AU9624398A - Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors - Google Patents

Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors

Info

Publication number
AU9624398A
AU9624398A AU96243/98A AU9624398A AU9624398A AU 9624398 A AU9624398 A AU 9624398A AU 96243/98 A AU96243/98 A AU 96243/98A AU 9624398 A AU9624398 A AU 9624398A AU 9624398 A AU9624398 A AU 9624398A
Authority
AU
Australia
Prior art keywords
pyrrolopyrrolidine
derivatives
protease inhibitors
serine protease
serine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU96243/98A
Inventor
Steven John Coote
Michael Dennis Dowle
Harry Finch
Michael Menteith Hann
Henry Anderson Kelly
Simon John Fawcett Macdonald
Neil Anthony Pegg
Nigel Grahame Ramsden
Nigel Stephen Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU9624398A publication Critical patent/AU9624398A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
AU96243/98A 1997-09-09 1998-09-07 Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors Abandoned AU9624398A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9719161.3A GB9719161D0 (en) 1997-09-09 1997-09-09 New therapeutic method
GB9719161 1997-09-09
PCT/EP1998/005744 WO1999012935A1 (en) 1997-09-09 1998-09-07 Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors

Publications (1)

Publication Number Publication Date
AU9624398A true AU9624398A (en) 1999-03-29

Family

ID=10818801

Family Applications (1)

Application Number Title Priority Date Filing Date
AU96243/98A Abandoned AU9624398A (en) 1997-09-09 1998-09-07 Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors

Country Status (5)

Country Link
EP (1) EP1015456A1 (en)
JP (1) JP2001515906A (en)
AU (1) AU9624398A (en)
GB (1) GB9719161D0 (en)
WO (1) WO1999012935A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221914B1 (en) 1997-11-10 2001-04-24 Array Biopharma Inc. Sulfonamide bridging compounds that inhibit tryptase activity
US6335324B1 (en) 1998-06-25 2002-01-01 Bristol-Myers Squibb Co. Beta lactam compounds and their use as inhibitors of tryptase
GB9821199D0 (en) * 1998-09-30 1998-11-25 Glaxo Group Ltd Chemical compounds
US20040235792A1 (en) * 2001-01-20 2004-11-25 Deadman John J Serine protease inhibitors compromising a hydrogen-bond acceptor
EP1325962A1 (en) * 2001-12-17 2003-07-09 Gentium S.p.A. A method for determining the biological activity of defibrotide
WO2004050637A2 (en) 2002-12-03 2004-06-17 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
US7138412B2 (en) 2003-03-11 2006-11-21 Bristol-Myers Squibb Company Tetrahydroquinoline derivatives useful as serine protease inhibitors
US7129264B2 (en) * 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
US7417063B2 (en) 2004-04-13 2008-08-26 Bristol-Myers Squibb Company Bicyclic heterocycles useful as serine protease inhibitors
CA2813413C (en) 2010-11-12 2018-03-06 Gentium S.P.A. Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (gvhd)
DK2864496T4 (en) 2012-06-22 2021-01-04 Gentium S R L EUGLOBULIN-BASED PROCEDURE FOR DETERMINING THE BIOLOGICAL ACTIVITY OF DEFIBROTID
EP3026122A1 (en) 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003278A1 (en) * 1993-07-26 1995-02-02 Zaidan Hojin Biseibutsu Kagaku Kenkyukai Pyrrolidine derivative or pharmaceutically acceptable salt thereof
DE69530683T2 (en) * 1994-03-11 2004-03-25 Pharmacopeia, Inc. SULPHONAMIDE DERIVATIVES AND THEIR USE
US6124291A (en) * 1996-06-18 2000-09-26 Warner-Lambert Company Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors
EP0973775A1 (en) * 1997-04-02 2000-01-26 Glaxo Group Limited Pyrolopyrrolone derivatives

Also Published As

Publication number Publication date
WO1999012935A1 (en) 1999-03-18
EP1015456A1 (en) 2000-07-05
GB9719161D0 (en) 1997-11-12
JP2001515906A (en) 2001-09-25

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase