EA201291370A1 - Способ получения плеуромутилинов - Google Patents

Способ получения плеуромутилинов

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Publication number
EA201291370A1
EA201291370A1 EA201291370A EA201291370A EA201291370A1 EA 201291370 A1 EA201291370 A1 EA 201291370A1 EA 201291370 A EA201291370 A EA 201291370A EA 201291370 A EA201291370 A EA 201291370A EA 201291370 A1 EA201291370 A1 EA 201291370A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
compound
compounds
pleuromutilins
producing
Prior art date
Application number
EA201291370A
Other languages
English (en)
Other versions
EA023273B1 (ru
Inventor
Роземари Ридль
Вернер Хайльмайер
Ли Спенс
Original Assignee
Набрива Терапьютикс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Набрива Терапьютикс Аг filed Critical Набрива Терапьютикс Аг
Publication of EA201291370A1 publication Critical patent/EA201291370A1/ru
Publication of EA023273B1 publication Critical patent/EA023273B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/08—Acetic acid
    • C07C53/10—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/08—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
    • C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Способ получения соединения формулы Iв виде отдельного стереоизомера в кристаллической форме, включающий удаление аминозащитной группы в соединении формулы IIaили в смеси соединения формулы IIa и соединения формулы IIbи выделение соединения формулы I из реакционной смеси; соединения и соли соединений формулы I в кристаллической форме; фармацевтические композиции, содержащие такие соли; способы получения промежуточных соединений и промежуточные соединения в способе получения соединения формулы I.
EA201291370A 2010-05-26 2011-05-23 Способ получения плеуромутилинов EA023273B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20100450092 EP2399904A1 (en) 2010-05-26 2010-05-26 Process for the preparation of pleuromutilins
PCT/AT2011/000237 WO2011146954A1 (en) 2010-05-26 2011-05-23 Process for the preparation of pleuromutilins

Publications (2)

Publication Number Publication Date
EA201291370A1 true EA201291370A1 (ru) 2013-09-30
EA023273B1 EA023273B1 (ru) 2016-05-31

Family

ID=42937801

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201291370A EA023273B1 (ru) 2010-05-26 2011-05-23 Способ получения плеуромутилинов

Country Status (29)

Country Link
US (1) US9120727B2 (ru)
EP (3) EP2399904A1 (ru)
JP (2) JP6038021B2 (ru)
KR (1) KR101935333B1 (ru)
CN (2) CN103080083B (ru)
AU (1) AU2011257938B2 (ru)
BR (1) BR112012029982A2 (ru)
CA (1) CA2799029C (ru)
DK (2) DK3299356T3 (ru)
EA (1) EA023273B1 (ru)
ES (2) ES2659729T3 (ru)
HK (1) HK1253006A1 (ru)
HR (1) HRP20220201T1 (ru)
HU (2) HUE057587T2 (ru)
IL (1) IL222999A (ru)
MA (1) MA34332B1 (ru)
MX (1) MX347176B (ru)
MY (1) MY164666A (ru)
NZ (1) NZ603804A (ru)
PL (2) PL2576505T3 (ru)
PT (2) PT2576505T (ru)
SG (1) SG185104A1 (ru)
SI (1) SI3299356T1 (ru)
TN (1) TN2012000506A1 (ru)
TR (1) TR201802636T4 (ru)
TW (1) TWI585073B (ru)
UA (1) UA108378C2 (ru)
WO (1) WO2011146954A1 (ru)
ZA (1) ZA201208056B (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104447294A (zh) * 2014-11-24 2015-03-25 苏州乔纳森新材料科技有限公司 一种3-环己烯-1-甲酸的手性拆分方法
LT3310331T (lt) * 2015-06-17 2021-01-11 Nabriva Therapeutics GmbH Švirkščiamos lefamulino farmacinės kompozicijos
TN2017000497A1 (en) 2015-06-18 2019-04-12 Mithra Pharmaceuticals S A Orodispersible dosage unit containing an estetrol component
LT3106148T (lt) 2015-06-18 2018-06-25 Mithra Pharmaceuticals S.A. Burnoje disperguojamos dozės vienetas, turintis estetrolio komponentą
TWI762573B (zh) * 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化
CN107417586A (zh) * 2017-06-21 2017-12-01 华南农业大学 一种截短侧耳素类抗生素及其制备方法和应用
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI755055B (zh) * 2019-09-18 2022-02-11 台灣神隆股份有限公司 用於製備惡拉戈利鈉及其中間體的方法
CN111170893B (zh) * 2020-01-19 2022-04-26 郑州依米花手性药物研究有限公司 Lefamulin的中间体化合物及其在Lefamulin制备中的应用
EP4135681A1 (en) 2020-04-17 2023-02-22 Nabriva Therapeutics GMBH Novel therapeutic use of pleuromutilins
BR112022020007A2 (pt) * 2020-04-17 2022-11-22 Nabriva Therapeutics GmbH Uso terapêutico de pleuromutilinas
WO2023152115A1 (en) 2022-02-09 2023-08-17 Nabriva Therapeutics GmbH Lefamulin and its derivatives for use in the treatment of a spiral shaped bacteria
EP4338732A1 (en) 2022-09-16 2024-03-20 Nabriva Therapeutics GMBH Lefamulin and its derivatives for use in the treatment of tularemia

