HUP0101640A3 - Certain thoil inhibitors of endothelin-converting enzyme - Google Patents

Certain thoil inhibitors of endothelin-converting enzyme

Info

Publication number: HUP0101640A3
Authority: HU; Hungary
Prior art keywords: thoil; endothelin; inhibitors; certain; converting enzyme
Prior art date: 1998-04-23

Application number

HU0101640A

Other languages

English (en)

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-23

Filing date

1999-04-21

Publication date

2002-10-28

1999-04-21 Application filed by Novartis Ag filed Critical Novartis Ag

2001-09-28 Publication of HUP0101640A2 publication Critical patent/HUP0101640A2/hu

2002-10-28 Publication of HUP0101640A3 publication Critical patent/HUP0101640A3/hu

Links

102000048186 Endothelin-converting enzyme 1 Human genes 0.000 title 1
108030001679 Endothelin-converting enzyme 1 Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

HU0101640A 1998-04-23 1999-04-21 Certain thoil inhibitors of endothelin-converting enzyme HUP0101640A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6526598A	1998-04-23	1998-04-23
PCT/EP1999/002690 WO1999055726A1 (en)	1998-04-23	1999-04-21	Certain thiol inhibitors of endothelin-converting enzyme

Publications (2)

Publication Number	Publication Date
HUP0101640A2 HUP0101640A2 (hu)	2001-09-28
HUP0101640A3 true HUP0101640A3 (en)	2002-10-28

Family

ID=22061502

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0101640A HUP0101640A3 (en)	1998-04-23	1999-04-21	Certain thoil inhibitors of endothelin-converting enzyme

Country Status (16)

Country	Link
EP (1)	EP1073674A1 (hu)
JP (1)	JP4350306B2 (hu)
KR (1)	KR20010034816A (hu)
CN (1)	CN1297453A (hu)
AU (1)	AU3819999A (hu)
BR (1)	BR9909805A (hu)
CA (1)	CA2323691A1 (hu)
HU (1)	HUP0101640A3 (hu)
ID (1)	ID26822A (hu)
IL (1)	IL138246A0 (hu)
NO (1)	NO20005293L (hu)
PL (1)	PL343594A1 (hu)
RU (1)	RU2000129510A (hu)
SK (1)	SK15812000A3 (hu)
WO (1)	WO1999055726A1 (hu)
ZA (1)	ZA200004680B (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6423727B1 (en)	1998-04-23	2002-07-23	Novartis Ag	Certain thiol inhibitors of endothelin-converting enzyme
US6426354B1 (en)	1998-04-23	2002-07-30	Novartis Ag	Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
WO2001077095A2 (en) *	2000-04-06	2001-10-18	Novartis Ag	Derivatives of alpha-mercaptoacetamide
US6777443B2 (en) *	2001-05-15	2004-08-17	Novartis Ag	Dipeptide derivatives
PT1430045E (pt) *	2001-09-21	2007-01-31	Novartis Ag	Derivados de pirano como inibidores de ace e nep
CA2473778A1 (en)	2002-02-08	2003-08-14	Merck & Co., Inc.	N-biphenylmethyl aminocycloalkanecarboxamide derivatives
AR038377A1 (es)	2002-02-08	2005-01-12	Merck & Co Inc	Derivados de n-bifenil-aminocicloalcancarboxamida (con sustitucion con metilo)
EP1481967B1 (en)	2002-03-05	2011-05-04	Sumitomo Chemical Company, Limited	Process for the preparation of biaryl compounds
US20060183753A1 (en) *	2002-12-20	2006-08-17	Bayer Healthcare Ag	Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
US7427611B2 (en)	2003-09-26	2008-09-23	Solvay Pharmaceuticals Gmbh	Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7262184B2 (en)	2003-09-26	2007-08-28	Solvay Pharmaceuticals Gmbh	Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7452875B2 (en)	2003-09-26	2008-11-18	Solvay Pharmaceuticals Gmbh	Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
CN101076339B (zh) *	2004-01-12	2011-02-09	索尔瓦药物有限公司	用于预防和治疗神经变性疾病的中性内肽酶(NEP)和人可溶内肽酶(hSEP)抑制剂
US8829209B2 (en)	2006-01-11	2014-09-09	Seikagaku Corporation	Cycloalkylcarbonylamino acid ester derivative and process for producing the same
JP4047365B2 (ja)	2006-01-11	2008-02-13	生化学工業株式会社	シクロアルカンカルボキサミド誘導体及びその製造方法
JP3975226B2 (ja)	2006-01-11	2007-09-12	生化学工業株式会社	シクロアルキルカルボニルアミノ酸誘導体及びその製造方法
EP2234608A2 (en)	2007-12-11	2010-10-06	Viamet Pharmaceuticals, Inc.	Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
CN104725279B (zh) *	2015-02-12	2018-03-02	威海迪素制药有限公司	一种N‑Boc‑联苯丙氨酸衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU691201B2 (en) *	1993-11-01	1998-05-14	Japat Ltd.	Endothelin receptor antagonists
ES2148305T3 (es) *	1993-11-16	2000-10-16	Novartis Ag	Derivados de aminoacidos ciclicos que tienen actividad inhibidora de ace y nep.
FR2745571B1 (fr) *	1996-03-04	1998-06-19	Inst Nat Sante Rech Med	Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant

