HUP0101640A3 - Certain thoil inhibitors of endothelin-converting enzyme - Google Patents
Certain thoil inhibitors of endothelin-converting enzymeInfo
- Publication number
- HUP0101640A3 HUP0101640A3 HU0101640A HUP0101640A HUP0101640A3 HU P0101640 A3 HUP0101640 A3 HU P0101640A3 HU 0101640 A HU0101640 A HU 0101640A HU P0101640 A HUP0101640 A HU P0101640A HU P0101640 A3 HUP0101640 A3 HU P0101640A3
- Authority
- HU
- Hungary
- Prior art keywords
- thoil
- endothelin
- inhibitors
- certain
- converting enzyme
- Prior art date
Links
- 102000048186 Endothelin-converting enzyme 1 Human genes 0.000 title 1
- 108030001679 Endothelin-converting enzyme 1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6526598A | 1998-04-23 | 1998-04-23 | |
PCT/EP1999/002690 WO1999055726A1 (en) | 1998-04-23 | 1999-04-21 | Certain thiol inhibitors of endothelin-converting enzyme |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0101640A2 HUP0101640A2 (en) | 2001-09-28 |
HUP0101640A3 true HUP0101640A3 (en) | 2002-10-28 |
Family
ID=22061502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0101640A HUP0101640A3 (en) | 1998-04-23 | 1999-04-21 | Certain thoil inhibitors of endothelin-converting enzyme |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1073674A1 (en) |
JP (1) | JP4350306B2 (en) |
KR (1) | KR20010034816A (en) |
CN (1) | CN1297453A (en) |
AU (1) | AU3819999A (en) |
BR (1) | BR9909805A (en) |
CA (1) | CA2323691A1 (en) |
HU (1) | HUP0101640A3 (en) |
ID (1) | ID26822A (en) |
IL (1) | IL138246A0 (en) |
NO (1) | NO20005293L (en) |
PL (1) | PL343594A1 (en) |
RU (1) | RU2000129510A (en) |
SK (1) | SK15812000A3 (en) |
WO (1) | WO1999055726A1 (en) |
ZA (1) | ZA200004680B (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6426354B1 (en) | 1998-04-23 | 2002-07-30 | Novartis Ag | Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme |
US6423727B1 (en) | 1998-04-23 | 2002-07-23 | Novartis Ag | Certain thiol inhibitors of endothelin-converting enzyme |
WO2001077095A2 (en) * | 2000-04-06 | 2001-10-18 | Novartis Ag | Derivatives of alpha-mercaptoacetamide |
US6777443B2 (en) | 2001-05-15 | 2004-08-17 | Novartis Ag | Dipeptide derivatives |
CN1304415C (en) * | 2001-09-21 | 2007-03-14 | 诺瓦提斯公司 | Pyrane derivatives as both ACE- and NEP- inhibitors |
EP1476419B1 (en) | 2002-02-08 | 2006-02-01 | Merck & Co., Inc. | N-biphenylmethyl aminocycloalkanecarboxamide derivatives |
AR038377A1 (en) | 2002-02-08 | 2005-01-12 | Merck & Co Inc | DERIVATIVES OF N-BIFENIL-AMINOCICLOALCANCARBOXAMIDA (WITH REPLACEMENT WITH METHYL) |
EP2161254B1 (en) | 2002-03-05 | 2014-08-13 | Sumitomo Chemical Company, Limited | Intermediate for preparing a biaryl compound |
CA2510811A1 (en) * | 2002-12-20 | 2004-07-08 | Bayer Healthcare Ag | Use of substituted 2,5-diamidoindoles for the treatment of urological diseases |
US7262184B2 (en) | 2003-09-26 | 2007-08-28 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them |
US7452875B2 (en) | 2003-09-26 | 2008-11-18 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them |
US7427611B2 (en) | 2003-09-26 | 2008-09-23 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them |
JP4951350B2 (en) * | 2004-01-12 | 2012-06-13 | アボツト・ヘルスケア・プロダクツ・ベー・ブイ | Neutral endopeptidase (NEP) and human soluble endopeptidase (HSEP) inhibitors for the prevention and treatment of neurodegenerative disorders |
JP3975226B2 (en) | 2006-01-11 | 2007-09-12 | 生化学工業株式会社 | Cycloalkylcarbonylamino acid derivative and process for producing the same |
JP4047365B2 (en) | 2006-01-11 | 2008-02-13 | 生化学工業株式会社 | Cycloalkanecarboxamide derivative and method for producing the same |
CA2636765C (en) * | 2006-01-11 | 2014-03-18 | Seikagaku Corporation | Cycloalkylcarbonylamino acid ester derivative and process for producing the same |
US20110015158A1 (en) | 2007-12-11 | 2011-01-20 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties |
