HUP0300243A2 - Dibenzo[b,f]azepin-származékok és eljárás azok előállítására - Google Patents

Dibenzo[b,f]azepin-származékok és eljárás azok előállítására

Info

Publication number
HUP0300243A2
HUP0300243A2 HU0300243A HUP0300243A HUP0300243A2 HU P0300243 A2 HUP0300243 A2 HU P0300243A2 HU 0300243 A HU0300243 A HU 0300243A HU P0300243 A HUP0300243 A HU P0300243A HU P0300243 A2 HUP0300243 A2 HU P0300243A2
Authority
HU
Hungary
Prior art keywords
dibenzo
preparation
production
azepine derivatives
oxcarbazepine
Prior art date
Application number
HU0300243A
Other languages
English (en)
Inventor
Ulrich Beutler
Peter Fünfschilling
Daniel Kaufmann
Olivier Lohse
Werner Zaugg
Original Assignee
Novartis Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9885081&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0300243(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag. filed Critical Novartis Ag.
Publication of HUP0300243A2 publication Critical patent/HUP0300243A2/hu
Publication of HUP0300243A3 publication Critical patent/HUP0300243A3/hu
Publication of HU229420B1 publication Critical patent/HU229420B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A találmány tárgya új eljárás gyógyászati hatású oxkarbazepinelőállítására, a találmány tárgya továbbá az ezen eljárássalelőállított új intermedierek és eljárás a szóban forgó intermedierekelőállítására. A találmány szerinti (I) általános képletű vegyültek,ahol a képletben R1 jelentése 1-4 szénatomos alkilcsoport és R2jelentése 1-4 szénatomos alkilcsoport vagy fenilcsoport, fontoskiindulási anyagok a gyógyászati hatású oxkarbazepin (Trileptal<)előállítására, mely vegyület az epilepszia kezelésében görcsoldókénthasználható. Ó
HU0300243A 2000-02-07 2001-02-07 Dibenzo [b,f]azepine derivatives and process for their preparation HU229420B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0002740.9A GB0002740D0 (en) 2000-02-07 2000-02-07 Organic compounds
PCT/EP2001/001330 WO2001056992A2 (en) 2000-02-07 2001-02-07 Dibenzo (b,f) azepine intermediates

Publications (3)

Publication Number Publication Date
HUP0300243A2 true HUP0300243A2 (hu) 2003-06-28
HUP0300243A3 HUP0300243A3 (en) 2005-07-28
HU229420B1 HU229420B1 (en) 2013-12-30

Family

ID=9885081

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300243A HU229420B1 (en) 2000-02-07 2001-02-07 Dibenzo [b,f]azepine derivatives and process for their preparation

Country Status (34)

Country Link
US (1) US7112673B2 (hu)
EP (2) EP2067772B1 (hu)
JP (1) JP4859322B2 (hu)
KR (5) KR20080103608A (hu)
CN (2) CN1244563C (hu)
AR (2) AR029442A1 (hu)
AT (2) ATE427938T1 (hu)
AU (1) AU767724B2 (hu)
BR (1) BR0107922A (hu)
CA (3) CA2395601C (hu)
CO (1) CO5271705A1 (hu)
CY (1) CY1111567T1 (hu)
CZ (1) CZ301572B6 (hu)
DE (2) DE60144456D1 (hu)
DK (1) DK2067772T3 (hu)
ES (2) ES2324900T3 (hu)
GB (1) GB0002740D0 (hu)
HK (1) HK1052501A1 (hu)
HU (1) HU229420B1 (hu)
IL (3) IL150613A0 (hu)
MX (1) MXPA02007629A (hu)
MY (1) MY136474A (hu)
NO (1) NO324949B1 (hu)
NZ (1) NZ520329A (hu)
PE (1) PE20011078A1 (hu)
PL (2) PL214039B1 (hu)
PT (2) PT1265868E (hu)
RU (1) RU2303591C2 (hu)
SI (1) SI2067772T1 (hu)
SK (1) SK287217B6 (hu)
TR (1) TR200201655T2 (hu)
TW (1) TWI284638B (hu)
WO (1) WO2001056992A2 (hu)
ZA (1) ZA200206219B (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670472B2 (en) 2001-10-09 2003-12-30 Max India Limited Process for the preparation of 10-methoxycarbamazepine
EP1302464A1 (en) * 2001-10-09 2003-04-16 Max India Limited Process for preparation of 10-methoxycarbamazepine
CA2486560A1 (en) * 2002-06-14 2003-12-24 Taro Pharmaceuticals U.S.A., Inc. Method of preparing a 5h-dibenz[b,f]azepine-5-carboxamide
ITMI20040452A1 (it) 2004-03-09 2004-06-09 Clariant Lsm Italia Spa Processo per la preparazione di oxcarbazepina
GEP20115364B (en) 2005-05-10 2011-12-26 Intermune Inc Method for modulation of stress-activated protein kinase system
MX2008013675A (es) * 2006-04-26 2009-03-06 Supernus Pharmaceuticals Inc Preparaciones de liberacion controlada de oxcarbacepina que tienen perfil de liberacion sigmoidal.
US20090082335A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched oxcarbazepine
ES2567283T3 (es) 2008-06-03 2016-04-21 Intermune, Inc. Compuestos y métodos para tratar trastornos inflamatorios y fibróticos
US20150232426A1 (en) 2012-09-26 2015-08-20 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
WO2015038743A1 (en) * 2013-09-11 2015-03-19 The Administrators Of The Tulane Educational Fund Novel anthranilic amides and the use thereof
MX2016012808A (es) 2014-04-02 2017-01-05 Intermune Inc Piridinonas anti-fibroticas.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847374A (en) * 1987-01-27 1989-07-11 Ciba-Geigy Corporation Process for the manufacture of N,N-(Dibenzohexatrienylene)ureas
IT1272897B (it) * 1995-01-13 1997-07-01 I F C Iniziative Finanziaarie Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide
US6355680B1 (en) * 1996-02-20 2002-03-12 Exocell, Inc. Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies
IT1283594B1 (it) * 1996-04-12 1998-04-22 Trifarma Srl Derivati della 5h-dibenz- (b,f)-azepin-5-carbossiammide, loro preparazione e uso come sostanze ad azione medicinale
NZ501277A (en) * 1997-07-01 2002-12-20 Warner Lambert Co -2(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
US6048856A (en) 1997-12-17 2000-04-11 Novo Nordisk A/S Heterocyclic compounds

