HUP0001094A2 - Eljárás naloxon és sói stabilizálására, és naloxont tartalmazó, stabilizált gyógyszerkészítmények - Google Patents

Eljárás naloxon és sói stabilizálására, és naloxont tartalmazó, stabilizált gyógyszerkészítmények

Info

Publication number
HUP0001094A2
HUP0001094A2 HU0001094A HUP0001094A HUP0001094A2 HU P0001094 A2 HUP0001094 A2 HU P0001094A2 HU 0001094 A HU0001094 A HU 0001094A HU P0001094 A HUP0001094 A HU P0001094A HU P0001094 A2 HUP0001094 A2 HU P0001094A2
Authority
HU
Hungary
Prior art keywords
naloxone
stabilization
pharmaceutical compositions
compositions containing
stable pharmaceutical
Prior art date
Application number
HU0001094A
Other languages
English (en)
Inventor
Bernd Raffelsberger
Original Assignee
Gödecke Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gödecke Aktiengesellschaft filed Critical Gödecke Aktiengesellschaft
Publication of HUP0001094A2 publication Critical patent/HUP0001094A2/hu
Publication of HUP0001094A3 publication Critical patent/HUP0001094A3/hu
Publication of HU224964B1 publication Critical patent/HU224964B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

A találmány tárgya eljárás nalőxőn és sói stabilizálására őldatőkban,valamint szilárd és félig szilárd anyagkeverékekben különösenfőlyékőny és szilárd gyógyszerfőrmákban. A találmány értelmébenszerves vagy szervetlen stabilizátőrt adnak a nalőxőnhőz őlyanmennyiségben, amely meggátőlja a nalőxőnnak 2,2'-dinalőxőnná történődimerizációját. A találmány tővábbi tárgyát képezik a stabilizátőrőkattartalmazó gyógyszerfőrmák. ŕ
HU0001094A 1997-02-14 1998-02-03 Process for stabilization of naloxone and stable pharmaceutical compositions containing naloxone HU224964B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19705537 1997-02-14
PCT/EP1998/000556 WO1998035679A1 (de) 1997-02-14 1998-02-03 Stabilisierung von naloxonhydrochlorid

Publications (3)

Publication Number Publication Date
HUP0001094A2 true HUP0001094A2 (hu) 2000-09-28
HUP0001094A3 HUP0001094A3 (en) 2001-02-28
HU224964B1 HU224964B1 (en) 2006-04-28

Family

ID=7820153

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001094A HU224964B1 (en) 1997-02-14 1998-02-03 Process for stabilization of naloxone and stable pharmaceutical compositions containing naloxone

Country Status (10)

Country Link
EP (1) EP0880352B1 (hu)
AT (1) ATE186643T1 (hu)
CZ (1) CZ297951B6 (hu)
DE (1) DE59800046D1 (hu)
ES (1) ES2141631T3 (hu)
GR (1) GR3032458T3 (hu)
HU (1) HU224964B1 (hu)
PL (1) PL190293B1 (hu)
SK (1) SK282549B6 (hu)
WO (1) WO1998035679A1 (hu)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE210983T1 (de) * 1997-11-03 2002-01-15 Stada Arzneimittel Ag Stabilisiertes kombinationsarzneimittel enthaltend naloxone und ein opiatanalgetikum
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
PL193273B1 (pl) 1997-12-22 2007-01-31 Euro Celtique Sa Postać dawkowania doustnego
PL341309A1 (en) 1997-12-22 2001-04-09 Euro Celtique Method of preventing overdosage of opioidic preparations
CN1423559A (zh) 2000-02-08 2003-06-11 欧罗赛铁克股份有限公司 包含阿片样激动剂和拮抗剂的控释组合物
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
DE60238756D1 (de) 2001-05-11 2011-02-10 Endo Pharmaceuticals Inc Opioid enthaltende arzneiform gegen missbrauch
WO2003013433A2 (en) 2001-08-06 2003-02-20 Euro-Celtique S.A. Sequestered antagonist formulations
DE60232417D1 (de) 2001-08-06 2009-07-02 Euro Celtique Sa Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist
US20140271788A1 (en) 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
CN1652752A (zh) 2002-03-14 2005-08-10 欧罗赛铁克股份有限公司 盐酸纳曲酮组合物
CA2478523A1 (en) 2002-04-05 2003-10-16 Euro-Celtique S.A. Matrix for sustained, invariant and independent release of active compounds
EP2422772A3 (en) 2002-09-20 2012-04-18 Alpharma, Inc. Sequestering subunit and related compositions and methods
PL2368553T3 (pl) 2003-04-08 2015-05-29 Progenics Pharm Inc Preparaty farmaceutyczne zawierające metylonaltrekson
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
HUE032156T2 (hu) 2006-06-19 2017-09-28 Alpharma Pharmaceuticals Llc Gyógyszerészeti készítmények
KR101491656B1 (ko) 2007-04-26 2015-02-09 도레이 카부시키가이샤 4,5-에폭시모르피난 유도체를 함유하는 안정한 고형 제제
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
ES2660001T3 (es) 2008-10-24 2018-03-20 Toray Industries, Inc. Comprimido estable que contiene un derivado de 4,5-epoximorfinano
ES2706407T3 (es) 2009-03-10 2019-03-28 Euro Celtique Sa Composiciones farmacéuticas de liberación inmediata que comprenden oxicodona y naloxona
NZ703564A (en) 2010-03-11 2016-08-26 Wyeth Llc Oral formulations and lipophilic salts of methylnaltrexone
KR20130030261A (ko) 2010-05-10 2013-03-26 유로-셀티큐 에스.에이. 활성제-무함유 과립 및 그를 포함하는 정제의 제조
CA2798885C (en) 2010-05-10 2014-11-18 Euro-Celtique S.A. Combination of active loaded granules with additional actives
CA2795324C (en) * 2012-11-09 2015-07-14 Purdue Pharma Pharmaceutical compositions comprising hydromorphone and naloxone
AU2014295042B2 (en) 2013-07-23 2017-03-30 Mundipharma Pty Limited A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
CN112716955A (zh) 2013-11-13 2021-04-30 欧洲凯尔特公司 用于治疗疼痛和阿片样物质肠功能障碍综合征的氢***酮和纳洛酮
WO2015095644A1 (en) 2013-12-20 2015-06-25 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
US11135155B2 (en) 2014-07-08 2021-10-05 Hikma Pharmaceuticals Usa Inc. Liquid naloxone spray
JP2017519803A (ja) * 2014-07-08 2017-07-20 インシス・ファーマ・インコーポレーテッド 舌下ナロキソンスプレー

