HUP0001843A3 - Process for synthesis of nucleoside analogs - Google Patents

Process for synthesis of nucleoside analogs

Info

Publication number
HUP0001843A3
HUP0001843A3 HU0001843A HUP0001843A HUP0001843A3 HU P0001843 A3 HUP0001843 A3 HU P0001843A3 HU 0001843 A HU0001843 A HU 0001843A HU P0001843 A HUP0001843 A HU P0001843A HU P0001843 A3 HUP0001843 A3 HU P0001843A3
Authority
HU
Hungary
Prior art keywords
synthesis
nucleoside analogs
nucleoside
analogs
Prior art date
Application number
HU0001843A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of HU0001843D0 publication Critical patent/HU0001843D0/hu
Publication of HUP0001843A2 publication Critical patent/HUP0001843A2/hu
Publication of HUP0001843A3 publication Critical patent/HUP0001843A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
HU0001843A 1999-05-11 2000-05-10 Process for synthesis of nucleoside analogs HUP0001843A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13365199P 1999-05-11 1999-05-11

Publications (3)

Publication Number Publication Date
HU0001843D0 HU0001843D0 (en) 2000-07-28
HUP0001843A2 HUP0001843A2 (hu) 2001-06-28
HUP0001843A3 true HUP0001843A3 (en) 2001-09-28

Family

ID=22459680

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001843A HUP0001843A3 (en) 1999-05-11 2000-05-10 Process for synthesis of nucleoside analogs

Country Status (22)

