 200102501T2
Authority
TR
Turkey
Prior art keywords
nucleoside analogs
antiviral nucleoside
antiviral
analogs
formula
Prior art date
Application number
TR2001/02501T
Other languages
English (en)
Inventor
Nguyen-Ba Nghe
Original Assignee
Shire Biochem Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Biochem Inc. filed Critical Shire Biochem Inc.
Publication of TR200102501T2 publication Critical patent/TR200102501T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Söz konusu bulus formül (I) ya da (Ia)'nin antiviral madde olarak kullanilan nükleozid analoglari ile ilgilidir.
TR2001/02501T 1998-12-23 1999-12-22 Antiviral nükleozid analoglar. TR200102501T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11379798P 1998-12-23 1998-12-23

Publications (1)

Publication Number Publication Date
TR200102501T2 true TR200102501T2 (tr) 2002-01-21

Family

ID=22351590

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02501T TR200102501T2 (tr) 1998-12-23 1999-12-22 Antiviral nükleozid analoglar.

Country Status (27)

Country Link
US (3) US6358963B1 (tr)
EP (1) EP1140937B1 (tr)
JP (1) JP2002533470A (tr)
KR (1) KR100653485B1 (tr)
CN (1) CN1117751C (tr)
AP (1) AP2001002207A0 (tr)
AT (1) ATE254126T1 (tr)
AU (1) AU760875B2 (tr)
BR (1) BR9916849A (tr)
CA (1) CA2355712C (tr)
CZ (1) CZ20012352A3 (tr)
DE (1) DE69912842T2 (tr)
DK (1) DK1140937T3 (tr)
EA (1) EA004767B1 (tr)
ES (1) ES2209532T3 (tr)
HU (1) HUP0104827A3 (tr)
ID (1) ID30477A (tr)
IL (1) IL143867A0 (tr)
MX (1) MXPA01006425A (tr)
NO (1) NO20013163L (tr)
NZ (1) NZ513094A (tr)
OA (1) OA11741A (tr)
PT (1) PT1140937E (tr)
TR (1) TR200102501T2 (tr)
UY (1) UY25878A1 (tr)
WO (1) WO2000039143A2 (tr)
ZA (1) ZA200105702B (tr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE254126T1 (de) * 1998-12-23 2003-11-15 Shire Biochem Inc Antivirale nukleosidanaloga
ATE360016T1 (de) 2000-02-11 2007-05-15 Shire Biochem Inc Ein stereoselektives verfahren zur herstellung von nukleosidanalogen
AU2003261114A1 (en) * 2002-07-03 2004-02-09 Triangle Pharmaceuticals, Inc. Combination therapy with 1,3-dioxolanes and inosine monophosphate dehydrogenase inhibitors
US6855821B2 (en) 2002-08-06 2005-02-15 Pharmasset, Ltd. Processes for preparing 1,3-dioxolane nucleosides
US7706405B2 (en) * 2002-09-12 2010-04-27 Interdigital Technology Corporation System for efficient recovery of Node-B buffered data following MAC layer reset
EP1573019B1 (en) 2002-11-18 2009-01-14 Shire BioChem Inc. Stereoselective process for the production of dioxolane nucleoside analogues
DE10335061B4 (de) * 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
EP1720840B1 (en) 2004-02-03 2016-02-03 Emory University Methods to manufacture 1,3-dioxolane nucleosides
US7322412B2 (en) * 2004-08-30 2008-01-29 Halliburton Energy Services, Inc. Casing shoes and methods of reverse-circulation cementing of casing
ATE516249T1 (de) * 2008-03-20 2011-07-15 Befesa Salzschlacke Gmbh Hochtonerdehaltiger rohstoff und verfahren zur herstellung
EP2606895A4 (en) * 2010-10-12 2014-04-02 Univ Wuhan TRANSDERMAL ABSORPTION STAMP OF ANTIVIRAL DRUG AND METHOD FOR PREPARING THE SAME

