HUE035861T2 - Egy pleuromutilin kristályos formája - Google Patents

Egy pleuromutilin kristályos formája

Info

Publication number
HUE035861T2
HUE035861T2 HUE11724938A HUE11724938A HUE035861T2 HU E035861 T2 HUE035861 T2 HU E035861T2 HU E11724938 A HUE11724938 A HU E11724938A HU E11724938 A HUE11724938 A HU E11724938A HU E035861 T2 HUE035861 T2 HU E035861T2
Authority
HU
Hungary
Prior art keywords
pleuromutilin
crystalline form
crystalline
Prior art date
Application number
HUE11724938A
Other languages
English (en)
Inventor
Rosemarie Riedl
Werner Heilmayer
Lee Spence
Original Assignee
Nabriva Therapeutics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nabriva Therapeutics GmbH filed Critical Nabriva Therapeutics GmbH
Publication of HUE035861T2 publication Critical patent/HUE035861T2/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40Y being a hydrogen or a carbon atom
    • C07C323/41Y being a hydrogen or an acyclic carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43Y being a hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/08Acetic acid
    • C07C53/10Salts thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13Dicarboxylic acids
    • C07C57/145Maleic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/08Lactic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/56Ring systems containing bridged rings
    • C07C2603/58Ring systems containing bridged rings containing three rings
    • C07C2603/76Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
    • C07C2603/82Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
HUE11724938A 2010-05-26 2011-05-23 Egy pleuromutilin kristályos formája HUE035861T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20100450092 EP2399904A1 (en) 2010-05-26 2010-05-26 Process for the preparation of pleuromutilins

Publications (1)

Publication Number Publication Date
HUE035861T2 true HUE035861T2 (hu) 2018-06-28

Family

ID=42937801

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE17197350A HUE057587T2 (hu) 2010-05-26 2011-05-23 Eljárás pleuromutilinek elõállítására
HUE11724938A HUE035861T2 (hu) 2010-05-26 2011-05-23 Egy pleuromutilin kristályos formája

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HUE17197350A HUE057587T2 (hu) 2010-05-26 2011-05-23 Eljárás pleuromutilinek elõállítására

Country Status (29)

Country Link
US (1) US9120727B2 (hu)
EP (3) EP2399904A1 (hu)
JP (2) JP6038021B2 (hu)
KR (1) KR101935333B1 (hu)
CN (2) CN103080083B (hu)
AU (1) AU2011257938B2 (hu)
BR (1) BR112012029982A2 (hu)
CA (1) CA2799029C (hu)
DK (2) DK2576505T3 (hu)
EA (1) EA023273B1 (hu)
ES (2) ES2659729T3 (hu)
HK (1) HK1253006A1 (hu)
HR (1) HRP20220201T1 (hu)
HU (2) HUE057587T2 (hu)
IL (1) IL222999A (hu)
MA (1) MA34332B1 (hu)
MX (1) MX347176B (hu)
MY (1) MY164666A (hu)
NZ (1) NZ603804A (hu)
PL (2) PL2576505T3 (hu)
PT (2) PT3299356T (hu)
SG (1) SG185104A1 (hu)
SI (1) SI3299356T1 (hu)
TN (1) TN2012000506A1 (hu)
TR (1) TR201802636T4 (hu)
TW (1) TWI585073B (hu)
UA (1) UA108378C2 (hu)
WO (1) WO2011146954A1 (hu)
ZA (1) ZA201208056B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104447294A (zh) * 2014-11-24 2015-03-25 苏州乔纳森新材料科技有限公司 一种3-环己烯-1-甲酸的手性拆分方法
LT3310331T (lt) * 2015-06-17 2021-01-11 Nabriva Therapeutics GmbH Švirkščiamos lefamulino farmacinės kompozicijos
PL3310333T3 (pl) 2015-06-18 2020-07-13 Estetra Sprl Ulegająca rozpadowi w jamie ustnej jednostka dawkowana zawierająca składnik estetrolowy
PL3106148T3 (pl) 2015-06-18 2018-08-31 Mithra Pharmaceuticals S A Jednostka dawkowania ulegająca rozpadowi w jamie ustnej zawierająca składnik estetrolowy
TWI762573B (zh) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化
CN107417586A (zh) * 2017-06-21 2017-12-01 华南农业大学 一种截短侧耳素类抗生素及其制备方法和应用
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI755055B (zh) * 2019-09-18 2022-02-11 台灣神隆股份有限公司 用於製備惡拉戈利鈉及其中間體的方法
CN111170893B (zh) * 2020-01-19 2022-04-26 郑州依米花手性药物研究有限公司 Lefamulin的中间体化合物及其在Lefamulin制备中的应用
TW202203908A (zh) 2020-04-17 2022-02-01 奧地利商納畢瓦治療有限責任公司 截短側耳素類之醫療用途
EP4135681A1 (en) * 2020-04-17 2023-02-22 Nabriva Therapeutics GMBH Novel therapeutic use of pleuromutilins
WO2023152115A1 (en) 2022-02-09 2023-08-17 Nabriva Therapeutics GmbH Lefamulin and its derivatives for use in the treatment of a spiral shaped bacteria
EP4338732A1 (en) 2022-09-16 2024-03-20 Nabriva Therapeutics GMBH Lefamulin and its derivatives for use in the treatment of tularemia