1999
- 1999-04-21 IL IL13824699A patent/IL138246A0/xx unknown
- 1999-04-21 AU AU38199/99A patent/AU3819999A/en not_active Abandoned
- 1999-04-21 JP JP2000545884A patent/JP4350306B2/ja not_active Expired - Fee Related
- 1999-04-21 PL PL99343594A patent/PL343594A1/xx not_active Application Discontinuation
- 1999-04-21 WO PCT/EP1999/002690 patent/WO1999055726A1/en not_active Application Discontinuation
- 1999-04-21 CA CA002323691A patent/CA2323691A1/en not_active Abandoned
- 1999-04-21 SK SK1581-2000A patent/SK15812000A3/sk unknown
- 1999-04-21 BR BR9909805-9A patent/BR9909805A/pt not_active IP Right Cessation
- 1999-04-21 EP EP99920729A patent/EP1073674A1/en not_active Withdrawn
- 1999-04-21 HU HU0101640A patent/HUP0101640A3/hu unknown
- 1999-04-21 CN CN99805180A patent/CN1297453A/zh active Pending
- 1999-04-21 RU RU2000129510/04A patent/RU2000129510A/ru not_active Application Discontinuation
- 1999-04-21 ID IDW20002106A patent/ID26822A/id unknown
- 1999-04-21 KR KR1020007011725A patent/KR20010034816A/ko not_active Application Discontinuation
2000
- 2000-09-06 ZA ZA200004680A patent/ZA200004680B/en unknown
- 2000-10-20 NO NO20005293A patent/NO20005293L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
IL138246A0 (en)	2001-10-31
ID26822A (id)	2001-02-15
WO1999055726A1 (en)	1999-11-04
JP2002513032A (ja)	2002-05-08
EP1073674A1 (en)	2001-02-07
HUP0101640A2 (hu)	2001-09-28
AU3819999A (en)	1999-11-16
KR20010034816A (ko)	2001-04-25
NO20005293L (no)	2000-12-18
CN1297453A (zh)	2001-05-30
NO20005293D0 (no)	2000-10-20
JP4350306B2 (ja)	2009-10-21
SK15812000A3 (sk)	2001-03-12
PL343594A1 (en)	2001-08-27
ZA200004680B (en)	2001-04-25
BR9909805A (pt)	2000-12-26
RU2000129510A (ru)	2002-11-10
CA2323691A1 (en)	1999-11-04

Publication	Publication Date	Title
IL137719A0 (en)	2001-10-31	Inhibitors of phospholipase enzymes
IL137718A0 (en)	2001-10-31	Inhibitors of phospholipase enzymes
EP1127054A4 (en)	2006-11-02	INHIBITORS OF IMPDH ENZYME
IL138387A0 (en)	2001-10-31	Enzyme inhibitors
AU3665199A (en)	1999-11-16	Inhibitors of impdh enzyme
AP9700973A0 (en)	1997-07-31	Inhibitors of IMPDH enzyme
AP9701054A0 (en)	1997-10-31	Inhibitors of cycteine protease
PL350911A1 (en)	2003-02-10	Inhibitors of impdh enzyme
PL349192A1 (en)	2002-07-01	Protease inhibitors
PL334846A1 (en)	2000-03-27	Sulphamidic inhibitors of metaloproteases
IL133368A0 (en)	2001-04-30	Urokinase inhibitors
HUP0101640A3 (en)	2002-10-28	Certain thoil inhibitors of endothelin-converting enzyme
PL337725A1 (en)	2000-08-28	Inhibitors of proteases
PL328665A1 (en)	1999-02-15	Inhibitors of serinic protease
PL334975A1 (en)	2000-03-27	Application of gasto-intestinal lipase inhibitors
AU3124300A (en)	2000-07-03	Inhibitors of beta-lactamases and uses therefor
AU9059798A (en)	2000-04-10	Urokinase inhibitors
EP0994707A4 (en)	2001-11-14	INHIBITORS OF NAALADASE ENZYMATIC ACTIVITY
AU2190400A (en)	2000-07-03	Inhibitors of beta-lactamases and uses therefor
GB9425701D0 (en)	1995-02-22	Enzyme inhibitors
EP1067894A4 (en)	2004-09-08	PROTHEASEINHIBITOREN
ZA983065B (en)	1998-10-20	Inhibitors of protein farnesyltranferase
EP1079821A4 (en)	2001-08-29	PROTEASE INHIBITORS
AU9624398A (en)	1999-03-29	Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors
GB9924522D0 (en)	1999-12-15	Enzyme inhibitors