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS276692B6 (cs) * 1990-08-29 1992-07-15 Z Presneho Strojirenstvi Zařízení k řazení hřebíků v násypce plníce
JPH07267862A (ja) * 1994-03-29 1995-10-17 Sekisui Chem Co Ltd 経皮吸収貼付剤
DE4423850A1 (de) * 1994-07-07 1996-01-11 Labtec Gmbh Transdermales therapeutisches System zur Applikation von Naloxon
AU2059297A (en) * 1996-03-12 1997-10-01 Alza Corporation Composition and dosage form comprising opioid antagonist

Also Published As

Publication number Publication date
DE59800046D1 (de) 1999-12-23
CZ289699A3 (cs) 2000-02-16
SK109299A3 (en) 2000-08-14
HUP0001094A3 (en) 2001-02-28
PL190293B1 (pl) 2005-11-30
WO1998035679A1 (de) 1998-08-20
SK282549B6 (sk) 2002-10-08
CZ297951B6 (cs) 2007-05-02
GR3032458T3 (en) 2000-05-31
HU224964B1 (en) 2006-04-28
EP0880352A2 (de) 1998-12-02
ES2141631T3 (es) 2000-03-16
ATE186643T1 (de) 1999-12-15
EP0880352B1 (de) 1999-11-17
PL335249A1 (en) 2000-04-10

Similar Documents

Publication Publication Date Title
HUP0001094A2 (hu) Eljárás naloxon és sói stabilizálására, és naloxont tartalmazó, stabilizált gyógyszerkészítmények
DK0722313T3 (da) Viskoelastiske sammensætninger af fluorerede organiske forbindelser
HUP0100625A2 (hu) Dibenzilidén-szorbitot és funkcionalizált szilikonokat tartalmazó kozmetikai készítmények
DE69812343D1 (de) Feste pharmazeutische formulierungen enthaltend eine physische mischung aus sulphoalkylethercyclodextrin und einem therapeutischen wirkstoff
BR9809865A (pt) Fixador de perfume, perfume e produto base misturados com o mesmo, e, produto perfumado.
RU94043772A (ru) Пропинил-диароматические соединения, фармацевтические и косметические составы на их основе
HUP9900717A2 (hu) Szilárd dezodoráló készítmény
KR960034164A (ko) 스틸벤 유도체 및 이를 함유하는 약제학적 조성물
IT1178235B (it) Composizioni farmaceutiche contenenti sucralfat e procedimento per la loro stabilizzazione
FI971486A0 (fi) Alfa-interferonin stabiilit vesiliuosformulaatiot
DE69313455D1 (de) Feuchthaltende lippenstiftzusammensetzungen
TR199800019T1 (xx) Trombosit topaklanmas�n� �nleyici yeni maddeler.
FI20000172A (fi) Itse-emulgoituvan valmisteen muodossa oleva farmaseuttinen koostumus happamia lipoifiilisia yhdisteitä varten
ATE321543T1 (de) Pharmazeutische zusammensetzungen mit hydroximsäurederivaten
HUP0103203A2 (hu) Azaadamantánszármazékok és ezeket tartalmazó gyógyszerkészítmények
SE8404065D0 (sv) Novel biologically active compounds
NO304598B1 (no) Forgrenet-amino-substituerte tiazoler, anvendelse av dem og farmas°ytiske blandinger inneholdende dem
HUT55034A (en) Process for producing peptides with hemoregulating effect and pharmaceutical compositions comprising such compounds as active ingredient
RU94038042A (ru) Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент
SE8600658D0 (sv) Novel composition of matter
HUT53481A (en) Process for stabilization of derivatives os izotiasolone
FI923751A0 (fi) Hexahydrobenso/f/kinolinoner.
HUP9702348A2 (hu) Új, véralvadásgátló hatású glikozidok és az ezeket tartalmazó gyógyszerkészítmények
IT1274483B (it) Composizioni farmaceutiche contenenti gemfibrozil
FR2768145B1 (fr) Nouveaux composes derives d'acide alkylene diamine di- ou tri-acetique, leur procede de preparation, leur utilisation dans des compositions cosmetiques et pharmaceutiques, et compositions les comprenant