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61207370A (ja) * 1985-03-11 1986-09-13 Seitetsu Kagaku Co Ltd 4−(メタンスルホニルオキシ)チオフエノ−ルの製法
GB0017031D0 (en) * 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
ES2295657T3 (es) * 2002-07-24 2008-04-16 Nabriva Therapeutics Forschungs Gmbh Derivados de pleuromutilina como antimicrobianos.
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
AU2004260779B2 (en) * 2003-08-04 2009-01-22 Grindeks Joint Stock Company Meldonium salts, method of their preparation and pharmaceutical composition on their basis
JP5043429B2 (ja) * 2003-08-18 2012-10-10 ハー・ルンドベック・アクチエゼルスカベット トランス−4−((1r,3s)−6−クロロ−3−フェニルインダン−1−イル)−1,2,2−トリメチルピペラジンのコハク酸塩およびマロン酸塩、および薬剤としての使用方法
JP5460947B2 (ja) * 2003-09-03 2014-04-02 グラクソ グループ リミテッド 新規調製方法、塩、組成物及び使用
US9697672B2 (en) 2006-07-20 2017-07-04 Bally Gaming, Inc. Wagering game with special-event eligibility feature based on passive game play
EP1908750A1 (en) * 2006-10-05 2008-04-09 Nabriva Therapeutics Forschungs GmbH Process for the preparation of pleuromutilins
SI1961735T1 (sl) * 2007-02-22 2010-01-29 Indena Spa Postopek za pripravo acetatne soli (2r,3s)-3-fenilizoserin-metilestra
EP1972618A1 (en) 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes
EP2014645A1 (en) 2007-07-13 2009-01-14 Nabriva Therapeutics AG Pleuromutilin derivatives and their use as antimicrobials
EP2159220A1 (en) * 2008-09-02 2010-03-03 Nabriva Therapeutics AG Organic compounds

Also Published As

Publication number Publication date
TN2012000506A1 (en) 2014-04-01
WO2011146954A1 (en) 2011-12-01
PL2576505T3 (pl) 2018-05-30
SI3299356T1 (sl) 2022-05-31
ES2909198T3 (es) 2022-05-05
EP2576505A1 (en) 2013-04-10
HUE057587T2 (hu) 2022-05-28
HRP20220201T1 (hr) 2022-04-29
EA023273B1 (ru) 2016-05-31
PT3299356T (pt) 2022-02-21
CN103080083A (zh) 2013-05-01
EP3299356A1 (en) 2018-03-28
SG185104A1 (en) 2012-12-28
US9120727B2 (en) 2015-09-01
DK3299356T3 (da) 2022-01-31
HK1253006A1 (zh) 2019-06-06
KR20130079406A (ko) 2013-07-10
DK2576505T3 (en) 2018-03-05
CA2799029C (en) 2019-01-29
NZ603804A (en) 2014-03-28
TWI585073B (zh) 2017-06-01
BR112012029982A2 (pt) 2020-09-01
MX2012013645A (es) 2013-05-01
JP6038021B2 (ja) 2016-12-07
EA201291370A1 (ru) 2013-09-30
JP2016210804A (ja) 2016-12-15
MX347176B (es) 2017-04-17
AU2011257938B2 (en) 2016-06-23
IL222999A0 (en) 2013-02-03
ES2659729T3 (es) 2018-03-19
TR201802636T4 (tr) 2018-03-21
EP2399904A1 (en) 2011-12-28
JP6501742B2 (ja) 2019-04-17
ZA201208056B (en) 2014-01-29
IL222999A (en) 2016-02-29
CA2799029A1 (en) 2011-12-01
UA108378C2 (uk) 2015-04-27
TW201209026A (en) 2012-03-01
CN103080083B (zh) 2016-03-02
JP2013528162A (ja) 2013-07-08
PL3299356T3 (pl) 2022-04-04
US20130079400A1 (en) 2013-03-28
KR101935333B1 (ko) 2019-01-04
PT2576505T (pt) 2018-03-05
EP2576505B1 (en) 2017-11-29
EP3299356B1 (en) 2021-11-24
MY164666A (en) 2018-01-30
CN105111117A (zh) 2015-12-02
MA34332B1 (fr) 2013-06-01

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