HUP0401886A2 - Kemokin receptor aktivitás modulátorokként alkalmazható piperidinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Kemokin receptor aktivitás modulátorokként alkalmazható piperidinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0401886A2
HUP0401886A2 HU0401886A HUP0401886A HUP0401886A2 HU P0401886 A2 HUP0401886 A2 HU P0401886A2 HU 0401886 A HU0401886 A HU 0401886A HU P0401886 A HUP0401886 A HU P0401886A HU P0401886 A2 HUP0401886 A2 HU P0401886A2
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HU
Hungary
Prior art keywords
group
optionally substituted
modulators
preparation
pharmaceutical compositions
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HU0401886A
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English (en)
Inventor
Richard Evans
Matthew Perry
Brian Springthorpe
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Astrazeneca Ab,
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Publication date
Priority claimed from GB0116179A external-priority patent/GB0116179D0/en
Priority claimed from GB0123037A external-priority patent/GB0123037D0/en
Application filed by Astrazeneca Ab, filed Critical Astrazeneca Ab,
Publication of HUP0401886A2 publication Critical patent/HUP0401886A2/hu

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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Abstract

A találmány tárgyát az általános képletű vegyületek képezik - ahol T=C=(O), vagy -S(O)2 csoport; W =C=(O) vagy -S(O)2 csoport, Xmetinilcsoport, oxigénatom vagy iminocsoport; Y -CR5- általánosképletű csoport vagy nitrogénatom; R1 adott esetben szubsztituáltaril- vagy adott esetben szubsztituált heterociklikus csoport; R2hidrogénatom vagy 1-6 szénatomos alkilcsoport; R3 hidrogénatom vagyadott esetben szubsztituált 1-6 szénatomos alkilcsoport; és R4 alkil-,adott esetben szubsztituált aril-, adott esetben szubsztituált aril-alkil- vagy adott esetben szubsztituált heterociklikus csoport -amelyek a kemokin (különösen a CCR3) aktivitás modulátorai és amelyekkülönösen hasznosak az asztma és/vagy rinitisz kezelésénél. Atalálmány kiterjed a vegyületek előállítására és ezeket tartalmazógyógyszerkészítményekre is. Ó
HU0401886A 2001-07-02 2002-07-01 Kemokin receptor aktivitás modulátorokként alkalmazható piperidinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények HUP0401886A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0116179A GB0116179D0 (en) 2001-07-02 2001-07-02 Chemical compounds
GB0123037A GB0123037D0 (en) 2001-09-25 2001-09-25 Chemical compounds
PCT/SE2002/001311 WO2003004487A1 (en) 2001-07-02 2002-07-01 Piperidine derivatives useful as modulators of chemokine receptor activity

Publications (1)

Publication Number Publication Date
HUP0401886A2 true HUP0401886A2 (hu) 2004-12-28

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HU0401886A HUP0401886A2 (hu) 2001-07-02 2002-07-01 Kemokin receptor aktivitás modulátorokként alkalmazható piperidinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

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US (1) US7307090B2 (hu)
EP (2) EP1604982A1 (hu)
JP (1) JP3857270B2 (hu)
KR (1) KR20040013090A (hu)
CN (1) CN1545509A (hu)
AR (1) AR042401A1 (hu)
AT (1) ATE319703T1 (hu)
BR (1) BR0210733A (hu)
CA (1) CA2452597A1 (hu)
CO (1) CO5540307A2 (hu)
CY (1) CY1106095T1 (hu)
DE (1) DE60209736T2 (hu)
DK (1) DK1404667T3 (hu)
ES (1) ES2258642T3 (hu)
HK (1) HK1062559A1 (hu)
HU (1) HUP0401886A2 (hu)
IL (1) IL159256A0 (hu)
IS (1) IS7094A (hu)
MX (1) MXPA03011722A (hu)
NO (1) NO20035729L (hu)
NZ (1) NZ530202A (hu)
PL (1) PL368041A1 (hu)
PT (1) PT1404667E (hu)
RU (1) RU2004100839A (hu)
SA (1) SA02230184B1 (hu)
WO (1) WO2003004487A1 (hu)

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PT1404667E (pt) 2006-07-31
IL159256A0 (en) 2004-06-01
CO5540307A2 (es) 2005-07-29
JP2004536112A (ja) 2004-12-02
RU2004100839A (ru) 2005-06-20
AR042401A1 (es) 2005-06-22
US20040235894A1 (en) 2004-11-25
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SA02230184B1 (ar) 2007-03-25
CY1106095T1 (el) 2011-06-08
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CA2452597A1 (en) 2003-01-16
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EP1404667A1 (en) 2004-04-07
EP1604982A1 (en) 2005-12-14
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BR0210733A (pt) 2004-07-20
DE60209736D1 (de) 2006-05-04
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