Also Published As

Publication number Publication date
IL150613A0 (en) 2003-02-12
EP1265868A2 (en) 2002-12-18
KR20080003016A (ko) 2008-01-04
DE60138271D1 (de) 2009-05-20
EP2067772A3 (en) 2009-08-19
CN100455572C (zh) 2009-01-28
AU4237301A (en) 2001-08-14
CZ301572B6 (cs) 2010-04-21
KR20080103608A (ko) 2008-11-27
MY136474A (en) 2008-10-31
EP2067772B1 (en) 2011-04-13
CN1394204A (zh) 2003-01-29
MXPA02007629A (es) 2002-12-13
AR029442A1 (es) 2003-06-25
TWI284638B (en) 2007-08-01
KR101216285B1 (ko) 2012-12-28
PL356404A1 (en) 2004-06-28
PT1265868E (pt) 2009-07-15
AU767724B2 (en) 2003-11-20
JP4859322B2 (ja) 2012-01-25
CA2639210A1 (en) 2001-08-09
CA2639210C (en) 2011-05-03
ES2324900T3 (es) 2009-08-19
KR20090102882A (ko) 2009-09-30
KR20100018069A (ko) 2010-02-16
JP2003521536A (ja) 2003-07-15
CA2724295C (en) 2011-07-26
NO324949B1 (no) 2008-01-14
US7112673B2 (en) 2006-09-26
CN1721409A (zh) 2006-01-18
HU229420B1 (en) 2013-12-30
KR20020071033A (ko) 2002-09-11
RU2002123334A (ru) 2004-01-10
RU2303591C2 (ru) 2007-07-27
BR0107922A (pt) 2002-10-22
PL217225B1 (pl) 2014-06-30
PE20011078A1 (es) 2001-11-16
NZ520329A (en) 2003-11-28
SK11262002A3 (sk) 2003-02-04
GB0002740D0 (en) 2000-03-29
HK1052501A1 (en) 2003-09-19
AR079237A2 (es) 2012-01-04
CO5271705A1 (es) 2003-04-30
NO20023575D0 (no) 2002-07-26
CA2724295A1 (en) 2001-08-09
PL214039B1 (pl) 2013-06-28
WO2001056992A3 (en) 2002-01-24
CA2395601A1 (en) 2001-08-09
PL392476A1 (pl) 2010-11-22
KR100931753B1 (ko) 2009-12-14
CY1111567T1 (el) 2015-10-07
CN1244563C (zh) 2006-03-08
ATE505459T1 (de) 2011-04-15
IL188183A (en) 2011-02-28
IL150613A (en) 2010-05-17
CZ20022676A3 (cs) 2002-11-13
DE60144456D1 (de) 2011-05-26
SK287217B6 (sk) 2010-03-08
NO20023575L (no) 2002-07-26
US20030032800A1 (en) 2003-02-13
DK2067772T3 (da) 2011-07-18
KR100966209B1 (ko) 2010-06-25
EP2067772A2 (en) 2009-06-10
WO2001056992A2 (en) 2001-08-09
PT2067772E (pt) 2011-07-13
SI2067772T1 (sl) 2011-08-31
HUP0300243A3 (en) 2005-07-28
EP1265868B1 (en) 2009-04-08
TR200201655T2 (tr) 2002-11-21
CA2395601C (en) 2010-01-05
ZA200206219B (en) 2003-04-04
ATE427938T1 (de) 2009-04-15
ES2363490T3 (es) 2011-08-05

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