Country Link
US (1) US6271370B1 (hu)
EP (1) EP1052264B1 (hu)
JP (1) JP2001011092A (hu)
KR (1) KR100403900B1 (hu)
CN (1) CN1275575A (hu)
AR (1) AR028991A1 (hu)
AT (1) ATE291582T1 (hu)
AU (1) AU3401100A (hu)
BR (1) BR0002089A (hu)
CA (1) CA2307951A1 (hu)
CZ (1) CZ20001710A3 (hu)
DE (1) DE60018833D1 (hu)
HU (1) HUP0001843A3 (hu)
ID (1) ID25992A (hu)
IL (1) IL136027A0 (hu)
IN (1) IN186850B (hu)
MX (1) MXPA00004532A (hu)
PL (1) PL340109A1 (hu)
RU (1) RU2200738C2 (hu)
TR (1) TR200001340A2 (hu)
YU (1) YU25500A (hu)
ZA (1) ZA200002263B (hu)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
MX2007013715A (es) 2005-05-05 2008-01-28 Ardea Biosciences Inc Diaril-purinas, azapurinas y deazapurinas como inhibidores no nucleosidos de transcriptasa inversa para el tratamiento del virus de inmunodeficiencia humana.
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
GB0516313D0 (en) 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
RU2442771C2 (ru) 2005-08-08 2012-02-20 Арджента Дискавери Лтд Производные бицикло[2,2,1]гепт-7-иламина и их применения
EP2532679B1 (en) 2005-10-21 2017-04-12 Novartis AG Human antibodies against il13 and therapeutic uses
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
CN101516885A (zh) 2006-09-29 2009-08-26 诺瓦提斯公司 作为pi3k脂质激酶抑制剂的吡唑并嘧啶类化合物
WO2008052734A1 (en) 2006-10-30 2008-05-08 Novartis Ag Heterocyclic compounds as antiinflammatory agents
DE602008005796D1 (de) 2007-12-14 2011-05-05 Pulmagen Therapeutics Asthma Ltd Indole und ihre therapeutische verwendung
EP2220091B1 (en) * 2007-12-14 2012-07-25 Ardea Biosciences, Inc. Reverse transcriptase inhibitors
EA201001129A1 (ru) 2008-01-11 2011-02-28 Новартис Аг Пиримидины в качестве ингибиторов киназы
ES2396023T3 (es) 2009-01-29 2013-02-18 Novartis Ag Bencimidazoles sustituidos para el tratamiento de astrocitomas
CN102395586A (zh) 2009-02-17 2012-03-28 奇斯药制品公司 作为p38map激酶抑制剂的***并吡啶衍生物
GB0902648D0 (en) 2009-02-17 2009-04-01 Argenta Discovery Ltd Pharmaceutical compounds and compositions
WO2011005860A2 (en) * 2009-07-07 2011-01-13 Alnylam Pharmaceuticals, Inc. 5' phosphate mimics
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
MX2012001838A (es) 2009-08-12 2012-02-29 Novartis Ag Compuestos de hidrazona heterociclico y sus usos para tratar cancer e inflamacion.
AU2010284254B2 (en) 2009-08-17 2015-09-17 Intellikine, Llc Heterocyclic compounds and uses thereof
JP5775871B2 (ja) 2009-08-20 2015-09-09 ノバルティス アーゲー ヘテロ環式オキシム化合物
GB201009731D0 (en) 2010-06-10 2010-07-21 Pulmagen Therapeutics Inflamma Kinase inhibitors
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
JP2014505088A (ja) 2011-02-10 2014-02-27 ノバルティス アーゲー Ｃ−ＭＥＴチロシンキナーゼ阻害剤としての［１，２，４］トリアゾロ［４，３−ｂ］ピリダジン化合物
WO2012116237A2 (en) 2011-02-23 2012-08-30 Intellikine, Llc Heterocyclic compounds and uses thereof
CN103492384B (zh) 2011-02-25 2016-05-11 诺华股份有限公司 作为trk抑制剂的化合物和组合物
BR112014006223A8 (pt) 2011-09-15 2018-01-09 Novartis Ag 3-(quinolin-6-iltio)-[1,2,4-triazol[4,3-a] piradinas 6-substituídas, seus usos, composições farmacêuticas, e combinação
US20130209543A1 (en) 2011-11-23 2013-08-15 Intellikine Llc Enhanced treatment regimens using mtor inhibitors
SG11201402986RA (en) 2011-12-09 2014-12-30 Chiesi Farma Spa Kinase inhibitors
CA2858420A1 (en) 2011-12-09 2013-06-13 Chiesi Farmaceutici S.P.A. Derivatives of 4-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl urea and their use in the treatment of, inter alia, diseases of the respiratory tract
EP2788349B1 (en) 2011-12-09 2016-10-26 Chiesi Farmaceutici S.p.A. Kinase inhibitors
CN104245701A (zh) 2012-04-03 2014-12-24 诺华有限公司 有酪氨酸激酶抑制剂的组合产品和其应用
EP2867236B1 (en) 2012-06-29 2017-06-14 Pfizer Inc Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors
EP2968340A4 (en) 2013-03-15 2016-08-10 Intellikine Llc COMBINING KINASE INHIBITORS AND USES THEREOF
CA2914432A1 (en) 2013-06-06 2014-12-11 Chiesi Farmaceutici S.P.A. Kinase inhibitors
CA2922770A1 (en) 2013-09-05 2015-03-12 F. Hoffmann-La Roche Ag Triazolopyridine compounds, compositions and methods of use thereof