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61207370A (ja) * 1985-03-11 1986-09-13 Seitetsu Kagaku Co Ltd ４−（メタンスルホニルオキシ）チオフエノ−ルの製法
GB0017031D0 (en) * 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
WO2004011431A1 (en) * 2002-07-24 2004-02-05 Sandoz Ag Pleuromutilin derivatives as antimicrobbials
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
UA82540C2 (ru) * 2003-08-04 2008-04-25 "Джоінт Сток Компані Гріндекс" Соли мелдония, способ их получения и фармацевтическая композиция (варианты) на их основе
JP5043429B2 (ja) * 2003-08-18 2012-10-10 ハー・ルンドベック・アクチエゼルスカベット トランス−４−（（１ｒ，３ｓ）−６−クロロ−３−フェニルインダン−１−イル）−１，２，２−トリメチルピペラジンのコハク酸塩およびマロン酸塩、および薬剤としての使用方法
US7875630B2 (en) * 2003-09-03 2011-01-25 Glaxo Group Limited Process salts compositions and use
WO2008011089A2 (en) 2006-07-20 2008-01-24 Wms Gaming Inc. Wagering game with special-event eligibility feature based on passive game play
EP1908750A1 (en) * 2006-10-05 2008-04-09 Nabriva Therapeutics Forschungs GmbH Process for the preparation of pleuromutilins
SI1961735T1 (sl) * 2007-02-22 2010-01-29 Indena Spa Postopek za pripravo acetatne soli (2r,3s)-3-fenilizoserin-metilestra
EP1972618A1 (en) 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes
EP2014645A1 (en) * 2007-07-13 2009-01-14 Nabriva Therapeutics AG Pleuromutilin derivatives and their use as antimicrobials
EP2159220A1 (en) * 2008-09-02 2010-03-03 Nabriva Therapeutics AG Organic compounds

Also Published As

Publication number Publication date
EP3299356A1 (en) 2018-03-28
PL3299356T3 (pl) 2022-04-04
HRP20220201T1 (hr) 2022-04-29
EP2576505A1 (en) 2013-04-10
CA2799029C (en) 2019-01-29
ES2659729T3 (es) 2018-03-19
TW201209026A (en) 2012-03-01
SG185104A1 (en) 2012-12-28
CN103080083A (zh) 2013-05-01
SI3299356T1 (sl) 2022-05-31
MX347176B (es) 2017-04-17
PT3299356T (pt) 2022-02-21
JP6501742B2 (ja) 2019-04-17
JP2013528162A (ja) 2013-07-08
TR201802636T4 (tr) 2018-03-21
PT2576505T (pt) 2018-03-05
EP3299356B1 (en) 2021-11-24
TN2012000506A1 (en) 2014-04-01
IL222999A (en) 2016-02-29
JP6038021B2 (ja) 2016-12-07
AU2011257938B2 (en) 2016-06-23
MX2012013645A (es) 2013-05-01
MY164666A (en) 2018-01-30
DK2576505T3 (en) 2018-03-05
CA2799029A1 (en) 2011-12-01
HUE035861T2 (hu) 2018-06-28
KR101935333B1 (ko) 2019-01-04
BR112012029982A2 (pt) 2020-09-01
MA34332B1 (fr) 2013-06-01
KR20130079406A (ko) 2013-07-10
EP2576505B1 (en) 2017-11-29
DK3299356T3 (da) 2022-01-31
ZA201208056B (en) 2014-01-29
HK1253006A1 (zh) 2019-06-06
ES2909198T3 (es) 2022-05-05
EA023273B1 (ru) 2016-05-31
UA108378C2 (uk) 2015-04-27
WO2011146954A1 (en) 2011-12-01
IL222999A0 (en) 2013-02-03
US9120727B2 (en) 2015-09-01
US20130079400A1 (en) 2013-03-28
CN105111117A (zh) 2015-12-02
TWI585073B (zh) 2017-06-01
JP2016210804A (ja) 2016-12-15
PL2576505T3 (pl) 2018-05-30
CN103080083B (zh) 2016-03-02
EP2399904A1 (en) 2011-12-28
NZ603804A (en) 2014-03-28
HUE057587T2 (hu) 2022-05-28

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