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000137A (en) 1975-06-10 1976-12-28 American Home Products Corporation Antitumor derivatives of periodate-oxidized nucleosides
US4041037A (en) 1975-06-10 1977-08-09 American Home Products Corporation Antitumor derivatives of periodate-oxidized cytidine
JPS5668674A (en) 1979-11-08 1981-06-09 Shionogi & Co Ltd 5-fluorouracil derivative
JPS5738774A (en) 1980-08-19 1982-03-03 Chugai Pharmaceut Co Ltd Uracil derivative and its preparation
US4479942A (en) 1981-08-10 1984-10-30 Fujisawa Pharmaceutical Co., Ltd. Tetrahydrofurnancarboxylic acid derivatives, processes for preparation thereof and pharmaceutical compositions thereof
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
HU198933B (en) 1987-11-02 1989-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new xanthine derivatives and pharmaceutical compositions comprising same as active ingredient
US5041449A (en) 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
US5047407A (en) 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5270315A (en) 1988-04-11 1993-12-14 Biochem Pharma Inc. 4-(purinyl bases)-substituted-1,3-dioxlanes
NZ228645A (en) * 1988-04-11 1991-09-25 Iaf Biochem Int 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
US4987224A (en) 1988-08-02 1991-01-22 University Of Georgia Research Foundation, Inc. Method of preparation of 2',3'-dideoxynucleosides
WO1994014802A1 (en) 1989-02-08 1994-07-07 Biochem Pharma Inc. Process for preparing substituted 1,3-oxathiolanes with antiviral properties
PT95516A (pt) * 1989-10-06 1991-08-14 Wellcome Found Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
US5914331A (en) 1990-02-01 1999-06-22 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5276151A (en) 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5700937A (en) 1990-02-01 1997-12-23 Emory University Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds
US5204466A (en) 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
GB9009861D0 (en) 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
JP2960164B2 (ja) 1990-11-13 1999-10-06 バイオケム ファーマ インコーポレイテッド 抗ウイルス特性を有する置換１，３−オキサチオラン類および置換１，３−ジチオラン類
AU9125991A (en) 1990-12-05 1992-07-08 University Of Georgia Research Foundation, Inc., The Enantiomerically pure beta -l-(-)-1,3-oxathiolane nucleosides
US5179104A (en) 1990-12-05 1993-01-12 University Of Georgia Research Foundation, Inc. Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides
US5925643A (en) 1990-12-05 1999-07-20 Emory University Enantiomerically pure β-D-dioxolane-nucleosides
US5444063A (en) 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
NZ241625A (en) 1991-02-22 1996-03-26 Univ Emory 1,3-oxathiolane derivatives, anti-viral compositions containing such and method of resolving racemic mixture of enantiomers
WO1992018517A1 (en) 1991-04-17 1992-10-29 Yale University Method of treating or preventing hepatitis b virus
GB9109506D0 (en) 1991-05-02 1991-06-26 Wellcome Found Therapeutic nucleosides
GB9110874D0 (en) 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
ZA923641B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9200150D0 (en) * 1992-01-06 1992-02-26 Wellcome Found Therapeutic nucleosides
US5869461A (en) 1995-03-16 1999-02-09 Yale University Reducing toxicity of L-nucleosides with D-nucleosides
GB9525606D0 (en) * 1995-12-14 1996-02-14 Iaf Biochem Int Method and compositions for the synthesis of dioxolane nucleosides with › - configuration
US5792773A (en) 1996-11-15 1998-08-11 Yale University L-β-dioxolane uridine analog administration for treating Epstein-Barr virus infection
ATE254126T1 (de) * 1998-12-23 2003-11-15 Shire Biochem Inc Antivirale nukleosidanaloga