CN104725279B (en) * | 2015-02-12 | 2018-03-02 | 威海迪素制药有限公司 | A kind of preparation method of N Boc biphenylalanine derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0728145A1 (en) * | 1993-11-01 | 1996-08-28 | Ciba-Geigy Japan Limited | Endothelin receptor antagonists |
ES2148305T3 (en) * | 1993-11-16 | 2000-10-16 | Novartis Ag | DERIVATIVES OF CYCLE AMINO ACIDS THAT HAVE ACE AND NEP INHIBITING ACTIVITY. |
FR2745571B1 (en) * | 1996-03-04 | 1998-06-19 | Inst Nat Sante Rech Med | NOVEL SULFUR DERIVATIVES COMPRISING AN AMIDE BINDING, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS, AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
1999
- 1999-04-21 HU HU0101640A patent/HUP0101640A3/en unknown
- 1999-04-21 SK SK1581-2000A patent/SK15812000A3/en unknown
- 1999-04-21 JP JP2000545884A patent/JP4350306B2/en not_active Expired - Fee Related
- 1999-04-21 PL PL99343594A patent/PL343594A1/en not_active Application Discontinuation
- 1999-04-21 ID IDW20002106A patent/ID26822A/en unknown
- 1999-04-21 WO PCT/EP1999/002690 patent/WO1999055726A1/en not_active Application Discontinuation
- 1999-04-21 AU AU38199/99A patent/AU3819999A/en not_active Abandoned
- 1999-04-21 CN CN99805180A patent/CN1297453A/en active Pending
- 1999-04-21 CA CA002323691A patent/CA2323691A1/en not_active Abandoned
- 1999-04-21 BR BR9909805-9A patent/BR9909805A/en not_active IP Right Cessation
- 1999-04-21 RU RU2000129510/04A patent/RU2000129510A/en not_active Application Discontinuation
- 1999-04-21 EP EP99920729A patent/EP1073674A1/en not_active Withdrawn
- 1999-04-21 IL IL13824699A patent/IL138246A0/en unknown
- 1999-04-21 KR KR1020007011725A patent/KR20010034816A/en not_active Application Discontinuation
-
2000
- 2000-09-06 ZA ZA200004680A patent/ZA200004680B/en unknown
- 2000-10-20 NO NO20005293A patent/NO20005293L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2002513032A (en) | 2002-05-08 |
SK15812000A3 (en) | 2001-03-12 |
KR20010034816A (en) | 2001-04-25 |
JP4350306B2 (en) | 2009-10-21 |
IL138246A0 (en) | 2001-10-31 |
AU3819999A (en) | 1999-11-16 |
PL343594A1 (en) | 2001-08-27 |
NO20005293D0 (en) | 2000-10-20 |
EP1073674A1 (en) | 2001-02-07 |
CN1297453A (en) | 2001-05-30 |
ID26822A (en) | 2001-02-15 |
ZA200004680B (en) | 2001-04-25 |
RU2000129510A (en) | 2002-11-10 |
WO1999055726A1 (en) | 1999-11-04 |
HUP0101640A2 (en) | 2001-09-28 |
BR9909805A (en) | 2000-12-26 |
CA2323691A1 (en) | 1999-11-04 |
NO20005293L (en) | 2000-12-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL137719A0 (en) | Inhibitors of phospholipase enzymes | |
IL137718A0 (en) | Inhibitors of phospholipase enzymes | |
EP1127054A4 (en) | Novel inhibitors of impdh enzyme | |
IL138387A0 (en) | Enzyme inhibitors | |
AU3665199A (en) | Inhibitors of impdh enzyme | |
AP9700973A0 (en) | Inhibitors of IMPDH enzyme | |
AP9701054A0 (en) | Inhibitors of cycteine protease | |
PL350911A1 (en) | Inhibitors of impdh enzyme | |
PL349192A1 (en) | Protease inhibitors | |
PL334846A1 (en) | Sulphamidic inhibitors of metaloproteases | |
IL133368A0 (en) | Urokinase inhibitors | |
HUP0101640A3 (en) | Certain thoil inhibitors of endothelin-converting enzyme | |
PL337725A1 (en) | Inhibitors of proteases | |
EP1093367A4 (en) | Protease inhibitors | |
PL328665A1 (en) | Inhibitors of serinic protease | |
PL334975A1 (en) | Application of gasto-intestinal lipase inhibitors | |
AU9059798A (en) | Urokinase inhibitors | |
EP0994707A4 (en) | Inhibitors of naaladase enzyme activity | |
AU2190400A (en) | Inhibitors of beta-lactamases and uses therefor | |
GB9425701D0 (en) | Enzyme inhibitors | |
EP1067894A4 (en) | Protease inhibitors | |
ZA983065B (en) | Inhibitors of protein farnesyltranferase | |
EP1079821A4 (en) | Protease inhibitors | |
AU9624398A (en) | Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors | |
GB9924522D0 (en) | Enzyme inhibitors |