TW201605450A (zh) 2013-12-03 2016-02-16 諾華公司 Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途
WO2015092592A1 (en) 2013-12-17 2015-06-25 Pfizer Inc. Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
WO2016011658A1 (en) 2014-07-25 2016-01-28 Novartis Ag Combination therapy
CA2954862A1 (en) 2014-07-31 2016-02-04 Novartis Ag Combination therapy
CN107428750A (zh) 2015-03-04 2017-12-01 豪夫迈·罗氏有限公司 ***并吡啶化合物及其使用方法
AU2016322813B2 (en) 2015-09-14 2021-04-01 Pfizer Inc. Novel imidazo (4,5-c) quinoline and imidazo (4,5-c)(1,5) naphthyridine derivatives as LRRK2 inhibitors
TW201720828A (zh) 2015-11-23 2017-06-16 赫孚孟拉羅股份公司 治療性化合物及組合物以及其使用方法
WO2017108736A1 (en) 2015-12-23 2017-06-29 Chiesi Farmaceutici S.P.A. N-[3-(3-{4-[[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl} -ureido)-phenyl]-methanesulfonamide derivatives and their use as p38 mapk inhibitors
AR107165A1 (es) 2015-12-23 2018-03-28 Chiesi Farm Spa Inhibidores de quinasa
MA44131A (fr) 2015-12-23 2021-05-26 Chiesi Farm Spa Dérivés de 1-(3-tert-butyl-2h-pyrazol-5-yl or 5-tert-butyl-isoxaol-3-yl)-3-(4-([1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro-naphthalenyl) urée et leur utlisation en tant qu'inhibiteurs de p38 mapk
JP7034942B2 (ja) 2016-05-05 2022-03-14 エフ．ホフマン－ラ ロシュ アーゲー ピラゾール誘導体、その組成物及び治療的使用
CN109890817B (zh) 2016-09-06 2022-06-17 豪夫迈·罗氏有限公司 8-(氮杂环丁烷-1-基)-[1,2,4]***并[1,5-a]吡啶基化合物、其组合物和应用方法
AU2017385543A1 (en) 2016-12-29 2019-05-23 F. Hoffmann-La Roche Ag Pyrazolopyrimidine compounds and methods of use thereof
CN110494434B (zh) 2017-03-14 2022-05-24 豪夫迈·罗氏有限公司 吡唑并氯苯基化合物、其组合物及其使用方法
EP3630766A1 (en) 2017-05-22 2020-04-08 H. Hoffnabb-La Roche Ag Therapeutic compounds and compositions, and methods of use thereof
US20180334465A1 (en) 2017-05-22 2018-11-22 Genentech, Inc. Therapeutic compounds and compositions, and methods of use thereof
US10364245B2 (en) 2017-06-07 2019-07-30 Chiesi Farmaceutici S.P.A. Kinase inhibitors
JP7339263B2 (ja) 2018-01-15 2023-09-05 エフ． ホフマン－ラ ロシュ アーゲー Ｊａｋ阻害剤としてのピラゾロピリミジン化合物
WO2020257143A1 (en) 2019-06-18 2020-12-24 Genentech, Inc. Pyrazolopyrimidine aryl ether inhibitors of jak kinases and uses thereof
TW202115069A (zh) 2019-06-18 2021-04-16 瑞士商赫孚孟拉羅股份公司 Ｊａｋ激酶之經四唑取代之吡唑并嘧啶抑制劑及其用途
JP2022537964A (ja) 2019-06-18 2022-08-31 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｊａｋキナーゼのピラゾロピリミジンスルホン阻害剤およびその使用
TW202140550A (zh) 2020-01-29 2021-11-01 瑞士商諾華公司 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61207400A (ja) * 1985-03-11 1986-09-13 Nippon Zoki Pharmaceut Co Ltd ヌクレオシド化合物の製造方法
US4751292A (en) 1985-07-02 1988-06-14 The Plant Cell Research Institute, Inc. Adamantyl purines
US4859677A (en) 1987-04-17 1989-08-22 University Of Kansas Nucleoside analogues having antiviral activity
US5246931A (en) 1988-10-25 1993-09-21 Bristol-Myers Squibb Company Carbocyclic nucleoside analogs
US5688778A (en) 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
GB8916480D0 (en) 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
US5763596A (en) 1989-09-15 1998-06-09 Metabasis Therapeutics, Inc. C-4' modified adenosine kinase inhibitors
US5674998A (en) 1989-09-15 1997-10-07 Gensia Inc. C-4' modified adenosine kinase inhibitors
US5276151A (en) 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5470857A (en) 1990-09-14 1995-11-28 Marion Merrell Dow Inc. Carbocyclic nucleoside analogs useful as immunosuppressants
SE9003151D0 (sv) 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
ZA923641B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9204015D0 (en) 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
TW374087B (en) 1993-05-25 1999-11-11 Univ Yale L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
AU3086495A (en) * 1994-08-02 1996-03-04 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles
US5659023A (en) 1995-02-01 1997-08-19 Gilead Sciences, Inc. Nucleotide analogues
BR9707185A (pt) 1996-01-23 1999-03-23 Glaxo Group Ltd Nucleosídeos de benzimidazol modificados como agentes antivirais

