ATE427938T1 - Herstellung von dibenzoab,fuazepine zwischenprodukte - Google Patents

Herstellung von dibenzoab,fuazepine zwischenprodukte

Info

Publication number
ATE427938T1
ATE427938T1 AT01915203T AT01915203T ATE427938T1 AT E427938 T1 ATE427938 T1 AT E427938T1 AT 01915203 T AT01915203 T AT 01915203T AT 01915203 T AT01915203 T AT 01915203T AT E427938 T1 ATE427938 T1 AT E427938T1
Authority
AT
Austria
Prior art keywords
fuazepine
dibenzoab
preparation
intermediate products
products
Prior art date
Application number
AT01915203T
Other languages
English (en)
Inventor
Nfschilling Peter F
Daniel Kaufmann
Olivier Lohse
Ulrich Beutler
Werner Zaugg
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9885081&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE427938(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE427938T1 publication Critical patent/ATE427938T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT01915203T 2000-02-07 2001-02-07 Herstellung von dibenzoab,fuazepine zwischenprodukte ATE427938T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0002740.9A GB0002740D0 (en) 2000-02-07 2000-02-07 Organic compounds

Publications (1)

Publication Number Publication Date
ATE427938T1 true ATE427938T1 (de) 2009-04-15

Family

ID=9885081

Family Applications (2)

Application Number Title Priority Date Filing Date
AT09153375T ATE505459T1 (de) 2000-02-07 2001-02-07 Dibenzoäb,füazepin-derivate und ihre herstellung
AT01915203T ATE427938T1 (de) 2000-02-07 2001-02-07 Herstellung von dibenzoab,fuazepine zwischenprodukte

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT09153375T ATE505459T1 (de) 2000-02-07 2001-02-07 Dibenzoäb,füazepin-derivate und ihre herstellung

Country Status (34)

Country Link
US (1) US7112673B2 (de)
EP (2) EP1265868B1 (de)
JP (1) JP4859322B2 (de)
KR (5) KR20080103608A (de)
CN (2) CN1244563C (de)
AR (2) AR029442A1 (de)
AT (2) ATE505459T1 (de)
AU (1) AU767724B2 (de)
BR (1) BR0107922A (de)
CA (3) CA2395601C (de)
CO (1) CO5271705A1 (de)
CY (1) CY1111567T1 (de)
CZ (1) CZ301572B6 (de)
DE (2) DE60138271D1 (de)
DK (1) DK2067772T3 (de)
ES (2) ES2324900T3 (de)
GB (1) GB0002740D0 (de)
HK (1) HK1052501A1 (de)
HU (1) HU229420B1 (de)
IL (3) IL150613A0 (de)
MX (1) MXPA02007629A (de)
MY (1) MY136474A (de)
NO (1) NO324949B1 (de)
NZ (1) NZ520329A (de)
PE (1) PE20011078A1 (de)
PL (2) PL214039B1 (de)
PT (2) PT1265868E (de)
RU (1) RU2303591C2 (de)
SI (1) SI2067772T1 (de)
SK (1) SK287217B6 (de)
TR (1) TR200201655T2 (de)
TW (1) TWI284638B (de)
WO (1) WO2001056992A2 (de)
ZA (1) ZA200206219B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1302464A1 (de) * 2001-10-09 2003-04-16 Max India Limited Verfahren zur Herstellung von 10-Methoxycarbamazepin
CA2407173C (en) 2001-10-09 2009-09-29 Max India Limited Process for the preparation of 10-methoxycarbamazepine
IL165694A0 (en) * 2002-06-14 2006-01-15 Taro Pharmaceuticals Usa Inc Method of preparing a 5h-dibenzÄb,fÜazepine-5-carboxamide
ITMI20040452A1 (it) 2004-03-09 2004-06-09 Clariant Lsm Italia Spa Processo per la preparazione di oxcarbazepina
PL1928454T3 (pl) 2005-05-10 2015-03-31 Intermune Inc Pochodne pirydonu do modulowania układu kinazy białkowej aktywowanego stresem
MX2008013675A (es) * 2006-04-26 2009-03-06 Supernus Pharmaceuticals Inc Preparaciones de liberacion controlada de oxcarbacepina que tienen perfil de liberacion sigmoidal.
US20090082335A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched oxcarbazepine
CA3034994A1 (en) 2008-06-03 2009-12-10 Intermune, Inc. Substituted aryl-2 pyridone compounds and use thereof for treating inflammatory and fibrotic disorders
US20150232426A1 (en) 2012-09-26 2015-08-20 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CA2923835C (en) * 2013-09-11 2022-11-29 The Administrators Of The Tulane Educational Fund Novel anthranilic amides and the use thereof
KR102373700B1 (ko) 2014-04-02 2022-03-11 인터뮨, 인크. 항섬유성 피리디논