Also Published As

Publication number Publication date
EP1140937B1 (en) 2003-11-12
AU760875B2 (en) 2003-05-22
DK1140937T3 (da) 2004-03-22
NO20013163L (no) 2001-08-20
NO20013163D0 (no) 2001-06-22
IL143867A0 (en) 2002-04-21
DE69912842D1 (de) 2003-12-18
WO2000039143A3 (en) 2000-11-02
HUP0104827A2 (en) 2002-06-29
ATE254126T1 (de) 2003-11-15
UY25878A1 (es) 2001-08-27
AP2001002207A0 (en) 2001-09-30
CA2355712C (en) 2009-03-17
DE69912842T2 (de) 2004-05-13
WO2000039143A2 (en) 2000-07-06
CA2355712A1 (en) 2000-07-06
PT1140937E (pt) 2004-04-30
MXPA01006425A (es) 2002-06-04
KR100653485B1 (ko) 2006-12-04
US20040058893A1 (en) 2004-03-25
CZ20012352A3 (cs) 2001-10-17
ZA200105702B (en) 2002-10-11
EA004767B1 (ru) 2004-08-26
CN1117751C (zh) 2003-08-13
KR20020013485A (ko) 2002-02-20
US20010049372A1 (en) 2001-12-06
EA200100711A1 (ru) 2001-12-24
US6545001B2 (en) 2003-04-08
JP2002533470A (ja) 2002-10-08
CN1334814A (zh) 2002-02-06
BR9916849A (pt) 2001-10-30
US6358963B1 (en) 2002-03-19
ES2209532T3 (es) 2004-06-16
AU1765700A (en) 2000-07-31
NZ513094A (en) 2004-05-28
OA11741A (en) 2005-05-13
EP1140937A2 (en) 2001-10-10
ID30477A (id) 2001-12-13
HUP0104827A3 (en) 2002-08-28

Similar Documents

Publication Publication Date Title
NO961377L (no) Distamycin A-analoger som antitumor eller antivirale midler
DK1280813T3 (da) Antivirale pyrimidin-nukleosidanaloger
CY1116145T1 (el) S-φθορομεθυλεστερας 6.αλφα.,9.αλφα-διφθορο-17.αλφα.-'(2-φουρανυλκαρβοξυλ) οξυ]-11.βητα.-υδροξυ-16.αλφα.-μεθυλ-3-οξο-ανδροστ-1,4-διεν-17-καρβοθειοτικου οξεος ως αντιφλεγμονωδης παραγοντας
TR200201001T2 (tr) Pürin türevleri
BR0111639A (pt) Uso de uma molécula de ácido oligodeoxinucléico, e composição farmacêutica contendo a mesma
NO20035524D0 (no) 4'-substituerte nukleosider
DZ3007A1 (fr) Analogues de (1 R, CIS)-4-(6-amino-9H-purin-9-YL)-2-cyclopentène-1-methanol comme agents antiviraux.
BG106569A (en) Purine derivatives
HUP0001843A2 (hu) Eljárás nukleozid analógok szintézisére
MY122262A (en) Lh-rh peptide analogues their uses and pharmaceutical compositions containing them
EA199900937A1 (ru) Фармацевтические композиции, содержащие вориконазол
TR199800436A2 (tr) Primidin türevlerinin kanserin önlenmesi için kullanilmasi.
PT996430E (pt) Composicoes de analogos nucleotidicos
MA27501A1 (fr) Derives d'imidazoquinoline en tant que ligands recepteurs de l'adenosine a3
TR200102501T2 (tr) Antiviral nükleozid analoglar.
DE60031886D1 (de) Purinderivate
MXPA02012493A (es) 1-aril-4-oxo, 1,4-dihidro-3-quinolincarboxamidas como agentes antivirales.
SE9801494D0 (sv) Novel use
DK1250337T3 (da) Substituerede homopiperidinylbenzimidazol-analoger som fundus-relaksanter
BR0115139A (pt) Compostos bis-heterocìclicos com atividade antitumor e quimiossensibilizante
TR200200494T2 (tr) Yağlı asit sintazı inhibitörleri.
SE9604582D0 (sv) Novel compounds
BR9907426A (pt) Tetrahidronaftalenos
BR0210201A (pt) Composição
SE9603726D0 (sv) Novel compounds