Also Published As

Publication number Publication date
EP1052264A2 (en) 2000-11-15
CN1275575A (zh) 2000-12-06
HUP0001843A2 (hu) 2001-06-28
IL136027A0 (en) 2001-05-20
EP1052264B1 (en) 2005-03-23
US6271370B1 (en) 2001-08-07
CZ20001710A3 (cs) 2001-09-12
CA2307951A1 (en) 2000-11-11
ID25992A (id) 2000-11-16
MXPA00004532A (es) 2002-03-08
IN186850B (hu) 2001-11-24
KR20010069193A (ko) 2001-07-23
PL340109A1 (en) 2000-11-20
EP1052264A3 (en) 2001-06-13
KR100403900B1 (ko) 2003-11-01
TR200001340A2 (tr) 2000-12-21
DE60018833D1 (de) 2005-04-28
ZA200002263B (en) 2001-12-24
RU2200738C2 (ru) 2003-03-20
AU3401100A (en) 2000-11-16
JP2001011092A (ja) 2001-01-16
AR028991A1 (es) 2003-06-04
ATE291582T1 (de) 2005-04-15
BR0002089A (pt) 2001-01-02
YU25500A (sh) 2003-08-29
HU0001843D0 (en) 2000-07-28

Similar Documents

Publication Publication Date Title
HUP0001843A3 (en) Process for synthesis of nucleoside analogs
EP1066308A4 (en) METHOD FOR SYNTHESIS OF OLIGONUCLEOTIDED
GR3031043T3 (en) Process for the diastereoselective synthesis of nucleoside analogues
TW419101U (en) Structure of fastening apparatus for instrument
HUP0004227A3 (en) Direct ortho-metalation process for the synthesis of 5-(2-substituted-phenyl)-tetrazol derivatives
HUP0102867A3 (en) Process for synthesis of morpholine derivatives
HUP0103241A3 (en) New process for the synthesis of (1h)-benzo[c]quinolizin-3-ones derivatives
SG94873A1 (en) Reactor for generating high purity moisture
EP1175432A4 (en) METHOD FOR PRODUCING OLIGOMERS USING PHOSPHORAMIDITE COMPOSITIONS
EP1554298A4 (en) PROCESS FOR PREPARING 9-BETA-ANOMERIC NUCLEOSIDE ANALOGUE
HUP0003984A3 (en) Process for synthesis of carbocyclyc chloropurine nucleoside analogues
IL150410A0 (en) METHODS FOR SYNTHESIS OF α-D-GAL (1-3) GAL-CONTAINING OLIGOSACCHARIDES
HUP0202315A2 (en) Process for deacylation of lipodepsipeptides
GB2356395B (en) Direct synthesis process of indium phosphide
PL343334A1 (en) Apparatus for obtaining aluminium of highest purity
EP1186612A4 (en) PROCESS FOR THE PREPARATION OF CYTIDIN DERIVATIVES
HUP0103105A3 (en) Process for the synthesis of exochelins
HUP0103672A3 (en) Process for preparation of exochelins
HU9904575D0 (en) Process for preparation of n-alkoxy-methyl-acidamides
PL343270A1 (en) Process for the preparation of nitroguanidine derivatives
HUP9901699A3 (en) Process for producing of l-asparagine-acid
ZA953235B (en) Process for the diastereoselective synthesis of nucleoside analogues
SI0757684T1 (en) Process for the diastereoselective synthesis of nucleoside analogues
EP1338654A4 (en) METHOD FOR PRODUCING A NUCLEOSIDE COMPOUND
SI0817784T1 (en) Process for the synthesis of nucleoside analogues