ES2141631T3 - Estabilizacion del hidrocloruro de naloxon. - Google Patents

Estabilizacion del hidrocloruro de naloxon.

Info

Publication number
ES2141631T3
ES2141631T3 ES98905128T ES98905128T ES2141631T3 ES 2141631 T3 ES2141631 T3 ES 2141631T3 ES 98905128 T ES98905128 T ES 98905128T ES 98905128 T ES98905128 T ES 98905128T ES 2141631 T3 ES2141631 T3 ES 2141631T3
Authority
ES
Spain
Prior art keywords
naloxon
hydrochloride
stabilization
sulphite
dinaloxon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98905128T
Other languages
English (en)
Inventor
Bernd Raffelsberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goedecke GmbH
Original Assignee
Goedecke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke GmbH filed Critical Goedecke GmbH
Application granted granted Critical
Publication of ES2141631T3 publication Critical patent/ES2141631T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cereal-Derived Products (AREA)
  • Organic Insulating Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION TRATA DE UN PROCEDIMIENTO DESTINADO A ESTABILIZAR NALOXON Y SUS SALES INHIBIENDO LA DIMERIZACION DEL NALOXON EN 2,2 - DINALOXON CON AYUDA DE LOS OPORTUNOS ESTABILIZANTES, ENTRE ELLOS DIOXIDO DE AZUFRE Y SULFITO SODICO.
ES98905128T 1997-02-14 1998-02-03 Estabilizacion del hidrocloruro de naloxon. Expired - Lifetime ES2141631T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19705537 1997-02-14

Publications (1)

Publication Number Publication Date
ES2141631T3 true ES2141631T3 (es) 2000-03-16

Family

ID=7820153

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98905128T Expired - Lifetime ES2141631T3 (es) 1997-02-14 1998-02-03 Estabilizacion del hidrocloruro de naloxon.

Country Status (10)

Country Link
EP (1) EP0880352B1 (es)
AT (1) ATE186643T1 (es)
CZ (1) CZ297951B6 (es)
DE (1) DE59800046D1 (es)
ES (1) ES2141631T3 (es)
GR (1) GR3032458T3 (es)
HU (1) HU224964B1 (es)
PL (1) PL190293B1 (es)
SK (1) SK282549B6 (es)
WO (1) WO1998035679A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0913152B1 (de) * 1997-11-03 2001-12-19 Stada Arzneimittel Ag Stabilisiertes Kombinationsarzneimittel enthaltend Naloxone und ein Opiatanalgetikum
ES2264226T3 (es) 1997-12-22 2006-12-16 Euro-Celtique S.A. Forma farmaceutica de dosificacion oral que comprende una combinacion de un agonista opioide y naltrexona.
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
YU39500A (sh) 1997-12-22 2003-02-28 Euro-Celtique S.A. Postupak sprečavanja zloupotrebe oblika za doziranje opijata
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
PT1255547E (pt) 2000-02-08 2008-11-24 Euro Celtique Sa Composições de libertação controlada contendo agonistas e antagonistas opióides
WO2002092060A1 (en) 2001-05-11 2002-11-21 Endo Pharmaceuticals, Inc. Abuse-resistant controlled-release opioid dosage form
NZ530971A (en) 2001-08-06 2004-08-27 Euro Celtique S Oral dosage forms comprising an opioid agonist with releasable and sequestered opioid antagonists
US20030157168A1 (en) 2001-08-06 2003-08-21 Christopher Breder Sequestered antagonist formulations
US20140271788A1 (en) 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
CA2748620C (en) 2002-03-14 2014-03-11 Euro-Celtique, S.A. Naltrexone hydrochloride compositions
US20050245556A1 (en) 2002-04-05 2005-11-03 Bianca Brogmann Pharmaceutical preparation containing oxycodone and naloxone
EP2422773A3 (en) 2002-09-20 2012-04-18 Alpharma, Inc. Sequestering subunit and related compositions and methods
BRPI0409133B8 (pt) 2003-04-08 2021-05-25 Progenics Pharm Inc preparações farmacêuticas estavéis compreendendo metilnaltrexona
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
PT2719378T (pt) 2006-06-19 2016-11-02 Alpharma Pharmaceuticals Llc Composições farmacêuticas
US8420662B2 (en) 2007-04-26 2013-04-16 Toray Industries, Inc. Stable solid preparation containing 4,5-epoxymorphinan derivative
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
WO2010047381A1 (ja) 2008-10-24 2010-04-29 東レ株式会社 ４，５－エポキシモルヒナン誘導体を含有する安定な錠剤
KR20140141727A (ko) 2009-03-10 2014-12-10 유로-셀티큐 에스.에이. 옥시코돈 및 날록손을 포함하는 즉시 방출 제약 조성물
NZ702826A (en) 2010-03-11 2016-08-26 Wyeth Llc Oral formulations and lipophilic salts of methylnaltrexone
WO2011141490A1 (en) 2010-05-10 2011-11-17 Euro-Celtique S.A. Combination of active loaded granules with additional actives
BR112012028788A2 (pt) 2010-05-10 2016-07-19 Euro Celtique Sa fabricação de grânulos sem ativos
CA2881144A1 (en) * 2012-11-09 2014-05-09 Purdue Pharma Pharmaceutical compositions comprising hydromorphone and naloxone
JP2016525138A (ja) 2013-07-23 2016-08-22 ユーロ−セルティーク エス．エイ． 疼痛および腸内ディスバイオシスをもたらす疾患および／または腸内細菌移行に対するリスクを高める疾患に罹患している患者における痛みの治療への使用のためのオキシコドンおよびナロキソンの組み合わせ
EP3068397A1 (en) 2013-11-13 2016-09-21 Euro-Celtique S.A. Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
CA2875384A1 (en) 2013-12-20 2015-06-20 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
US9642848B2 (en) * 2014-07-08 2017-05-09 Insys Development Company, Inc. Sublingual naloxone spray
US11135155B2 (en) 2014-07-08 2021-10-05 Hikma Pharmaceuticals Usa Inc. Liquid naloxone spray

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS276692B6 (cs) * 1990-08-29 1992-07-15 Z Presneho Strojirenstvi Zařízení k řazení hřebíků v násypce plníce
JPH07267862A (ja) * 1994-03-29 1995-10-17 Sekisui Chem Co Ltd 経皮吸収貼付剤
DE4423850A1 (de) * 1994-07-07 1996-01-11 Labtec Gmbh Transdermales therapeutisches System zur Applikation von Naloxon
AU2059297A (en) * 1996-03-12 1997-10-01 Alza Corporation Composition and dosage form comprising opioid antagonist

Also Published As

Publication number Publication date
CZ297951B6 (cs) 2007-05-02
SK109299A3 (en) 2000-08-14
PL335249A1 (en) 2000-04-10
HU224964B1 (en) 2006-04-28
EP0880352B1 (de) 1999-11-17
HUP0001094A2 (hu) 2000-09-28
CZ289699A3 (cs) 2000-02-16
EP0880352A2 (de) 1998-12-02
HUP0001094A3 (en) 2001-02-28
DE59800046D1 (de) 1999-12-23
SK282549B6 (sk) 2002-10-08
PL190293B1 (pl) 2005-11-30
GR3032458T3 (en) 2000-05-31
WO1998035679A1 (de) 1998-08-20
ATE186643T1 (de) 1999-12-15

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