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847374A (en) * 1987-01-27 1989-07-11 Ciba-Geigy Corporation Process for the manufacture of N,N-(Dibenzohexatrienylene)ureas
IT1272897B (it) * 1995-01-13 1997-07-01 I F C Iniziative Finanziaarie Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide
US6355680B1 (en) * 1996-02-20 2002-03-12 Exocell, Inc. Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies
IT1283594B1 (it) * 1996-04-12 1998-04-22 Trifarma Srl Derivati della 5h-dibenz- (b,f)-azepin-5-carbossiammide, loro preparazione e uso come sostanze ad azione medicinale
NZ501277A (en) * 1997-07-01 2002-12-20 Warner Lambert Co -2(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
US6048856A (en) * 1997-12-17 2000-04-11 Novo Nordisk A/S Heterocyclic compounds

Also Published As

Publication number Publication date
KR20090102882A (ko) 2009-09-30
GB0002740D0 (en) 2000-03-29
HK1052501A1 (en) 2003-09-19
NZ520329A (en) 2003-11-28
EP1265868A2 (de) 2002-12-18
KR20080103608A (ko) 2008-11-27
CO5271705A1 (es) 2003-04-30
ZA200206219B (en) 2003-04-04
BR0107922A (pt) 2002-10-22
AU4237301A (en) 2001-08-14
CN100455572C (zh) 2009-01-28
CA2724295A1 (en) 2001-08-09
KR101216285B1 (ko) 2012-12-28
US7112673B2 (en) 2006-09-26
EP2067772B1 (de) 2011-04-13
MY136474A (en) 2008-10-31
CY1111567T1 (el) 2015-10-07
ES2324900T3 (es) 2009-08-19
KR20080003016A (ko) 2008-01-04
KR20100018069A (ko) 2010-02-16
IL150613A0 (en) 2003-02-12
NO20023575D0 (no) 2002-07-26
DE60138271D1 (de) 2009-05-20
CA2724295C (en) 2011-07-26
CA2639210A1 (en) 2001-08-09
JP2003521536A (ja) 2003-07-15
AU767724B2 (en) 2003-11-20
CA2395601C (en) 2010-01-05
DK2067772T3 (da) 2011-07-18
SK287217B6 (sk) 2010-03-08
PL356404A1 (en) 2004-06-28
HU229420B1 (en) 2013-12-30
KR100931753B1 (ko) 2009-12-14
CZ20022676A3 (cs) 2002-11-13
DE60144456D1 (de) 2011-05-26
RU2002123334A (ru) 2004-01-10
TR200201655T2 (tr) 2002-11-21
EP2067772A3 (de) 2009-08-19
ATE505459T1 (de) 2011-04-15
KR100966209B1 (ko) 2010-06-25
NO324949B1 (no) 2008-01-14
CN1394204A (zh) 2003-01-29
WO2001056992A3 (en) 2002-01-24
IL188183A (en) 2011-02-28
CA2639210C (en) 2011-05-03
MXPA02007629A (es) 2002-12-13
US20030032800A1 (en) 2003-02-13
PL217225B1 (pl) 2014-06-30
PT2067772E (pt) 2011-07-13
CN1244563C (zh) 2006-03-08
PT1265868E (pt) 2009-07-15
SI2067772T1 (sl) 2011-08-31
JP4859322B2 (ja) 2012-01-25
PL392476A1 (pl) 2010-11-22
IL150613A (en) 2010-05-17
CZ301572B6 (cs) 2010-04-21
PL214039B1 (pl) 2013-06-28
WO2001056992A2 (en) 2001-08-09
PE20011078A1 (es) 2001-11-16
EP1265868B1 (de) 2009-04-08
KR20020071033A (ko) 2002-09-11
CN1721409A (zh) 2006-01-18
HUP0300243A3 (en) 2005-07-28
HUP0300243A2 (hu) 2003-06-28
CA2395601A1 (en) 2001-08-09
EP2067772A2 (de) 2009-06-10
AR029442A1 (es) 2003-06-25
SK11262002A3 (sk) 2003-02-04
TWI284638B (en) 2007-08-01
NO20023575L (no) 2002-07-26
AR079237A2 (es) 2012-01-04
RU2303591C2 (ru) 2007-07-27
ES2363490T3 (es) 2011-08-05

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